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Biochemical Journal, ISSN 0264-6021, 11/2014, Volume 463, Issue 3, pp. 413 - 427
The Vps34 (vacuolar protein sorting 34) class III PI3K (phosphoinositide 3-kinase) phosphorylates PtdIns (phosphatidylinositol) at endosomal membranes to... 
Mammalian target of rapamycin (mTOR) | Phosphoinositide 3-kinase (PI3K) | Protein kinase inhibitor | Signal transduction inhibitor | N-Myc downstream-regulated gene-1 (NDRG1) | Protein Structure, Tertiary | Cell Line | Phosphorylation | Class II Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol Phosphates - metabolism | Class I Phosphatidylinositol 3-Kinases - metabolism | Class II Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Humans | Inositol Polyphosphate 5-Phosphatases | Class III Phosphatidylinositol 3-Kinases - metabolism | Pyrimidines - pharmacology | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Endosomes - metabolism | Amino Acid Motifs | Aminopyridines - pharmacology | Hydrophobic and Hydrophilic Interactions | Protein Binding | Class III Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases | Phosphoric Monoester Hydrolases - metabolism | Protein-Serine-Threonine Kinases - metabolism | SGK3, serum- and glucocorticoid-regulated kinase-3 | signal transduction inhibitor | PI3K, phosphoinositide 3-kinase | ITC, isothermal titration calorimetry | SHIP1 | mTORC, mammalian target of rapamycin complex | EEA1, early endosome antigen 1 | INPP4B, inositol polyphosphate 4-phosphatase type II | TSC2, tuberous sclerosis complex 2 | phosphoinositide 3-kinase (PI3K) | HRP, horseradish peroxidase | PDK1, phosphoinositide-dependent kinase 1 | DMEM, Dulbecco's modified Eagle's medium | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | IP1, inositol phosphate | 4E-BP1, eukaryotic initiation factor 4E-binding protein 1 | PX, Phox homology | mammalian target of rapamycin (mTOR) | Accelerated Publication | PH, pleckstrin homology | PtdIns, phosphatidylinositol | PRAS40, proline-rich Akt substrate 40 kDa | protein kinase inhibitor | 2, Src homology 2-domain-containing inositol phosphatase 1 | Vps34, vacuolar protein sorting 34 | VSV-G, vesicular stomatitis virus glycoprotein
Journal Article
Journal Article
PLoS Genetics, ISSN 1553-7390, 10/2011, Volume 7, Issue 10, p. e1002319
We previously reported that autosomal recessive demyelinating Charcot-Marie-Tooth (CMT) type 4B1 neuropathy with myelin outfoldings is caused by loss of MTMR2... 
CELLS | PIKFYVE | MYOTUBULARIN-RELATED PROTEIN-2 | PHOSPHOINOSITIDE PHOSPHATASE | DISEASE | GENETICS & HEREDITY | NEURODEGENERATION | PHOSPHATIDYLINOSITOL 3,5-BISPHOSPHATE | GROWTH-FACTOR | MYOPATHY | FAMILY | Axons - enzymology | Phosphatidylinositol Phosphates - metabolism | Heterocyclic Compounds, 3-Ring - pharmacology | Charcot-Marie-Tooth Disease - enzymology | Humans | Phosphatidylinositol 3-Kinases - metabolism | Charcot-Marie-Tooth Disease - genetics | Myelin Sheath - metabolism | Protein Tyrosine Phosphatases, Non-Receptor - genetics | Neurons - metabolism | Peripheral Nerves - metabolism | Phospholipids - metabolism | Charcot-Marie-Tooth Disease - metabolism | Flavoproteins - metabolism | Flavoproteins - genetics | Mice, Inbred C57BL | Axons - metabolism | Rats | Schwann Cells - metabolism | Phospholipids - genetics | Phosphatidylinositol Phosphates - genetics | Mice, Knockout | Phosphatidylinositol 3-Kinases - genetics | Peripheral Nerves - enzymology | Animals | Aminopyridines - pharmacology | Myelin Sheath - genetics | Neurons - enzymology | Protein Tyrosine Phosphatases, Non-Receptor - metabolism | Phosphoinositide Phosphatases | Mice | Mutation | Peripheral Nerves - growth & development | Schwann Cells - enzymology | Phosphatases | Gene mutations | Charcot-Marie-Tooth disease | Physiological aspects | Genetic aspects | Research | Health aspects | Risk factors | Aminopyridines | Heterocyclic Compounds, 3-Ring | Peripheral Nerves | Schwann Cells | Neurons | Phospholipids | Phosphatidylinositol Phosphates | Protein Tyrosine Phosphatases, Non-Receptor | Phosphatidylinositol 3-Kinases | Charcot-Marie-Tooth Disease | Life Sciences | Axons | Myelin Sheath | Genetics | Flavoproteins | Proteins | Yeast | Homeostasis | Kinases | Experiments | Evacuations & rescues
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2017, Volume 474, Issue 11, pp. 1867 - 1877
Until recently, one of the major limitations of hydrogen/deuterium exchange mass spectrometry (HDX-MS) was the peptide-level resolution afforded by proteolytic... 
