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Journal Article
Circulation Research, ISSN 0009-7330, 10/2004, Volume 95, Issue 7, pp. 726 - 733
Altered gap junction coupling of cardiac myocytes during ischemia may contribute to development of lethal arrhythmias. The phosphoprotein connexin 43 (Cx43) is... 
Ischemia | Gap junctions | Glycolysis | Okadaic acid | Protein phosphatases | Connexin43 | Protein phosphorylation | AMP kinase | gap junctions | PROTEIN-KINASE-C | CARDIAC & CARDIOVASCULAR SYSTEMS | connexin43 | PHOSPHORYLATION | GAP JUNCTIONAL COMMUNICATION | glycolysis | CARDIAC MYOCYTES | ACTIN GENE | protein phosphorylation | okadaic acid | ischemia | IN-VITRO | INTERCELLULAR COMMUNICATION | PERIPHERAL VASCULAR DISEASE | JUN KINASE | protein phosphatases | RAT VENTRICULAR MYOCYTES | HEMATOLOGY | ADRENERGIC REGULATION | Okadaic Acid - pharmacology | Tetradecanoylphorbol Acetate - pharmacology | Maleimides - pharmacology | Recombinant Fusion Proteins - physiology | Myocardial Contraction - drug effects | Brefeldin A - pharmacology | Phenanthridines - pharmacology | Antimycin A - pharmacology | Aminoimidazole Carboxamide - pharmacology | Cell Hypoxia | Ribonucleotides - pharmacology | Alkaloids | Protein Processing, Post-Translational - drug effects | Adenosine Triphosphate - metabolism | Deoxyglucose - pharmacology | Tacrolimus - pharmacology | Indoles - pharmacology | Flavonoids - pharmacology | Potassium Cyanide - pharmacology | JNK Mitogen-Activated Protein Kinases - genetics | Phosphorylation - drug effects | Ouabain - pharmacology | Cells, Cultured - drug effects | Connexin 43 - metabolism | Rats | Imidazoles - pharmacology | Cycloheximide - pharmacology | Pyrroles - pharmacology | Animals | Myocytes, Cardiac - drug effects | Aminoimidazole Carboxamide - analogs & derivatives | Benzophenanthridines | JNK Mitogen-Activated Protein Kinases - physiology | Myocytes, Cardiac - metabolism | Cells, Cultured - metabolism | Pyridines - pharmacology | Carbazoles - pharmacology | Staurosporine - pharmacology | Index Medicus
Journal Article
European Journal of Neuroscience, ISSN 0953-816X, 01/2005, Volume 21, Issue 1, pp. 151 - 160
The mechanisms by which uridine triphosphate (UTP) stimulates ATP release from Schwann cells cultured from the sciatic nerve were investigated using online... 
Bioluminescence | Protein kinase C | Purinergic receptors | Exocytosis | purinergic receptors | NERVE | MECHANISMS | RELEASE | ASTROCYTES | NEUROSCIENCES | UTP | NUCLEOTIDE RECEPTORS | bioluminescence | GLUTAMATE | CALCIUM | NEURONS | exocytosis | SMOOTH-MUSCLE-CELLS | protein kinase C | Guanosine Triphosphate - pharmacology | Nucleic Acid Synthesis Inhibitors - pharmacology | Calcium - metabolism | Adenosine Triphosphate - secretion | Brefeldin A - pharmacology | Phorbol 12,13-Dibutyrate - pharmacology | Receptors, Purinergic P2Y2 | Cytochalasin D - pharmacology | Phenanthridines - pharmacology | Type C Phospholipases - antagonists & inhibitors | Diagnostic Imaging - methods | Dose-Response Relationship, Drug | Alkaloids | Botulinum Toxins - pharmacology | Glycyrrhetinic Acid - pharmacology | Drug Interactions | Isoquinolines - pharmacology | Glyburide - pharmacology | Time Factors | Botulinum Toxins, Type A | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Sciatic Nerve - cytology | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Protein Synthesis Inhibitors - pharmacology | Pyridoxal Phosphate - analogs & derivatives | Schwann Cells - secretion | Suramin - pharmacology | Schwann Cells - drug effects | Animals, Newborn | Pyridoxal Phosphate - pharmacology | Uridine Triphosphate - pharmacology | Purinergic P2 Receptor Antagonists | Rats | Protein Kinase C - antagonists & inhibitors | Purinergic P2 Receptor Agonists | Sulfonamides - pharmacology | Microscopy, Confocal - methods | Rats, Sprague-Dawley | Immunohistochemistry - methods | Animals | Benzophenanthridines | Receptors, Purinergic P2 - metabolism | Thapsigargin - pharmacology | Furosemide - pharmacology | Index Medicus
Journal Article
American Journal of Pathology, ISSN 0002-9440, 07/2004, Volume 165, Issue 1, pp. 219 - 226
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 2000, Volume 74, Issue 6, pp. 2268 - 2277
An excess of the free radical nitric oxide (NO) is viewed as a deleterious factor involved in various CNS disorders. Numerous studies have shown that the... 
