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1. Full Text Recent progress in biological activities of synthesized phenothiazines
by Pluta, Krystian and Morak-Młodawska, Beata and Jeleń, Małgorzata
European journal of medicinal chemistry, ISSN 0223-5234, 2011, Volume 46, Issue 8, pp. 3179 - 3189
Multi-drug resistance | Antifungal | Antibacterial | Azaphenothiazines | Anticancer | Phenothiazines | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | General aspects | Pharmacology. Drug treatments | Bones, joints and connective tissue. Antiinflammatory agents | Biological and medical sciences | Medical sciences | Antineoplastic agents | Antibiotics. Antiinfectious agents. Antiparasitic agents | Analgesics - pharmacology | Drug Resistance, Multiple | Humans | Bacteria - drug effects | Cell Membrane Permeability | Trypanocidal Agents - chemistry | Antifungal Agents - chemistry | Structure-Activity Relationship | Anticonvulsants - pharmacology | Antiviral Agents - chemistry | Phenothiazines - pharmacology | Anti-Bacterial Agents - chemistry | Antineoplastic Agents - pharmacology | Immunosuppressive Agents - pharmacology | Antifungal Agents - pharmacology | Rabbits | Antiviral Agents - pharmacology | Anti-Inflammatory Agents - pharmacology | Solubility | Rats | Viruses - drug effects | Antineoplastic Agents - chemistry | Antimalarials - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Antipsychotic Agents - chemistry | Phenothiazines - chemistry | Trypanocidal Agents - pharmacology | Analgesics - chemistry | Anticonvulsants - chemistry | Antimalarials - chemistry | Hydrophobic and Hydrophilic Interactions | Anti-Bacterial Agents - pharmacology | Mice | Antipsychotic Agents - pharmacology | Immunosuppressive Agents - chemistry | Index Medicus
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2. Full Text Inhibition of Heparin-induced Tau Filament Formation by Phenothiazines, Polyphenols, and Porphyrins
by Sayuri Taniguchi and Nobuyuki Suzuki and Masami Masuda and Shin-ichi Hisanaga and Takeshi Iwatsubo and Michel Goedert and Masato Hasegawa
The Journal of biological chemistry, ISSN 0021-9258, 03/2005, Volume 280, Issue 9, pp. 7614 - 7623
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Models, Chemical | Humans | Porphyrins - chemistry | Benzophenones - pharmacology | tau Proteins - metabolism | tau Proteins - chemistry | Brain - metabolism | Dose-Response Relationship, Drug | Microtubules - metabolism | Neurofibrillary Tangles - metabolism | Time Factors | tau Proteins - physiology | Microtubules - ultrastructure | Polyphenols | Fluorescent Dyes - pharmacology | Flavonoids - pharmacology | Catechin - pharmacology | Phenols - pharmacology | Electrophoresis, Polyacrylamide Gel | Quinacrine Mustard - pharmacology | Enzyme Inhibitors - pharmacology | Antioxidants - pharmacology | Azure Stains - pharmacology | Methylene Blue - pharmacology | Phenothiazines - chemistry | Protein Binding | Phenols - chemistry | Catechin - analogs & derivatives | Flavonoids - chemistry | Heparin - chemistry | Index Medicus
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3. Full Text Phenothiazine: the seven lives of pharmacology's first lead structure
by Ohlow, Maike J and Moosmann, Bernd
Drug discovery today, ISSN 1359-6446, 2011, Volume 16, Issue 3, pp. 119 - 131
Phenothiazines - chemical synthesis | Phenothiazines - chemistry | Phenothiazines - pharmacology | Models, Molecular | Drug Discovery - methods | Molecular Structure | Structure-Activity Relationship | Antioxidants | Pharmacology | Phenothiazine | Neurological diseases | Antihistaminics | Dyes | Antibiotics | Phenothiazines | Chains | Derivatives | Index Medicus
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4. Full Text Azaphenothiazines – promising phenothiazine derivatives. An insight into nomenclature, synthesis, structure elucidation and biological properties
by Pluta, Krystian and Jeleń, Małgorzata and Morak-Młodawska, Beata and Zimecki, Michał and Artym, Jolanta and Kocięba, Maja and Zaczyńska, Ewa
European journal of medicinal chemistry, ISSN 0223-5234, 09/2017, Volume 138, pp. 774 - 806
Structure - activity relationship | Azaphenothiazines | Phenothiazines | Multiple biological activities | Structural analysis | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Antineoplastic Agents - chemical synthesis | Humans | Bacteria - drug effects | Antifungal Agents - chemical synthesis | Antifungal Agents - chemistry | Antipsychotic Agents - chemical synthesis | Phenothiazines - pharmacology | Anti-Bacterial Agents - chemistry | Leishmania - drug effects | Antiprotozoal Agents - chemical synthesis | Antineoplastic Agents - pharmacology | Molecular Structure | Antifungal Agents - pharmacology | Fungi - drug effects | Antiprotozoal Agents - chemistry | Antineoplastic Agents - chemistry | Antiprotozoal Agents - pharmacology | Neoplasms - drug therapy | Anti-Bacterial Agents - chemical synthesis | Phenothiazines - chemical synthesis | Animals | Antipsychotic Agents - chemistry | Phenothiazines - chemistry | Anti-Bacterial Agents - pharmacology | Antipsychotic Agents - pharmacology | Alkaloids | Pyrimidines | Pyridine | Pharmacy | Analysis | Quinoline | Nitrogen | Phenothiazine | Index Medicus
