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Journal of Controlled Release, ISSN 0168-3659, 04/2012, Volume 159, Issue 1, pp. 135 - 142
Lymph nodes (LNs) are peripheral lymphoid organs essential for vaccine-induced immune responses. Although cationic liposomes have been documented as a novel... 
Vaccine | PEGylation | Lymphatic trafficking | Antigen-presenting cells | Biodistribution | Cationic liposome | ANTIGEN-DELIVERY | ACTIVATION | DENDRITIC CELLS | INNATE | CHEMISTRY, MULTIDISCIPLINARY | CANCER VACCINE | PHARMACOLOGY & PHARMACY | Adjuvants, Immunologic - administration & dosage | Immunoglobulin G - blood | Ovalbumin - immunology | Liposomes - administration & dosage | Dendritic Cells - immunology | Fatty Acids, Monounsaturated - administration & dosage | Vaccination | Polyethylene Glycols - chemistry | Quaternary Ammonium Compounds - chemistry | Antigens - administration & dosage | Tissue Distribution | Vaccines - chemistry | Adjuvants, Immunologic - chemistry | Fatty Acids, Monounsaturated - chemistry | Female | Lymph Nodes - drug effects | Ovalbumin - chemistry | Mice, Inbred C57BL | Cells, Cultured | Lymph Nodes - metabolism | Vaccines - immunology | Phosphatidylethanolamines - administration & dosage | Lymph Nodes - immunology | Antigen-Presenting Cells - immunology | Antigens - chemistry | Polyethylene Glycols - administration & dosage | Liposomes - chemistry | Animals | Ovalbumin - administration & dosage | Quaternary Ammonium Compounds - administration & dosage | Antigens - immunology | Mice | Mice, Inbred BALB C | Vaccines - administration & dosage | Phosphatidylethanolamines - chemistry | Viral antibodies | Antibodies | Immune response | Spleen | Adjuvants | Fluorescent indicators | Vaccines | imaging | Lymph nodes | Drainage | Blood circulation | Immunogenicity | Liposomes | Controlled release
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 12/2017, Volume 363, Issue 3, pp. 348 - 357
This article describes the preclinical pharmacology and pharmacokinetics (PK) of hexadecyl-treprostinil (C16TR), a prodrug of treprostinil (TRE), formulated in... 
PROSTACYCLIN RECEPTOR | EP4 RECEPTOR | ANALOGS | ARTERIAL-HYPERTENSION | IP | PHARMACOLOGY & PHARMACY | BINDING | ILOPROST | Antihypertensive Agents - pharmacology | Nanoparticles - chemistry | Vasodilator Agents - pharmacokinetics | Phosphatidylethanolamines - adverse effects | Humans | Excipients - adverse effects | Male | Polyethylene Glycols - chemistry | Squalene - analogs & derivatives | Drug Compounding | Hypertension, Pulmonary - drug therapy | Epoprostenol - pharmacokinetics | Guinea Pigs | Squalene - adverse effects | Antihypertensive Agents - therapeutic use | Excipients - administration & dosage | Rats, Sprague-Dawley | Epoprostenol - analogs & derivatives | Lung - drug effects | Vasodilation - drug effects | Phosphatidylethanolamines - chemistry | Drug Delivery Systems - adverse effects | Epoprostenol - administration & dosage | Prodrugs - administration & dosage | Epoprostenol - metabolism | Vasodilator Agents - therapeutic use | Antihypertensive Agents - administration & dosage | Polyethylene Glycols - adverse effects | Hypertension, Pulmonary - blood | Nanoparticles - adverse effects | Dose-Response Relationship, Drug | Epoprostenol - therapeutic use | Excipients - chemistry | Epoprostenol - pharmacology | Female | Lung - metabolism | Platelet Aggregation - drug effects | Drug Evaluation, Preclinical | Squalene - chemistry | Vasodilator Agents - pharmacology | Administration, Inhalation | Phosphatidylethanolamines - administration & dosage | Squalene - administration & dosage | Antihypertensive Agents - pharmacokinetics | Polyethylene Glycols - administration & dosage | Animals | Prodrugs - pharmacokinetics | Dogs | Nanoparticles - administration & dosage | Prodrugs - therapeutic use | Lung - blood supply | Prodrugs - pharmacology | Vasodilator Agents - administration & dosage | Index Medicus
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 12/2017, Volume 268, pp. 92 - 101
Myelodysplastic syndromes (MDS) are a diverse group of bone marrow disorders and clonal hematopoietic stem cell disorders characterized by abnormal blood... 
