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1. Phase II of the International Study of Asthma and Allergies in Childhood (ISAAC II): Rationale and methods
by Weiland, Stephan K and Björkstén, B and Brunekreef, B and Cookson, W.O.C and von Mutius, E and Strachan, D.P and Bjsorkstén, B and Brunekreff, B and Cookson, W and von Mutius, E and Strachan, D and Wieland, S.K and Büchele, G and Rzehak, P and Weinmayr, G and Priftanji, A and Shkurti, A and Simenati, J and Grabocka, E and Shyti, K and Agolli, S and Gurakuqi, A and Stein, R.T and Urrutia de Pereira, M and Jones, M.H and Pitrez, P.M and Chen, Y.Z and Zhong, N.S and Lai, C and Wong, G and Cooper, P.J and Chico, M and Riikjärv, M.-A and Annus, T and Annesi-Maesano, I and Gotua, M and Rukhadze, M and Abramidze, T and Kvachadze, I and Karsanide, L and Kiladze, M and Dolidze, N and Leupold, W and Keil, U and von Mutuis, E and Arthur, P and Addo-Yobo, E and Gratziou, C and Priftis, C and Papadopoulou, A and Katsardis, C and Tsanakas, J and Hatziagorou, E and Kirvassilis, F and Clausen, M and Shah, J.R and Mathur, R.S and Khubchandani, R.P and Mantri, S and Forastiere, F and Di Domenicantonio, R and De Sario, M and Sammarro, S and Pistelli, R and Serra, M.G and Corbo, G and Perucci, C.A and Svabe, V and Sebre, D and Casno, G and Novikova, I and Bagrade, L and Schram, D and Doekes, G and Jansen-van Vliet, P.H.N and Janssen, N.A.H and Aarts, F.J.H and de Meer, G and Crane, J and Wickens, K and Barry, D and Nystad, W and Bolle, R and Lund, E and Batlles Garrido, J and Rubi Ruiz, T and Bonillo Perales, A and Gonzalez Jimenez, Y and Aguire Rodriguez, J and Momblan de Cabo, J and Losilla Maldonado, A and Daza Torres, M and Garcia-Marcos, L and Martinez Torres, A and Guillén Pérez, J.J and Piñana López, A and Castejon Robles, S and Garcia Hernandez, G and Martinez Gimeno, A and International Study Asthma Aller and International Study of Asthma and Allergies in Childhood Phase II Study Group
European Respiratory Journal, ISSN 0903-1936, 09/2004, Volume 24, Issue 3, pp. 406 - 412
International comparative studies, investigating whether disease incidence or prevalence rates differ between populations and, if so, which factors explain the... 
International Study of Asthma and Allergies in Childhood Phase II | Rhinitis | Epidemiology | Childhood | Eczema | Asthma | childhood | ATOPIC ECZEMA | asthma | rhinitis | WORLDWIDE VARIATIONS | SYMPTOMS | PREVALENCE | in childhood phase II | BLOOD-PRESSURE | CHILDREN | epidemiology | international study of asthma and allergies | RESPIRATORY SYSTEM | eczema | RHINOCONJUNCTIVITIS | RESPIRATORY-HEALTH-SURVEY | Eczema - epidemiology | Prevalence | Skin Tests | Cross-Sectional Studies | Dermatitis, Atopic - epidemiology | Humans | Bronchial Provocation Tests | Surveys and Questionnaires | Child | Immunoglobulin E - blood | Asthma - epidemiology | Rhinitis, Allergic, Perennial - epidemiology
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2. A phase I study of combination-therapy using personalized peptide vaccine and UFT/UZEL for advanced or recurrent colorectal cancer
by Hattori, Takashi and Okuno, Kiyotaka and Yoshida, Kazumi and Kokubu, Takako and Mine, Takashi and Yamada, Ryou and Itoh, Kyogo and Shiozaki, Hitoshi
Gan to kagaku ryoho. Cancer & chemotherapy, ISSN 0385-0684, 11/2006, Volume 33, Issue 12, p. 1745
We herein administered combination-therapy using a personalized vaccination and the oral administration of UFT/UZEL for the treatment of either advanced or... 
