Food and Chemical Toxicology, ISSN 0278-6915, 09/2013, Volume 59, pp. 199 - 206
Although individual phlorotannins contained in the edible brown algae have been reported to possess strong anti-inflammatory activity, the responsible...
Phlorotannin | Fucosterol | Anti-inflammation | ROS | Eisenia bicyclis | FOOD SCIENCE & TECHNOLOGY | ALPHA-GLUCOSIDASE | STEROLS | FUCOXANTHIN | INHIBITORY-ACTIVITIES | IN-VITRO | PHLOROFUCOFUROECKOL | ANTIOXIDANT | NITRIC-OXIDE | TOXICOLOGY | ECKLONIA-STOLONIFERA | NF-KAPPA-B | Plant Extracts - chemistry | Reactive Oxygen Species - metabolism | Kelp - chemistry | Plant Extracts - pharmacology | Solvents - chemistry | Stigmasterol - pharmacology | Functional Food - analysis | Anti-Inflammatory Agents - metabolism | Dioxanes - analysis | Anti-Inflammatory Agents - analysis | Dioxanes - isolation & purification | Osmolar Concentration | Dioxanes - adverse effects | Nitric Oxide Synthase Type II - antagonists & inhibitors | Phloroglucinol - isolation & purification | Phloroglucinol - pharmacology | Anti-Inflammatory Agents - isolation & purification | Dioxanes - pharmacology | Stigmasterol - analogs & derivatives | Macrophages - immunology | Republic of Korea | Stigmasterol - isolation & purification | Plant Leaves - chemistry | Cell Survival - drug effects | Nitric Oxide - antagonists & inhibitors | Stigmasterol - analysis | Cyclooxygenase 2 - chemistry | Stigmasterol - adverse effects | Plant Extracts - isolation & purification | Down-Regulation - drug effects | Macrophages - enzymology | Macrophages - metabolism | Reactive Oxygen Species - antagonists & inhibitors | Animals | Anti-Inflammatory Agents - chemistry | Cyclooxygenase 2 - metabolism | Phloroglucinol - analysis | Macrophages - drug effects | Mice | Oxidative Stress - drug effects | Nitric Oxide - metabolism | Phloroglucinol - adverse effects | Phloroglucinol - analogs & derivatives | Cell Line, Transformed | Nitric Oxide Synthase Type II - metabolism | Plant Extracts - adverse effects | Anti-inflammatory drugs | Macrophages | Index Medicus
Phlorotannin | Fucosterol | Anti-inflammation | ROS | Eisenia bicyclis | FOOD SCIENCE & TECHNOLOGY | ALPHA-GLUCOSIDASE | STEROLS | FUCOXANTHIN | INHIBITORY-ACTIVITIES | IN-VITRO | PHLOROFUCOFUROECKOL | ANTIOXIDANT | NITRIC-OXIDE | TOXICOLOGY | ECKLONIA-STOLONIFERA | NF-KAPPA-B | Plant Extracts - chemistry | Reactive Oxygen Species - metabolism | Kelp - chemistry | Plant Extracts - pharmacology | Solvents - chemistry | Stigmasterol - pharmacology | Functional Food - analysis | Anti-Inflammatory Agents - metabolism | Dioxanes - analysis | Anti-Inflammatory Agents - analysis | Dioxanes - isolation & purification | Osmolar Concentration | Dioxanes - adverse effects | Nitric Oxide Synthase Type II - antagonists & inhibitors | Phloroglucinol - isolation & purification | Phloroglucinol - pharmacology | Anti-Inflammatory Agents - isolation & purification | Dioxanes - pharmacology | Stigmasterol - analogs & derivatives | Macrophages - immunology | Republic of Korea | Stigmasterol - isolation & purification | Plant Leaves - chemistry | Cell Survival - drug effects | Nitric Oxide - antagonists & inhibitors | Stigmasterol - analysis | Cyclooxygenase 2 - chemistry | Stigmasterol - adverse effects | Plant Extracts - isolation & purification | Down-Regulation - drug effects | Macrophages - enzymology | Macrophages - metabolism | Reactive Oxygen Species - antagonists & inhibitors | Animals | Anti-Inflammatory Agents - chemistry | Cyclooxygenase 2 - metabolism | Phloroglucinol - analysis | Macrophages - drug effects | Mice | Oxidative Stress - drug effects | Nitric Oxide - metabolism | Phloroglucinol - adverse effects | Phloroglucinol - analogs & derivatives | Cell Line, Transformed | Nitric Oxide Synthase Type II - metabolism | Plant Extracts - adverse effects | Anti-inflammatory drugs | Macrophages | Index Medicus
Journal Article
American journal of therapeutics, ISSN 1075-2765, 11/2018, Volume 25, Issue 6, pp. e747 - e748
Journal Article
Expert Opinion on Drug Metabolism & Toxicology, ISSN 1742-5255, 10/2017, Volume 13, Issue 10, pp. 1047 - 1062
Introduction: St. John's wort (SJW) is a common medicinal herb used for the treatment of mild to moderate depression. Hyperforin, one of the chief components...
