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Psychopharmacology, ISSN 0033-3158, 1/2014, Volume 231, Issue 1, pp. 269 - 281
Journal Article
Neuropharmacology, ISSN 0028-3908, 08/2015, Volume 95, pp. 243 - 251
Journal Article
Neuropharmacology, ISSN 0028-3908, 03/2013, Volume 66, pp. 264 - 273
The group II metabotropic glutamate (mGlu) receptors comprised of the mGlu2 and mGlu3 receptor subtypes have gained recognition in recent years as potential... 
mGlu3 | Primary neuronal cultures | Rat cortical neurons | Spontaneous Ca2+ oscillations | Fluorescent imaging plate reader | Mouse cortical neurons | Metabotropic glutamate receptor | mGlu2 | Spontaneous Ca | oscillations | ANXIETY | AGONIST LY354740 | NEUROSCIENCES | CALCIUM TRANSIENTS | PHENCYCLIDINE | CA2+ SPIKES | POTENT | MODELS | FREQUENCY | PHARMACOLOGY & PHARMACY | OSCILLATIONS | Glycine - analogs & derivatives | Primary Cell Culture - methods | Allosteric Regulation | Amino Acids, Dicarboxylic - pharmacology | Amino Acids - pharmacology | Cerebral Cortex - metabolism | Optical Imaging - instrumentation | Biphenyl Compounds - pharmacology | Receptors, Metabotropic Glutamate - genetics | Proline - pharmacology | Neurons - metabolism | Cerebral Cortex - drug effects | Neurons - drug effects | Cyclic AMP - metabolism | Optical Imaging - methods | Cyclopropanes - pharmacology | Bridged Bicyclo Compounds - pharmacology | Proline - analogs & derivatives | Rats | Mice, Transgenic | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Receptors, Metabotropic Glutamate - biosynthesis | Sulfonamides - pharmacology | Rats, Sprague-Dawley | Mice, Inbred ICR | Mice, Knockout | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | Glycine - pharmacology | Calcium Signaling - drug effects | Ligands | Mice | Pyridines - pharmacology | Receptors, Metabotropic Glutamate - agonists | Receptors, Metabotropic Glutamate - antagonists & inhibitors | Indans - pharmacology | Tranquilizing drugs | Neurosciences | Neurons | Analysis | Physiological aspects | Schizophrenia | Amino acids | Glutamate | Action potential
Journal Article
Psychopharmacology, ISSN 0033-3158, 7/2013, Volume 228, Issue 2, pp. 271 - 282
The nucleus accumbens (NAc) is a site critical for the actions of many drugs of abuse. Psychoactive compounds, such as N-methyl-d-aspartate receptor (NMDAR)... 
High frequency oscillations | Gamma | Neurosciences | Biomedicine | Accumbens | Rat | Local field potentials | Serotonin receptor | Lysergic acid diethylamide | Pharmacology/Toxicology | Psychiatry | Hallucinogens | FREELY MOVING RATS | PSYCHIATRY | NEUROSCIENCES | PREFRONTAL CORTEX | PHENCYCLIDINE | ANTIPSYCHOTIC-DRUGS | I-125 DOI | NMDA RECEPTOR HYPOFUNCTION | PHARMACOLOGY & PHARMACY | LSD | STRIATAL NEURONS | FIELD POTENTIALS | BRAIN | Piperazines - administration & dosage | Rats, Wistar | Amphetamines - pharmacology | Nucleus Accumbens - metabolism | Pyrazines - administration & dosage | Male | Amphetamines - administration & dosage | Serotonin Receptor Agonists - pharmacology | Dose-Response Relationship, Drug | Lysergic Acid Diethylamide - administration & dosage | Receptor, Serotonin, 5-HT2A - drug effects | Methylamines - pharmacology | Hallucinogens - administration & dosage | Hallucinogens - pharmacology | Bridged Bicyclo Compounds - pharmacology | Injections, Intraperitoneal | Methylamines - administration & dosage | Rats | Bridged Bicyclo Compounds - administration & dosage | Serotonin Antagonists - pharmacology | Piperazines - pharmacology | Animals | Lysergic Acid Diethylamide - pharmacology | Ketamine - pharmacology | Nucleus Accumbens - drug effects | Pyrazines - pharmacology | Receptor, Serotonin, 5-HT2A - metabolism | Serotonin Receptor Agonists - administration & dosage | Nucleus accumbens | Brain | Physiological aspects | Hallucinogenic drugs | Dosage and administration | Health aspects | Electric properties | Rodents | Psychopharmacology | Original Investigation
Journal Article
Journal Article
Therapeutic Drug Monitoring, ISSN 0163-4356, 10/2010, Volume 32, Issue 5, pp. 544 - 549
In recent years, besides the classic designer drugs of the amphetamine type, a series of new drug classes appeared on the illicit drugs market. The chemistry,... 