Leucovorin - administration & dosage | Administration, Oral | Cancer Vaccines - administration & dosage | Humans | Middle Aged | Neoplasm Recurrence, Local - therapy | Peptides - immunology | Male | Colorectal Neoplasms - therapy | Fluorouracil - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Adult | Female | Aged | Clinical Trials, Phase I as Topic
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3. Fracture of dual phase steel sheets under uniaxial tension (I): experimental study with dic techniques
by Gui, Liangjin and Gao, Fuhai and Fan, Zijie
Yingyong Lixue Xuebao (Chinese Journal of Applied Mechanics), ISSN 1000-4939, 04/2010, Volume 27, Issue 2, pp. 380 - 383
Dual phase (DP) steel is one of the most promising materials for the present automotive lightweight design. However, the widespread use of DP steel in the... 
Deformation | Fracture mechanics | Automotive industry | Images | Necking | Structural steels | Automotive components | Automotive engineering | Dual phase steels
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4. Fracture of dual phase steel sheets under uniaxial tension (I): experimental study with dic techniques
by Gui, Liangjin and Gao, Fuhai and Fan, Zijie
Yingyong Lixue Xuebao (Chinese Journal of Applied Mechanics), ISSN 1000-4939, 04/2010, Volume 27, Issue 2, pp. 380 - 383
Dual phase (DP) steel is one of the most promising materials for the present automotive lightweight design. However, the widespread use of DP steel in the... 
Fracture mechanics | Deformation | Automotive industry | Necking | Images | Structural steels | Automotive components | Automotive engineering | Dual phase steels
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5. Guideline for phase I study on new anticancer agents
by Shimoyama, M
Gan to kagaku ryoho. Cancer & chemotherapy, ISSN 0385-0684, 02/2001, Volume 28, Issue 2, p. 261
Since more than 50% of patients with cancer could no be cured by present standard therapy, new effective anticancer agents are needed in clinical level. In the... 
Clinical Trials, Phase I as Topic - standards | Humans | Antineoplastic Agents - therapeutic use | Neoplasms - drug therapy
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6. Phase I study
by Taguchi, T
Gan to kagaku ryoho. Cancer & chemotherapy, ISSN 0385-0684, 04/1995, Volume 22, Issue 5, p. 603
Criticisms and proposals were presented from the standpoint of implementation with regard to the objectives, person in charge, test facilities, patients tested... 
Multicenter Studies as Topic | Cost-Benefit Analysis | Humans | Clinical Trials, Phase I as Topic - economics | Clinical Trials, Phase I as Topic - methods | Research Design | Cohort Studies | Neoplasms - drug therapy | Patient Selection | Practice Guidelines as Topic
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7. Early clinical trial of antineoplastic agents--recent perspectives of pharmacological analysis in phase I study
by Sasaki, Y
Gan to kagaku ryoho. Cancer & chemotherapy, ISSN 0385-0684, 03/2001, Volume 28, Issue 3, p. 411
Importance pharmacological analysis has been widely recognized in conducting early clinical trials of antineoplastic agents, especially phase I trials, in... 
Humans | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Clinical Trials, Phase I as Topic
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8. Detailed kinetics model of Fischer-Tropsch synthesis over an industrial Fe-Mn catalyst I. Kinetics study on olefin readsorption
by Teng, BT and Chang, J and Liu, Y and Zhang, CH and Yang, J and Zheng, HY and Zhang, RL and Bai, L and Xiang, HW and Li, YW
CHINESE JOURNAL OF CATALYSIS, ISSN 0253-9837, 08/2005, Volume 26, Issue 8, pp. 693 - 700
A Fischer-Tropsch synthesis kinetics model based on the detailed reaction mechanism was studied in a continuous spinning basket reactor over an industrial... 