Neuroprotection | Flavonoids | Protein kinase C | Ischemia | Ginkgo biloba extract (EGb 761) | Nitric oxide | Hippocampal cells | GERBIL HIPPOCAMPUS | nitric oxide | LIPID-PEROXIDATION | hippocampal cells | BIOCHEMISTRY & MOLECULAR BIOLOGY | OXIDATIVE-METABOLISM | NEUROSCIENCES | ischemia | SIGNAL-TRANSDUCTION | neuroprotection | DOUBLE-BLIND | PLATELET-ACTIVATING-FACTOR | RAT-BRAIN | flavonoids | CEREBRAL-ISCHEMIA | SUPEROXIDE-DISMUTASE | protein kinase C | MEDIATED NEUROTOXICITY | Free Radical Scavengers - pharmacology | Nitric Oxide Donors - toxicity | Brain Ischemia - metabolism | Neurons - cytology | Molsidomine - analogs & derivatives | Phenanthridines - pharmacology | Lactones - pharmacology | Organoselenium Compounds - pharmacology | Alkaloids | Neuroprotective Agents - pharmacology | Protein Kinase C - metabolism | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Flavonoids - pharmacology | Molsidomine - toxicity | Neurons - drug effects | Plant Extracts | Cells, Cultured | Enzyme Inhibitors - pharmacology | Alzheimer Disease - drug therapy | Phosphodiesterase Inhibitors - pharmacology | Rats | Calcium Channels, L-Type - physiology | Antioxidants - pharmacology | Nitrendipine - pharmacology | Azoles - pharmacology | Calcium Channel Blockers - pharmacology | Hippocampus - cytology | Rats, Sprague-Dawley | Ginkgolides | Ginkgo biloba | Nitroprusside - toxicity | Animals | Vasodilator Agents - toxicity | Signal Transduction - drug effects | Benzophenanthridines | Brain Ischemia - drug therapy | Neurons - enzymology | Alzheimer Disease - metabolism | Diterpenes | Oxidative Stress - drug effects | Nitric Oxide - metabolism | Flavonoids - chemistry | Plants, Medicinal | Index Medicus
Journal Article
Journal Article
Journal Article
Neuroscience, ISSN 0306-4522, 2003, Volume 118, Issue 2, pp. 477 - 490
Brain-derived neurotrophic factor (BDNF) plays fundamental roles in synaptic plasticity in rat hippocampus. Recently, using rat hippocampal slices, we found... 
