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Pharmaceutical Research, ISSN 0724-8741, 05/2015, Volume 32, Issue 5, pp. 1585 - 1603
Journal Article
Journal Article
Journal Article
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ISSN 0939-6411, 10/2011, Volume 79, Issue 2, pp. 276 - 284
The objective of the present study was to evaluate the potential of paclitaxel loaded micelles fabricated from PEG(5000)-DSPE as a sustained release system... 
PEG-lipid micelles | DRUG-DELIVERY | CHITOSAN NANOPARTICLES | BIODISTRIBUTION | RELEASE | POLYMERIC MICELLES | CELL LUNG-CANCER | PEG-DSPE | IN-VITRO | Sustained release | SYSTEMS | PHARMACOLOGY & PHARMACY | Tissue distribution | Pharmacokinetics | INHALED ULTRAFINE PARTICLES | LIPOSOMES | Intratracheal administration | Chemistry, Pharmaceutical - methods | Drug Carriers - administration & dosage | Drug Carriers - toxicity | Male | Polyethylene Glycols - chemistry | Paclitaxel - pharmacokinetics | Drug Carriers - chemistry | Tissue Distribution | Paclitaxel - chemistry | Antineoplastic Agents, Phytogenic - administration & dosage | Micelles | Phosphatidylethanolamines - pharmacokinetics | Lung - metabolism | Paclitaxel - administration & dosage | Antineoplastic Agents, Phytogenic - pharmacokinetics | Trachea | Polyethylene Glycols - pharmacokinetics | Rats | Antineoplastic Agents, Phytogenic - chemistry | Phosphatidylethanolamines - administration & dosage | Polyethylene Glycols - toxicity | Rats, Sprague-Dawley | Polyethylene Glycols - administration & dosage | Antineoplastic Agents, Phytogenic - toxicity | Animals | Phosphatidylethanolamines - toxicity | Lung - drug effects | Drug Carriers - pharmacokinetics | Delayed-Action Preparations | Drug Delivery Systems - methods | Phosphatidylethanolamines - chemistry | Drug Delivery Systems - adverse effects | Index Medicus
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 2006, Volume 115, Issue 3, pp. 251 - 258
The “accelerated blood clearance (ABC) phenomenon”, causing PEGylated liposomes to be cleared very rapidly from the circulation upon repeated injection, has... 
Complement system | Accelerate blood clearance (ABC) phenomenon | PEGylated liposome | Doxorubicin | Polyethylene glycol (PEG) | MECHANISM | complement system | RATS | accelerate blood clearance (ABC) phenomenon | TOXICITY | polyethylene glycol (PEG) | CHEMISTRY, MULTIDISCIPLINARY | SPLEEN | IMMUNOGENICITY | PHARMACOKINETICS | SURFACE | PHARMACOLOGY & PHARMACY | doxorubicin | ACCUMULATION | Dose-Response Relationship, Immunologic | Injections, Intravenous | Spleen - immunology | Complement Activation | Rats, Wistar | Cholesterol - administration & dosage | Male | Metabolic Clearance Rate | Tritium | Antigen-Antibody Reactions | Tissue Distribution | Antibiotics, Antineoplastic - immunology | Cholesterol - pharmacokinetics | Drug Compounding | Phosphatidylethanolamines - pharmacokinetics | Antibiotics, Antineoplastic - pharmacokinetics | Doxorubicin - administration & dosage | Cholesterol - analogs & derivatives | Radiopharmaceuticals - pharmacokinetics | Polyethylene Glycols - pharmacokinetics | Rats | Chemistry, Pharmaceutical | Doxorubicin - pharmacokinetics | Antibiotics, Antineoplastic - administration & dosage | Radiopharmaceuticals - administration & dosage | Animals | Immunoglobulin M - blood | Spleen - metabolism | Liposomes | Doxorubicin - immunology | Immunoglobulins | Anthracyclines | Polyethylene glycol | Analysis | Lipids | Glucose | Dextrose
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 12/2017, Volume 363, Issue 3, pp. 348 - 357
This article describes the preclinical pharmacology and pharmacokinetics (PK) of hexadecyl-treprostinil (C16TR), a prodrug of treprostinil (TRE), formulated in... 
