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Journal Article
Investigational New Drugs, ISSN 0167-6997, 6/2014, Volume 32, Issue 3, pp. 452 - 464
Background Recurrent malignant brain tumors (RMBTs) carry a poor prognosis. Dichloroacetate (DCA) activates mitochondrial oxidative metabolism and has shown... 
Dichloroacetate | Medicine & Public Health | Pyruvate dehydrogenase complex | Oncology | Malignant (high grade) glioma | Pyruvate dehydrogenase kinase | Pharmacology/Toxicology | Phase 1 trial | Warburg effect | MULTIPLE-MYELOMA | RESPONSE CRITERIA | GLIOMA | KINASE | PYRUVATE-DEHYDROGENASE COMPLEX | TEMOZOLOMIDE | CONTROLLED CLINICAL-TRIAL | CONGENITAL LACTIC-ACIDOSIS | ONCOLOGY | I TRIAL | THERAPEUTIC TARGET | PHARMACOLOGY & PHARMACY | Haplotypes | Dichloroacetic Acid - adverse effects | Humans | Middle Aged | Male | Alanine Transaminase - blood | Antineoplastic Agents - administration & dosage | Brain Neoplasms - metabolism | Dichloroacetic Acid - blood | Glutathione Transferase - genetics | Maleates - urine | Antineoplastic Agents - adverse effects | Pyruvic Acid - metabolism | Adult | Female | Antineoplastic Agents - pharmacokinetics | Acetone - analogs & derivatives | Acetone - urine | Breath Tests | Brain Neoplasms - genetics | Brain Neoplasms - drug therapy | Dichloroacetic Acid - administration & dosage | Aspartate Aminotransferases - blood | Dichloroacetic Acid - pharmacokinetics | Antineoplastic Agents - blood | Aged | Antimitotic agents | Complications and side effects | Gliomas | Dosage and administration | Research | Antineoplastic agents | Drug therapy | Research & development--R&D | Toxicity | Brain cancer | Cancer therapies | Drug dosages | Patients | Pharmaceuticals | Tumors | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2011, Volume 6, Issue 9, p. e24413
Background: In a previous Phase 1/2b malaria vaccine trial testing the 3D7 isoform of the malaria vaccine candidate Merozoite surface protein 2 (MSP2),... 
MEROZOITE SURFACE PROTEIN-2 | IMMUNOGENICITY | HUMORAL RESPONSE | CLINICAL MALARIA | MULTIDISCIPLINARY SCIENCES | ANCHORED MEMBRANE-PROTEINS | IN-VITRO GROWTH | INHIBITORY ANTIBODIES | ENDEMIC AREA | PLASMODIUM-FALCIPARUM MALARIA | PAPUA-NEW-GUINEA | Protozoan Proteins - adverse effects | Antigens, Protozoan - immunology | Dose-Response Relationship, Immunologic | Immunity, Humoral - immunology | Humans | Plasmodium falciparum - immunology | Life Cycle Stages - immunology | Malaria Vaccines - chemistry | Young Adult | Protein Isoforms - chemistry | Malaria Vaccines - adverse effects | Malaria Vaccines - immunology | Antibodies - immunology | Adult | Protozoan Proteins - chemistry | Antigens, Protozoan - adverse effects | Antigens, Protozoan - chemistry | Protein Isoforms - adverse effects | Chemistry, Pharmaceutical | Mannitol - analogs & derivatives | Immunity, Cellular - immunology | Animals | Adolescent | Mannitol - chemistry | Plasmodium falciparum - growth & development | Protein Isoforms - immunology | Oleic Acids - chemistry | Protozoan Proteins - immunology | Cohort Studies | Malaria | Malaria vaccine | Immunoglobulin G | Vaccination | Clinical trials | Product development | Vaccines | Enzyme-linked immunosorbent assay | Erythrocytes | Antibodies | Infections | Biochemistry | Parasites | Merozoite surface protein 2 | Western blotting | Proteins | Technology transfer | Children | Recombinant | Vector-borne diseases | Medical research | Antigens | Immunization | Immunoglobulins | Polypeptides | Melanoma | Microscopy | Collaboration | Isoforms | Adults | Immunofluorescence
Journal Article
European Journal of Cancer, ISSN 0959-8049, 2013, Volume 49, Issue 14, pp. 2972 - 2978
Abstract Background Poly(ADP-ribose) polymerase (PARP)-inhibitors and anti-angiogenics have activity in recurrent ovarian and breast cancer; however, the... 
Hematology, Oncology and Palliative Medicine | PARP-inhibitor | Breast | Olaparib | Ovarian | Phase 1 | Anti-angiogenic | Cediranib | CELLS | SOLID TUMORS | BEVACIZUMAB | DOWN-REGULATION | BRCA1 | HYPOXIA | RAD51 | ONCOLOGY | HOMOLOGOUS RECOMBINATION | DNA-REPAIR | Piperazines - administration & dosage | Receptors, Estrogen - metabolism | Nausea - chemically induced | Tablets | Humans | Middle Aged | Ovarian Neoplasms - pathology | Receptor, ErbB-2 - metabolism | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Fatigue - chemically induced | Diarrhea - chemically induced | Breast Neoplasms - metabolism | Receptors, Progesterone - metabolism | Dose-Response Relationship, Drug | Capsules | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Adult | Female | Quinazolines - administration & dosage | Ovarian Neoplasms - drug therapy | Neoplasms, Glandular and Epithelial - pathology | Phthalazines - administration & dosage | Drug Administration Schedule | Administration, Oral | Neoplasm Recurrence, Local | Treatment Outcome | Breast Neoplasms - drug therapy | Piperazines - adverse effects | Poly(ADP-ribose) Polymerase Inhibitors | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast Neoplasms - pathology | Neoplasms, Glandular and Epithelial - drug therapy | Quinazolines - adverse effects | Carcinoma, Ovarian Epithelial | Aged | Phthalazines - adverse effects | Antimitotic agents | Product development | Breast cancer | Antineoplastic agents | Vascular endothelial growth factor | Sugars | Monosaccharides | Index Medicus
Journal Article
Journal Article
Frontiers in Neurology, ISSN 1664-2295, 06/2018, Volume 9, p. 198
Background: There is increasing interest in stem cell therapy as another treatment modality in stroke, particularly for patients who are unable to receive... 
Amnion | Stroke | Trial | Phase 1 | Stem cell | STEM-CELLS | EFFICACY | TIME | stroke | NEUROSCIENCES | trial | CLINICAL NEUROLOGY | phase 1 | REPAIR | stem cell | EPITHELIAL-CELLS | THROMBOLYSIS | BRAIN | amnion | CLINICAL-OUTCOMES | BLOOD | Stroke (Disease) | Clinical trials | Care and treatment | Transplantation | Ischemia | Stem cells
Journal Article