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Nature Cell Biology, ISSN 1465-7392, 11/2014, Volume 16, Issue 12, pp. 1180 - 1191
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2008, Volume 283, Issue 36, pp. 24748 - 24759
The generation of reactive oxygen species is a central feature of inflammation that results in the oxidation of host phospholipids. Oxidized phospholipids,... 
ACTIVATION | ESCHERICHIA-COLI LIPOPOLYSACCHARIDE | INDUCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIPID RAFTS | ENDOTHELIAL-CELLS | LOW-DENSITY-LIPOPROTEIN | HEME OXYGENASE-1 | MONOCYTE CHEMOTACTIC PROTEIN-1 | OXIDATION-PRODUCTS | T-LYMPHOCYTES | Phosphatidylcholines - immunology | Reactive Oxygen Species - metabolism | Toll-Like Receptor 2 - genetics | Membrane Glycoproteins - metabolism | Lymphocyte Antigen 96 - metabolism | Humans | Tumor Necrosis Factor-alpha - genetics | Macrophages, Peritoneal - cytology | Flagellin - pharmacology | Lymphocyte Antigen 96 - agonists | Oxidation-Reduction - drug effects | Tumor Necrosis Factor-alpha - immunology | Toll-Like Receptor 4 - agonists | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Carrier Proteins - immunology | Guanosine - analogs & derivatives | Poly I-C - pharmacology | Macrophages, Peritoneal - immunology | Toll-Like Receptor 4 - genetics | Lipopolysaccharide Receptors - immunology | Toll-Like Receptor 4 - immunology | p38 Mitogen-Activated Protein Kinases - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Signal Transduction - drug effects | Lipopolysaccharides - pharmacology | Toll-Like Receptor 2 - immunology | I-kappa B Kinase - immunology | Mice | Mice, Inbred BALB C | Macrophages, Peritoneal - metabolism | Oligodeoxyribonucleotides - pharmacology | Immunologic Factors - pharmacology | Lymphocyte Antigen 96 - immunology | Tumor Necrosis Factor-alpha - metabolism | Toll-Like Receptor 2 - agonists | Acute-Phase Proteins - genetics | Lipopolysaccharide Receptors - metabolism | Lymphocyte Antigen 96 - genetics | Carrier Proteins - agonists | I-kappa B Kinase - metabolism | Reactive Oxygen Species - immunology | Female | Membrane Glycoproteins - immunology | Cell Line | Acute-Phase Proteins - metabolism | Phosphatidylcholines - pharmacology | Membrane Glycoproteins - agonists | p38 Mitogen-Activated Protein Kinases - genetics | I-kappa B Kinase - genetics | Membrane Glycoproteins - genetics | Carrier Proteins - genetics | Phosphatidylcholines - genetics | Animals | Carrier Proteins - metabolism | RNA - pharmacology | Guanosine - pharmacology | Lipopolysaccharide Receptors - genetics | Signal Transduction - physiology | Acute-Phase Proteins - agonists | Acute-Phase Proteins - immunology | Lipids and Lipoproteins | Metabolism, Regulation, and Signaling
Journal Article
Journal of The American Society for Mass Spectrometry, ISSN 1044-0305, 5/2015, Volume 26, Issue 5, pp. 818 - 825
The use of ion/ion reactions to effect gas-phase alkylation is demonstrated. Commonly used fixed-charge “onium” cations are well-suited for ion/ion reactions... 
Biotechnology | Chemistry | Analytical Chemistry | Proteomics | Bioinformatics | Ion/ion reactions | “Onium” cations | Alkyl ion transfer | Esterification | Organic Chemistry | "Onium" cations | AMMONIUM CATION | CHEMISTRY, ANALYTICAL | QUANTIFICATION | BIOCHEMICAL RESEARCH METHODS | CROSS-LINKING | CHEMISTRY, PHYSICAL | ELECTROSPRAY MASS-SPECTROMETRY | NHS-ESTER | ION-TRAP | DISSOCIATION | SPECTROSCOPY | DEPROTONATED PEPTIDES | PHOSPHATIDYLCHOLINE | IONIZATION | Tetraethylammonium - pharmacology | CME-Carbodiimide - analogs & derivatives | Cross-Linking Reagents - pharmacology | Protein Conformation - drug effects | Quaternary Ammonium Compounds - chemistry | Tandem Mass Spectrometry | Spectrometry, Mass, Electrospray Ionization | Volatilization | Edetic Acid - pharmacology | Indicators and Reagents - pharmacology | Organophosphorus Compounds - pharmacology | CME-Carbodiimide - pharmacology | Catalysis | Indicators and Reagents - chemistry | Oligopeptides - chemistry | Tetraethylammonium - chemistry | Sulfonium Compounds - pharmacology | Cross-Linking Reagents - chemistry | Chelating Agents - chemistry | Models, Molecular | Organophosphorus Compounds - chemistry | Chelating Agents - pharmacology | Hot Temperature | Static Electricity | Edetic Acid - chemistry | Sulfonium Compounds - chemistry | CME-Carbodiimide - chemistry | Alkylation - drug effects | Energy Transfer | Quaternary Ammonium Compounds - pharmacology | Surface active agents | Chemical tests and reagents | Density functionals | Analytical chemistry | Anions | Reagents | Ions | Density functional theory | Cations | Alkylation | Ion | ion reactions
Journal Article
Nature, ISSN 0028-0836, 04/2011, Volume 472, Issue 7341, pp. 57 - 65
Metabolomics studies hold promise for the discovery of pathways linked to disease processes. Cardiovascular disease (CVD) represents the leading cause of death... 
