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Leukemia, ISSN 1476-5551, 2018, Volume 32, Issue 9, pp. 1958 - 1969
The PI 3-kinases (PI3K) are essential mediators of chemokine receptor signaling necessary for migration of chronic lymphocytic leukemia (CLL... 
G-BETA-GAMMA | P110-GAMMA ISOFORM | ONCOLOGY | PHOSPHATIDYLINOSITOL 3-KINASE | REGULATORY SUBUNITS | CHRONIC LYMPHOCYTIC-LEUKEMIA | SURVIVAL SIGNALS | ZAP-70 EXPRESSION | HEMATOLOGY | MARROW STROMAL CELLS | T-LYMPHOCYTES | DIFFERENTIAL ROLES | Leukemia, B-Cell - metabolism | Class I Phosphatidylinositol 3-Kinases - genetics | Class I Phosphatidylinositol 3-Kinases - metabolism | Class Ib Phosphatidylinositol 3-Kinase - genetics | Humans | Cell Survival - genetics | Lymphoma, B-Cell - genetics | Cell Movement - genetics | Gene Knockdown Techniques | CD40 Ligand - metabolism | Class Ib Phosphatidylinositol 3-Kinase - metabolism | ZAP-70 Protein-Tyrosine Kinase - metabolism | Antineoplastic Agents - pharmacology | B-Lymphocytes - pathology | Gene Expression Regulation, Neoplastic - drug effects | Mesenchymal Stem Cells - metabolism | B-Lymphocytes - metabolism | Quinazolinones - pharmacology | Cell Survival - drug effects | Cell Adhesion - genetics | Lymphoma, B-Cell - metabolism | Purines - pharmacology | Interleukin-4 - metabolism | Leukemia, B-Cell - pathology | Cell Adhesion - drug effects | Chemotaxis - genetics | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Cell Movement - drug effects | Leukemia, B-Cell - genetics | Lymphoma, B-Cell - pathology | Cytoskeleton - metabolism | Chemokines - metabolism | Class Ib Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Mutation | Immunoglobulin Heavy Chains - genetics | CXCL12 protein | Chronic lymphatic leukemia | Leukocyte migration | Leukemia | Cytology | Adhesion tests | Crosslinking | ZAP-70 protein | Lymphatic leukemia | Kinases | CD40L protein | Adhesion | Cell morphology | 1-Phosphatidylinositol 3-kinase | Cell adhesion & migration | Interleukin 4 | Inhibitors | Lymphocytes B | Actin | Morphology | Stromal cells | Inhibition | Chemokines | Cell migration
Journal Article
Biochemical journal, ISSN 1470-8728, 2014, Volume 463, Issue 3, pp. 413 - 427
We characterize VPS34-IN, a potent and selective inhibitor of class III Vps34 PI3K. Using VPS34-IN1, we demonstrate that PtdIns(3)P, produced by Vps34 controls... 
Mammalian target of rapamycin (mTOR) | Phosphoinositide 3-kinase (PI3K) | Protein kinase inhibitor | Signal transduction inhibitor | N-Myc downstream-regulated gene-1 (NDRG1) | Protein Structure, Tertiary | Cell Line | Phosphorylation | Class II Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol Phosphates - metabolism | Class I Phosphatidylinositol 3-Kinases - metabolism | Class II Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Humans | Inositol Polyphosphate 5-Phosphatases | Class III Phosphatidylinositol 3-Kinases - metabolism | Pyrimidines - pharmacology | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Endosomes - metabolism | Amino Acid Motifs | Aminopyridines - pharmacology | Hydrophobic and Hydrophilic Interactions | Protein Binding | Class III Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases | Phosphoric Monoester Hydrolases - metabolism | Protein-Serine-Threonine Kinases - metabolism | SGK3, serum- and glucocorticoid-regulated kinase-3 | signal transduction inhibitor | PI3K, phosphoinositide 3-kinase | ITC, isothermal titration calorimetry | SHIP1 | mTORC, mammalian target of rapamycin complex | EEA1, early endosome antigen 1 | INPP4B, inositol polyphosphate 4-phosphatase type II | TSC2, tuberous sclerosis complex 2 | phosphoinositide 3-kinase (PI3K) | HRP, horseradish peroxidase | PDK1, phosphoinositide-dependent kinase 1 | DMEM, Dulbecco's modified Eagle's medium | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | IP1, inositol phosphate | 4E-BP1, eukaryotic initiation factor 4E-binding protein 1 | PX, Phox homology | mammalian target of rapamycin (mTOR) | Accelerated Publication | PH, pleckstrin homology | PtdIns, phosphatidylinositol | PRAS40, proline-rich Akt substrate 40 kDa | protein kinase inhibitor | 2, Src homology 2-domain-containing inositol phosphatase 1 | Vps34, vacuolar protein sorting 34 | VSV-G, vesicular stomatitis virus glycoprotein
Journal Article
The Journal of cell biology, ISSN 1540-8140, 2003, Volume 161, Issue 2, pp. 429 - 439
Shear stress induces endothelial polarization and migration in the direction of flow accompanied by extensive remodeling of the actin cytoskeleton. The GTPases... 