PROSTACYCLIN RECEPTOR | EP4 RECEPTOR | ANALOGS | ARTERIAL-HYPERTENSION | PHARMACOLOGY & PHARMACY | BINDING | ILOPROST | Antihypertensive Agents - pharmacology | Nanoparticles - chemistry | Vasodilator Agents - pharmacokinetics | Phosphatidylethanolamines - adverse effects | Humans | Excipients - adverse effects | Male | Polyethylene Glycols - chemistry | Squalene - analogs & derivatives | Drug Compounding | Hypertension, Pulmonary - drug therapy | Epoprostenol - pharmacokinetics | Guinea Pigs | Squalene - adverse effects | Antihypertensive Agents - therapeutic use | Excipients - administration & dosage | Rats, Sprague-Dawley | Epoprostenol - analogs & derivatives | Lung - drug effects | Vasodilation - drug effects | Phosphatidylethanolamines - chemistry | Drug Delivery Systems - adverse effects | Epoprostenol - administration & dosage | Prodrugs - administration & dosage | Epoprostenol - metabolism | Vasodilator Agents - therapeutic use | Antihypertensive Agents - administration & dosage | Polyethylene Glycols - adverse effects | Hypertension, Pulmonary - blood | Nanoparticles - adverse effects | Dose-Response Relationship, Drug | Epoprostenol - therapeutic use | Excipients - chemistry | Epoprostenol - pharmacology | Female | Lung - metabolism | Platelet Aggregation - drug effects | Drug Evaluation, Preclinical | Squalene - chemistry | Vasodilator Agents - pharmacology | Administration, Inhalation | Phosphatidylethanolamines - administration & dosage | Squalene - administration & dosage | Antihypertensive Agents - pharmacokinetics | Polyethylene Glycols - administration & dosage | Animals | Prodrugs - pharmacokinetics | Dogs | Nanoparticles - administration & dosage | Prodrugs - therapeutic use | Lung - blood supply | Prodrugs - pharmacology | Vasodilator Agents - administration & dosage | Index Medicus
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 12/2017, Volume 268, pp. 92 - 101
Myelodysplastic syndromes (MDS) are a diverse group of bone marrow disorders and clonal hematopoietic stem cell disorders characterized by abnormal blood... 
Bone marrow | Decitabine | Arsenic trioxide | Delivery | Nanoparticle | Myelodysplastic syndrome | APOPTOSIS | DNA METHYLATION | DRUG-DELIVERY | 5-AZACYTIDINE | COMBINATION | CANCER | CHEMISTRY, MULTIDISCIPLINARY | CHEMOTHERAPY | RETINOIC ACID | PHARMACOLOGY & PHARMACY | POLYMER HYBRID NANOPARTICLES | ACUTE PROMYELOCYTIC LEUKEMIA | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Nanoparticles - chemistry | Apoptosis - drug effects | Oxides - chemistry | Azacitidine - chemistry | Phosphatidylethanolamines - therapeutic use | Polyethylene Glycols - chemistry | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Polyethylene Glycols - therapeutic use | Alendronate - chemistry | Alendronate - therapeutic use | Tissue Distribution | Arsenicals - therapeutic use | Nanoparticles - therapeutic use | Bone and Bones - metabolism | Phosphatidylethanolamines - pharmacokinetics | Bone Marrow Cells - drug effects | Antineoplastic Agents - pharmacokinetics | Arsenicals - pharmacokinetics | Alendronate - pharmacokinetics | Myelodysplastic Syndromes - drug therapy | Oxides - administration & dosage | Azacitidine - administration & dosage | Oxides - therapeutic use | Cell Survival - drug effects | Arsenic Trioxide | Azacitidine - pharmacokinetics | Myelodysplastic Syndromes - metabolism | Cells, Cultured | Polyethylene Glycols - pharmacokinetics | Azacitidine - analogs & derivatives | Mice, Transgenic | Phosphatidylethanolamines - administration & dosage | Antineoplastic Agents - chemistry | Polyethylene Glycols - administration & dosage | Oxides - pharmacokinetics | Arsenicals - administration & dosage | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Arsenicals - chemistry | Nanoparticles - administration & dosage | Phosphatidylethanolamines - chemistry | Alendronate - administration & dosage | Azacitidine - therapeutic use | Medical research | Medical colleges | Medical examination | Arsenic | Analysis | Medicine, Experimental | Hematopoietic stem cells | Blood | Index Medicus | delivery | nanoparticle | decitabine | arsenic trioxide | bone marrow
Journal Article
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 02/2005, Volume 23, Issue 5, pp. 965 - 972
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 08/2016, Volume 235, pp. 245 - 258
The traditional drug delivery systems always suffer from the unexpected drug release during circulation and the sluggish release of drug in target site. To... 
