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Nature, ISSN 0028-0836, 2016, Volume 538, Issue 7625, pp. 344 - 349
Antimalarial drugs have thus far been chiefly derived from two sources-natural products and synthetic drug-like compounds. Here we investigate whether... 
IN-VITRO | TRANSFER-RNA SYNTHETASE | MALARIA CONTROL | PLASMODIUM-FALCIPARUM | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | LIVER | TARGETS | PROTEIN-SYNTHESIS | NEXT-GENERATION | HEPATIC STAGES | Azabicyclo Compounds - pharmacology | Plasmodium falciparum - enzymology | Malaria, Falciparum - prevention & control | Male | Plasmodium falciparum - cytology | Azetidines - pharmacology | Plasmodium falciparum - drug effects | Cytosol - enzymology | Malaria, Falciparum - transmission | Liver - drug effects | Azabicyclo Compounds - chemical synthesis | Azabicyclo Compounds - therapeutic use | Female | Safety | Antimalarials - chemical synthesis | Disease Models, Animal | Life Cycle Stages - drug effects | Malaria, Falciparum - drug therapy | Azabicyclo Compounds - administration & dosage | Azetidines - adverse effects | Phenylurea Compounds - therapeutic use | Antimalarials - therapeutic use | Macaca mulatta - parasitology | Phenylalanine-tRNA Ligase - antagonists & inhibitors | Drug Discovery | Antimalarials - pharmacology | Animals | Azetidines - administration & dosage | Phenylurea Compounds - chemical synthesis | Antimalarials - administration & dosage | Azetidines - therapeutic use | Phenylurea Compounds - administration & dosage | Mice | Phenylurea Compounds - pharmacology | Liver - parasitology | Plasmodium falciparum - growth & development | Prevention | Antimalarials | Disease transmission | Health aspects | Transfer RNA | Proteins | Cytochrome | Malaria | Liver | Parasites | Kinases | Drug resistance | Drug dosages | Index Medicus
Journal Article
Nature Biotechnology, ISSN 1087-0156, 01/2010, Volume 28, Issue 1, pp. 63 - 70
Phosphodiesterase 4 (PDE4), the primary cAMP-hydrolyzing enzyme in cells, is a promising drug target for a wide range of conditions. Here we present seven... 
CAMP-SPECIFIC PHOSPHODIESTERASE | PHOSPHORYLATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PROTEIN-KINASE | GENE COMPOSER | SUNCUS-MURINUS | AMP-SPECIFIC PHOSPHODIESTERASE | INHIBITORS | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE | ROLIPRAM BINDING | ANTIDEPRESSANT DRUGS | Phosphodiesterase Inhibitors - therapeutic use | Phosphodiesterase Inhibitors - adverse effects | Humans | Molecular Sequence Data | Crystallography, X-Ray | Structure-Activity Relationship | Benzhydryl Compounds - chemistry | Benzhydryl Compounds - adverse effects | Phenylurea Compounds - adverse effects | Phenylurea Compounds - chemistry | Drug Design | Phosphodiesterase 4 Inhibitors | Behavior, Animal - drug effects | Biological Assay | Phosphodiesterase Inhibitors - chemistry | Benzhydryl Compounds - therapeutic use | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Disease Models, Animal | Allosteric Regulation - drug effects | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | Catalytic Domain | Models, Molecular | Phenylurea Compounds - therapeutic use | Phosphodiesterase Inhibitors - pharmacology | Vomiting - drug therapy | Cognition - drug effects | Animals | Benzhydryl Compounds - pharmacology | Mice | Phenylurea Compounds - pharmacology | Kinetics | Care and treatment | Schizophrenia | Physiological aspects | Genetic aspects | Cellular signal transduction | Cyclic adenylic acid | Research | Phosphodiesterases | Enzymes | Biotechnology | Cellular biology | Molecular biology | Cognitive ability | Crystal structure | Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2013, Volume 56, Issue 22, pp. 9275 - 9295
Journal Article
Talanta, ISSN 0039-9140, 11/2013, Volume 116, pp. 376 - 381
The paper presents a novel approach for the determination of three cytokinin compounds, thidiazuron (TDZ), 1,3-diphenylurea (1,3-DPU) and forchlorfenuron... 
