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Enfermedades Infecciosas y Microbiologia Clinica, ISSN 0213-005X, 01/2017, Volume 35, pp. 22 - 27
Dalbavancin is a new lipoglycopeptide antibiotic whose structure influences its pharmacokinetic profile. It is not absorbed after oral administration and is... 
Pharmacokinetics | Pharmacokinetics/pharmacodynamics | Dalbavancin
Journal Article
Clinical Infectious Diseases, ISSN 1058-4838, 12/2015, Volume 61, Issue 12, pp. 1778 - 1780
Journal Article
European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 07/2015, Volume 74, pp. 45 - 62
Morphine is a widely used opioid for treatment of moderate to severe pain, but large interindividual variability in patient response and no clear guidance on... 
Analgesia | Simulations | Morphine | Modelling | Morphine-6-glucuronide | Pharmacokinetics/pharmacodynamics
Journal Article
Drug Metabolism and Pharmacokinetics, ISSN 1347-4367, 10/2019
Journal Article
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, ISSN 0066-4804, 07/2019, Volume 63, Issue 7
A two-compartment pharmacokinetic (PK) population model of anidulafungin was fitted to PK data from 23 critically ill patients (age, 65 years [range, 28 to 81... 
anidulafungin | MICAFUNGIN | Candida | pharmacokinetics/pharmacodynamics | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | critical care unit | Monte Carlo simulation
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 09/2019, Volume 108, Issue 9, pp. 3124 - 3129
Microdialysis is a technique that utilizes a semipermeable membrane to sample analytes present within tissue interstitial fluid. Analyte-specific calibration... 
mass spectrometry | metabolism | microdialysis | biomarkers | pharmacokinetics/pharmacodynamics | immunotherapy | CHEMISTRY, MEDICINAL | PHARMACOLOGY & PHARMACY | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Current Opinion in Pharmacology, ISSN 1471-4892, 10/2017, Volume 36, pp. 107 - 113
Monte Carlo simulation is used to generate data for pharmacokinetic–pharmacodynamic (PK-PD) target attainment analyses to assess antibacterial dosing regimens... 
PHARMACOKINETICS-PHARMACODYNAMICS | TIGECYCLINE | BACTERIA | BREAKPOINT | PHARMACOLOGY & PHARMACY | STAPHYLOCOCCUS-AUREUS | INFECTION MODEL | EXPOSURE
Journal Article
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, ISSN 0066-4804, 07/2019, Volume 63, Issue 7
Mycobacterium abscessus is responsible for difficult-to-treat chronic pulmonary infections in humans. Current regimens, including parenteral administrations of... 
PULMONARY | cefoxitin | BIOPHARMACEUTICAL CHARACTERIZATION | ANTIMICROBIAL AGENTS | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | pharmacokinetics-pharmacodynamics | Mycobacterium abscessus | nebulization | Index Medicus
Journal Article
by Roberts, Jason A and Paul, Sanjoy K and Akova, Murat and Bassetti, Matteo and De Waele, Jan J and Dimopoulos, George and Kaukonen, Kirsi-Maija and Koulenti, Despoina and Martin, Claude and Montravers, Philippe and Rello, Jordi and Rhodes, Andrew and Starr, Therese and Wallis, Steven C and Lipman, Jeffrey and Margarit Ribas, Antonio and De Crop, Luc and Spapen, Herbert and Wauters, Joost and Dugernier, Thierry and Jorens, Philippe and Dapper, Ilse and De Backer, Daniel and Taccone, Fabio S and Ruano, Laura and Afonso, Elsa and Alvarez-Lerma, Francisco and Gracia-Arnillas, Maria Pilar and Fernández, Francisco and Feijoo, Neus and Bardolet, Neus and Rovira, Assumpta and Garro, Pau and Colon, Diana and Castillo, Carlos and Fernado, Juan and Lopez, Maria Jesus and Fernandez, Jose Luis and Arribas, Ana Maria and Teja, Jose Luis and Ots, Elsa and Carlos Montejo, Juan and Catalan, Mercedes and Prieto, Isidro and Gonzalo, Gloria and Galvan, Beatriz and Blasco, Miguel Angel and Meyer, Estibaliz and Del Nogal, Frutos and Vidaur, Loreto and Sebastian, Rosa and Garde, Pila Marco and Martin Velasco, Maria Del Mar and Zaragoza Crespo, Rafael and Esperatti, Mariano and Torres, Antoni and Baldesi, Olivier and Dupont, Herve and Mahjoub, Yazine and Lasocki, Sigismond and Constantin, Jean Michel and Payen, Jean François and Albanese, Jacques and Malledant, Yannick and Pottecher, Julien and Lefrant, Jean-Yves and Jaber, Samir and Joannes-Boyau, Olivier and Orban, Christophe and Ostermann, Marlies and McKenzie, Cathrine and Berry, William and Smith, John and Lei, Katie and Rubulotta, Francesca and Gordon, Anthony and Brett, Stephen and Stotz, Martin and Templeton, Maie and Ebm, Claudia and Moran, Carl and Pettilä, Ville and Xristodoulou, Aglaia and Theodorou, Vassiliki and Kouliatsis, Georgios and Sertaridou, Eleni and Anthopoulos, Georgios and Choutas, George and Rantis, Thanos and Karatzas, Stylianos and Balla, Margarita and Papanikolaou, Metaxia and Myrianthefs, Pavlos and Gavala, Alexandra and Fildisis, Georgios and Koutsoukou, Antonia and Kyriakopoulou, Magdalini and Petrochilou, Kalomoira and Kompoti, Maria and Michalia, Martha and ...