One-demand drug release | Photodynamic-chemotherapy | Fullerene (C | Nanomedicine | ROS-manipulated drug release | SYSTEM | CELLS | RNAI | DRUG-DELIVERY | DOXORUBICIN | PHOTODYNAMIC ACTIVITY | Fullerene (C-60) | RELEASE | CHEMISTRY, MULTIDISCIPLINARY | PHOTOTHERMAL THERAPY | PHARMACOLOGY & PHARMACY | C-60 | COPOLYMER | Neoplasms - metabolism | Doxorubicin - therapeutic use | Reactive Oxygen Species - metabolism | Phosphatidylethanolamines - therapeutic use | Delayed-Action Preparations - chemistry | Polyethylene Glycols - chemistry | Doxorubicin - chemistry | Polyethylene Glycols - therapeutic use | Delayed-Action Preparations - administration & dosage | Drug Delivery Systems | Antibiotics, Antineoplastic - chemistry | Delayed-Action Preparations - pharmacokinetics | Phosphatidylethanolamines - pharmacokinetics | Female | Fullerenes - chemistry | Antibiotics, Antineoplastic - pharmacokinetics | Fullerenes - administration & dosage | Doxorubicin - administration & dosage | Cell Survival - drug effects | Fullerenes - therapeutic use | Polyethylene Glycols - pharmacokinetics | Phosphatidylethanolamines - administration & dosage | Doxorubicin - pharmacokinetics | Polyethylene Glycols - administration & dosage | Neoplasms - drug therapy | Antibiotics, Antineoplastic - administration & dosage | Animals | Antibiotics, Antineoplastic - therapeutic use | Tumor Burden - drug effects | Cell Line, Tumor | Delayed-Action Preparations - therapeutic use | Mice | Mice, Inbred BALB C | Neoplasms - pathology | Fullerenes - pharmacokinetics | Phosphatidylethanolamines - chemistry | Drugs | Chemotherapy | Drug delivery systems | Drug therapy | Cancer | Vehicles | Anthracyclines | Lasers | Photochemotherapy | Index Medicus
Journal Article
European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 12/2018, Volume 125, pp. 11 - 22
Drug-fortified cationic liposomes of 6‑methoxy‑2‑naphthylacetic acid (6‑MNA) were prepared and characterized by various techniques. The residence time of... 
Arthritis | Non-steroidal anti-inflammatory drugs (NSAIDs) | Liposomes | 6‑Methoxy‑2‑naphthylacetic acid (6‑MNA) | Intra-articular (IA) delivery | INTRAARTICULAR INJECTION | SYNOVIAL-FLUID | FATE | DELIVERY | CARTILAGE | RABBITS | PAIN | PHARMACOLOGY & PHARMACY | OSTEOARTHRITIS | 6-Methoxy-2-naphthylacetic acid (6-MNA) | NIH 3T3 Cells | Arthritis, Experimental - drug therapy | Fatty Acids, Monounsaturated - administration & dosage | Phosphatidylcholines - administration & dosage | Male | Naphthaleneacetic Acids - administration & dosage | Arthritis, Experimental - metabolism | Delayed-Action Preparations - administration & dosage | Arthritis, Experimental - pathology | Phosphatidylcholines - pharmacokinetics | Delayed-Action Preparations - pharmacokinetics | Phosphatidylethanolamines - pharmacokinetics | Naphthaleneacetic Acids - pharmacokinetics | Cell Survival - drug effects | Phosphatidylethanolamines - administration & dosage | Rats, Sprague-Dawley | Cartilage, Articular - pathology | Animals | Quaternary Ammonium Compounds - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics | Fatty Acids, Monounsaturated - pharmacokinetics | Mice | Quaternary Ammonium Compounds - pharmacokinetics | Cartilage, Articular - drug effects | Thin films | C-reactive protein | Medical examination | Analysis | Models | Dielectric films | Nonsteroidal anti-inflammatory drugs | Drug therapy | Blood
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 03/2016, Volume 225, pp. 87 - 95
Mitomycin C (MMC) is a powerful anti-bacterial, anti-fungal and anti-tumor antibiotic, often active against multidrug resistant cells. Despite a broad spectrum... 
Mitomycin-C | Chemotherapy | Liposomes | Prodrug | Folate-receptor | Targeting | LIPID-BASED PRODRUG | BLADDER-CANCER | LOCAL HYPERTHERMIA | PERITONEAL CARCINOMATOSIS | DRUG-RELEASE | CHEMISTRY, MULTIDISCIPLINARY | TUMOR-LOCALIZATION | STEALTH LIPOSOMES | THERAPEUTIC-EFFICACY | MEDIATED ENDOCYTOSIS | PHARMACOLOGY & PHARMACY | SOLID TUMOR | Folic Acid Transporters - metabolism | Mitomycin - chemistry | Neoplasms - metabolism | Prodrugs - administration & dosage | Humans | Polyethylene Glycols - chemistry | Prodrugs - chemistry | Antibiotics, Antineoplastic - blood | Molecular Targeted Therapy | Folic Acid - administration & dosage | Cholesterol - chemistry | Antibiotics, Antineoplastic - chemistry | Phosphatidylethanolamines - pharmacokinetics | Female | Antibiotics, Antineoplastic - pharmacokinetics | Mitomycin - blood | Cell Survival - drug effects | Folic Acid - chemistry | Polyethylene Glycols - pharmacokinetics | Phosphatidylethanolamines - administration & dosage | Folic Acid - pharmacokinetics | Polyethylene Glycols - administration & dosage | Antibiotics, Antineoplastic - administration & dosage | Animals | Prodrugs - pharmacokinetics | Mice, Nude | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Mitomycin - pharmacokinetics | Peritoneal Diseases - metabolism | Mitomycin - administration & dosage | Phosphatidylethanolamines - chemistry | Lymphomas | Mitomycin | Folic acid | Cancer | Index Medicus
Journal Article
Journal Article