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Plant, Cell & Environment, ISSN 0140-7791, 02/2012, Volume 35, Issue 2, pp. 388 - 404
ABSTRACT Ascorbate and anthocyanins act as photoprotectants during exposure to high light (HL). They accumulate in Arabidopsis leaves in response to HL on a... 
vtc mutants | light stress | mRNA‐Seq | cyanidin | abscisic acid | kaempferol glycosides | LC–MS/MS | metabolite profiling | jasmonic acid | oxidative stress | LC-MS/MS | Oxidative stress | Cyanidin | Metabolite profiling | Light stress | MRNA-Seq | Abscisic acid | Kaempferol glycosides | Jasmonic acid | WILD-TYPE | EXPRESSION ANALYSIS | MS | ACID DEFICIENCY | mRNA-Seq | L-GALACTOSE PHOSPHORYLASE | PLANT SCIENCES | LC-MS | GENE-EXPRESSION | PHOTOSYSTEM-II | DEFICIENT MUTANT | HYDROGEN-PEROXIDE | ELECTRON-TRANSPORT | Arabidopsis - physiology | Oxidative Stress | Ascorbic Acid - metabolism | Arabidopsis Proteins - metabolism | Arabidopsis - radiation effects | Phenylpropionates - metabolism | Time Factors | Light | Malates - metabolism | Abscisic Acid - metabolism | Kaempferols - metabolism | Arabidopsis Proteins - genetics | Gene Expression Regulation, Plant - radiation effects | Arabidopsis - chemistry | Ascorbic Acid - analysis | Oxidation-Reduction | Gene Expression Regulation, Plant - genetics | Acclimatization | Plant Leaves - radiation effects | Transcription Factors - genetics | Anthocyanins - metabolism | Pancreatitis-Associated Proteins | Arabidopsis - genetics | Transcription Factors - metabolism | Oxylipins - metabolism | Plant Leaves - genetics | Plant Leaves - metabolism | Glycosides - metabolism | Cyclopentanes - metabolism | Ecotype | Mutation | Plant Growth Regulators - metabolism | Arabidopsis thaliana | Anthocyanin | Enzymes | Metabolites | Analysis | Physiological aspects | Chromophores | DNA binding proteins | Mass spectrometry | upstream | Biosynthesis | Hormones | ecotypes | flavonoids | Mutants
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, p. e87548
Background: Inhibition of the transporter-mediated hepatobiliary elimination of bile salts is a putative mechanism for liver toxicity observed with some... 
BILE-ACID TRANSPORT | IN-VITRO | RAT HEPATOCYTES | PULMONARY ARTERIAL-HYPERTENSION | SALT EXPORT PUMP | BILIARY-EXCRETION | MULTIDISCIPLINARY SCIENCES | HEPATIC-UPTAKE | KNOCKOUT MICE | FAMILIAL INTRAHEPATIC CHOLESTASIS | P-GLYCOPROTEIN | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Humans | Middle Aged | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Bile - metabolism | Male | Hepatocytes - metabolism | Pyridazines - pharmacology | Neoplasm Proteins - metabolism | Organic Anion Transporters - metabolism | Liver - drug effects | Organic Anion Transporters, Sodium-Independent - metabolism | ATP-Binding Cassette Transporters - metabolism | Adult | Female | Membrane Transport Proteins - metabolism | Endothelin Receptor Antagonists | Hepatocytes - drug effects | Solute Carrier Organic Anion Transporter Family Member 1B3 | Taurocholic Acid - pharmacology | Liver - metabolism | Receptors, Endothelin - metabolism | Thiophenes - pharmacology | Bile Acids and Salts - metabolism | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Symporters - metabolism | Isoxazoles - pharmacology | Phenylpropionates - pharmacology | Bile - drug effects | Solute Carrier Organic Anion Transporter Family Member 1b1 | Multidrug Resistance-Associated Proteins - metabolism | Organic Anion Transporters, Sodium-Dependent - metabolism | Drug resistance in microorganisms | Endothelin | Bile acids | Research | Analysis | Salts | Transplants & implants | Toxicity | Pathogenesis | Liver | Gallbladder diseases | Accumulation | Bioaccumulation | Rodents | Protein transport | P-Glycoprotein | Efflux | Polypeptides | Mortality | Multidrug resistance | Glycoprotein | Substrate inhibition | Breast cancer | Substrates | Bile salts | Organic anion transporting polypeptide | Molecular modelling | Acids | Sodium | Hepatocytes | Transporter | Cancer | Bile
Journal Article
Canadian Journal of Physiology and Pharmacology, ISSN 0008-4212, 06/2010, Volume 88, Issue 6, pp. 682 - 691
To evaluate potential mechanisms of clinical hepatotoxicity, 4 endothelin receptor antagonists (ERAs) were examined for substrate activity and inhibition of... 
