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by Weiland, Stephan K and Björkstén, B and Brunekreef, B and Cookson, W.O.C and von Mutius, E and Strachan, D.P and Bjsorkstén, B and Brunekreff, B and Cookson, W and von Mutius, E and Strachan, D and Wieland, S.K and Büchele, G and Rzehak, P and Weinmayr, G and Priftanji, A and Shkurti, A and Simenati, J and Grabocka, E and Shyti, K and Agolli, S and Gurakuqi, A and Stein, R.T and Urrutia de Pereira, M and Jones, M.H and Pitrez, P.M and Chen, Y.Z and Zhong, N.S and Lai, C and Wong, G and Cooper, P.J and Chico, M and Riikjärv, M.-A and Annus, T and Annesi-Maesano, I and Gotua, M and Rukhadze, M and Abramidze, T and Kvachadze, I and Karsanide, L and Kiladze, M and Dolidze, N and Leupold, W and Keil, U and von Mutuis, E and Arthur, P and Addo-Yobo, E and Gratziou, C and Priftis, C and Papadopoulou, A and Katsardis, C and Tsanakas, J and Hatziagorou, E and Kirvassilis, F and Clausen, M and Shah, J.R and Mathur, R.S and Khubchandani, R.P and Mantri, S and Forastiere, F and Di Domenicantonio, R and De Sario, M and Sammarro, S and Pistelli, R and Serra, M.G and Corbo, G and Perucci, C.A and Svabe, V and Sebre, D and Casno, G and Novikova, I and Bagrade, L and Schram, D and Doekes, G and Jansen-van Vliet, P.H.N and Janssen, N.A.H and Aarts, F.J.H and de Meer, G and Crane, J and Wickens, K and Barry, D and Nystad, W and Bolle, R and Lund, E and Batlles Garrido, J and Rubi Ruiz, T and Bonillo Perales, A and Gonzalez Jimenez, Y and Aguire Rodriguez, J and Momblan de Cabo, J and Losilla Maldonado, A and Daza Torres, M and Garcia-Marcos, L and Martinez Torres, A and Guillén Pérez, J.J and Piñana López, A and Castejon Robles, S and Garcia Hernandez, G and Martinez Gimeno, A and International Study Asthma Aller and International Study of Asthma and Allergies in Childhood Phase II Study Group
European Respiratory Journal, ISSN 0903-1936, 09/2004, Volume 24, Issue 3, pp. 406 - 412
Journal Article
Yingyong Lixue Xuebao (Chinese Journal of Applied Mechanics), ISSN 1000-4939, 04/2010, Volume 27, Issue 2, pp. 380 - 383
Dual phase (DP) steel is one of the most promising materials for the present automotive lightweight design. However, the widespread use of DP steel in the... 
Deformation | Fracture mechanics | Automotive industry | Images | Necking | Structural steels | Automotive components | Automotive engineering | Dual phase steels
Journal Article
Yingyong Lixue Xuebao (Chinese Journal of Applied Mechanics), ISSN 1000-4939, 04/2010, Volume 27, Issue 2, pp. 380 - 383
Dual phase (DP) steel is one of the most promising materials for the present automotive lightweight design. However, the widespread use of DP steel in the... 
Fracture mechanics | Deformation | Automotive industry | Necking | Images | Structural steels | Automotive components | Automotive engineering | Dual phase steels
Journal Article
Gan to kagaku ryoho. Cancer & chemotherapy, ISSN 0385-0684, 02/2001, Volume 28, Issue 2, p. 261
Since more than 50% of patients with cancer could no be cured by present standard therapy, new effective anticancer agents are needed in clinical level. In the... 
Clinical Trials, Phase I as Topic - standards | Humans | Antineoplastic Agents - therapeutic use | Neoplasms - drug therapy
Journal Article
Gan to kagaku ryoho. Cancer & chemotherapy, ISSN 0385-0684, 04/1995, Volume 22, Issue 5, p. 603
Criticisms and proposals were presented from the standpoint of implementation with regard to the objectives, person in charge, test facilities, patients tested... 
Multicenter Studies as Topic | Cost-Benefit Analysis | Humans | Clinical Trials, Phase I as Topic - economics | Clinical Trials, Phase I as Topic - methods | Research Design | Cohort Studies | Neoplasms - drug therapy | Patient Selection | Practice Guidelines as Topic
Journal Article
Gan to kagaku ryoho. Cancer & chemotherapy, ISSN 0385-0684, 03/2001, Volume 28, Issue 3, p. 411
Importance pharmacological analysis has been widely recognized in conducting early clinical trials of antineoplastic agents, especially phase I trials, in... 
Humans | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Clinical Trials, Phase I as Topic
Journal Article
CHINESE JOURNAL OF CATALYSIS, ISSN 0253-9837, 08/2005, Volume 26, Issue 8, pp. 693 - 700
A Fischer-Tropsch synthesis kinetics model based on the detailed reaction mechanism was studied in a continuous spinning basket reactor over an industrial... 