Herbal medicine | metabolism | adverse drug reaction | St John's wort | drug interaction | review | PHARMACOKINETIC INTERACTION | STEREOSPECIFIC METABOLISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN LIVER-MICROSOMES | TANDEM MASS-SPECTROMETRY | CYTOCHROME-P450 3A4 | P-GLYCOPROTEIN | IN-VITRO | PHARMACOLOGY & PHARMACY | RENAL-TRANSPLANT PATIENTS | TOXICOLOGY | HEALTHY-VOLUNTEERS | DRUG-DRUG INTERACTIONS | Terpenes - isolation & purification | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Plant Preparations - administration & dosage | Terpenes - pharmacology | Depression - drug therapy | Cytochrome P-450 Enzyme System - drug effects | Animals | Herb-Drug Interactions | Plant Preparations - pharmacology | Phloroglucinol - isolation & purification | Phloroglucinol - pharmacology | Plant Preparations - adverse effects | Pharmacokinetics | Phloroglucinol - analogs & derivatives | Hypericum - chemistry | Index Medicus
Herbal medicine | metabolism | adverse drug reaction | St John's wort | drug interaction | review | PHARMACOKINETIC INTERACTION | STEREOSPECIFIC METABOLISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN LIVER-MICROSOMES | TANDEM MASS-SPECTROMETRY | CYTOCHROME-P450 3A4 | P-GLYCOPROTEIN | IN-VITRO | PHARMACOLOGY & PHARMACY | RENAL-TRANSPLANT PATIENTS | TOXICOLOGY | HEALTHY-VOLUNTEERS | DRUG-DRUG INTERACTIONS | Terpenes - isolation & purification | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Plant Preparations - administration & dosage | Terpenes - pharmacology | Depression - drug therapy | Cytochrome P-450 Enzyme System - drug effects | Animals | Herb-Drug Interactions | Plant Preparations - pharmacology | Phloroglucinol - isolation & purification | Phloroglucinol - pharmacology | Plant Preparations - adverse effects | Pharmacokinetics | Phloroglucinol - analogs & derivatives | Hypericum - chemistry | Index Medicus
Journal Article
European Journal of Pharmaceutics and Biopharmaceutics, ISSN 0939-6411, 06/2012, Volume 81, Issue 2, pp. 346 - 350
A cream containing a Hypericum perforatum extract protects against radical formation. Hyperforin, a major constituent of St. John’s Wort ( , HP), provides...
Hypericum perforatum | Ultraviolet erythema test | Infrared radiation | Reactive oxygen species | Electron spin resonance spectroscopy | Minimal erythema dose | TOPICAL APPLICATION | HUMAN SKIN | LIGHT | INFLAMMATION | PHARMACOLOGY & PHARMACY | ST-JOHNS-WORT | EXTRACT | Free Radical Scavengers - pharmacology | Plant Extracts - pharmacology | Humans | Middle Aged | Male | Erythema - prevention & control | Terpenes - pharmacology | Young Adult | Inflammation - drug therapy | Swine | Phloroglucinol - pharmacology | Adult | Female | Double-Blind Method | Anti-Inflammatory Agents - pharmacology | Antioxidants - pharmacology | Ultraviolet Rays - adverse effects | Animals | Terpenes - administration & dosage | Keratinocytes - drug effects | Skin - radiation effects | Phloroglucinol - administration & dosage | Antioxidants - administration & dosage | Administration, Topical | Phloroglucinol - analogs & derivatives | Skin - drug effects | Hypericum - chemistry | Antioxidants | Anti-inflammatory drugs | Nuclear radiation | Radiation
Hypericum perforatum | Ultraviolet erythema test | Infrared radiation | Reactive oxygen species | Electron spin resonance spectroscopy | Minimal erythema dose | TOPICAL APPLICATION | HUMAN SKIN | LIGHT | INFLAMMATION | PHARMACOLOGY & PHARMACY | ST-JOHNS-WORT | EXTRACT | Free Radical Scavengers - pharmacology | Plant Extracts - pharmacology | Humans | Middle Aged | Male | Erythema - prevention & control | Terpenes - pharmacology | Young Adult | Inflammation - drug therapy | Swine | Phloroglucinol - pharmacology | Adult | Female | Double-Blind Method | Anti-Inflammatory Agents - pharmacology | Antioxidants - pharmacology | Ultraviolet Rays - adverse effects | Animals | Terpenes - administration & dosage | Keratinocytes - drug effects | Skin - radiation effects | Phloroglucinol - administration & dosage | Antioxidants - administration & dosage | Administration, Topical | Phloroglucinol - analogs & derivatives | Skin - drug effects | Hypericum - chemistry | Antioxidants | Anti-inflammatory drugs | Nuclear radiation | Radiation
Journal Article
Journal of Agricultural and Food Chemistry, ISSN 0021-8561, 08/2014, Volume 62, Issue 32, pp. 8023 - 8033
The application of phenolic compounds to suppress Maillard chemistry and off-flavor development in ultrahigh-termperature (UHT)-processed milk during...