Bone marrow | Decitabine | Arsenic trioxide | Delivery | Nanoparticle | Myelodysplastic syndrome | APOPTOSIS | DNA METHYLATION | DRUG-DELIVERY | 5-AZACYTIDINE | COMBINATION | CANCER | CHEMISTRY, MULTIDISCIPLINARY | CHEMOTHERAPY | RETINOIC ACID | PHARMACOLOGY & PHARMACY | POLYMER HYBRID NANOPARTICLES | ACUTE PROMYELOCYTIC LEUKEMIA | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Nanoparticles - chemistry | Apoptosis - drug effects | Oxides - chemistry | Azacitidine - chemistry | Phosphatidylethanolamines - therapeutic use | Polyethylene Glycols - chemistry | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Polyethylene Glycols - therapeutic use | Alendronate - chemistry | Alendronate - therapeutic use | Tissue Distribution | Arsenicals - therapeutic use | Nanoparticles - therapeutic use | Bone and Bones - metabolism | Phosphatidylethanolamines - pharmacokinetics | Bone Marrow Cells - drug effects | Antineoplastic Agents - pharmacokinetics | Arsenicals - pharmacokinetics | Alendronate - pharmacokinetics | Myelodysplastic Syndromes - drug therapy | Oxides - administration & dosage | Azacitidine - administration & dosage | Oxides - therapeutic use | Cell Survival - drug effects | Arsenic Trioxide | Azacitidine - pharmacokinetics | Myelodysplastic Syndromes - metabolism | Cells, Cultured | Polyethylene Glycols - pharmacokinetics | Azacitidine - analogs & derivatives | Mice, Transgenic | Phosphatidylethanolamines - administration & dosage | Antineoplastic Agents - chemistry | Polyethylene Glycols - administration & dosage | Oxides - pharmacokinetics | Arsenicals - administration & dosage | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Arsenicals - chemistry | Nanoparticles - administration & dosage | Phosphatidylethanolamines - chemistry | Alendronate - administration & dosage | Azacitidine - therapeutic use | Medical research | Medical colleges | Medical examination | Arsenic | Analysis | Medicine, Experimental | Hematopoietic stem cells | Blood | Index Medicus | delivery | nanoparticle | decitabine | arsenic trioxide | bone marrow
Journal Article
Biomaterials, ISSN 0142-9612, 2015, Volume 77, pp. 243 - 254
Abstract Following intravenous injection of anti-cancer nanomedicines, many barriers need to be overcome en route to the tumor. Cell-mediated delivery of... 
Advanced Basic Science | Dentistry | Nanoparticles | Liposomes | Cell-mediated drug delivery | Tumor targeting | Cytotoxic T lymphocytes | THERAPEUTIC NANOPARTICLES | MATERIALS SCIENCE, BIOMATERIALS | SOLID TUMORS | MECHANISM | DRUG-DELIVERY | ENGINEERING, BIOMEDICAL | MEDIATED DELIVERY | BARRIERS | CHALLENGES | CELL | NANOTECHNOLOGY | ANTIGEN | Phosphatidylglycerols - administration & dosage | Hydrogels | Nanoparticles - chemistry | Ovalbumin - immunology | Liposomes - administration & dosage | Phosphatidylcholines - administration & dosage | Drug Delivery Systems | Glutathione - pharmacology | T-Lymphocytes, Cytotoxic - transplantation | Disulfides - chemistry | Lymphocytes, Tumor-Infiltrating - chemistry | Receptors, Antigen, T-Cell - immunology | Thymoma - therapy | Thymoma - pathology | Lymphocytes, Tumor-Infiltrating - cytology | Pyridines - administration & dosage | Immunotherapy, Adoptive | Lymphocyte Activation | Thymoma - immunology | Methacrylates - administration & dosage | Lymphocytes, Tumor-Infiltrating - transplantation | Phosphatidylethanolamines - administration & dosage | Liposomes - chemistry | T-Lymphocytes, Cytotoxic - chemistry | Animals | Cell Line, Tumor | Mice | Nanoparticles - administration & dosage | RNA, Small Interfering - administration & dosage | Dextrans - administration & dosage | T-Lymphocytes, Cytotoxic - cytology | Extravasation of Diagnostic and Therapeutic Materials | Cell Movement | Cytotoxicity, Immunologic | Drugs | Drug delivery systems | T cells | Analysis | Vehicles | Lymphocytes | Barriers | Activation | Joining | Nanostructure | Tumors
Journal Article
Journal Article
Molecular Pharmaceutics, ISSN 1543-8384, 09/2014, Volume 11, Issue 9, pp. 3017 - 3026
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2016, Volume 113, Issue 11, pp. 2868 - 2873
A central challenge to the development of protein-based therapeutics is the inefficiency of delivery of protein cargo across the mammalian cell membrane,... 
