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Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2008, Volume 105, Issue 35, pp. 13057 - 13062
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2012, Volume 109, Issue 6, pp. 2003 - 2008
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2010, Volume 107, Issue 12, pp. 5471 - 5476
The phosphatidylinositol 3-kinase (PI3K) signaling pathway is deregulated in many human diseases including cancer, diabetes, obesity, and autoimmunity. PI3K... 
Proteins | Phosphatases | HeLa cells | Lipids | Insulin resistance | Gene expression regulation | Physiological regulation | Insulin | Phosphatidylinositols | Cancer | Explains mouse phenotypes | Lipid phosphatase | Protein:protein interactions | PTEN tumor suppressor | Insulin signaling | CATALYTIC SUBUNIT | MULTIDISCIPLINARY SCIENCES | P85-ALPHA SUBUNIT | PHOSPHOINOSITIDE 3-KINASE | CANCER | MICE LACKING | 3'-KINASE | insulin signaling | GENE | PI3K | NEOPLASIA | lipid phosphatase | protein:protein interactions | explains mouse phenotypes | INCREASED INSULIN SENSITIVITY | Protein Subunits | Sequence Deletion | Humans | Cercopithecus aethiops | Phosphatidylinositol 3-Kinases - metabolism | Recombinant Fusion Proteins - metabolism | Phosphatidylinositol 3-Kinases - deficiency | Protein Interaction Domains and Motifs | Peptide Fragments - genetics | PTEN Phosphohydrolase - genetics | PTEN Phosphohydrolase - deficiency | Peptide Fragments - metabolism | Signal Transduction | Phosphatidylinositol 3-Kinases - chemistry | PTEN Phosphohydrolase - metabolism | Epidermal Growth Factor - metabolism | Recombinant Fusion Proteins - chemistry | Mice, Knockout | Phosphatidylinositol 3-Kinases - genetics | Insulin - metabolism | Peptide Fragments - chemistry | Phenotype | Animals | Protein Binding | Recombinant Fusion Proteins - genetics | Mice | HeLa Cells | COS Cells | PTEN Phosphohydrolase - chemistry | Phosphatidylinositol | Chemical properties | Research | Phosphotransferases | Protein-protein interactions | Tumors | Biological Sciences
Journal Article
Nature Medicine, ISSN 1078-8956, 10/2012, Volume 18, Issue 10, pp. 1560 - 1569
Journal Article
Gastroenterology, ISSN 0016-5085, 2010, Volume 139, Issue 3, pp. 869 - 881.e9
Background & Aims Mechanisms responsible for crypt architectural distortion in chronic ulcerative colitis (CUC) are not well understood. Data indicate that... 
Gastroenterology and Hepatology | Intestinal Progenitor Cells | PI3K | Pik3r1 | Intestinal Stem Cells | ULCERATIVE-COLITIS | SELF-RENEWAL | COLORECTAL-CARCINOMA | IDENTIFICATION | INTERLEUKIN-10-DEFICIENT MICE | CANCER | INFLAMMATORY-BOWEL-DISEASE | PATHWAY | GENE-EXPRESSION | WNT | GASTROENTEROLOGY & HEPATOLOGY | Stem Cells - immunology | Colon - enzymology | Phosphorylation | Cell Proliferation | T-Lymphocytes - enzymology | Colitis - genetics | Humans | Colitis - complications | Colon - drug effects | Colitis - pathology | Colon - immunology | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Wnt Proteins - metabolism | Intestinal Mucosa - drug effects | Phosphatidylinositol 3-Kinases - deficiency | Stem Cells - enzymology | Time Factors | Intestinal Mucosa - immunology | Colonoscopy | Intestinal Mucosa - enzymology | Colitis - immunology | Proto-Oncogene Proteins c-akt - metabolism | Disease Models, Animal | Interleukin-10 - deficiency | Colon - pathology | Mice, Inbred C57BL | beta Catenin - metabolism | Mice, Knockout | Phosphatidylinositol 3-Kinases - genetics | Animals | Colitis - enzymology | Signal Transduction - drug effects | Biopsy | Colonic Neoplasms - pathology | Interleukin-10 - genetics | Stem Cells - drug effects | Stem Cells - pathology | T-Lymphocytes - immunology | Colonic Neoplasms - enzymology | Mice | Protein Kinase Inhibitors - pharmacology | Intestinal Mucosa - pathology
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2007, Volume 104, Issue 2, pp. 612 - 617
Journal Article
Science Translational Medicine, ISSN 1946-6234, 04/2012, Volume 4, Issue 131, pp. 131ra50 - 131ra50
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 09/2017, Volume 37, Issue 11, pp. 2075 - 2086
Journal Article
Nature reviews. Clinical oncology, ISSN 1759-4774, 2014, Volume 11, Issue 4, pp. 184 - 186
Journal Article