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Neuroscience Letters, ISSN 0304-3940, 01/2003, Volume 335, Issue 3, pp. 167 - 170
Some anticonvulsants show neuroprotective effects, and may be of use in reducing neuronal death resulting from stroke or traumatic brain injury. Here I report... 
Oxygen/glucose deprivation | Hippocampal slice cultures | Neuroprotection | Anticonvulsants | OXYGEN | INHIBITION | IN-VITRO ISCHEMIA | neuroprotection | DRUGS | hippocampal slice cultures | oxygen/glucose deprivation | GLUCOSE DEPRIVATION | anticonvulsants | NEUROSCIENCES | DAMAGE | Phenobarbital - pharmacology | Hypoxia - drug therapy | Amines | Felbamate | Gabapentin | Rats, Wistar | Phenylcarbamates | Anticonvulsants - administration & dosage | Hippocampus - drug effects | Anticonvulsants - pharmacology | Valproic Acid - pharmacology | Hypoxia - metabolism | Dose-Response Relationship, Drug | Oxcarbazepine | Tiagabine | Neuroprotective Agents - pharmacology | Piracetam - pharmacology | Phenytoin - pharmacology | Chlordiazepoxide - pharmacology | Neurons - metabolism | Cell Death - drug effects | Neurons - drug effects | Neuroprotective Agents - administration & dosage | Nipecotic Acids - pharmacology | Carbamates - pharmacology | Propylene Glycols - pharmacology | gamma-Aminobutyric Acid | Carbamazepine - pharmacology | Triazines - pharmacology | Carbamazepine - analogs & derivatives | Cells, Cultured | Ischemia - metabolism | Rats | Hippocampus - cytology | Glucose - deficiency | Hippocampus - metabolism | Animals | Ischemia - drug therapy | Piracetam - analogs & derivatives | Phenylenediamines - pharmacology | Acetates - pharmacology | Cyclohexanecarboxylic Acids | Ethosuximide - pharmacology | Midazolam - pharmacology | Lamotrigine | Levetiracetam | Brain | Cell death | Injuries | Stroke (Disease)
Journal Article
Psychopharmacology, ISSN 0033-3158, 7/2015, Volume 232, Issue 14, pp. 2463 - 2479
Seizures occur when the excitability of brain circuits is not sufficiently restrained by inhibitory mechanisms. Although modafinil is reported to reduce... 
Maximal electroshock-induced seizures | Neurosciences | Pharmacokinetic/pharmacodynamic interaction | Biomedicine | Modafinil | GBR 12909 | Pharmacology/Toxicology | Psychiatry | Antiepileptic drugs | P-ISOPROPOXYPHENYLSUCCINIMIDE | PSYCHIATRY | DOPAMINE TRANSPORTERS | CONSCIOUS RAT | VALPROATE | ISOBOLOGRAPHIC ANALYSIS | NEUROSCIENCES | AGENT MODAFINIL | THRESHOLD | PHENYTOIN | PHARMACOLOGY & PHARMACY | MICE | TIAGABINE | Phenobarbital - pharmacology | Valproic Acid - pharmacokinetics | Central Nervous System Stimulants - pharmacology | Seizures - prevention & control | Male | Sulfones - pharmacology | Anticonvulsants - pharmacology | Valproic Acid - pharmacology | Brain - metabolism | Dose-Response Relationship, Drug | Drug Interactions | Phenytoin - pharmacology | Hand Strength | Carbamazepine - pharmacology | Anticonvulsants - pharmacokinetics | Phenobarbital - pharmacokinetics | Psychomotor Performance - drug effects | Brain - drug effects | Drug Synergism | Animals | Avoidance Learning - drug effects | Benzhydryl Compounds - pharmacology | Mice | Carbamazepine - pharmacokinetics | Electroshock | Phenytoin - pharmacokinetics | Anticonvulsants | Metabolites | Drug interactions | Physiological aspects | Dosage and administration | Seizures (Medicine) | Observations | Health aspects | Drugs | Convulsions & seizures | Psychopharmacology | Rodents | Epilepsy | pharmacodynamic interaction | Original Investigation | Pharmacokinetic
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2017, Volume 12, Issue 8, p. e0183873
Accumulating evidence indicates that cannabinoid CB1 receptor ligands play a pivotal role in seizures, not only in preclinical studies on animals, but also in... 
ELECTROSHOCK-INDUCED SEIZURES | CB1 RECEPTOR AGONIST | WIN 55,212-2 MESYLATE | 6 HZ | ANTICONVULSANT ACTIVITY | MULTIDISCIPLINARY SCIENCES | ENDOGENOUS CANNABINOID SYSTEM | INDUCED SEIZURE MODEL | PENTYLENETETRAZOLE-INDUCED SEIZURE | ISOBOLOGRAPHIC ANALYSIS | HOT-PLATE TEST | Phenobarbital - pharmacology | Cornea | Acetamides - pharmacology | Epilepsy, Complex Partial - physiopathology | Male | Anticonvulsants - pharmacology | Valproic Acid - pharmacology | Receptor, Cannabinoid, CB1 - agonists | Piracetam - pharmacology | Phenylmethylsulfonyl Fluoride - pharmacology | Drug Therapy, Combination | Nipecotic Acids - pharmacology | Epilepsy, Complex Partial - metabolism | Disease Models, Animal | Benzodiazepines - pharmacology | Psychomotor Performance - drug effects | Arachidonic Acids - pharmacology | Drug Synergism | Animals | Piracetam - analogs & derivatives | Electroshock - methods | Avoidance Learning - drug effects | Mice | Muscle Strength - drug effects | Epilepsy, Complex Partial - drug therapy | Physiological aspects | Anticonvulsants | Seizures (Medicine) | Drug therapy | Testing | Drugs | Brain | Laboratories | Epilepsy | Memory | Stimulation | Antiepileptic agents | Motor task performance | Experiments | Tiagabine | Convulsions & seizures | Fluoride | Muscular strength | Drug dosages | Seizures | Seizing | Phenylmethylsulfonyl fluoride | Pharmacology | Liquid chromatography | Cannabinoid CB1 receptors | Valproic acid | High-performance liquid chromatography | Medical screening | Etiracetam | Side effects | Phenobarbital | Psychomotor performance | Neurotransmission
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, p. e0122752
Background Infection is a common cause of acute lung injury (ALI). This study was aimed to explore whether Toll-like receptors 4 (TLR4) of airway smooth muscle... 