PRECIPITATED IRON CATALYST | SLURRY PHASE | olefin readsorption | PERFORMANCE | CHEMISTRY, PHYSICAL | manganese | ENGINEERING, CHEMICAL | Fischer-Tropsch synthesis | PERIOD | iron | industrial catalyst | CHEMISTRY, APPLIED | kinetics | SELECTIVITY
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9. Full Text 臨床開発中のＤＤＳ製剤　　シスプラチン内包ミセルＮＣ‐６００４のイギリスでの臨床第Ｉ相試験を行って
by 清水, 隆 and 加藤, 泰己
Drug Delivery System, ISSN 0913-5006, 2009, Volume 24, Issue 1, pp. 45 - 53
ナノ粒子製剤である高分子ミセル制がん剤の臨床応用が進んでいる．シスプラチン内包ミセルであるNC-6004は，粒子径が30... 
polymeric micelle | NC-6004 | phase I study | cisplatin | anti-tumor drug
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10. The strategy of combination phase I/II study
by Murakami, H and Ohe, Y and Saijo, N
Gan to kagaku ryoho. Cancer & chemotherapy, ISSN 0385-0684, 11/2000, Volume 27, Issue 13, p. 2151
Combination chemotherapy plays an important role in anticancer chemotherapy. Many new anticancer drugs, including target-based drugs, have been introduced... 
Clinical Trials, Phase I as Topic - standards | Humans | Clinical Trials, Phase I as Topic - methods | Clinical Trials, Phase II as Topic - standards | Clinical Trials, Phase II as Topic - methods
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11. A combination phase I/II study--dose escalation plan
by Yamamoto, N
Gan to kagaku ryoho. Cancer & chemotherapy, ISSN 0385-0684, 12/2000, Volume 27, Issue 14, p. 2267
There are no guidelines for dose escalation methods of combination chemotherapy. Thus, in order to evaluate this method, we selected 30 reports on two drug... 
Drug Administration Schedule | Humans | Clinical Trials, Phase I as Topic - methods | Antineoplastic Agents - administration & dosage | Clinical Trials, Phase II as Topic - methods | Research Design | Neoplasms - drug therapy
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12. Full Text Randomized angiographic trial of recombinant tissue-type plasminogen activator (alteplase) in myocardial infarction
by Carney, Robert J and Murphy, Gregory A and Brandt, Thomas R and Daley, Patrick J and Pickering, Ernest and White, Harvey J and McDonough, Timothy J and Vermilya, Suzanne K and Teichman, Sam L
Journal of the American College of Cardiology, ISSN 0735-1097, 07/1992, Volume 20, Issue 1, pp. 17 - 23
Clot dissolution with restoration of infarct-related artery blood flow is the likely mechanism for the improved prognosis and mortality reduction seen after... 
SURVIVAL | MULTICENTER | CARDIAC & CARDIOVASCULAR SYSTEMS | ARTERIAL PATENCY | 12-MONTH FOLLOW-UP | INTRAVENOUS STREPTOKINASE | TIMI TRIAL | REPERFUSION THERAPY | PHASE-I | THROMBOLYTIC THERAPY | LEFT-VENTRICULAR FUNCTION
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13. Full Text 臨床開発中のＤＤＳ製剤　　パクリタキセル内包ミセルＮＫ１０５の臨床試験の状況
by 加藤, 健
Drug Delivery System, ISSN 0913-5006, 2009, Volume 24, Issue 1, pp. 28 - 34
NK105は，パクリタキセルを内包した高分子ミセルである．前臨床において，すぐれた血中滞留性と抗腫瘍効果，そして神経毒性の軽減が認められ，臨床第I相試験が行われた．推奨用量は150... 
polymeric micelle | paclitaxel | drug delivery system | phase I study | phase II study
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14. Full Text ライフサイエンスのためのアイソトープ測定機器（第四シリーズ）　ＩＩ　　加速器質量分析（ＡＭＳ）による｀１４´Ｃ標識薬物のヒトでのマスバランス試験
by 野口, 英世
RADIOISOTOPES, ISSN 0033-8303, 2003, Volume 52, Issue 4, pp. 195 - 202
mass balance study | pharmaceutical | safety evaluation | Phase I study | carbon-14 | accelerator mass spectrometry
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15. Study on cationic fluorocarbon surfactants I. Growth and properties of micelles in aqueous solution
by Dong, SL and Li, X and Xu, GY
ACTA CHIMICA SINICA, ISSN 0567-7351, 10/2006, Volume 64, Issue 20, pp. 2051 - 2056
The micellar properties such as critical micelle concentration (cmc), counterion binding, and the micellar growth of cationic fluorocarbon surfactant,... 