PRECIPITATED IRON CATALYST | SLURRY PHASE | olefin readsorption | PERFORMANCE | CHEMISTRY, PHYSICAL | manganese | ENGINEERING, CHEMICAL | Fischer-Tropsch synthesis | PERIOD | iron | industrial catalyst | CHEMISTRY, APPLIED | kinetics | SELECTIVITY
Journal Article
Drug Delivery System, ISSN 0913-5006, 2009, Volume 24, Issue 1, pp. 45 - 53
ナノ粒子製剤である高分子ミセル制がん剤の臨床応用が進んでいる.シスプラチン内包ミセルであるNC-6004は,粒子径が30... 
polymeric micelle | NC-6004 | phase I study | cisplatin | anti-tumor drug
Journal Article
Gan to kagaku ryoho. Cancer & chemotherapy, ISSN 0385-0684, 11/2000, Volume 27, Issue 13, p. 2151
Combination chemotherapy plays an important role in anticancer chemotherapy. Many new anticancer drugs, including target-based drugs, have been introduced... 
Clinical Trials, Phase I as Topic - standards | Humans | Clinical Trials, Phase I as Topic - methods | Clinical Trials, Phase II as Topic - standards | Clinical Trials, Phase II as Topic - methods
Journal Article
Gan to kagaku ryoho. Cancer & chemotherapy, ISSN 0385-0684, 12/2000, Volume 27, Issue 14, p. 2267
There are no guidelines for dose escalation methods of combination chemotherapy. Thus, in order to evaluate this method, we selected 30 reports on two drug... 
Drug Administration Schedule | Humans | Clinical Trials, Phase I as Topic - methods | Antineoplastic Agents - administration & dosage | Clinical Trials, Phase II as Topic - methods | Research Design | Neoplasms - drug therapy
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 07/1992, Volume 20, Issue 1, pp. 17 - 23
Clot dissolution with restoration of infarct-related artery blood flow is the likely mechanism for the improved prognosis and mortality reduction seen after... 
SURVIVAL | MULTICENTER | CARDIAC & CARDIOVASCULAR SYSTEMS | ARTERIAL PATENCY | 12-MONTH FOLLOW-UP | INTRAVENOUS STREPTOKINASE | TIMI TRIAL | REPERFUSION THERAPY | PHASE-I | THROMBOLYTIC THERAPY | LEFT-VENTRICULAR FUNCTION
Journal Article
Drug Delivery System, ISSN 0913-5006, 2009, Volume 24, Issue 1, pp. 28 - 34
NK105は,パクリタキセルを内包した高分子ミセルである.前臨床において,すぐれた血中滞留性と抗腫瘍効果,そして神経毒性の軽減が認められ,臨床第I相試験が行われた.推奨用量は150... 
polymeric micelle | paclitaxel | drug delivery system | phase I study | phase II study
Journal Article
by Dong, SL and Li, X and Xu, GY
ACTA CHIMICA SINICA, ISSN 0567-7351, 10/2006, Volume 64, Issue 20, pp. 2051 - 2056
The micellar properties such as critical micelle concentration (cmc), counterion binding, and the micellar growth of cationic fluorocarbon surfactant,... 
SYSTEM | DODECYL-SULFATE | dynamic light scattering | BEHAVIOR | SIZE | CHEMISTRY, MULTIDISCIPLINARY | micelle | PHASE | cationic fluorocarbon surfactant | VESICLE FORMATION | transient electric birefringence | salt effect | SCATTERING | WATER
Journal Article
JAPANESE JOURNAL OF NEUROPSYCHOPHARMACOLOGY, ISSN 0388-7588, 06/1997, Volume 19, Issue 6, pp. 425 - 447
The pharmacokinetics and safety of sertraline hydrochloride, a new antidepressant, were investigated in a phase I trial at a dose of 100 mg/day administered... 
SSRI | UPTAKE INHIBITOR | ANTIDEPRESSANTS | antidepressant | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | phase I | SEROTONIN | CP519741 | NEUROSCIENCES | sertraline | OBSESSIVE-COMPULSIVE DISORDER
Journal Article
肺癌, ISSN 0386-9628, 1993, Volume 33, Issue 1, pp. 95 - 100
A phase I trial was conducted to study the effect of a prolonged administration of oral etoposide for SCLC. Each of 18 patients entered into this study was... 
Etoposide | Phase I study | Small cell lung cancer | Prolonged oral administration
Journal Article
by Tai, X and Hu, QF and Yang, QY and Yin, JY
SPECTROSCOPY AND SPECTRAL ANALYSIS, ISSN 1000-0593, 01/2004, Volume 24, Issue 1, pp. 125 - 127
The color reaction of silver(I) with 2-(2-quinolinylazo)-1, 5-dihydroxidebenzene (QADHB) and the solid phase extraction of the colored chelate with Waters... 
silver | solid phase extraction spectrophotometry | SPECTROSCOPY | 2-(2-quinolinylazo)-1 | 5-dihydroxidebenzene | Benzene - chemistry | Spectrophotometry - methods | Sodium Dodecyl Sulfate - chemistry | Spectrophotometry, Ultraviolet - methods | Silver Compounds - chemistry | Silver - analysis
Journal Article
Oncology Research and Treatment, ISSN 2296-5270, 1990, Volume 13, Issue 6, pp. 429 - 433
Journal Article
Drug Delivery System, ISSN 0913-5006, 2004, Volume 19, Issue 6, pp. 520 - 529
Immunoliposome, a type of liposome on which cancer cell specific antibody is conjugated, is expected as ideal drug delivery system which exhibits superior... 
phase I clinical study | immutoliposomes | doxorubicin | human monoclonal antibody | polyethylene-glycol
Journal Article
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