1,3-Diphenylurea | Thidiazuron | Dispersive liquid—liquid microextraction (DLLME) | Liquid chromatography with time-of-flight mass spectrometry (LC—TOFMS) | Forchlorfenuron | Fruits | Liquid chromatography with time-of-flight mass spectrometry (LC - TOFMS) | Dispersive liquid - liquid microextraction (DLLME) | Dispersive liquid-liquid microextraction (DLLME) | CHEMISTRY, ANALYTICAL | GRAPES | ANTIBODY-BASED IMMUNOASSAY | FORCHLORFENURON RESIDUES | VALIDATION | DIODE ARRAY DETECTION | PLANT-GROWTH REGULATORS | MULTIRESIDUE ANALYSIS | UNCERTAINTY | Liquid chromatography with time-of-flight mass spectrometry (LC-TOFMS) | SOLID-PHASE EXTRACTION | WATER | Limit of Detection | Vitis - chemistry | Citrullus - chemistry | Ethanol | Liquid Phase Microextraction - methods | Fruit - chemistry | Phenylurea Compounds - isolation & purification | Environmental Pollutants - isolation & purification | Factor Analysis, Statistical | Actinidia - chemistry | Vegetables - chemistry | Spectrometry, Mass, Electrospray Ionization | Acetonitriles | Thiadiazoles - isolation & purification | Lycopersicon esculentum - chemistry | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Carbanilides - isolation & purification | Ethylene Dichlorides | Pyridines - isolation & purification | Nitriles | Liquid chromatography | Vegetables | Mass spectrometry | Analysis | Index Medicus
Journal Article
Photochemistry and Photobiology, ISSN 0031-8655, 10/2017, Volume 93, Issue 5, pp. 1187 - 1192
A new photoreaction mechanism of “Three‐state molecular switch” fluorescence sensor based on ON 1 ‐ OFF ‐ ON 2 sequence was achieved by anthracene‐diurea... 
COMPLEX | CHEMOSENSOR | ANION | BIOPHYSICS | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ON-OFF SWITCH | HIGHLIGHTS | DERIVATIVES | BINDING | UREA | FLUORIDE | Protons | Urea | Hydrogen | Analysis | Fluorescence | Nuclear magnetic resonance spectroscopy | Sensors | Compound A | Molecular machines | Anthracene | Nuclear magnetic resonance--NMR | Radiation | Phenylurea | Hydrogen bonding | Switching | Quenching | Anions | Chemical bonds | Irradiation | Acetic acid | Bonding
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 01/2017, Volume 35, Issue 2, pp. 157 - 157
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2014, Volume 9, Issue 11, pp. e112027 - e112027
Objective: Diacylglycerol O-acyltransferase 1 (DGAT1) catalyzes the final committed step in triglyceride biosynthesis. DGAT1 null mice are known to be... 