CHLAMYDIA-PNEUMONIAE | TRIMETHYLAMINE-N-OXIDE | DNA METHYLATION | MULTIDISCIPLINARY SCIENCES | MURINE MACROPHAGES | MOUSE | GENE-EXPRESSION | ATHEROSCLEROSIS | MICE | CORONARY-HEART-DISEASE | MASS-SPECTROMETRY | Choline - metabolism | Dietary Fats - metabolism | Metabolomics | Liver - enzymology | Diet - adverse effects | Atherosclerosis - genetics | Betaine - metabolism | Humans | Phosphatidylcholines - administration & dosage | Phosphatidylcholines - metabolism | Choline - blood | Dietary Fats - pharmacology | Oxygenases - metabolism | Cardiovascular Diseases - blood | Female | Atherosclerosis - microbiology | Betaine - blood | Methylamines - pharmacology | Cardiovascular Diseases - diagnosis | Methylamines - metabolism | Receptors, Scavenger - metabolism | Biomarkers - metabolism | Phosphatidylcholines - blood | Cardiovascular Diseases - metabolism | Risk Assessment | Atherosclerosis - chemically induced | Mice, Inbred C57BL | Phosphatidylcholines - pharmacology | Gene Expression Regulation | Methylamines - blood | Gastrointestinal Tract - microbiology | Biomarkers - blood | Dietary Fats - blood | Atherosclerosis - metabolism | Gastrointestinal Tract - metabolism | Cardiovascular Diseases - microbiology | Macrophages - metabolism | Phenotype | Animals | Choline - administration & dosage | Choline - pharmacology | Germ-Free Life | Cholesterol, HDL - blood | Mice | Oxygenases - genetics | Lecithin | Microbiota (Symbiotic organisms) | Physiological aspects | Research | Cardiovascular diseases | Metabolism | Health aspects | Risk factors | Plasma | Nuclear magnetic resonance--NMR | Heart attacks | Pathogenesis | Lipids | Cardiovascular disease | Probiotics | Metabolites | Diet | Atherosclerosis | Bacteria | Insulin resistance | Mass spectrometry | atherosclerosis | intestinal microbiota | choline | diet | phospholipid | metabolomics
Journal Article
Breast Cancer Research and Treatment, ISSN 0167-6806, 8/2013, Volume 141, Issue 1, pp. 55 - 65
Natural compounds have been studied as a source of countless bioactive compounds with diverse activities. Among them, many dietary phytochemicals have been... 
Medicine & Public Health | Curcuminoids | Immunoliposome | Resveratrol | Oncology | Curcumin | Breast cancer | HER2 | ANTI-HER2 IMMUNOLIPOSOMES | APOPTOSIS | STERICALLY STABILIZED LIPOSOMES | EFFICACY | MONOCLONAL-ANTIBODY | PROLIFERATION | DELIVERY | GENE | PHARMACOKINETICS | ONCOLOGY | EXPRESSION | Phosphatidylcholines | Stilbenes - administration & dosage | Humans | Gene Expression Regulation, Neoplastic | Biological Availability | Biological Products - pharmacology | Cell Line, Tumor - drug effects | Antineoplastic Agents - administration & dosage | Chromatography, High Pressure Liquid | Stilbenes - pharmacology | Curcumin - administration & dosage | Immunoconjugates - administration & dosage | Breast Neoplasms - metabolism | Immunoconjugates - pharmacology | Antibodies, Monoclonal, Humanized - administration & dosage | Anticarcinogenic Agents - administration & dosage | Antibodies, Monoclonal, Humanized - pharmacology | Drug Compounding | Carcinoma, Ductal, Breast - pathology | Female | Antineoplastic Agents - pharmacology | Neoplasm Proteins - genetics | Anticarcinogenic Agents - pharmacology | Carcinoma, Ductal, Breast - metabolism | Cell Line, Tumor - metabolism | Receptor, ErbB-2 - biosynthesis | Neoplasm Proteins - biosynthesis | Curcumin - pharmacology | Cell Division - drug effects | Cholesterol | Particle Size | Phosphatidylethanolamines | Breast Neoplasms - pathology | Genes, erbB-2 | Biological Products - administration & dosage | Liposomes | Trastuzumab | Drug Screening Assays, Antitumor | Cancer cells
Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 09/2013, Volume 454, Issue 1, pp. 21 - 30
Tumor metastasis is the leading cause of breast cancer-related mortality and remains to be the principal obstacle for the successful chemotherapy of breast... 