Maillard reaction | thermal processing | off-flavor inhibition | UHT milk | reactive carbonyls species | phenolic chemistry | QUANTIFICATION | FOOD SCIENCE & TECHNOLOGY | REACTIVITY | ODORANTS | EPICATECHIN | AGRICULTURE, MULTIDISCIPLINARY | TEA CATECHINS | TRAPPING REACTIONS | CHEMISTRY, APPLIED | Sensation | Food Preferences | Milk - chemistry | Food Quality | Antioxidants - chemistry | Hot Temperature - adverse effects | Humans | Food Storage | Genistein - chemistry | Minnesota | Phloroglucinol - chemistry | Pasteurization - methods | Animals | Cattle | Food Preservatives - chemistry | Maillard Reaction | Phenols - chemistry | Molecular Structure | Taste | Catechin - chemistry
Maillard reaction | thermal processing | off-flavor inhibition | UHT milk | reactive carbonyls species | phenolic chemistry | QUANTIFICATION | FOOD SCIENCE & TECHNOLOGY | REACTIVITY | ODORANTS | EPICATECHIN | AGRICULTURE, MULTIDISCIPLINARY | TEA CATECHINS | TRAPPING REACTIONS | CHEMISTRY, APPLIED | Sensation | Food Preferences | Milk - chemistry | Food Quality | Antioxidants - chemistry | Hot Temperature - adverse effects | Humans | Food Storage | Genistein - chemistry | Minnesota | Phloroglucinol - chemistry | Pasteurization - methods | Animals | Cattle | Food Preservatives - chemistry | Maillard Reaction | Phenols - chemistry | Molecular Structure | Taste | Catechin - chemistry
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2015, Volume 10, Issue 6, p. e0128003
A role as UV sunscreens has been suggested for phlorotannins, the phenolic compounds that accumulate in brown algae in response to a number of external stimuli...
PHENOLIC SUBSTANCES | TOLERANCE | MULTIDISCIPLINARY SCIENCES | POLYSACCHARIDES | RESISTANCE | EUKARYOTES | INDUCTION | STRESS | SERRATUS | PHOTOSYNTHESIS | MACROALGAE | Fucus - physiology | Molecular Weight | Phloroglucinol - metabolism | Fucus - radiation effects | Fucus - metabolism | Transcriptome - radiation effects | Phloroglucinol - chemistry | Ultraviolet Rays - adverse effects | Fucus - genetics | Heat shock proteins | Photosynthesis | Gene expression | Genes | Radiation | Profiling | Sun screens | Phloroglucinol | Vanadium | Physiology | Deoxyribonucleic acid--DNA | Radiation effects | Aryl sulfotransferase | Crosslinking | Hsp70 protein | Exposure | Metabolism | Molecular chains | Radiation dosage | Sulfation | Studies | Ultraviolet radiation | Scientific imaging | Kinetics | Herbivores | Mass spectrometry | Reactive oxygen species | Transcription | Gene regulation | Vanadium bromoperoxidase | Biosynthesis | Biology | Physiological responses | Accumulation | Molecular weight | Metabolites | Aromatic compounds | Low molecular weights | Reaction kinetics | Evolution | U.V. radiation | Cell walls | Algae | Phenolic compounds | Climate change | Sunscreens | External stimuli | Sulfotransferase | Phenols | Heat shock | Environmental Sciences | Deoxyribonucleic acid | DNA
PHENOLIC SUBSTANCES | TOLERANCE | MULTIDISCIPLINARY SCIENCES | POLYSACCHARIDES | RESISTANCE | EUKARYOTES | INDUCTION | STRESS | SERRATUS | PHOTOSYNTHESIS | MACROALGAE | Fucus - physiology | Molecular Weight | Phloroglucinol - metabolism | Fucus - radiation effects | Fucus - metabolism | Transcriptome - radiation effects | Phloroglucinol - chemistry | Ultraviolet Rays - adverse effects | Fucus - genetics | Heat shock proteins | Photosynthesis | Gene expression | Genes | Radiation | Profiling | Sun screens | Phloroglucinol | Vanadium | Physiology | Deoxyribonucleic acid--DNA | Radiation effects | Aryl sulfotransferase | Crosslinking | Hsp70 protein | Exposure | Metabolism | Molecular chains | Radiation dosage | Sulfation | Studies | Ultraviolet radiation | Scientific imaging | Kinetics | Herbivores | Mass spectrometry | Reactive oxygen species | Transcription | Gene regulation | Vanadium bromoperoxidase | Biosynthesis | Biology | Physiological responses | Accumulation | Molecular weight | Metabolites | Aromatic compounds | Low molecular weights | Reaction kinetics | Evolution | U.V. radiation | Cell walls | Algae | Phenolic compounds | Climate change | Sunscreens | External stimuli | Sulfotransferase | Phenols | Heat shock | Environmental Sciences | Deoxyribonucleic acid | DNA
Journal Article
Experimental Dermatology, ISSN 0906-6705, 05/2013, Volume 22, Issue 5, pp. 354 - 357
The formation of radicals plays an important role in the development of atopic eczema or barrier‐disrupted skin. We evaluated the radical scavenging effect of...