drugs of abuse | herbal drugs | metabolism | designer drugs | pharmacology | HEPATIC CYTOCHROME-P450 ISOZYMES | MAIN METABOLITES | ISOLATED RAT HEPATOCYTES | CHROMATOGRAPHY-MASS-SPECTROMETRY | DESIGNER DRUG | MITRAGYNA-SPECIOSA | TOXICOLOGICAL DETECTION | HALLUCINOGENIC MESCALINE ANALOGS | QUANTITATIVE STRUCTURE-ACTIVITY | PHARMACOLOGY & PHARMACY | TOXICOLOGY | MEDICAL LABORATORY TECHNOLOGY | 4-BROMO-2,5-DIMETHOXYPHENETHYLAMINE 2C-B | Substance Abuse Detection - methods | Phencyclidine - pharmacology | Phencyclidine - chemistry | Designer Drugs - metabolism | Amphetamines - pharmacology | Humans | Drugs, Chinese Herbal - pharmacology | Street Drugs - metabolism | Piperazines - metabolism | Piperazines - chemistry | Drugs, Chinese Herbal - metabolism | Forensic Toxicology - methods | Cannabinoids - metabolism | Mitragyna | Amphetamines - chemistry | Designer Drugs - pharmacology | Substance-Related Disorders - metabolism | Phenethylamines - pharmacology | Secologanin Tryptamine Alkaloids - chemistry | Secologanin Tryptamine Alkaloids - pharmacology | Cannabinoids - chemistry | Phenethylamines - chemistry | Phenethylamines - metabolism | Secologanin Tryptamine Alkaloids - metabolism | Piperazines - pharmacology | Cannabinoids - pharmacology | Designer Drugs - chemistry | Animals | Amphetamines - metabolism | Drugs, Chinese Herbal - chemistry | Phencyclidine - metabolism | Street Drugs - pharmacology | Street Drugs - chemistry | Index Medicus
Journal Article
Journal Article
Psychopharmacology, ISSN 0033-3158, 9/2007, Volume 193, Issue 4, pp. 521 - 537
Cognitive deficits in schizophrenia are severe and do not respond well to available treatments. The development and validation of animal models of cognitive... 
5-CSRTT | Animal model | Impulsivity | Attention | Schizophrenia | Cognition | Clozapine | Biomedicine | Phencyclidine | Pharmacology/Toxicology | Risperidone | Psychiatry | Atypical antipsychotic medications | atypical antipsychotic medications | cognition | RECEPTOR ANTAGONISTS | PSYCHIATRY | risperidone | MEMORY IMPAIRMENT | BEHAVIORAL SENSITIZATION | CHRONIC-SCHIZOPHRENIA | schizophrenia | NEUROSCIENCES | REACTION-TIME-TASK | phencyclidine | SIGNAL-DETECTION | RESPONSE-INHIBITION | impulsivity | attention | clozapine | ATTENTIONAL PERFORMANCE | PHARMACOLOGY & PHARMACY | animal model | BRIGHTNESS-DISCRIMINATION | WORKING-MEMORY | Phencyclidine - pharmacology | Rats, Wistar | Clozapine - administration & dosage | Cognition Disorders - chemically induced | Haloperidol - administration & dosage | Male | Dose-Response Relationship, Drug | Clozapine - pharmacology | Reaction Time - drug effects | Attention - drug effects | Haloperidol - pharmacology | Disease Models, Animal | Impulsive Behavior | Schizophrenia - chemically induced | Benzodiazepines - pharmacology | Hallucinogens - pharmacology | Dibenzothiazepines - pharmacology | Quetiapine Fumarate | Risperidone - administration & dosage | Risperidone - pharmacology | Rats | Cognition Disorders - drug therapy | Dibenzothiazepines - administration & dosage | Antipsychotic Agents - administration & dosage | Animals | Benzodiazepines - administration & dosage | Antipsychotic Agents - pharmacology | Schizophrenia - drug therapy | Psychotropic drugs | Pharmacology | Cognition & reasoning | Rodents
Journal Article
NEUROPSYCHOPHARMACOLOGY, ISSN 0893-133X, 08/2013, Volume 38, Issue 9, pp. 1816 - 1824
The neuronal mechanisms underlying social withdrawal, one of the core negative symptoms of schizophrenia, are not well understood. Recent studies suggest an... 