signaling pathway | plasticity | CaMKII | CREB | hippocampus | BDNF | Signaling pathway | Hippocampus | Plasticity | MAP KINASE | DEPENDENT PROTEIN-KINASE | ELEMENT-BINDING PROTEIN | SYNAPTIC PLASTICITY | NEUROSCIENCES | NERVE GROWTH-FACTOR | SIGNAL-TRANSDUCTION | GENE-EXPRESSION | LONG-TERM POTENTIATION | DENTATE GYRUS | GRANULE CELLS | Immunohistochemistry | Enzyme Inhibitors | Phosphorylation | Calcium - metabolism | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Male | Phenanthridines - pharmacology | Alkaloids | Cell Nucleus - metabolism | Time Factors | Acetophenones - pharmacology | Indoles - pharmacology | Brain-Derived Neurotrophic Factor - metabolism | Flavonoids - pharmacology | Benzopyrans - pharmacology | Chromones - pharmacology | Intracellular Signaling Peptides and Proteins | Morpholines - pharmacology | Rats | Imidazoles - pharmacology | Tyrphostins - pharmacology | Hippocampus - cytology | Blotting, Western | Precipitin Tests | Naphthalenes - pharmacology | Antibodies - pharmacology | Hippocampus - metabolism | Carbazoles | Pyrroles - pharmacology | Animals | Androstadienes - pharmacology | Benzophenanthridines | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Wortmannin | Cyclic AMP Response Element-Binding Protein - metabolism | Cytosol - metabolism | Protein-Serine-Threonine Kinases - immunology | Signal Transduction - physiology | Pyridines - pharmacology | Calmodulin - pharmacology | In Vitro Techniques | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Index Medicus | Life Sciences | Cognitive Sciences | Neurons and Cognition
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 03/2001, Volume 280, Issue 3, pp. 1346 - 1353
Stimulation of the δ1-opioid receptor confers cardioprotection to the ischemic myocardium. We examined the role of protein kinase C (PKC) after δ-opioid... 
Ischemia | Preconditioning | Protein kinase C | PROTEIN-KINASE-C | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | PROTECTION | K-ATP CHANNELS | INVOLVEMENT | preconditioning | ischemia | ISCHEMIC-INJURY | PATHWAY | CA2 | PERIPHERAL VASCULAR DISEASE | RAT-HEART | RECEPTORS | INHIBITOR | protein kinase C | Naltrexone - analogs & derivatives | Analgesics - pharmacology | Myocardial Ischemia - metabolism | Rats, Wistar | Maleimides - pharmacology | Male | Phenanthridines - pharmacology | Quinolines - pharmacology | Alkaloids | Naltrexone - pharmacology | Isoenzymes - metabolism | Protein Kinase C - metabolism | Acetophenones - pharmacology | Enkephalin, Leucine-2-Alanine - pharmacology | Indoles - pharmacology | Receptors, Opioid, delta - antagonists & inhibitors | Myocardial Reperfusion Injury - drug therapy | Benzopyrans - pharmacology | Protein Kinase C-delta | Heart Rate | Enzyme Inhibitors - pharmacology | Rats | Myocardial Infarction - metabolism | Enzyme Activation - drug effects | Myocardial Ischemia - drug therapy | Myocardial Reperfusion Injury - metabolism | Myocardium - enzymology | Animals | Benzylidene Compounds - pharmacology | Myocardial Infarction - drug therapy | Benzophenanthridines | Ischemic Preconditioning, Myocardial | Narcotic Antagonists - pharmacology | Receptors, Opioid, delta - agonists | Index Medicus
Journal Article
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 02/2005, Volume 25, Issue 7, pp. 1769 - 1777
Overproduction of the amyloid beta (Abeta) peptide is a key factor in the pathogenesis of Alzheimer's disease (AD), but the mechanisms of its pathogenic... 
