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Nature, ISSN 0028-0836, 2016, Volume 538, Issue 7625, pp. 344 - 349
Antimalarial drugs have thus far been chiefly derived from two sources-natural products and synthetic drug-like compounds. Here we investigate whether... 
IN-VITRO | TRANSFER-RNA SYNTHETASE | MALARIA CONTROL | PLASMODIUM-FALCIPARUM | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | LIVER | TARGETS | PROTEIN-SYNTHESIS | NEXT-GENERATION | HEPATIC STAGES | Azabicyclo Compounds - pharmacology | Plasmodium falciparum - enzymology | Malaria, Falciparum - prevention & control | Male | Plasmodium falciparum - cytology | Azetidines - pharmacology | Plasmodium falciparum - drug effects | Cytosol - enzymology | Malaria, Falciparum - transmission | Liver - drug effects | Azabicyclo Compounds - chemical synthesis | Azabicyclo Compounds - therapeutic use | Female | Safety | Antimalarials - chemical synthesis | Disease Models, Animal | Life Cycle Stages - drug effects | Malaria, Falciparum - drug therapy | Azabicyclo Compounds - administration & dosage | Azetidines - adverse effects | Phenylurea Compounds - therapeutic use | Antimalarials - therapeutic use | Macaca mulatta - parasitology | Phenylalanine-tRNA Ligase - antagonists & inhibitors | Drug Discovery | Antimalarials - pharmacology | Animals | Azetidines - administration & dosage | Phenylurea Compounds - chemical synthesis | Antimalarials - administration & dosage | Azetidines - therapeutic use | Phenylurea Compounds - administration & dosage | Mice | Phenylurea Compounds - pharmacology | Liver - parasitology | Plasmodium falciparum - growth & development | Prevention | Antimalarials | Disease transmission | Health aspects | Transfer RNA | Proteins | Cytochrome | Malaria | Liver | Parasites | Kinases | Drug resistance | Drug dosages
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2011, Volume 54, Issue 20, pp. 7066 - 7083
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2012, Volume 109, Issue 42, pp. 16986 - 16991
Macrophages acquire strikingly different properties that enable them to play key roles during the initiation, propagation, and resolution of inflammation.... 
14-3-3 proteins | Bacteriophages | Phosphorylation | Messenger RNA | Antiinflammatories | Cytokines | Secretion | Drug regulation | Genes | Macrophages | MRT67307 | HG-9-91-01 | AMPK-related kinases | Toll-like receptor | MRT199665 | MULTIDISCIPLINARY SCIENCES | CYTOKINE | FAMILY | CROSS-TALK | CREB | IN-VIVO | AMPK | RECEPTORS | POLARIZATION | INNATE IMMUNITY | Pyrimidines - chemical synthesis | DNA, Complementary - genetics | Immunoblotting | DNA Primers - genetics | Pyrimidines - chemistry | RNA Interference | Phenylurea Compounds - chemistry | Cyclobutanes - pharmacology | Polymerase Chain Reaction | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Interleukin-10 - metabolism | Molecular Structure | Macrophages - immunology | Protein-Serine-Threonine Kinases - metabolism | Morpholines - chemical synthesis | Cell Line | Cytokines - metabolism | Magnetic Resonance Spectroscopy | Protein-Serine-Threonine Kinases - genetics | Morpholines - pharmacology | Inflammation - immunology | Pyrimidines - pharmacology | Cyclobutanes - chemical synthesis | Mice, Knockout | Transcription Factors - metabolism | Macrophages - metabolism | Animals | Phenylurea Compounds - chemical synthesis | Analysis of Variance | Interleukin-10 - genetics | Fluorescent Antibody Technique | Proteomics | Mice | Phenylurea Compounds - pharmacology | Indans - pharmacology | Physiological aspects | Toll-like receptors | Research | Phosphotransferases | Health aspects | Biological Sciences
Journal Article
Nature Medicine, ISSN 1078-8956, 03/2012, Volume 18, Issue 3, pp. 456 - 462
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 05/2017, Volume 25, Issue 9, pp. 2569 - 2576
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2012, Volume 55, Issue 11, pp. 5591 - 5600
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2015, Volume 58, Issue 10, pp. 4165 - 4179
Journal Article
Journal Article
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 10/2010, Volume 18, Issue 20, pp. 7260 - 7273
We synthesized a series of pyrrolo[3,2-d]pyrimidine derivatives and evaluated their application as type-II inhibitors of vascular endothelial growth factor... 
VEGFR | Diphenylurea | Pyrrolo[3,2-d]pyrimidine | Type-II inhibitor | ACTIVATION | CHEMISTRY, MEDICINAL | PROTEIN | BEVACIZUMAB | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | MECHANISMS | TUMOR ANGIOGENESIS | HYPOXIA | PACLITAXEL | CELL LUNG-CANCER | diphenylurea | RECEPTORS | EXPRESSION | Pyrimidines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Crystallography, X-Ray | Pyrimidines - chemistry | Antineoplastic Agents - toxicity | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Protein Kinase Inhibitors - chemistry | Pyrimidines - toxicity | Phenylurea Compounds - chemistry | Drug Design | Receptor, TIE-2 - metabolism | Binding Sites | Bridged Bicyclo Compounds, Heterocyclic - chemical synthesis | Protein Structure, Tertiary | Receptor, TIE-2 - antagonists & inhibitors | Protein Kinase Inhibitors - chemical synthesis | Administration, Oral | Bridged Bicyclo Compounds, Heterocyclic - chemistry | Cells, Cultured | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Antineoplastic Agents - chemistry | Xenograft Model Antitumor Assays | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | Phenylurea Compounds - chemical synthesis | Pyrroles - chemical synthesis | Mice, Nude | Pyrroles - toxicity | Protein Binding | Protein Kinase Inhibitors - toxicity | Pyrroles - chemistry | Mice | Phenylurea Compounds - pharmacology | Vascular endothelial growth factor | Pyrimidines | Analysis
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 09/2018, Volume 28, Issue 16, pp. 2675 - 2678
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2013, Volume 56, Issue 13, pp. 5247 - 5260
Journal Article