ACYLTRANSFERASE 1 INHIBITION | DIACYLGLYCEROL ACYLTRANSFERASE | SKELETAL-MUSCLE | POTENT | LIPID-METABOLISM | STEATOSIS | MULTIDISCIPLINARY SCIENCES | INTRAMUSCULAR TRIGLYCERIDE | SENSITIVITY | SECRETION | TRIGLYCERIDE SYNTHESIS | Intestines - drug effects | Obesity - drug therapy | Humans | Biphenyl Compounds - adverse effects | Male | Intestines - metabolism | Enzyme Inhibitors - chemical synthesis | Biphenyl Compounds - therapeutic use | Diacylglycerol O-Acyltransferase - antagonists & inhibitors | Tissue Distribution | Enzyme Inhibitors - pharmacokinetics | Phenylurea Compounds - adverse effects | Phenylurea Compounds - pharmacokinetics | Enzyme Inhibitors - adverse effects | Biphenyl Compounds - pharmacokinetics | Mice, Inbred C57BL | Insulin Resistance | Phenylurea Compounds - therapeutic use | Enzyme Inhibitors - therapeutic use | Hep G2 Cells | HT29 Cells | Animals | Phenylurea Compounds - chemical synthesis | Biphenyl Compounds - chemical synthesis | Mice | Diacylglycerol O-Acyltransferase - metabolism | Skin - drug effects | Enzymes | Obesity | Insulin resistance | Triglycerides | Skin | Intellectual property | Enzyme activity | Laboratories | Diacylglycerol | Lipids | Biosynthesis | Skin resistance | Enzymatic activity | Intestine | Diacylglycerol O-acyltransferase | Rodents | Inhibition | Pharmaceutical industry | Distribution patterns | Compound A | Abnormalities | Insulin | Musculoskeletal system | Tobacco | Diet | Patent applications | In vivo methods and tests | Diabetes | Aberration | Binding sites | Endocrinology | Metabolic disorders | Index Medicus
Journal Article
Environmental science & technology, ISSN 0013-936X, 07/2019, Volume 53, Issue 16, pp. 9594 - 9603
Journal Article
European Journal of Cancer, ISSN 0959-8049, 2013, Volume 49, Issue 16, pp. 3412 - 3419
Abstract Purpose We assessed the safety of the multikinase inhibitor regorafenib in patients with hepatocellular carcinoma (HCC) that had progressed following... 
Hematology, Oncology and Palliative Medicine | Second line | Regorafenib | Hepatocellular carcinoma | Tolerability | Safety | Receptor kinase inhibition | Safety Second line | MANAGEMENT | EFFICACY | ONCOLOGY | SUNITINIB | Carcinoma, Hepatocellular - mortality | Humans | Middle Aged | Pyridines - pharmacokinetics | Male | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Liver Neoplasms - mortality | Pyridines - adverse effects | Carcinoma, Hepatocellular - drug therapy | Time Factors | Antineoplastic Agents - adverse effects | Phenylurea Compounds - adverse effects | Adult | Female | Liver Neoplasms - pathology | Antineoplastic Agents - pharmacokinetics | Phenylurea Compounds - pharmacokinetics | Liver Neoplasms - enzymology | Pyridines - therapeutic use | Protein Kinase Inhibitors - pharmacokinetics | Pyridines - administration & dosage | Drug Administration Schedule | Europe | Kaplan-Meier Estimate | Liver Neoplasms - drug therapy | Phenylurea Compounds - therapeutic use | Treatment Outcome | Carcinoma, Hepatocellular - enzymology | Disease Progression | Protein Kinase Inhibitors - administration & dosage | Phenylurea Compounds - administration & dosage | Asia | Protein Kinase Inhibitors - therapeutic use | Carcinoma, Hepatocellular - pathology | Aged | Neoplasm Staging | Care and treatment | Safety and security measures | Hepatoma | Index Medicus
Journal Article
Journal of Chromatography A, ISSN 0021-9673, 01/2019, Volume 1583, pp. 39 - 47
This work presents a simple and eco-friendly synthetic approach to fabricate a novel -hydroxyazobenzene porous organic polymer (HAzo-POP) by diazo-coupling of... 
o-Hydroxyazobenzene | Porous organic polymer | Phenylurea herbicides | Adsorbent | m-Trihydroxybenzene | CHEMISTRY, ANALYTICAL | LIQUID MICROEXTRACTION | POLLUTANTS | BIOCHEMICAL RESEARCH METHODS | FRAMEWORKS | FLUORESCENCE | ENRICHMENT | SURFACE | SAMPLES | SOLID-PHASE EXTRACTION
Journal Article