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Toxicology and Applied Pharmacology, ISSN 0041-008X, 10/2012, Volume 264, Issue 2, pp. 212 - 221
Fibroblast growth factor-21 (FGF21) is a potential metabolic regulator with multiple beneficial effects on metabolic diseases. FGF21 is mainly expressed in the... 
Hypoxia-inducible factor | Fibroblast growth factor-21 | Hypoxia | Cobalt chloride | Caco-2 | PPAR-ALPHA | FIBROBLAST-GROWTH-FACTOR-21 | LIPOPROTEIN METABOLISM | FACTOR 1-ALPHA | MOUSE EMBRYONIC FIBROBLASTS | MESSENGER-RNA | ROS | ACTIVATED-RECEPTOR-GAMMA | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | TOXICOLOGY | HEPATIC LIPID-METABOLISM | Caco-2 Cells | Coloring Agents | Humans | Hypoxia-Inducible Factor 1 - physiology | Aryl Hydrocarbon Receptor Nuclear Translocator - biosynthesis | Fibroblast Growth Factors - biosynthesis | Blotting, Western | Triglycerides - metabolism | RNA, Messenger - biosynthesis | PPAR gamma - physiology | Cell Nucleus - metabolism | Cobalt - pharmacology | RNA Interference | PPAR alpha - physiology | Azo Compounds | Superoxides - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis | Oxidative Stress - drug effects | Cell Nucleus - drug effects | Real-Time Polymerase Chain Reaction | Oxidative stress | Messenger RNA | Analysis | Physiological aspects | Triglycerides | Fibroblast growth factors | Lipase | Cobalt | Statistics | Index Medicus | Hypoxia-inducible factors | Reactive oxygen species | Liver | Acetylcysteine | Triacylglycerol lipase | Hormones | cobalt chloride | Gene silencing | Sterols | Intestine | Lipid metabolism | Metabolic disorders | mRNA stability | OXIDATION | LIPASES | ANTIOXIDANTS | STEROLS | CELL PROLIFERATION | CYSTEINE | TRIGLYCERIDES | ANIMAL TISSUES | INTESTINES | COENZYMES | 60 APPLIED LIFE SCIENCES | BIOLOGICAL STRESS | FIBROBLASTS | COBALT CHLORIDES | GROWTH FACTORS | INHIBITION | ANOXIA | LIVER | FATS | ABSORPTION | METABOLIC DISEASES | HORMONES
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2011, Volume 250, Issue 2, pp. 147 - 153
and genotoxicity tests indicate methanol (MeOH) is not mutagenic, but carcinogenic potential has been claimed in one controversial long-term rodent cancer... 
8-oxoguanine (8-oxoG) | Carcinogenesis | DNA damage | Methanol | Oxoguanine glycosylase 1 (Ogg1) | MITOCHONDRIAL ALDEHYDE DEHYDROGENASE | OGG1 | RATS | TOXICITY | CANCER | INTOXICATION | POLYMORPHISMS | 8-oxogua nine (8-oxoG) | IN-VIVO | CARCINOGENICITY | PHARMACOLOGY & PHARMACY | TOXICOLOGY | FORMALDEHYDE | DNA Damage - drug effects | Rabbits | Kidney - drug effects | Reactive Oxygen Species - metabolism | Species Specificity | Liver - metabolism | DNA Glycosylases - genetics | Methanol - administration & dosage | Macaca fascicularis | Male | Methanol - toxicity | Chromatography, High Pressure Liquid | DNA Repair - genetics | Mice, Knockout | Environmental Exposure - adverse effects | Kidney - metabolism | Animals | Liver - drug effects | Bromates - toxicity | Lung - drug effects | Deoxyguanosine - metabolism | Lung - metabolism | Mice | Deoxyguanosine - analogs & derivatives | Primates | DNA | Liver | Index Medicus | ELECTROCHEMISTRY | DIGESTIVE SYSTEM | LUNGS | ISLANDS | NEW ZEALAND | CHROMATOGRAPHY | 60 APPLIED LIFE SCIENCES | NUCLEIC ACIDS | PRIMATES | DNA DAMAGES | KIDNEYS | HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY | BIOLOGICAL RECOVERY | RABBITS | DEVELOPED COUNTRIES | REPAIR | HYDROXY COMPOUNDS | GLANDS | IN VITRO | LIQUID COLUMN CHROMATOGRAPHY | SEPARATION PROCESSES | CHEMISTRY | VERTEBRATES | MICE | MONKEYS | AGE GROUPS | MAMMALS | ANIMALS | METHANOL | RODENTS | NEOPLASMS | ORGANIC COMPOUNDS | ADULTS | CARCINOGENS | IN VIVO | AUSTRALASIA | DAMAGE | ALCOHOLS | ORGANS | DISEASES | RESPIRATORY SYSTEM | LIVER | DNA REPAIR | BIOLOGICAL REPAIR | ENVIRONMENTAL EXPOSURE | BODY
Journal Article
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2010, Volume 243, Issue 1, pp. 13 - 18
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 02/2011, Volume 250, Issue 3, pp. 299 - 311
Deoxynivalenol (DON) is a mycotoxin produced by several species and is often detected in grains. Because of its high abundance, there has been a large interest... 
Lymphocyte activation | Deoxynivalenol | Transcriptomics | Thymus | IMMUNE-RESPONSE | MOUSE | MECHANISMS | TRICHOTHECENE VOMITOXIN DEOXYNIVALENOL | ORAL-EXPOSURE | TISSUE DISTRIBUTION | IN-VIVO | NEGATIVE SELECTION | PHARMACOLOGY & PHARMACY | TOXICOLOGY | HUMAN CELL-CYCLE | T-CELLS | Mice, Inbred C57BL | NFATC Transcription Factors - metabolism | Male | Thymus Gland - drug effects | Trichothecenes - administration & dosage | Mycotoxins - toxicity | Mycotoxins - administration & dosage | Protein Transport | Dose-Response Relationship, Drug | Gene Expression Regulation - drug effects | Trichothecenes - toxicity | Animals | T-Lymphocytes - drug effects | Polymerase Chain Reaction | Thymus Gland - pathology | Protein Array Analysis | T-Lymphocytes - immunology | Thymus Gland - immunology | Cell Proliferation - drug effects | Mice | Genome | Animal experimentation | Analysis | Genetic research | Protein biosynthesis | Mitochondrial DNA | T cells | Gene expression | Index Medicus | BODY FLUIDS | MITOCHONDRIA | ANIMAL CELLS | 60 APPLIED LIFE SCIENCES | LYMPHATIC SYSTEM | ABUNDANCE | ALKALINE EARTH METALS | THYMUS | ELEMENTS | POLYMERASE CHAIN REACTION | METALS | CALCIUM | GENES | CYTOPLASM | VERTEBRATES | BLOOD CELLS | GENE AMPLIFICATION | MICE | SOMATIC CELLS | CONNECTIVE TISSUE CELLS | BLOOD | MAMMALS | HUMAN POPULATIONS | ANIMALS | PRECURSOR | RODENTS | BIOLOGICAL MATERIALS | POPULATIONS | THYMOCYTES | ORGANS | LEUKOCYTES | SYNTHESIS | BODY | MATERIALS | CELL CONSTITUENTS | LYMPHOCYTES | in-vivo | mouse | negative selection | t-cells | human cell-cycle | trichothecene vomitoxin deoxynivalenol | mechanisms | oral-exposure | tissue distribution | immune-response
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2007, Volume 225, Issue 2, pp. 142 - 153
The H295R cell bioassay was used to evaluate the potential endocrine disrupting effects of 18 of the most commonly used pharmaceuticals in the United States.... 