Hepatic transport | BSEP | Endothelin | Transporter substrate | Pulmonary artery hypertension | Endothelin receptor antagonists | OATP | PHARMACOKINETIC INTERACTION | PHYSIOLOGY | pulmonary artery hypertension | RAT HEPATOCYTES | PULMONARY ARTERIAL-HYPERTENSION | SALT EXPORT PUMP | transporter substrate | HEPATIC-UPTAKE | endothelin receptor antagonists | CLINICAL-PRACTICE GUIDELINES | endothelin | CYCLOSPORINE-A | THERAPY | BILIARY-EXCRETION | KETOCONAZOLE | PHARMACOLOGY & PHARMACY | hepatic transport | Antihypertensive Agents - pharmacology | Estradiol - analogs & derivatives | Taurocholic Acid - metabolism | Humans | Middle Aged | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Male | Thiophenes - metabolism | Antihypertensive Agents - metabolism | Hepatocytes - metabolism | Pyridazines - pharmacology | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Organic Anion Transporters - metabolism | Pyrimidines - metabolism | Young Adult | Phenylpropionates - metabolism | Symporters - antagonists & inhibitors | ATP-Binding Cassette Transporters - metabolism | Adult | Female | Pyridazines - metabolism | Biological Transport - drug effects | Cell Culture Techniques | Endothelin Receptor Antagonists | Hepatocytes - drug effects | Estradiol - metabolism | Organic Anion Transporters - antagonists & inhibitors | Isoxazoles - metabolism | Organic Anion Transporters, Sodium-Dependent - antagonists & inhibitors | Cells, Cultured | Thiophenes - pharmacology | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Symporters - metabolism | Isoxazoles - pharmacology | Phenylpropionates - pharmacology | ATP Binding Cassette Subfamily B Member 11 | Enkephalin, D-Penicillamine (2,5)- - metabolism | Adolescent | Sulfonamides - metabolism | Aged | Multidrug Resistance-Associated Proteins - metabolism | Organic Anion Transporters, Sodium-Dependent - metabolism | ATP-Binding Cassette Transporters - antagonists & inhibitors | Cell receptors | Genetic aspects | Research | Diagnosis | Properties | Health aspects | Liver cells | Pulmonary hypertension
Journal Article
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 10/2016, Volume 479, Issue 4, pp. 933 - 939
Journal Article
The Plant Cell, ISSN 1040-4651, 3/2001, Volume 13, Issue 3, pp. 535 - 551
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 03/2018, Volume 10, Issue 3, p. n/a
Brown adipose tissue (BAT) activation stimulates energy expenditure in human adults, which makes it an attractive target to combat obesity and related... 
GPR120 | brown adipose tissue | Ca2 | mitochondria | lipid metabolism | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | ACTIVATION | PROTEIN | INSULIN-SECRETION | THERMOGENESIS | POTENT | GLUCOSE-METABOLISM | GENE-EXPRESSION | ACID RECEPTOR GPR40 | ADIPOSE-TISSUE | Adipocytes, White - cytology | Adipocytes, Brown - metabolism | Receptors, G-Protein-Coupled - metabolism | Adipose Tissue, White - metabolism | Body Weight - drug effects | Lipids | Male | Receptors, G-Protein-Coupled - agonists | Adipocytes, White - drug effects | Biphenyl Compounds - pharmacology | Cell Respiration - drug effects | Adiposity - drug effects | Oxidation-Reduction | Adipocytes, Brown - drug effects | Uncoupling Protein 1 - metabolism | Mice, Inbred C57BL | Mitochondria - metabolism | Mitochondria - drug effects | Gene Expression Regulation - drug effects | Phenylpropionates - pharmacology | Animals | Receptors, G-Protein-Coupled - deficiency | Cell Differentiation - drug effects | Models, Biological | Oxygen Consumption - drug effects | Glucose - metabolism | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Adipocytes, Brown - cytology | Adipocytes, White - metabolism | Adipose Tissue, White - drug effects | Physiological aspects | Obesity | G proteins | Body weight | Membrane proteins | Pharmacology & Drug Discovery | Metabolism | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Cell and Molecular Biology | Cell- och molekylärbiologi
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2016, Volume 11, Issue 9, p. e0162512
Induction of brown-like adipocytes (beige/brite cells) in white adipose tissue (WAT) suggests a new approach for preventing and treating obesity via induction... 