Hypericum perforatum | electron paramagnetic resonance spectroscopy | St. John's wort | Electron paramagnetic resonance spectroscopy | ATOPIC-DERMATITIS | IRRADIATION | HUMAN SKIN | CAROTENOIDS | SUNSCREENS | ST-JOHNS-WORT | John's wort | DERMATOLOGY | Double-Blind Method | Electron Spin Resonance Spectroscopy | Infrared Rays - adverse effects | Humans | Light - adverse effects | Male | Young Adult | Animals | Terpenes - administration & dosage | Swine | Phloroglucinol - administration & dosage | Antioxidants - administration & dosage | Skin Cream - administration & dosage | Placebos | Adult | Female | Administration, Topical | Phloroglucinol - analogs & derivatives | Hypericum - chemistry | Evaluation | Dermatologic agents | Dermatology | Analysis | Methods | Formulae, receipts, prescriptions
Hypericum perforatum | electron paramagnetic resonance spectroscopy | St. John's wort | Electron paramagnetic resonance spectroscopy | ATOPIC-DERMATITIS | IRRADIATION | HUMAN SKIN | CAROTENOIDS | SUNSCREENS | ST-JOHNS-WORT | John's wort | DERMATOLOGY | Double-Blind Method | Electron Spin Resonance Spectroscopy | Infrared Rays - adverse effects | Humans | Light - adverse effects | Male | Young Adult | Animals | Terpenes - administration & dosage | Swine | Phloroglucinol - administration & dosage | Antioxidants - administration & dosage | Skin Cream - administration & dosage | Placebos | Adult | Female | Administration, Topical | Phloroglucinol - analogs & derivatives | Hypericum - chemistry | Evaluation | Dermatologic agents | Dermatology | Analysis | Methods | Formulae, receipts, prescriptions
Journal Article
ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE, ISSN 0151-9638, 06/2017, Volume 144, Issue 6-7, pp. 423 - 425
Background. - Acute generalized exanthematous pustulosis (AGEP) is a severe drug eruption. We report herein the first case of AGEP induced by phloroglucinol...
Acute generalized exanthematous pustulosis | Pregnancy | Phloroglucinol | DRUGS | DERMATOLOGY | Pregnancy Complications - etiology | Humans | Acetaminophen - administration & dosage | Renal Colic - drug therapy | Pregnancy Complications - diagnosis | Acute Generalized Exanthematous Pustulosis - diagnosis | Acute Generalized Exanthematous Pustulosis - etiology | Biopsy | Female | Antipyretics - administration & dosage | Phloroglucinol - adverse effects | Skin - pathology | Indicators and Reagents - adverse effects
Acute generalized exanthematous pustulosis | Pregnancy | Phloroglucinol | DRUGS | DERMATOLOGY | Pregnancy Complications - etiology | Humans | Acetaminophen - administration & dosage | Renal Colic - drug therapy | Pregnancy Complications - diagnosis | Acute Generalized Exanthematous Pustulosis - diagnosis | Acute Generalized Exanthematous Pustulosis - etiology | Biopsy | Female | Antipyretics - administration & dosage | Phloroglucinol - adverse effects | Skin - pathology | Indicators and Reagents - adverse effects
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 10/2004, Volume 76, Issue 4, pp. 330 - 340
Objective Hyperforin (HYF) has been discussed as a potential cause of the reduction in the bioavailability of numerous drugs seen with St John's wort (SJW)...