SYSTEM | DODECYL-SULFATE | dynamic light scattering | BEHAVIOR | SIZE | CHEMISTRY, MULTIDISCIPLINARY | micelle | PHASE | cationic fluorocarbon surfactant | VESICLE FORMATION | transient electric birefringence | salt effect | SCATTERING | WATER
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16. Phase I study of sertraline hydrochloride (CP-51,974-1) - Multiple dose study
by Kamijima, K and Hashimoto, T and Fujiwara, A and Shiina, K and Yoshino, F and Yajima, T and Yajima, Y and Yagi, G and Kinami, Y
JAPANESE JOURNAL OF NEUROPSYCHOPHARMACOLOGY, ISSN 0388-7588, 06/1997, Volume 19, Issue 6, pp. 425 - 447
The pharmacokinetics and safety of sertraline hydrochloride, a new antidepressant, were investigated in a phase I trial at a dose of 100 mg/day administered... 
SSRI | UPTAKE INHIBITOR | ANTIDEPRESSANTS | antidepressant | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | phase I | SEROTONIN | CP519741 | NEUROSCIENCES | sertraline | OBSESSIVE-COMPULSIVE DISORDER
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17. Full Text 肺小細胞癌を対象としたエトポシド長期経口投与法のｐｈａｓｅ　Ｉ　ｓｔｕｄｙ
by 今村, 文生 and 池上, 晴通 and 田村, 伸介 and 桝野, 富弥 and 西川, 秀樹 and 相原, 信之 and 小牟田, 清
肺癌, ISSN 0386-9628, 1993, Volume 33, Issue 1, pp. 95 - 100
A phase I trial was conducted to study the effect of a prolonged administration of oral etoposide for SCLC. Each of 18 patients entered into this study was... 
Etoposide | Phase I study | Small cell lung cancer | Prolonged oral administration
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18. Study on spectrophotometric determination of silver(I) with 2-(2-quinolinylazo)-1, 5-dihydroxidebenzene
by Tai, X and Hu, QF and Yang, QY and Yin, JY
SPECTROSCOPY AND SPECTRAL ANALYSIS, ISSN 1000-0593, 01/2004, Volume 24, Issue 1, pp. 125 - 127
The color reaction of silver(I) with 2-(2-quinolinylazo)-1, 5-dihydroxidebenzene (QADHB) and the solid phase extraction of the colored chelate with Waters... 
silver | solid phase extraction spectrophotometry | SPECTROSCOPY | 2-(2-quinolinylazo)-1 | 5-dihydroxidebenzene | Benzene - chemistry | Spectrophotometry - methods | Sodium Dodecyl Sulfate - chemistry | Spectrophotometry, Ultraviolet - methods | Silver Compounds - chemistry | Silver - analysis
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19. Full Text Kontinuierliche infusion von natürlichem interleukin 2 (n IL-2) zur behandlung maligner erkrankungen: Phase-i-studie
by Lenz, Heinz-Josef and Brunner, T and Dopfer, R and Schlag, H and Ehninger, G
Oncology Research and Treatment, ISSN 2296-5270, 1990, Volume 13, Issue 6, pp. 429 - 433
Natural IL-2 | Phase I study | Continuous infusion
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20. Full Text リポソームとＤＤＳ　　ドキソルビシン封入イムノリポソーム製剤の研究開発
by 田川, 俊明 and 高橋, 和展
Drug Delivery System, ISSN 0913-5006, 2004, Volume 19, Issue 6, pp. 520 - 529
Immunoliposome, a type of liposome on which cancer cell specific antibody is conjugated, is expected as ideal drug delivery system which exhibits superior... 
phase I clinical study | immutoliposomes | doxorubicin | human monoclonal antibody | polyethylene-glycol
Journal Article
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