ACTIVATION | AMIDE HYDROGENS | PROTEIN | HDX-MS | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTRAMOLECULAR MIGRATION | KINASE | IDENTIFICATION | CAPTURE DISSOCIATION | BINDING | Oligonucleotides - genetics | Oligonucleotides - chemistry | Class Ia Phosphatidylinositol 3-Kinase - metabolism | Electron Transport | Molecular Weight | Humans | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Enzyme Inhibitors - chemistry | Oligonucleotides - antagonists & inhibitors | Signal Processing, Computer-Assisted | Binding Sites | Peptide Fragments - genetics | Drug Evaluation, Preclinical - methods | Triazines - metabolism | Triazines - pharmacology | Indazoles - chemistry | Enzyme Inhibitors - metabolism | Purines - metabolism | Enzyme Inhibitors - pharmacology | Models, Molecular | Indazoles - metabolism | Recombinant Fusion Proteins - chemistry | Sulfonamides - pharmacology | Class Ia Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Indazoles - pharmacology | Oligonucleotides - metabolism | Peptide Fragments - chemistry | Class I Phosphatidylinositol 3-Kinases | Purines - chemistry | Peptide Fragments - antagonists & inhibitors | Protein Conformation | Quinazolinones - chemistry | Quinazolinones - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Recombinant Fusion Proteins - metabolism | Quinolines - pharmacology | Antineoplastic Agents - metabolism | Tandem Mass Spectrometry | Class Ia Phosphatidylinositol 3-Kinase - chemistry | Deuterium Exchange Measurement | Triazines - chemistry | Antineoplastic Agents - pharmacology | Class Ia Phosphatidylinositol 3-Kinase - genetics | Quinazolinones - pharmacology | Peptide Fragments - metabolism | Reproducibility of Results | Sulfonamides - chemistry | Purines - pharmacology | Quinolines - chemistry | Phosphatidylinositol 3-Kinases - chemistry | Antineoplastic Agents - chemistry | Phosphatidylinositol 3-Kinases - genetics | Quinolines - metabolism | Sulfonamides - metabolism | ETD | PI3K
Journal Article
Leukemia & Lymphoma, ISSN 1042-8194, 10/2015, Volume 56, Issue 10, pp. 2779 - 2786
Idelalisib is a first-in-class selective, oral, phosphatidylinositol 3-kinase delta (PI3Kδ) inhibitor approved for the treatment of several types of blood... 
phosphatidylinositol 3-kinase delta (PI3Kδ) inhibitor | transaminitis | colitis | pneumonitis | Idelalisib | diarrhea | Idelalisib, phosphatidylinositol 3-kinase delta (PI3Kδ) inhibitor | phosphatidylinositol 3-kinase delta (PI3K) inhibitor | CAL-101 | DELTA | P110-DELTA | PI3K | ONCOLOGY | INHIBITOR | HEMATOLOGY | SUBUNIT | Index Medicus | Reviews | Review
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 8/2008, Volume 182, Issue 4, pp. 685 - 701
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2007, Volume 104, Issue 13, pp. 5569 - 5574
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 29, pp. 12256 - 12266
Class IA PI3Ks are involved in the generation of the key lipid signaling molecule phosphatidylinositol 3,4,5-trisphosphate (PIP3), and inappropriate activation... 
EXCHANGE MASS-SPECTROMETRY | G-BETA-GAMMA | P110-ALPHA | PROTEIN | SPECIFICITY | RAS MUTATIONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISTINCT | FUNCTIONAL-ANALYSIS | PHOSPHOLIPASE A | BINDING | Class I Phosphatidylinositol 3-Kinases - genetics | Phosphatidylinositol Phosphates - metabolism | Class I Phosphatidylinositol 3-Kinases - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Phosphatidylinositol 3-Kinases - metabolism | Spodoptera | Deuterium Exchange Measurement | Sf9 Cells | Proto-Oncogene Proteins p21(ras) - chemistry | Protein Interaction Domains and Motifs | Peptide Fragments - genetics | Second Messenger Systems | Proto-Oncogene Proteins p21(ras) - metabolism | Recombinant Proteins - metabolism | Peptide Fragments - metabolism | Mutagenesis, Site-Directed | Class I Phosphatidylinositol 3-Kinases - chemistry | Phosphatidylinositol 3-Kinases - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Protein Transport | Phosphatidylinositol 3-Kinases - genetics | Point Mutation | Peptide Fragments - chemistry | Animals | Protein Conformation | Enzyme Activation | Lipid Bilayers - metabolism | Liposomes | Amino Acid Substitution | hydrogen exchange mass spectrometry | Signal Transduction | lipid–protein interaction | Ras protein | phosphatidylinositide 3-kinase (PI 3-kinase) | lipid signaling | phosphoinositide
Journal Article
Cancer Discovery, ISSN 2159-8274, 06/2011, Volume 1, Issue 2, pp. 170 - 185
Journal Article
Biochemical Journal, ISSN 0264-6021, 03/2015, Volume 466, Issue 2, pp. 359 - 367