PHARMACOKINETIC INTERACTION | DEPRESSION | HYPERICUM-PERFORATUM | LIVER-TRANSPLANTATION | METABOLISM | X RECEPTOR | PHARMACOLOGY & PHARMACY | RENAL-TRANSPLANT PATIENTS | RANDOMIZED CONTROLLED-TRIAL | P-GLYCOPROTEIN | BLOOD | Plant Extracts - chemistry | Area Under Curve | Plant Extracts - pharmacology | Humans | Hypericum | Immunosuppressive Agents - pharmacokinetics | Middle Aged | Male | Kidney Transplantation | Terpenes - analysis | Cross-Over Studies | Plant Extracts - administration & dosage | Drug Interactions | Antidepressive Agents - chemistry | Cyclosporine - pharmacokinetics | Adult | Antidepressive Agents - administration & dosage | Female | Antidepressive Agents - pharmacology | Antidepressive Agents - adverse effects | Phytotherapy | Bridged Bicyclo Compounds | Phloroglucinol - analogs & derivatives | Plant Extracts - adverse effects
PHARMACOKINETIC INTERACTION | DEPRESSION | HYPERICUM-PERFORATUM | LIVER-TRANSPLANTATION | METABOLISM | X RECEPTOR | PHARMACOLOGY & PHARMACY | RENAL-TRANSPLANT PATIENTS | RANDOMIZED CONTROLLED-TRIAL | P-GLYCOPROTEIN | BLOOD | Plant Extracts - chemistry | Area Under Curve | Plant Extracts - pharmacology | Humans | Hypericum | Immunosuppressive Agents - pharmacokinetics | Middle Aged | Male | Kidney Transplantation | Terpenes - analysis | Cross-Over Studies | Plant Extracts - administration & dosage | Drug Interactions | Antidepressive Agents - chemistry | Cyclosporine - pharmacokinetics | Adult | Antidepressive Agents - administration & dosage | Female | Antidepressive Agents - pharmacology | Antidepressive Agents - adverse effects | Phytotherapy | Bridged Bicyclo Compounds | Phloroglucinol - analogs & derivatives | Plant Extracts - adverse effects
Journal Article
FOOD & FUNCTION, ISSN 2042-6496, 8/2016, Volume 7, Issue 8, pp. 3628 - 3636
Erlotinib (Tarceva®) is a chemotherapeutic drug approved for the treatment of pancreatic cancer and non-small cell lung cancer. Its primary mode of action is...
DELPHINIDIN | RECEPTOR TYROSINE KINASES | INHIBITION | METABOLISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOOD SCIENCE & TECHNOLOGY | GROWTH | FACTOR-KAPPA-B | ANTHOCYANINS | CANCER | EXPRESSION | BIOAVAILABILITY | Anthocyanins - pharmacology | Erlotinib Hydrochloride - adverse effects | Glucosides - pharmacology | Phosphorylation | Epithelial Cells - metabolism | ErbB Receptors - metabolism | Gallic Acid - pharmacology | Plant Extracts - pharmacology | Epithelial Cells - drug effects | Humans | Polyphenols - pharmacology | Vaccinium myrtillus - chemistry | Cytostatic Agents - adverse effects | Soybeans - chemistry | Genistein - pharmacology | Phloroglucinol - pharmacology | Cell Line, Tumor | Index Medicus
DELPHINIDIN | RECEPTOR TYROSINE KINASES | INHIBITION | METABOLISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOOD SCIENCE & TECHNOLOGY | GROWTH | FACTOR-KAPPA-B | ANTHOCYANINS | CANCER | EXPRESSION | BIOAVAILABILITY | Anthocyanins - pharmacology | Erlotinib Hydrochloride - adverse effects | Glucosides - pharmacology | Phosphorylation | Epithelial Cells - metabolism | ErbB Receptors - metabolism | Gallic Acid - pharmacology | Plant Extracts - pharmacology | Epithelial Cells - drug effects | Humans | Polyphenols - pharmacology | Vaccinium myrtillus - chemistry | Cytostatic Agents - adverse effects | Soybeans - chemistry | Genistein - pharmacology | Phloroglucinol - pharmacology | Cell Line, Tumor | Index Medicus
Journal Article
Pharmacological Research, ISSN 1043-6618, 2011, Volume 63, Issue 1, pp. 37 - 43
Vascular endothelial growth factor (VEGF) is a key player in neo-angiogenesis; it sustains the progression of solid neoplasias, brain tumours included. It has...