endocannabinoid | ANTERIOR CINGULATE CORTEX | HEALTHY-SUBJECTS | PSYCHIATRY | SUSCEPTIBILITY | cholecystokinin | RATS | NEUROSCIENCES | NUCLEUS-ACCUMBENS | GENE | ENDOCANNABINOIDS | negative symptoms | social interaction | PHARMACOLOGY & PHARMACY | HEBEPHRENIC SCHIZOPHRENIA | PCP | EXPRESSION | Endocannabinoids - metabolism | Phencyclidine - pharmacology | Amygdala - drug effects | Male | Piperidines - antagonists & inhibitors | Cannabinoid Receptor Agonists - pharmacology | Receptor, Cannabinoid, CB1 - physiology | Dose-Response Relationship, Drug | Arachidonic Acids - metabolism | Endocannabinoids - physiology | Prefrontal Cortex - drug effects | Receptor, Cannabinoid, CB1 - agonists | Piperidines - pharmacology | Schizophrenia - physiopathology | Social Behavior | Cannabinoid Receptor Antagonists - pharmacology | Benzamides - pharmacology | Cyclohexanols - pharmacology | Quinazolinones - pharmacology | Carbamates - pharmacology | Pyrazoles - pharmacology | Phencyclidine - antagonists & inhibitors | Amygdala - metabolism | Receptor, Cholecystokinin B - antagonists & inhibitors | Rats | Amidohydrolases - antagonists & inhibitors | Polyunsaturated Alkamides - metabolism | Animals | Prefrontal Cortex - metabolism | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Pyrazoles - antagonists & inhibitors | animal models | antipsychotics | cannabinoids | Neuropharmacology | schizophrenia | Original
Journal Article
Psychopharmacology, ISSN 0033-3158, 7/2007, Volume 193, Issue 1, pp. 121 - 136
Data from both preclinical and clinical studies have provided proof of concept that modulation of limbic and forebrain glutamate, via mGlu2/3 receptor... 
Animal models | Biomedicine | mGlu2/3 receptor agonist | Schizophrenia | Antipsychotic | Anxiety | Pharmacology/Toxicology | Psychiatry | Psychiatric disorders | Anxiolytic | Metabotropic glutamate (mGlu) receptors | MGlu2/3 receptor agonist | SINGLY HOUSED MICE | animal models | METABOTROPIC GLUTAMATE-RECEPTOR | RAT | PSYCHIATRY | ACID LY354740 | schizophrenia | metabotropic glutamate (mGlu) receptors | NEUROSCIENCES | NUCLEUS-ACCUMBENS | PHENCYCLIDINE | anxiety | MESSENGER-RNA | MEDIAL PREFRONTAL CORTEX | PHARMACOLOGY & PHARMACY | antipsychotic | anxiolytic | psychiatric disorders | STRESS-INDUCED HYPERTHERMIA | Cyclic S-Oxides - chemistry | Phencyclidine - pharmacology | Rats, Inbred F344 | Motor Activity - drug effects | Male | Amino Acids - pharmacology | Diazepam - pharmacology | Dose-Response Relationship, Drug | Prefrontal Cortex - drug effects | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Behavior, Animal - drug effects | Cyclic S-Oxides - pharmacology | Molecular Structure | Xanthenes - pharmacology | Disease Models, Animal | Bridged Bicyclo Compounds, Heterocyclic - chemistry | Amphetamine - pharmacology | Rats | Rats, Sprague-Dawley | Mental Disorders - psychology | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Cyclic S-Oxides - therapeutic use | Animals | Mental Disorders - drug therapy | Prefrontal Cortex - metabolism | Mice