ANTIOXIDANT ACTIVITY | ACTIVATION | INSULIN ACTION | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | PRDM16 | GENE-EXPRESSION | FAT | MUSCLE | CONSTITUENTS | Adipocytes, White - cytology | Thermogenesis - genetics | Adipocytes, Brown - metabolism | Adipose Tissue, White - metabolism | Male | PPAR gamma - metabolism | Obesity - genetics | DNA-Binding Proteins - metabolism | Adipocytes, White - drug effects | Adipose Tissue, White - cytology | Propolis - chemistry | Energy Metabolism - genetics | PPAR gamma - genetics | Cell Line | Uncoupling Protein 1 - agonists | Uncoupling Protein 1 - genetics | Signal Transduction | Adipocytes, Brown - drug effects | Administration, Oral | Uncoupling Protein 1 - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Anti-Obesity Agents - isolation & purification | Obesity - metabolism | Obesity - pathology | Phenylpropionates - isolation & purification | Transcription Factors - metabolism | Phenylpropionates - pharmacology | Adipose Tissue, Brown - cytology | Animals | Obesity - prevention & control | PPAR gamma - agonists | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Mice | Primary Cell Culture | Thermogenesis - drug effects | Anti-Obesity Agents - pharmacology | Adipocytes, Brown - cytology | Adipocytes, White - metabolism | Adipose Tissue, White - drug effects | Energy Metabolism - drug effects | Obesity | Fat cells | Care and treatment | Research | Propolis | Biotechnology | Adipose tissue | Body fat | Homology | Nervous system | Adipocytes | Kinases | Proteins | Signal transduction | Uncoupling protein 1 | Rodents | Food | Oral administration | Energy expenditure | Sympathetic nervous system | Metabolism | Gene expression | Insulin | Signaling | Browning | Thermogenesis | Diet | Morphology
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 11/2017, Volume 112, pp. 191 - 199
Excessive bone resorption caused by increased osteoclast number or activity leads to a variety of bone diseases including osteoporosis, rheumatoid arthritis... 
Bone resorption | Reactive oxygen species | Osteoclast | Apoptosis | DEFICIENCY BONE LOSS | OXIDATIVE STRESS | NADPH-OXIDASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NECROSIS-FACTOR-ALPHA | CRUCIAL ROLE | IN-VIVO | ENDOCRINOLOGY & METABOLISM | RECEPTOR ACTIVATOR | DIFFERENTIATION | LIGAND | NF-KAPPA-B | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics | Fas Ligand Protein - metabolism | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Apoptosis - genetics | Male | NF-kappa B - metabolism | Osteoclasts - cytology | fas Receptor - metabolism | RANK Ligand - pharmacology | Caspases - metabolism | fas Receptor - genetics | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism | Female | NF-E2-Related Factor 2 - genetics | Cell Differentiation | Osteogenesis - genetics | Diterpenes - pharmacology | Bone Resorption | Signal Transduction | Caspases - genetics | Mice, Inbred C57BL | NFATC Transcription Factors - metabolism | Osteogenesis - drug effects | Gene Expression Regulation | Proto-Oncogene Proteins c-fos - metabolism | Macrophages - cytology | Osteoclasts - metabolism | Phenylpropionates - pharmacology | Macrophages - metabolism | Reactive Oxygen Species - antagonists & inhibitors | Animals | NF-kappa B - genetics | RANK Ligand - antagonists & inhibitors | NF-E2-Related Factor 2 - metabolism | Macrophages - drug effects | Proto-Oncogene Proteins c-fos - genetics | Mice | Primary Cell Culture | Fas Ligand Protein - genetics | Osteoclasts - drug effects | NFATC Transcription Factors - genetics | Cell differentiation | Rheumatoid factor | Osteoporosis | Arthritis | Biomedical engineering
Journal Article