Hyperforin | CNS tumours | VEGF | HYPERICUM-PERFORATUM | ANGIOGENESIS | BRAIN-TUMORS | GREEN TEA | IN-VITRO | INVASION | THERAPEUTIC TARGET | PHARMACOLOGY & PHARMACY | DIFFERENTIATION | TRANSCRIPTIONAL REGULATION | ENDOTHELIAL GROWTH-FACTOR | Neovascularization, Physiologic - drug effects | Transcription, Genetic - drug effects | Up-Regulation | Apoptosis - drug effects | Terpenes - adverse effects | Humans | Cerebellar Neoplasms - blood supply | Brain Neoplasms - blood supply | Vascular Endothelial Growth Factor A - metabolism | RNA, Messenger - metabolism | Vascular Endothelial Growth Factor A - genetics | Brain Neoplasms - metabolism | Dose-Response Relationship, Drug | Terpenes - pharmacology | Matrix Metalloproteinase 9 - metabolism | Transfection | Bridged Bicyclo Compounds - adverse effects | Glioblastoma - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Gelatinases - metabolism | Phloroglucinol - pharmacology | Glioblastoma - metabolism | Antidepressive Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Medulloblastoma - genetics | Cerebellar Neoplasms - metabolism | Bridged Bicyclo Compounds - pharmacology | Enzyme-Linked Immunosorbent Assay | Endothelial Cells - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Brain Neoplasms - genetics | Medulloblastoma - metabolism | Cerebellar Neoplasms - genetics | Reverse Transcriptase Polymerase Chain Reaction | Enzyme Precursors - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Medulloblastoma - blood supply | Antidepressive Agents - adverse effects | Glioblastoma - blood supply | Phloroglucinol - adverse effects | Phloroglucinol - analogs & derivatives | Endothelial Cells - drug effects | Phosphates | Antidepressants | Fluorescein | Albumin | Vascular endothelial growth factor | Enzyme-linked immunosorbent assay | Endothelium | Tumors
Hyperforin | CNS tumours | VEGF | HYPERICUM-PERFORATUM | ANGIOGENESIS | BRAIN-TUMORS | GREEN TEA | IN-VITRO | INVASION | THERAPEUTIC TARGET | PHARMACOLOGY & PHARMACY | DIFFERENTIATION | TRANSCRIPTIONAL REGULATION | ENDOTHELIAL GROWTH-FACTOR | Neovascularization, Physiologic - drug effects | Transcription, Genetic - drug effects | Up-Regulation | Apoptosis - drug effects | Terpenes - adverse effects | Humans | Cerebellar Neoplasms - blood supply | Brain Neoplasms - blood supply | Vascular Endothelial Growth Factor A - metabolism | RNA, Messenger - metabolism | Vascular Endothelial Growth Factor A - genetics | Brain Neoplasms - metabolism | Dose-Response Relationship, Drug | Terpenes - pharmacology | Matrix Metalloproteinase 9 - metabolism | Transfection | Bridged Bicyclo Compounds - adverse effects | Glioblastoma - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Gelatinases - metabolism | Phloroglucinol - pharmacology | Glioblastoma - metabolism | Antidepressive Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Medulloblastoma - genetics | Cerebellar Neoplasms - metabolism | Bridged Bicyclo Compounds - pharmacology | Enzyme-Linked Immunosorbent Assay | Endothelial Cells - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Brain Neoplasms - genetics | Medulloblastoma - metabolism | Cerebellar Neoplasms - genetics | Reverse Transcriptase Polymerase Chain Reaction | Enzyme Precursors - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Medulloblastoma - blood supply | Antidepressive Agents - adverse effects | Glioblastoma - blood supply | Phloroglucinol - adverse effects | Phloroglucinol - analogs & derivatives | Endothelial Cells - drug effects | Phosphates | Antidepressants | Fluorescein | Albumin | Vascular endothelial growth factor | Enzyme-linked immunosorbent assay | Endothelium | Tumors
Journal Article
Pakistan journal of pharmaceutical sciences, ISSN 1011-601X, 07/2016, Volume 29, Issue 4, pp. 1375 - 1378
To observe the effect of phloroglucinol on plasma angiotensin II and D-dimer index when it was applied to patients with severe pregnancy-induced hypertension....
D-dimer | PHARMACOLOGY & PHARMACY | Angiotensin II | Phloroglucinol | pregnancy-induced hypertension disease | effect | Phloroglucinol - therapeutic use | Antihypertensive Agents - pharmacology | Hypertension, Pregnancy-Induced - blood | Fibrin Fibrinogen Degradation Products - analysis | Humans | Angiotensin II - blood | Antihypertensive Agents - therapeutic use | Hypertension, Pregnancy-Induced - drug therapy | Antihypertensive Agents - adverse effects | Pregnancy | Phloroglucinol - pharmacology | Adult | Female | Phloroglucinol - adverse effects
D-dimer | PHARMACOLOGY & PHARMACY | Angiotensin II | Phloroglucinol | pregnancy-induced hypertension disease | effect | Phloroglucinol - therapeutic use | Antihypertensive Agents - pharmacology | Hypertension, Pregnancy-Induced - blood | Fibrin Fibrinogen Degradation Products - analysis | Humans | Angiotensin II - blood | Antihypertensive Agents - therapeutic use | Hypertension, Pregnancy-Induced - drug therapy | Antihypertensive Agents - adverse effects | Pregnancy | Phloroglucinol - pharmacology | Adult | Female | Phloroglucinol - adverse effects
Journal Article
Photochemistry and Photobiology, ISSN 0031-8655, 03/2012, Volume 88, Issue 2, pp. 381 - 388
Excessive amounts of reactive oxygen species (ROS) induced by ultraviolet (UV) radiation cause skin aging via basement membrane/extracellular matrix...