Clinical Infectious Diseases, ISSN 1058-4838, 04/2014, Volume 58, Issue 8, pp. 1072 - 1083
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 02/2018, Volume 62, Issue 2
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 09/2019, Volume 108, Issue 9, pp. 3099 - 3105
The aims of this study were to evaluate the pharmacokinetics of doripenem (Finibax , Doribax , S-4661), a parenteral carbapenem antibiotic, in pediatric... 
antiinfectives | clinical pharmacokinetics | Monte Carlo | pharmacokinetics-pharmacodynamics | doripenem | pediatric | CHEMISTRY, MEDICINAL | SIZE | PHARMACOLOGY & PHARMACY | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 08/2018, Volume 62, Issue 8
pulmonary infection is a global problem. Standard combination therapy consists of isoniazid at 300 mg/day, rifampin at 600 mg/day, and ethambutol at 15 mg/kg... 
Standard therapy | Efflux pumps | Pharmacokinetics/pharmacodynamics | Benchmarking model | Hollow-fiber system model
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 04/2018, Volume 62, Issue 4
We previously demonstrated that the rate and extent of an antimicrobial agent's bactericidal effects were coupled to the bacterial replication rate, the latter... 
Pharmacokinetics-pharmacodynamics | Therapy duration | Bacterial replication | therapy duration | bacterial replication | PSEUDOMONAS-AERUGINOSA | GROWTH | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | pharmacokinetics-pharmacodynamics | TAZOBACTAM | CEFTOLOZANE
Journal Article
Journal Article
Clinical Infectious Diseases, ISSN 1058-4838, 11/2018, Volume 67, Issue suppl_3, pp. S303 - S307
Abstract Background Amikacin has been used for over 40 years in multidrug resistant tuberculosis (MDR-TB), but there is still debate on the right dose. The aim... 
optimal dose | Monte Carlo simulation | pharmacokinetics/pharmacodynamics | probability of target attainment | INFECTIOUS DISEASES | EARLY BACTERICIDAL ACTIVITY | REGIMEN | MICROBIOLOGY | IMMUNOLOGY | PHARMACOKINETICS | CLEARANCE LIPOSOMAL AMIKACIN | EXPOSURE | DOSAGE | Index Medicus
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 7/2011, Volume 28, Issue 7, pp. 1460 - 1464
Journal Article
The Journal of antimicrobial chemotherapy, ISSN 0305-7453, 06/2019, Volume 74, Issue 6, pp. 1607 - 1617
Background: MDR-TB and XDR-TB have poor outcomes. Objectives: To examine the efficacy of tigecycline monotherapy in the hollow fibre system model of TB.... 
INFECTIOUS DISEASES | EARLY BACTERICIDAL ACTIVITY | TUBERCULOSIS | AMIKACIN | PENETRATION | MICROBIOLOGY | MODEL | EMERGENCE | PHARMACOKINETICS-PHARMACODYNAMICS | IN-VITRO | GLYCYLCYCLINE | PHARMACOLOGY & PHARMACY | OUTCOMES
Journal Article