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Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 12/2015, Volume 107, Issue 12, p. djv274
Background: Cancer cachexia is a debilitating condition that impacts patient morbidity, mortality, and quality of life and for which effective therapies are... 
SKELETAL-MUSCLE ATROPHY | MURINE MODEL | FOXO | OXIDATIVE STRESS | TUMOR-BEARING MICE | ONCOLOGY | INSULIN-RESISTANCE | ADENOCARCINOMA | BIOCHEMISTRY | HDAC COMPLEXES | MECHANISMS | Cachexia - drug therapy | Histone Deacetylase Inhibitors - administration & dosage | Muscle, Skeletal - metabolism | Weight Loss - drug effects | Leukemia Inhibitory Factor - metabolism | Tripartite Motif Proteins | Carcinoma, Lewis Lung - complications | Forkhead Transcription Factors - metabolism | Mitochondrial Proteins - metabolism | Muscle, Skeletal - drug effects | Phenylbutyrates - administration & dosage | Cachexia - etiology | Muscle Proteins - metabolism | Phenylbutyrates - pharmacology | Cachexia - metabolism | Interleukin-6 - metabolism | Cytokines - metabolism | Neoplasms, Experimental - complications | Administration, Oral | Ubiquitin-Protein Ligases - metabolism | SKP Cullin F-Box Protein Ligases - metabolism | Lipase - metabolism | Adenocarcinoma - complications | Cachexia - prevention & control | Colonic Neoplasms - complications | Gene Expression Regulation - drug effects | Animals | Cytokines - drug effects | Ion Channels - metabolism | Survival Analysis | MEF2 Transcription Factors - metabolism | Histone Deacetylase Inhibitors - pharmacology | Forkhead Box Protein O1 | Mice | Muscle Strength - drug effects | Adipose Tissue - drug effects | Uncoupling Protein 3 | Cytokines - biosynthesis | Receptors, Interleukin-6 - metabolism | Care and treatment | Synthesis | Proteolysis | Glycogen | Patient outcomes | Colorectal cancer | Development and progression | Research
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 08/2013, Volume 305, Issue 3, pp. H344 - H353
A contributing factor to increased peripheral resistance seen during hypertension is an increased production of endothelium-derived contractile factors... 
Cyclooxygenase | EDCF | ERK1/2 | cPLA | Endoplasmic reticulum stress | CYTOSOLIC PHOSPHOLIPASE A | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | MESENTERIC-ARTERIES | ER STRESS | OLETF RATS | cyclooxygenase | endoplasmic reticulum stress | PROSTANOID RECEPTORS | UNFOLDED PROTEIN RESPONSE | GENE-EXPRESSION | RENAL-ARTERIES | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | Antihypertensive Agents - pharmacology | Epoprostenol - metabolism | Phosphorylation | Muscle, Smooth, Vascular - metabolism | Rats, Inbred WKY | Endothelium, Vascular - drug effects | Hypertension - drug therapy | Male | Aorta - metabolism | Dinoprost - metabolism | Muscle, Smooth, Vascular - physiopathology | Dose-Response Relationship, Drug | Taurochenodeoxycholic Acid - pharmacology | Phenylbutyrates - pharmacology | tert-Butylhydroperoxide - pharmacology | Blood Pressure - drug effects | Membrane Proteins - metabolism | Aorta - physiopathology | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - metabolism | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Rats, Inbred SHR | Vasoconstrictor Agents - pharmacology | Vasodilator Agents - pharmacology | Endoplasmic Reticulum Stress - drug effects | Acetylcholine - pharmacology | Aorta - drug effects | Cells, Cultured | Endothelium, Vascular - physiopathology | bcl-2-Associated X Protein - metabolism | Rats | Vasoconstriction - drug effects | Hypertension - physiopathology | Phospholipases A2, Cytosolic - metabolism | Hydrogen Peroxide - metabolism | Hypertension - metabolism | Thromboxane A2 - metabolism | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Endothelium, Vascular - metabolism | Arachidonic Acid - pharmacology | Cyclooxygenase 1 - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Hypertension | Physiological aspects | Stress (Physiology) | Endoplasmic reticulum | Health aspects | Muscle contraction | cPLA2 | Vascular Biology and Microcirculation | ERK1
Journal Article
Science, ISSN 0036-8075, 8/2006, Volume 313, Issue 5790, pp. 1137 - 1140
Journal Article
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 06/2006, Volume 97, Issue 5, pp. 1259 - 1268
Endoplasmic reticulum (ER) stress is defined as an accumulation of unfolded proteins in the endoplasmic reticulum. 4‐phenylbutyrate (4‐PBA) has been... 