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5. Full Text The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease
by Justin Lamb and Emily D. Crawford and David Peck and Joshua W. Modell and Irene C. Blat and Matthew J. Wrobel and Jim Lerner and Jean-Philippe Brunet and Aravind Subramanian and Kenneth N. Ross and Michael Reich and Haley Hieronymus and Guo Wei and Scott A. Armstrong and Stephen J. Haggarty and Paul A. Clemons and Ru Wei and Steven A. Carr and Eric S. Lander and Todd R. Golub
Science (American Association for the Advancement of Science), ISSN 0036-8075, 9/2006, Volume 313, Issue 5795, pp. 1929 - 1935
Molecules | Databases | Disease models | Epithelial cells | Genes | Estrogens | Cell lines | Connectivity | Cultured cells | Research Articles | Signatures | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Hematologic and hematopoietic diseases | Diabetes. Impaired glucose tolerance | Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Medical sciences | Endocrine pancreas. Apud cells (diseases) | Estrogens - pharmacology | Gene Expression - drug effects | Oligonucleotide Array Sequence Analysis | Humans | Drug Resistance, Neoplasm | Gene Expression Profiling | Obesity - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Dexamethasone - pharmacology | Phenothiazines - pharmacology | Databases, Factual | Cell Line | Drug Evaluation, Preclinical - methods | Sirolimus - therapeutic use | Enzyme Inhibitors - pharmacology | Alzheimer Disease - drug therapy | Obesity - physiopathology | Sirolimus - pharmacology | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - physiopathology | Limonins - pharmacology | Dexamethasone - therapeutic use | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Cell Line, Tumor | Histone Deacetylase Inhibitors | Software | Alzheimer Disease - genetics | Drugs | Complications and side effects | Research | Genetic variation | Analysis | Diseases | Cell culture | Feasibility | Disease | Gene expression | Index Medicus
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6. Full Text Thioridazine as chemotherapy for Mycobacterium avium complex diseases
by Deshpande, Devyani and Srivastava, Shashikant and Musuka, Sandirai and Gumbo, Tawanda
Antimicrobial agents and chemotherapy, ISSN 0066-4804, 08/2016, Volume 60, Issue 8, pp. 4652 - 4658
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Ethambutol - pharmacology | Humans | Half-Life | Drug Resistance - drug effects | Mycobacterium avium Complex - drug effects | Mutation - drug effects | Mycobacterium avium-intracellulare Infection - drug therapy | Phenothiazines - pharmacology | Thioridazine - pharmacology | Macrolides - pharmacology | Anti-Bacterial Agents - pharmacology | Antipsychotic Agents - pharmacology | Microbial Sensitivity Tests - methods | Index Medicus
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7. Full Text N‑Heterocyclic (4-Phenylpiperazin-1-yl)methanones Derived from Phenoxazine and Phenothiazine as Highly Potent Inhibitors of Tubulin Polymerization
by Prinz, Helge and Ridder, Ann-Kathrin and Vogel, Kirsten and Böhm, Konrad J and Ivanov, Igor and Ghasemi, Jahan B and Aghaee, Elham and Müller, Klaus
Journal of medicinal chemistry, ISSN 0022-2623, 01/2017, Volume 60, Issue 2, pp. 749 - 766
Tubulin Modulators - chemistry | Tubulin Modulators - pharmacology | Alkylating Agents - pharmacology | Humans | Polymerization | Piperazines - chemistry | Antineoplastic Agents - chemistry | Piperazines - pharmacology | Ethylenediamines - pharmacology | Tubulin - metabolism | G2 Phase Cell Cycle Checkpoints - drug effects | Phenothiazines - chemistry | Phenothiazines - pharmacology | K562 Cells | Antineoplastic Agents - pharmacology | Molecular Docking Simulation | Oxazines - chemistry | Tubulin - chemistry | Quantitative Structure-Activity Relationship | Oxazines - pharmacology | Index Medicus
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8. Full Text The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. Novel insights into drug mechanisms of action
by Boshoff, Helena I. M and Myers, Timothy G and Copp, Brent R and McNeil, Michael R and Wilson, Michael A and Barry III, Clifton E
The Journal of biological chemistry, ISSN 0021-9258, 09/2004, Volume 279, Issue 38, pp. 40174 - 40184
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Genome, Bacterial | Electron Transport - drug effects | Oligonucleotide Array Sequence Analysis | Ethambutol - pharmacology | Transcriptional Activation - drug effects | Antitubercular Agents - pharmacology | Enzyme Inhibitors - pharmacology | Azoles - pharmacology | Mycobacterium tuberculosis - drug effects | Gene Expression Regulation, Bacterial - physiology | DNA Gyrase - metabolism | Gene Expression Regulation, Bacterial - drug effects | Cell Wall - drug effects | Phenothiazines - pharmacology | Cell Wall - metabolism | Fluoroquinolones - pharmacology | Topoisomerase II Inhibitors | Drug Design | Antipsychotic Agents - pharmacology | Mycobacterium tuberculosis - metabolism | Energy Metabolism - drug effects | Mycobacterium tuberculosis - genetics | Index Medicus
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