gp91 | Reactive oxygen species | Hydroethidine | Cerebral blood flow | Alzheimer's disease | Tg2576 | OXIDATIVE STRESS | ENDOTHELIAL DYSFUNCTION | SUPEROXIDE-PRODUCTION | ALZHEIMERS-DISEASE BRAINS | SOMATOSENSORY ACTIVATION | NEUROSCIENCES | gp91(phox) | reactive oxygen species | NITRIC-OXIDE | A-BETA | cerebral blood flow | PRECURSOR PROTEIN | hydroethidine | CEREBRAL-BLOOD-FLOW | TRANSGENIC MOUSE MODEL | Reactive Oxygen Species - metabolism | Oxidative Stress | Peptide Fragments - toxicity | Humans | Molecular Sequence Data | Male | Glycoproteins - pharmacology | Phenanthridines - pharmacology | NADPH Oxidases - deficiency | Membrane Glycoproteins - physiology | NADPH Oxidases - genetics | Female | Nitric Oxide Donors - pharmacology | Peptide Fragments - genetics | X Chromosome - genetics | Bradykinin - pharmacology | Amino Acid Sequence | Alzheimer Disease - physiopathology | Nerve Tissue Proteins - physiology | Acetylcholine - pharmacology | Amyloid beta-Peptides - toxicity | Amyloid beta-Peptides - biosynthesis | Mice, Inbred C57BL | Hyperemia - etiology | Mice, Transgenic | Cerebrovascular Circulation | Adenosine - pharmacology | Laser-Doppler Flowmetry | Calcimycin - pharmacology | NADPH Oxidase 2 | Peptide Fragments - biosynthesis | Membrane Glycoproteins - genetics | Amyloid beta-Protein Precursor - genetics | Animals | Vibrissae - physiology | Alzheimer Disease - metabolism | Mice | NADPH Oxidases - physiology | S-Nitroso-N-Acetylpenicillamine - pharmacology | Membrane Glycoproteins - deficiency | Amyloid beta-Protein Precursor - biosynthesis | Index Medicus | Neurobiology of Disease | gp91phox
Journal Article
Science, ISSN 0036-8075, 10/2004, Volume 306, Issue 5697, pp. 882 - 884
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2012, Volume 109, Issue 30, pp. 11987 - 11992
Monofunctional platinum(II) complexes of general formula cis-[Pt(NH₃)₂(N-heterocycle)Cl]Cl bind DNA at a single site, inducing little distortion in the double... 
Cell culture techniques | HT29 cells | Reactivity | Platinum | DNA | Cell lines | Antineoplastics | Ligands | Kinetics | Adducts | X-ray crystallography | Metals in medicine | Cancer therapy | DNA damage | Transcription inhibition | cancer therapy | RESPONSES | COMPLEX | CISPLATIN | MULTIDISCIPLINARY SCIENCES | KINETIC CONTROL | metals in medicine | ADDUCTS | CIS-DIAMMINEDICHLOROPLATINUM(II) | transcription inhibition | Phenanthridines - chemistry | Crystallography, X-Ray | Drug Discovery - methods | Platinum Compounds - chemistry | Platinum Compounds - pharmacokinetics | Phenanthridines - pharmacology | Organoplatinum Compounds - pharmacology | Antineoplastic Agents - metabolism | Luciferases | Organoplatinum Compounds - metabolism | Organoplatinum Compounds - pharmacokinetics | Inhibitory Concentration 50 | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Deoxyguanine Nucleotides - metabolism | Molecular Structure | Gene Expression Regulation, Neoplastic - drug effects | Organoplatinum Compounds - chemistry | Phenanthridines - pharmacokinetics | Models, Molecular | DNA - metabolism | Antineoplastic Agents - chemistry | Genetic Vectors | Phenanthridines - metabolism | Platinum Compounds - pharmacology | Platinum Compounds - metabolism | Antimitotic agents | Composition | Platinum compounds | Physiological aspects | Genetic aspects | DNA binding proteins | Research | Antineoplastic agents | Health aspects | Pharmaceutical chemistry | Chemistry | RNA polymerase | Chemical compounds | Deoxyribonucleic acid--DNA | Binding sites | Pharmaceuticals | Index Medicus | Biological Sciences | Physical Sciences
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 1997, Volume 29, Issue 3, pp. 859 - 870
Journal Article