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The New England Journal of Medicine, ISSN 0028-4793, 11/2012, Volume 367, Issue 22, pp. 2075 - 2088
Ponatinib was developed to overcome resistance to the tyrosine kinase inhibitors used to treat leukemias that are positive for the Philadelphia chromosome. In... 
CHRONIC MYELOGENOUS LEUKEMIA | MEDICINE, GENERAL & INTERNAL | RESPONSE CRITERIA | KINASE DOMAIN MUTATIONS | DIAGNOSED CHRONIC-PHASE | TYROSINE KINASE | INTERNATIONAL-WORKING-GROUP | FOLLOW-UP | CLINICAL RESISTANCE | BCR-ABL INHIBITOR | CHRONIC MYELOID-LEUKEMIA | Amylases - blood | Lipase - blood | Follow-Up Studies | Humans | Middle Aged | Imidazoles - chemistry | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Imidazoles - administration & dosage | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Drug Resistance, Neoplasm | Male | Structure-Activity Relationship | Antineoplastic Agents - administration & dosage | Dose-Response Relationship, Drug | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Protein-Tyrosine Kinases - genetics | Antineoplastic Agents - adverse effects | Pyridazines - administration & dosage | Aged, 80 and over | Adult | Female | Pyridazines - adverse effects | Imidazoles - adverse effects | Antineoplastic Agents - chemistry | Pancreatitis - chemically induced | Pyridazines - chemistry | Fusion Proteins, bcr-abl - genetics | Fusion Proteins, bcr-abl - antagonists & inhibitors | Aged | Mutation | Protein-Tyrosine Kinases - antagonists & inhibitors | Patient outcomes | BCR-ABL tyrosine kinase inhibitors | Dosage and administration | Genetic aspects | Acute lymphocytic leukemia | Research | Drug therapy | Tyrosine | BCR protein | Acute lymphatic leukemia | Myeloid leukemia | Leukemia | Pancreatitis | Abl protein | Chronic myeloid leukemia | Lymphatic leukemia | Lipase | Kinases | Philadelphia chromosome | Proteins | Myelosuppression | Fusion protein | Protein-tyrosine kinase | Binding sites | Index Medicus | Abridged Index Medicus
Journal Article
Biology of Blood and Marrow Transplantation, ISSN 1083-8791, 08/2018, Volume 24, Issue 8, pp. 1621 - 1628
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 11/2013, Volume 369, Issue 19, pp. 1783 - 1796
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 11/2009, Volume 27, Issue 31, pp. 5175 - 5181
Journal Article
Leukemia, ISSN 0887-6924, 05/2018, Volume 32, Issue 5, pp. 1057 - 1069
This document updates the recommendations on the management of Philadelphia chromosome-negative myeloproliferative neoplasms (Ph-neg MPNs) published in 2011 by... 
CALR MUTATIONS | TRANSFUSION-DEPENDENCY | ERYTHROPOIESIS-STIMULATING AGENTS | WORKING GROUP | POST-POLYCYTHEMIA-VERA | ONCOLOGY | CYTOGENETIC-RISK CATEGORIZATION | OPEN-LABEL | ESSENTIAL THROMBOCYTHEMIA MYELOFIBROSIS | HEMATOLOGY | INTERNATIONAL PROGNOSTIC SCORE | MYELOID METAPLASIA | Myeloproliferative Disorders - diagnosis | Pyrazoles - therapeutic use | Splenomegaly - drug therapy | Myeloproliferative Disorders - therapy | Europe | Humans | Neoplasms - diagnosis | Randomized Controlled Trials as Topic | Neoplasms - therapy | Stem Cell Transplantation - methods | Disease Management | Myeloproliferative Disorders - complications | Philadelphia Chromosome | Splenomegaly | Transfusion | Transplants & implants | Hematocrit | Clinical trials | Stem cell transplantation | Risk | Polycythemia vera | Hydroxyurea | Transplantation | Neoplasms | Consortia | α-Interferon | Randomization | Polycythemia | Quality | Janus kinase 2 | Peripheral blood | Bone marrow | Hemoglobin | Janus kinase | Diagnosis | Recombinant | Myelofibrosis | Risk groups | Anemia | Health risks | Patients | Philadelphia chromosome | Stem cells | Cytogenetics | Interferon | Diagnostic systems | Mutation | Tumors | Clinical Medicine | Medical and Health Sciences | Hematology | Hematologi | Medicin och hälsovetenskap | Klinisk medicin | Cancer and Oncology | Cancer och onkologi
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 08/2010, Volume 28, Issue 24, pp. 3880 - 3889
Journal Article