INDUCED CELL-DAMAGE | APOPTOSIS | BIOPHYSICS | C-FOS | HUMAN DERMAL FIBROBLASTS | INDUCED OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN SKIN FIBROBLASTS | HUMAN EPIDERMAL-KERATINOCYTES | INDUCTION | EXPRESSION | Phosphorylation | Reactive Oxygen Species - metabolism | Gene Expression - drug effects | Oxidative Stress | Calcium - metabolism | Keratinocytes - radiation effects | Transcription Factor AP-1 - genetics | Humans | Proto-Oncogene Proteins c-jun - antagonists & inhibitors | Gene Knockdown Techniques | Phloroglucinol - pharmacology | Matrix Metalloproteinase 1 - genetics | Proto-Oncogene Proteins c-fos - antagonists & inhibitors | Cell Line | Cell Survival - drug effects | Cell Survival - radiation effects | Gene Expression - radiation effects | Ultraviolet Rays - adverse effects | Reactive Oxygen Species - antagonists & inhibitors | Transcription Factor AP-1 - antagonists & inhibitors | Keratinocytes - drug effects | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Keratinocytes - metabolism | Skin - radiation effects | Matrix Metalloproteinase Inhibitors | Mitogen-Activated Protein Kinases - genetics | Proto-Oncogene Proteins c-fos - genetics | Skin - drug effects
INDUCED CELL-DAMAGE | APOPTOSIS | BIOPHYSICS | C-FOS | HUMAN DERMAL FIBROBLASTS | INDUCED OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN SKIN FIBROBLASTS | HUMAN EPIDERMAL-KERATINOCYTES | INDUCTION | EXPRESSION | Phosphorylation | Reactive Oxygen Species - metabolism | Gene Expression - drug effects | Oxidative Stress | Calcium - metabolism | Keratinocytes - radiation effects | Transcription Factor AP-1 - genetics | Humans | Proto-Oncogene Proteins c-jun - antagonists & inhibitors | Gene Knockdown Techniques | Phloroglucinol - pharmacology | Matrix Metalloproteinase 1 - genetics | Proto-Oncogene Proteins c-fos - antagonists & inhibitors | Cell Line | Cell Survival - drug effects | Cell Survival - radiation effects | Gene Expression - radiation effects | Ultraviolet Rays - adverse effects | Reactive Oxygen Species - antagonists & inhibitors | Transcription Factor AP-1 - antagonists & inhibitors | Keratinocytes - drug effects | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Keratinocytes - metabolism | Skin - radiation effects | Matrix Metalloproteinase Inhibitors | Mitogen-Activated Protein Kinases - genetics | Proto-Oncogene Proteins c-fos - genetics | Skin - drug effects
Journal Article
Journal of Histochemistry & Cytochemistry, ISSN 0022-1554, 1/2013, Volume 61, Issue 1, pp. 63 - 74
Phloroglucinol (PG) is a phenolic compound isolated from Ecklonia cava, a brown algae abundant on Jeju island, Korea. Previous reports have suggested that PG...
apoptosis | phloroglucinol | immunohistochemistry | ionizing radiation | crypt cell | ECKOL | MOUSE | DAMAGE | P53 | PHLOROTANNINS | CELL BIOLOGY | GAMMA-IRRADIATION | GENE | IN-VIVO | BCL-2 FAMILY | EXPRESSION | Immunohistochemistry | Phloroglucinol - therapeutic use | Gamma Rays - adverse effects | Intestine, Small - pathology | Apoptosis - drug effects | Mice, Inbred C57BL | Antioxidants - pharmacology | Radiation Injuries, Experimental - pathology | Apoptosis Regulatory Proteins - metabolism | Antioxidants - therapeutic use | Radiation Injuries, Experimental - prevention & control | Animals | Intestine, Small - drug effects | Phloroglucinol - pharmacology | Stem Cells - drug effects | Stem Cells - pathology | Intestine, Small - radiation effects | Mice | Cytoprotection | Radiation Injuries, Experimental - metabolism
apoptosis | phloroglucinol | immunohistochemistry | ionizing radiation | crypt cell | ECKOL | MOUSE | DAMAGE | P53 | PHLOROTANNINS | CELL BIOLOGY | GAMMA-IRRADIATION | GENE | IN-VIVO | BCL-2 FAMILY | EXPRESSION | Immunohistochemistry | Phloroglucinol - therapeutic use | Gamma Rays - adverse effects | Intestine, Small - pathology | Apoptosis - drug effects | Mice, Inbred C57BL | Antioxidants - pharmacology | Radiation Injuries, Experimental - pathology | Apoptosis Regulatory Proteins - metabolism | Antioxidants - therapeutic use | Radiation Injuries, Experimental - prevention & control | Animals | Intestine, Small - drug effects | Phloroglucinol - pharmacology | Stem Cells - drug effects | Stem Cells - pathology | Intestine, Small - radiation effects | Mice | Cytoprotection | Radiation Injuries, Experimental - metabolism
Journal Article
THERAPIE, ISSN 0040-5957, 06/2016, Volume 71, Issue 3, pp. 343 - 345
Anaphylaxis | Phloroglucinol | RESORCINOL | PHARMACOLOGY & PHARMACY | Spasfon (R) | Drug challenge test | Drug hypersensitivity | Drug Eruptions - etiology | Phloroglucinol - metabolism | Humans | Adolescent | Gastrointestinal Agents - therapeutic use | Hypersensitivity, Immediate - chemically induced | Domperidone - therapeutic use | Male | Gastrointestinal Agents - adverse effects | Phloroglucinol - adverse effects | Drug Combinations | Gastrointestinal Agents - metabolism
Journal Article
Journal of Clinical Psychiatry, ISSN 0160-6689, 02/2006, Volume 67, Issue 2, pp. 305 - 309
Background: Herbal preparations for depression, such as St. John's wort, are often preferred over pharmaceutical preparations by mothers and midwives after...