Endocrine disruptors | Dose–response | Steroidogenesis | Bioassay | Drug mixtures | Pharmaceuticals | Dose-response | CONTAMINANTS | ANTIBIOTICS | BEHAVIOR | endocrine disruptors | steroidogenesis | bioassay | pharmaceuticals | SEWAGE | IN-VITRO | drug mixtures | WASTE-WATER | DRUGS | dose-response | PHARMACOLOGY & PHARMACY | TOXICOLOGY | CHROMATOGRAPHY-MASS SPECTROMETRY | SURFACE WATERS | ZEARALENONE | Cytochrome P-450 CYP11B2 - drug effects | Humans | Gonadal Steroid Hormones - biosynthesis | Testosterone - biosynthesis | 3-Hydroxysteroid Dehydrogenases - drug effects | Steroid 11-beta-Hydroxylase - genetics | Reverse Transcriptase Polymerase Chain Reaction | Steroid 11-beta-Hydroxylase - drug effects | Dose-Response Relationship, Drug | Gene Expression Regulation - drug effects | Aromatase - drug effects | Aromatase - genetics | Cytochrome P-450 Enzyme System - drug effects | Drug Interactions | Endocrine Disruptors - pharmacology | Adrenocortical Carcinoma - metabolism | Cell Line, Tumor | Cytochrome P-450 Enzyme System - genetics | Progesterone - biosynthesis | Steroid 17-alpha-Hydroxylase - genetics | Steroid 17-alpha-Hydroxylase - drug effects | 3-Hydroxysteroid Dehydrogenases - genetics | Estradiol - biosynthesis | Cytochrome P-450 CYP11B2 - genetics | Drugs | Genetic research | Progesterone | Gene expression | Cytochrome P-450 | BINARY MIXTURES | POLYMERASE CHAIN REACTION | PROGESTERONE | DOSES | TESTOSTERONE | ERYTHROMYCIN | ESTRADIOL | GENES | 60 APPLIED LIFE SCIENCES | BIOASSAY
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 01/2013, Volume 266, Issue 2, pp. 260 - 266
The farnesoid X receptor (FXR) is a bile acid-activated transcription factor belonging to the nuclear receptor superfamily. FXR deficiency in mice results in... 
Farnesoid X receptor | Post-translational modification | Nuclear receptor | Mice | Parp1 | Proteomics | FXR | POLY(ADP-RIBOSE) | HOMEOSTASIS | BILE-ACID RECEPTOR | IDENTIFICATION | ORPHAN NUCLEAR RECEPTOR | HEPATOCELLULAR-CARCINOMA | GENE | TARGETS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | DNA-REPAIR | Phosphorylation - physiology | Age Factors | Liver - metabolism | Mice, Inbred C57BL | DNA Repair - physiology | Electrophoresis, Gel, Two-Dimensional | Male | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Cytoplasmic and Nuclear - genetics | Blotting, Western | Protein Processing, Post-Translational - physiology | Mice, Knockout | Poly(ADP-ribose) Polymerases - metabolism | Animals | Electrophoresis | Poly (ADP-Ribose) Polymerase-1 | Real-Time Polymerase Chain Reaction | Proteins | Liver cancer | Promoters (Genetics) | Genetic transcription | Analysis | Post-transcription | poly(ADP-ribose) polymerase 1 | Phosphorylation | Transcription factors | proteomics | Gel electrophoresis | Liver | Nuclear receptors | DNA repair | Western blotting | farnesoid X receptors | Polymerase chain reaction | Intestine | Post-translation | Tumorigenesis | Cholestasis | Metabolic disorders | Index Medicus | TRANSCRIPTION FACTORS | HEPATOMAS | PHOSPHORYLATION | MITOCHONDRIA | RIBOSE | INTESTINES | 60 APPLIED LIFE SCIENCES | ADP | AGE DEPENDENCE | PATHOGENESIS | POLYMERASE CHAIN REACTION | ELECTROPHORESIS | LIGANDS | MESSENGER-RNA | ANOXIA | PROMOTERS | GENES | LIVER | DNA REPAIR | KNOCK-OUT REACTIONS | MICE | RECEPTORS | BILE ACIDS
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2009, Volume 234, Issue 3, pp. 293 - 299
Journal Article