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Cancer Research, ISSN 0008-5472, 06/2007, Volume 67, Issue 12, pp. 5840 - 5850
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 10/2009, Volume 101, Issue 19, pp. 1308 - 1324
The monoclonal antibodies panitumumab and cetuximab that target the epidermal growth factor receptor (EGFR) have expanded the range of treatment options for... 
CELL LUNG-CANCER | PHASE-III TRIAL | TYROSINE KINASE INHIBITORS | COLON-CANCER | KRAS MUTATIONS | K-RAS MUTATIONS | PROGRESSION-FREE-SURVIVAL | ONCOLOGY | CETUXIMAB PLUS IRINOTECAN | IN-SITU HYBRIDIZATION | GENE COPY NUMBER | PTEN Phosphohydrolase - drug effects | Predictive Value of Tests | Proto-Oncogene Proteins p21(ras) - genetics | Colorectal Neoplasms - genetics | Humans | Antibodies, Monoclonal - therapeutic use | Antibodies, Monoclonal, Humanized | Receptor, Epidermal Growth Factor - metabolism | Colorectal Neoplasms - drug therapy | Phosphatidylinositol 3-Kinases - drug effects | Biomarkers, Tumor - metabolism | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Cetuximab | Odds Ratio | PTEN Phosphohydrolase - genetics | Proto-Oncogene Proteins - drug effects | Antibodies, Monoclonal - pharmacology | Proto-Oncogene Proteins - genetics | Randomized Controlled Trials as Topic | Phosphatidylinositol 3-Kinases - genetics | Disease-Free Survival | Proto-Oncogene Proteins p21(ras) - drug effects | Animals | Class I Phosphatidylinositol 3-Kinases | Mutation - drug effects | Proto-Oncogene Proteins B-raf - drug effects | Proto-Oncogene Proteins B-raf - genetics | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Colorectal Neoplasms - pathology | Neoplasm Staging | Research Design | Usage | Care and treatment | Prognosis | Gene mutations | Colorectal cancer | Monoclonal antibodies | Development and progression | Genetic aspects | Research | Biological markers | Health aspects | Review
Journal Article
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 02/2018, Volume 9, p. 237
The phosphatidylinositol-3-kinase (PI3K)/Akt pathway is important for multiple stages of herpesvirus replication including virus entry, replication, latency,... 
APDS | Cytomegalovirus | Phosphatidylinositol-3-kinase | PASLI | PIK3CD | Epstein-Barr virus | Akt | PIK3R1 | 3-KINASE DELTA SYNDROME | HUMAN IMMUNODEFICIENCY | phosphatidylinositol-3-kinase | SARCOMA-ASSOCIATED HERPESVIRUS | PI3K-DELTA SYNDROME | IMMUNOLOGY | CELL-SURVIVAL | VIRAL REPLICATION | cytomegalovirus | SIGNALING PATHWAY | GROWTH-FACTOR | LYMPHOPROLIFERATIVE DISORDERS | EPSTEIN-BARR-VIRUS | Class I Phosphatidylinositol 3-Kinases - genetics | Class I Phosphatidylinositol 3-Kinases - metabolism | Humans | Immunosuppressive Agents - therapeutic use | Cytomegalovirus Infections - immunology | Phosphatidylinositol 3-Kinases - metabolism | Class I Phosphatidylinositol 3-Kinases - immunology | Cytomegalovirus Infections - genetics | Phosphatidylinositol 3-Kinases - immunology | Herpesvirus 4, Human - isolation & purification | T-Lymphocytes - metabolism | Cytomegalovirus Infections - virology | Epstein-Barr Virus Infections - genetics | Class I Phosphatidylinositol 3-Kinases - drug effects | Gain of Function Mutation | Immunologic Deficiency Syndromes - immunology | Proto-Oncogene Proteins c-akt - metabolism | Immunosuppressive Agents - pharmacology | Cytomegalovirus - isolation & purification | Genetic Predisposition to Disease | Epstein-Barr Virus Infections - virology | Epstein-Barr Virus Infections - immunology | Herpesvirus 4, Human - immunology | Viremia - genetics | Viremia - drug therapy | Immunologic Deficiency Syndromes - virology | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Epstein-Barr Virus Infections - drug therapy | Phosphatidylinositol 3-Kinases - genetics | Cytomegalovirus - immunology | Proto-Oncogene Proteins c-akt - immunology | Viremia - virology | Cytomegalovirus Infections - drug therapy | Immunologic Deficiency Syndromes - genetics | T-Lymphocytes - immunology | Viremia - immunology
Journal Article
Cancer Treatment Reviews, ISSN 0305-7372, 2014, Volume 40, Issue 6, pp. 750 - 759
Abstract The hedgehog (Hh) pathway is aberrantly activated in a number of tumors. In medulloblastoma, basal cell carcinoma, and rhabdomyosarcoma, mutations in... 
Hematology, Oncology and Palliative Medicine | Hedgehog | Smoothened | Combination chemotherapy | Targeted therapy | Novel antitumor agents | Cell signaling | STEM-CELLS | ACTIVATED PROTEIN-KINASE | SELF-RENEWAL | CHRONIC MYELOID-LEUKEMIA | EPITHELIAL-MESENCHYMAL TRANSITION | GLI TRANSCRIPTION FACTORS | ONCOLOGY | BASAL-CELL CARCINOMA | PROSTATE-CANCER | TARGETING HEDGEHOG | SONIC-HEDGEHOG | Hedgehog Proteins - drug effects | Neoplasms - metabolism | TOR Serine-Threonine Kinases - metabolism | Receptors, Notch - metabolism | Humans | Hedgehog Proteins - metabolism | Receptor, Epidermal Growth Factor - drug effects | Phosphatidylinositol 3-Kinases - metabolism | raf Kinases - metabolism | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Receptor, Epidermal Growth Factor - metabolism | Phosphatidylinositol 3-Kinases - drug effects | Proto-Oncogene Proteins c-akt - metabolism | TOR Serine-Threonine Kinases - drug effects | Janus Kinase 2 - antagonists & inhibitors | Molecular Targeted Therapy - methods | Proto-Oncogene Proteins p21(ras) - metabolism | Receptors, Notch - drug effects | Fusion Proteins, bcr-abl - drug effects | Neoplasms - drug therapy | Proto-Oncogene Proteins p21(ras) - drug effects | Animals | MAP Kinase Signaling System - drug effects | Signal Transduction - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | raf Kinases - drug effects | Fusion Proteins, bcr-abl - metabolism | Proto-Oncogene Proteins c-akt - drug effects | Receptor Cross-Talk - drug effects | Care and treatment | Health aspects | Leukemia | Analysis | Cancer
Journal Article