T lymphocytes | Statics | Cell motility | Human umbilical vein endothelial cells | Shear stress | Stress fibers | Pseudopodia | Physiological regulation | Endothelial cells | Cells | Rho-kinase | Polarity | Rho GTPases | Actin cytoskeleton | Migration | ACTIVATION | DISTINCT ROLES | PHOSPHOINOSITIDE 3-KINASE | 3T3 FIBROBLASTS | CELL BIOLOGY | actin cytoskeleton | migration | GENE-EXPRESSION | FOCAL ADHESION KINASE | SMOOTH-MUSCLE CELLS | polarity | MOTILITY | rho GTP-Binding Proteins - antagonists & inhibitors | Recombinant Fusion Proteins - pharmacology | Humans | Stress, Mechanical | rac GTP-Binding Proteins - metabolism | Endothelium, Vascular - drug effects | cdc42 GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Endothelium, Vascular - enzymology | Hemodynamics - physiology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Cell Movement - physiology | rac GTP-Binding Proteins - antagonists & inhibitors | cdc42 GTP-Binding Protein - antagonists & inhibitors | Cell Polarity - drug effects | Cell Size - drug effects | Cells, Cultured | Enzyme Inhibitors - pharmacology | Cell Size - physiology | Mutation - genetics | Cell Movement - drug effects | rho GTP-Binding Proteins - metabolism | Fluorescent Antibody Technique | Cell Polarity - physiology | Cytology | Research | Rho GTPases; actin cytoskeleton; Rho-kinase; migration; polarity
Journal Article
Nature reviews. Immunology, ISSN 1474-1741, 2016, Volume 16, Issue 11, pp. 702 - 714
Primary immunodeficiencies are inherited disorders of the immune system, often caused by the mutation of genes required for lymphocyte development and... 
Signal Transduction | Humans | Gene Expression Regulation | Lymphocytes/cytology | Immune System/cytology | Molecular Targeted Therapy | Immunity | Immunologic Deficiency Syndromes/etiology | Cellular Senescence/genetics | Phosphatidylinositol 3-Kinases/antagonists & inhibitors | Animals | Lymphocyte Activation/genetics | Protein Subunits/genetics | Cell Differentiation/genetics | Enzyme Activation | Mutation | T-CELL RESPONSES | IMPAIRED B-CELL | GAIN-OF-FUNCTION | TRANSCRIPTION FACTOR FOXO1 | PHOSPHATIDYLINOSITOL 3-KINASE | PHOSPHOINOSITIDE 3-KINASE P110-DELTA | HYPER IGM SYNDROME | P85-ALPHA SUBUNIT | IMMUNOLOGY | CLASS-IA PI3K | CUTTING EDGE | Immunologic Deficiency Syndromes - etiology | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Protein Subunits - metabolism | Cell Differentiation - genetics | Cellular Senescence - immunology | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | Lymphocytes - immunology | Immune System - immunology | Protein Subunits - genetics | Lymphocytes - metabolism | Cellular Senescence - genetics | Immunologic Deficiency Syndromes - therapy | Phosphatidylinositol 3-Kinases - chemistry | Lymphocytes - cytology | Immune System - cytology | Phosphatidylinositol 3-Kinases - genetics | Cell Differentiation - immunology | Immune System - metabolism | Immunologic Deficiency Syndromes - metabolism
Journal Article
Molecular cancer therapeutics, ISSN 1538-8514, 2009, Volume 8, Issue 7, pp. 1725 - 1738
Journal Article
Cancer cell, ISSN 1535-6108, 2014, Volume 26, Issue 1, pp. 136 - 149
Activation of the phosphoinositide 3-kinase (PI3K) pathway occurs frequently in breast cancer. However, clinical results of single-agent PI3K inhibitors have... 
DRUG | INACTIVATION | ADVANCED SOLID TUMORS | MAMMARY-TUMORS | GENE | ONCOLOGY | PATHWAY INHIBITORS | CYCLIN D1 EXPRESSION | GROWTH | PHASE-I | PRECLINICAL EVALUATION | CELL BIOLOGY | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Phosphorylation | Phosphatidylinositol Phosphates - metabolism | Cyclin-Dependent Kinase 4 - genetics | Humans | Drug Resistance, Neoplasm | Phosphatidylinositol 3-Kinases - metabolism | Molecular Targeted Therapy | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | Breast Neoplasms - enzymology | Transfection | MCF-7 Cells | RNA Interference | Time Factors | Female | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - metabolism | Cell Survival - drug effects | Genetic Predisposition to Disease | Retinoblastoma Protein - metabolism | Cyclin-Dependent Kinase 6 - genetics | Treatment Outcome | Cyclin-Dependent Kinase 6 - metabolism | Cyclin-Dependent Kinase 4 - metabolism | Mice, SCID | Breast Neoplasms - drug therapy | Drug Synergism | Phosphatidylinositol 3-Kinases - genetics | Xenograft Model Antitumor Assays | Protein Kinase Inhibitors - administration & dosage | Phenotype | Animals | Breast Neoplasms - genetics | Class I Phosphatidylinositol 3-Kinases | Signal Transduction - drug effects | Breast Neoplasms - pathology | Mice, Nude | Cell Proliferation - drug effects | Mice | Mutation | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Medical colleges | Breast cancer
Journal Article
Cancer cell, ISSN 1535-6108, 2015, Volume 27, Issue 6, pp. 837 - 851
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2009, Volume 284, Issue 41, pp. 28392 - 28400
Journal Article
The Journal of cell biology, ISSN 1540-8140, 2001, Volume 155, Issue 1, pp. 19 - 26
Journal Article