ISCHEMIA/REPERFUSION INJURY | OXIDATIVE STRESS | TLR4 PATHWAY | ISOFLURANE | MULTIDISCIPLINARY SCIENCES | ALVEOLAR MACROPHAGES | MICE | EXPRESSION | BINDING | LPS | Tumor Necrosis Factor-alpha - metabolism | Interleukin-1 - genetics | Nitriles - pharmacology | Tumor Necrosis Factor-alpha - genetics | Myocytes, Smooth Muscle - pathology | Acute Lung Injury - genetics | NF-kappa B - metabolism | Sulfones - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Lipopolysaccharides | Acute Lung Injury - prevention & control | Muscle Relaxants, Central - pharmacology | Female | Lung - metabolism | Toll-Like Receptor 4 - antagonists & inhibitors | Myocytes, Smooth Muscle - drug effects | Interleukin-6 - metabolism | Myocytes, Smooth Muscle - metabolism | Interleukin-1 - metabolism | Lung - pathology | NF-kappa B - antagonists & inhibitors | Vasodilator Agents - pharmacology | Interleukin-6 - genetics | Signal Transduction | Acetylcholine - pharmacology | Mice, Inbred C57BL | Gene Expression Regulation | Toll-Like Receptor 4 - genetics | Bronchodilator Agents - pharmacology | Methyl Ethers - pharmacology | Acute Lung Injury - pathology | Toll-Like Receptor 4 - metabolism | Sevoflurane | Animals | Acute Lung Injury - chemically induced | NF-kappa B - genetics | Isoproterenol - pharmacology | Lung - drug effects | Mice | Bronchoalveolar Lavage Fluid - chemistry | Primary Cell Culture | Smooth muscle | Segments | Activation | Isoproterenol | Interleukin 6 | Proteins | Respiratory tract | Receptors | Bronchoalveolar lavage | Rodents | Methacholine | Interleukin 1 | Toll-like receptors | Anesthesia | Chronic obstructive pulmonary disease | Alveoli | Trachea | Immune system | Sensitizing | Antigens | NF-κB protein | Cytokines | Contractility | Muscles | Bronchus | Inflammation | Pharmacology | TLR4 protein | Tumor necrosis factor-α | Gene expression | Muscle contraction | Asthma | Phenobarbital | Hospitals | Lungs | In vivo methods and tests | Acetylcholine | Infiltration | Anesthesiology
Journal Article
Journal Article
Progress in Neuropsychopharmacology & Biological Psychiatry, ISSN 0278-5846, 12/2011, Volume 35, Issue 8, pp. 1870 - 1876
The aim of this study was to determine the effect of WIN 55,212-2 mesylate (WIN — a non-selective cannabinoid CB1 and CB2 receptor agonist) on the protective... 
Cannabinoids | Pentylenetetrazole | Antiepileptic drugs | Pharmacokinetic/pharmacodynamic interactions | WIN 55,212-2 mesylate | PSYCHIATRY | SYNAPTIC-TRANSMISSION | ANTICONVULSANT | MAXIMAL ELECTROSHOCK SEIZURE | ISOBOLOGRAPHIC ANALYSIS | NEUROSCIENCES | CLINICAL NEUROLOGY | RAT HIPPOCAMPAL-NEURONS | CONVENTIONAL ANTIEPILEPTIC DRUGS | CALCIUM-CHANNELS | PHARMACOLOGY | PHARMACOLOGY & PHARMACY | EPILEPSY | CB1 RECEPTORS | Phenobarbital - pharmacology | Valproic Acid - pharmacokinetics | Ethosuximide - pharmacokinetics | Seizures - drug therapy | Male | Cannabinoid Receptor Agonists - pharmacology | Anticonvulsants - pharmacology | Valproic Acid - pharmacology | Seizures - chemically induced | Benzoxazines - pharmacokinetics | Cannabinoid Receptor Agonists - therapeutic use | Valproic Acid - therapeutic use | Naphthalenes - pharmacokinetics | Clonazepam - pharmacokinetics | Clonazepam - therapeutic use | Hand Strength | Morpholines - therapeutic use | Disease Models, Animal | Anticonvulsants - pharmacokinetics | Ethosuximide - therapeutic use | Anticonvulsants - therapeutic use | Clonazepam - pharmacology | Morpholines - pharmacology | Phenobarbital - pharmacokinetics | Benzoxazines - therapeutic use | Naphthalenes - pharmacology | Brain - drug effects | Drug Synergism | Phenobarbital - therapeutic use | Animals | Benzoxazines - pharmacology | Avoidance Learning - drug effects | Cannabinoid Receptor Agonists - pharmacokinetics | Mice | Morpholines - pharmacokinetics | Ethosuximide - pharmacology | Naphthalenes - therapeutic use
Journal Article
Journal Article
Neuropharmacology, ISSN 0028-3908, 2006, Volume 50, Issue 1, pp. 98 - 110
Journal Article
Journal Article