Protein delivery | Genome editing | CRISPR/Cas9 | Cre recombinase | Lipid nanoparticle | THERAPEUTICS | genome editing | COMBINATORIAL LIBRARY | VIVO | RNA | CELLS IN-VITRO | CAS9 PROTEIN | TRANSFECTION | MULTIDISCIPLINARY SCIENCES | CANCER-THERAPY | lipid nanoparticle | protein delivery | INTRACELLULAR DELIVERY | Endonucleases - genetics | Thalamus - metabolism | Nanoparticles - chemistry | Humans | Green Fluorescent Proteins - genetics | Structure-Activity Relationship | Recombinant Proteins - biosynthesis | Endosomes - metabolism | Drug Carriers | Luminescent Proteins - biosynthesis | RNA - genetics | Cholesterol - chemistry | Endocytosis | Lipids - chemistry | Integrases - administration & dosage | Endonucleases - administration & dosage | Recombination, Genetic | Nanoparticles - metabolism | Molecular Structure | Genes, Reporter | Genetic Engineering - methods | Bacterial Proteins - genetics | Genes, Synthetic | Ceramides - chemistry | Lipids - administration & dosage | Gene Knockout Techniques | Static Electricity | Nanoparticles - toxicity | Bacterial Proteins - administration & dosage | Animals | Hypothalamus - metabolism | Lipids - chemical synthesis | Green Fluorescent Proteins - biosynthesis | CRISPR-Cas Systems | Luminescent Proteins - genetics | Mice | Nanoparticles - administration & dosage | HeLa Cells | Integrases - genetics | Phosphatidylethanolamines - chemistry | Nanoparticles | Genetic aspects | Nucleotide sequencing | Lipid metabolism | Health aspects | Methods | DNA sequencing | CRISPR | Physical Sciences | Cas9
Journal Article
Journal Article
Journal Article
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ISSN 0939-6411, 10/2011, Volume 79, Issue 2, pp. 276 - 284
The objective of the present study was to evaluate the potential of paclitaxel loaded micelles fabricated from PEG(5000)-DSPE as a sustained release system... 
PEG-lipid micelles | DRUG-DELIVERY | CHITOSAN NANOPARTICLES | BIODISTRIBUTION | RELEASE | POLYMERIC MICELLES | CELL LUNG-CANCER | PEG-DSPE | IN-VITRO | Sustained release | SYSTEMS | PHARMACOLOGY & PHARMACY | Tissue distribution | Pharmacokinetics | INHALED ULTRAFINE PARTICLES | LIPOSOMES | Intratracheal administration | Chemistry, Pharmaceutical - methods | Drug Carriers - administration & dosage | Drug Carriers - toxicity | Male | Polyethylene Glycols - chemistry | Paclitaxel - pharmacokinetics | Drug Carriers - chemistry | Tissue Distribution | Paclitaxel - chemistry | Antineoplastic Agents, Phytogenic - administration & dosage | Micelles | Phosphatidylethanolamines - pharmacokinetics | Lung - metabolism | Paclitaxel - administration & dosage | Antineoplastic Agents, Phytogenic - pharmacokinetics | Trachea | Polyethylene Glycols - pharmacokinetics | Rats | Antineoplastic Agents, Phytogenic - chemistry | Phosphatidylethanolamines - administration & dosage | Polyethylene Glycols - toxicity | Rats, Sprague-Dawley | Polyethylene Glycols - administration & dosage | Antineoplastic Agents, Phytogenic - toxicity | Animals | Phosphatidylethanolamines - toxicity | Lung - drug effects | Drug Carriers - pharmacokinetics | Delayed-Action Preparations | Drug Delivery Systems - methods | Phosphatidylethanolamines - chemistry | Drug Delivery Systems - adverse effects | Index Medicus
Journal Article
Drug Delivery, ISSN 1071-7544, 01/2017, Volume 24, Issue 1, pp. 270 - 277
In the present study, we select the Sylysia 350 (Sylysia) as mesoporous material, distearoylphosphatidylethanolamine-poly(ethylene glycol) 2000 (DSPE-PEG) as... 
poorly water-soluble drugs | nanomatrix | anti-tumor activity | Sorafenib tosylate | bioavailability | Poorly water-soluble drugs | Bioavailability | Nanomatrix | Anti-tumor activity | DRUG-DELIVERY | BEHAVIOR | MESOPOROUS SILICA NANOPARTICLES | RELEASE | STRATEGIES | DISSOLUTION | SYSTEMS | PHARMACOLOGY & PHARMACY | ORAL DELIVERY | Niacinamide - analogs & derivatives | Polymers - administration & dosage | Nanoparticles - chemistry | Lactose - administration & dosage | Humans | Lactose - analogs & derivatives | Methylcellulose - analogs & derivatives | Male | Polyethylene Glycols - chemistry | Antineoplastic Agents - administration & dosage | Tumor Burden - physiology | Niacinamide - chemistry | Phenylurea Compounds - chemistry | Female | Methylcellulose - administration & dosage | Rats | Phosphatidylethanolamines - administration & dosage | Random Allocation | Antineoplastic Agents - chemistry | Rats, Sprague-Dawley | Polyethylene Glycols - administration & dosage | Niacinamide - administration & dosage | Methylcellulose - chemistry | Animals | Phenylurea Compounds - administration & dosage | Tumor Burden - drug effects | Mice, Nude | Cell Line, Tumor | Lactose - chemistry | Polymers - chemistry | Mice | Mice, Inbred BALB C | Nanoparticles - administration & dosage | Drug Delivery Systems - methods | Phosphatidylethanolamines - chemistry | Drugs | Drug delivery systems | Laboratories | Cellulose | Crystallization | Lipids | Metastasis | Nanoparticles | Angiogenesis | Nanocrystals | Silicas | Polymers | Pharmaceutical sciences | Cancer | Index Medicus
Journal Article
International Journal of Nanomedicine, ISSN 1176-9114, 2012, Volume 7, pp. 651 - 661
Journal Article