Nanoparticles | Breast cancer | Metastasis | Silibinin | TPGS | EPITHELIAL-MESENCHYMAL TRANSITIONS | CHITOSAN NANOSPHERES | LOCAL INJECTION | VITAMIN-E TPGS | LYMPH-NODE METASTASES | MATRIX METALLOPROTEINASES | TRANSGENIC ADENOCARCINOMA | PHARMACOLOGY & PHARMACY | BSA NANOSPHERES | TUMOR-GROWTH | PROGRESSION | Humans | Lung Neoplasms - metabolism | Vitamin E - analogs & derivatives | Polyethylene Glycols - chemistry | Silymarin - chemistry | Phosphatidylcholines - metabolism | Breast Neoplasms - metabolism | Drug Carriers | Antineoplastic Agents - metabolism | Dose-Response Relationship, Drug | Tissue Distribution | Matrix Metalloproteinase 9 - metabolism | Biological Transport | Lung Neoplasms - secondary | Time Factors | Female | Antineoplastic Agents - pharmacology | Silymarin - metabolism | Silymarin - pharmacology | Vitamin E - chemistry | Snail Family Transcription Factors | Wound Healing - drug effects | Polyethylene Glycols - pharmacology | Polyethylene Glycols - metabolism | Neoplasm Invasiveness | Mice, Inbred C57BL | Phosphatidylcholines - pharmacology | Solubility | Technology, Pharmaceutical - methods | Phosphatidylcholines - chemistry | Antineoplastic Agents - chemistry | Breast Neoplasms - drug therapy | Chemistry, Pharmaceutical | Drug Synergism | Particle Size | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Cell Movement - drug effects | Animals | Lung Neoplasms - prevention & control | Breast Neoplasms - pathology | Mice, Nude | Cell Line, Tumor | Vitamin E - metabolism | Mice | Vitamin E - pharmacology | Prevention | Cancer | Index Medicus
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 01/2012, Volume 417, Issue 2, pp. 903 - 909
► Diospyrin diethylether (D7) caused oxidative stress-dependent activation of PC-PLC. ► Activated PC-PLC induced a sustained-release of Ca from endoplasmic... 
Phosphatidylcholine-specific phospholipase C | Calpain-caspase12 | Cytoplasmic calcium | Diospyrin diethylether | Mitochondrial alterations | Human breast cancer cells | Apoptosis | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEATH | RADIATION | BIOPHYSICS | DIETHYLETHER | GENERATION | CYTOTOXICITY | Calcium Channels - metabolism | Apoptosis - drug effects | Calcium - metabolism | Humans | Endoplasmic Reticulum - metabolism | Type C Phospholipases - metabolism | Type C Phospholipases - antagonists & inhibitors | Breast Neoplasms - metabolism | Endoplasmic Reticulum - drug effects | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Egtazic Acid - analogs & derivatives | Oxidation-Reduction - drug effects | Female | Antineoplastic Agents - pharmacology | Phosphodiesterase Inhibitors - pharmacology | Naphthoquinones - pharmacology | Mitochondria - metabolism | Chelating Agents - pharmacology | Mitochondria - drug effects | Egtazic Acid - pharmacology | Ruthenium Red - pharmacology | Acetylcysteine - pharmacology | Cell Line, Tumor | Cytosol - metabolism | Carcinoma - metabolism | Care and treatment | Mitochondrial DNA | Breast cancer | Nuclear radiation | Cancer | Fodrin | Calcium | Acetylcysteine | Calpain | Calcium (mitochondrial) | Phospholipase C | Antioxidants | Cytochrome c | Breast carcinoma | Mitochondria | Ruthenium red | quinonoids | Chelating agents | Heparin | Membrane potential | Endoplasmic reticulum | thapsigargin | Tumors | OXIDATION | APOPTOSIS | ENDOPLASMIC RETICULUM | ANTIOXIDANTS | MAMMARY GLANDS | CALCIUM IONS | MITOCHONDRIA | CARCINOMAS | RUTHENIUM | HEPARIN | 60 APPLIED LIFE SCIENCES | LECITHINS
Journal Article