unfolded protein response | parkinsonism | chemical chaperone | endoplasmic reticulum | endoplasmic reticulum stress | 4‐phenylbutyrate | Parkinsonism | Chemical chaperone | Endoplasmic reticulum | 4-phenylbutyrate | Endoplasmic reticulum stress | Unfolded protein response | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATES HSC70 | TRAFFICKING | PREVENTION | RESTORATION | NEUROSCIENCES | CELL-DEATH | FETAL-HEMOGLOBIN | SODIUM 4-PHENYLBUTYRATE | CYSTIC-FIBROSIS | EXPRESSION | Molecular Chaperones - metabolism | Receptors, G-Protein-Coupled - metabolism | Humans | Nerve Degeneration - physiopathology | Endoplasmic Reticulum - metabolism | Nerve Degeneration - metabolism | Neuroprotective Agents - metabolism | Antineoplastic Agents - metabolism | Parkinsonian Disorders - metabolism | Receptor Aggregation - drug effects | Neuroprotective Agents - pharmacology | Endoplasmic Reticulum - drug effects | Phenylbutyrates - metabolism | Stress, Physiological - metabolism | Phenylbutyrates - pharmacology | Antineoplastic Agents - pharmacology | Neurons - metabolism | Cell Death - drug effects | Inclusion Bodies - metabolism | Neurons - drug effects | Receptors, G-Protein-Coupled - drug effects | Molecular Chaperones - pharmacology | Serum Albumin, Bovine - drug effects | Parkinsonian Disorders - physiopathology | Inclusion Bodies - drug effects | Serum Albumin, Bovine - metabolism | Protein Folding | Lactalbumin - metabolism | Cell Death - physiology | Signal Transduction - drug effects | Tunicamycin - pharmacology | Cell Line, Tumor | Signal Transduction - physiology | Saccharomyces cerevisiae | Nerve Degeneration - drug therapy | Lactalbumin - drug effects | Cystic fibrosis | Neurosciences | Chemistry | Protein folding | Apoptosis
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2012, Volume 131, Issue 2, pp. 532 - 540.e2
Background Increased vascular permeability is a fundamental characteristic of inflammation. Substances that are released during inflammation, such as... 
Allergy and Immunology | ACTIVATION | ANGIOGENESIS | EP4 | endothelial barrier | neutrophil trafficking | FACTOR-I | IMMUNOLOGY | acute lung injury | vascular leakage | ALLERGY | CELL-MIGRATION | ENHANCEMENT | prostaglandins | Chronic obstructive pulmonary disease | EXPRESSION | Capillary Permeability - physiology | Humans | Actins - metabolism | Microvessels - metabolism | Capillary Permeability - drug effects | Endothelium, Vascular - drug effects | Microvessels - immunology | Cell Movement - physiology | Coronary Vessels - metabolism | Pulmonary Artery - metabolism | Phenylbutyrates - pharmacology | Lung - metabolism | Nitric Oxide Synthase Type III - metabolism | Cyclic AMP - metabolism | Neutrophils - metabolism | Wound Healing - drug effects | Endothelium, Vascular - immunology | Receptors, Prostaglandin E, EP4 Subtype - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Cytochalasin B - pharmacology | Coronary Vessels - drug effects | Endothelial Cells - metabolism | Neutrophils - drug effects | Cells, Cultured | Neutrophils - immunology | Microvessels - drug effects | Methyl Ethers - pharmacology | Pulmonary Artery - drug effects | Cell Adhesion - drug effects | Naphthalenes - pharmacology | Dinoprostone - metabolism | Endothelial Cells - immunology | Cell Movement - drug effects | Cell Adhesion - physiology | Endothelium, Vascular - metabolism | Lung - drug effects | Wound Healing - physiology | rac1 GTP-Binding Protein - metabolism | Endothelial Cells - drug effects | Medical colleges | Actin | Prostaglandins E | Sphingosine | Permeability | Muscle proteins | Adenylic acid | Protein kinases | Endothelium | Leucocytes | Flow cytometry | Microscopy | Pulmonary arteries | Rodents | Cytoskeleton | Software | Biophysics | Binding sites | Cell adhesion & migration
Journal Article
Metabolic Brain Disease, ISSN 0885-7490, 3/2014, Volume 29, Issue 1, pp. 9 - 17
There is substantial clinical and experimental evidence that ammonia is a major factor in the pathogenesis of hepatic encephalopathy. In the article is... 
Biochemistry, general | Neurology | Ammonia | Neurosciences | Branched-chain amino acids | Biomedicine | Liver | Metabolic Diseases | Oncology | Phenylbutyrate | Glutamine | ACUTE LIVER-FAILURE | LEUCINE METABOLISM | UREA-CYCLE | AMMONIA METABOLISM | INDUCED HYPERAMMONEMIA | ALPHA-KETOGLUTARATE | CHAIN AMINO-ACIDS | NEUROSCIENCES | SKELETAL-MUSCLE | MONOSODIUM GLUTAMATE | ENDOCRINOLOGY & METABOLISM | RENAL AMMONIA | Hepatic Encephalopathy - diet therapy | Phenylbutyrates - therapeutic use | Amino Acids, Branched-Chain - therapeutic use | Hepatic Encephalopathy - metabolism | Hyperammonemia - metabolism | Enterocytes - metabolism | Amino Acids, Branched-Chain - metabolism | Humans | Phenylbutyrates - adverse effects | Critical Illness | Glutamine - metabolism | Ketoglutaric Acids - adverse effects | Muscle, Skeletal - metabolism | Hepatic Encephalopathy - drug therapy | Brain - metabolism | Hyperammonemia - drug therapy | Kidney - metabolism | Microbiota | Drug Interactions | Glutamic Acid - therapeutic use | Ketoglutaric Acids - therapeutic use | Ketoglutaric Acids - pharmacology | Phenylbutyrates - pharmacology | Hyperammonemia - etiology | Glutamic Acid - pharmacology | Ammonia - metabolism | Liver - metabolism | Organ Specificity | Glutaminase - antagonists & inhibitors | Intestines - microbiology | Glutamic Acid - metabolism | Urea | Branched chain amino acids | Physiological aspects | Muscles | Health aspects | Hepatic encephalopathy | Amino acids | Review
Journal Article
Cell Death and Disease, ISSN 2041-4889, 07/2010, Volume 1, Issue 7, pp. e52 - e52
Journal Article
Autophagy, ISSN 1554-8627, 09/2015, Volume 11, Issue 9, pp. 1688 - 1699
Journal Article
Critical Reviews in Biochemistry and Molecular Biology, ISSN 1040-9238, 6/2011, Volume 46, Issue 3, pp. 181 - 199
Journal Article