UNITED-STATES | ALTERNATIVE MEDICINE | PSYCHOLOGY, CLINICAL | PSYCHIATRY | FLUOXETINE | NURSING INFANTS | Humans | Depressive Disorder - drug therapy | Infant | Milk, Human - chemistry | Phytotherapy - adverse effects | Mass Spectrometry | Plant Preparations - pharmacokinetics | Bridged Bicyclo Compounds - therapeutic use | Maternal Exposure - adverse effects | Adult | Female | Phytotherapy - methods | Depressive Disorder - blood | Plant Preparations - analysis | Milk, Human - metabolism | Phloroglucinol - therapeutic use | Hypericum - adverse effects | Maternal-Fetal Exchange | Hypericum - metabolism | Depressive Disorder - metabolism | Pregnancy | Breast Feeding - adverse effects | Terpenes - pharmacokinetics | Terpenes - therapeutic use | Plant Preparations - blood | Bridged Bicyclo Compounds - pharmacokinetics | Phloroglucinol - analogs & derivatives | Phloroglucinol - pharmacokinetics
UNITED-STATES | ALTERNATIVE MEDICINE | PSYCHOLOGY, CLINICAL | PSYCHIATRY | FLUOXETINE | NURSING INFANTS | Humans | Depressive Disorder - drug therapy | Infant | Milk, Human - chemistry | Phytotherapy - adverse effects | Mass Spectrometry | Plant Preparations - pharmacokinetics | Bridged Bicyclo Compounds - therapeutic use | Maternal Exposure - adverse effects | Adult | Female | Phytotherapy - methods | Depressive Disorder - blood | Plant Preparations - analysis | Milk, Human - metabolism | Phloroglucinol - therapeutic use | Hypericum - adverse effects | Maternal-Fetal Exchange | Hypericum - metabolism | Depressive Disorder - metabolism | Pregnancy | Breast Feeding - adverse effects | Terpenes - pharmacokinetics | Terpenes - therapeutic use | Plant Preparations - blood | Bridged Bicyclo Compounds - pharmacokinetics | Phloroglucinol - analogs & derivatives | Phloroglucinol - pharmacokinetics
Journal Article
Journal of Affective Disorders, ISSN 0165-0327, 2004, Volume 82, Issue 2, pp. 303 - 307
Rationale: Hypericum extracts have been regarded as antidepressant drugs wihtout specific side effects by patients, medical professionals and researchers...
Hypericum | Extract | Outpatients | extract | METAANALYSIS | EFFICACY | PSYCHIATRY | DOUBLE-BLIND | outpatients | ST-JOHNS-WORT | PERFORATUM | CLINICAL NEUROLOGY | Phloroglucinol - therapeutic use | Double-Blind Method | Terpenes - adverse effects | Humans | Risk | Randomized Controlled Trials as Topic | Antidepressive Agents - therapeutic use | Dose-Response Relationship, Drug | Multicenter Studies as Topic | Bridged Bicyclo Compounds - adverse effects | Terpenes - therapeutic use | Bridged Bicyclo Compounds - therapeutic use | Antidepressive Agents - adverse effects | Phytotherapy | Phloroglucinol - adverse effects | Phloroglucinol - analogs & derivatives | Plant Extracts - therapeutic use | Depressive Disorder, Major - drug therapy | Plant Extracts - adverse effects
Hypericum | Extract | Outpatients | extract | METAANALYSIS | EFFICACY | PSYCHIATRY | DOUBLE-BLIND | outpatients | ST-JOHNS-WORT | PERFORATUM | CLINICAL NEUROLOGY | Phloroglucinol - therapeutic use | Double-Blind Method | Terpenes - adverse effects | Humans | Risk | Randomized Controlled Trials as Topic | Antidepressive Agents - therapeutic use | Dose-Response Relationship, Drug | Multicenter Studies as Topic | Bridged Bicyclo Compounds - adverse effects | Terpenes - therapeutic use | Bridged Bicyclo Compounds - therapeutic use | Antidepressive Agents - adverse effects | Phytotherapy | Phloroglucinol - adverse effects | Phloroglucinol - analogs & derivatives | Plant Extracts - therapeutic use | Depressive Disorder, Major - drug therapy | Plant Extracts - adverse effects
Journal Article