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PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, pp. e76405 - e76405
Journal Article
Leukemia, ISSN 0887-6924, 09/2018, Volume 32, Issue 9, pp. 1958 - 1969
The PI 3-kinases (PI3K) are essential mediators of chemokine receptor signaling necessary for migration of chronic lymphocytic leukemia (CLL) cells and their... 
G-BETA-GAMMA | P110-GAMMA ISOFORM | ONCOLOGY | PHOSPHATIDYLINOSITOL 3-KINASE | REGULATORY SUBUNITS | CHRONIC LYMPHOCYTIC-LEUKEMIA | SURVIVAL SIGNALS | ZAP-70 EXPRESSION | HEMATOLOGY | MARROW STROMAL CELLS | T-LYMPHOCYTES | DIFFERENTIAL ROLES | Leukemia, B-Cell - metabolism | Class I Phosphatidylinositol 3-Kinases - genetics | Class I Phosphatidylinositol 3-Kinases - metabolism | Class Ib Phosphatidylinositol 3-Kinase - genetics | Humans | Cell Survival - genetics | Lymphoma, B-Cell - genetics | Cell Movement - genetics | Gene Knockdown Techniques | CD40 Ligand - metabolism | Class Ib Phosphatidylinositol 3-Kinase - metabolism | ZAP-70 Protein-Tyrosine Kinase - metabolism | Antineoplastic Agents - pharmacology | B-Lymphocytes - pathology | Gene Expression Regulation, Neoplastic - drug effects | Mesenchymal Stem Cells - metabolism | B-Lymphocytes - metabolism | Quinazolinones - pharmacology | Cell Survival - drug effects | Cell Adhesion - genetics | Lymphoma, B-Cell - metabolism | Purines - pharmacology | Interleukin-4 - metabolism | Leukemia, B-Cell - pathology | Cell Adhesion - drug effects | Chemotaxis - genetics | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Cell Movement - drug effects | Leukemia, B-Cell - genetics | Lymphoma, B-Cell - pathology | Cytoskeleton - metabolism | Chemokines - metabolism | Class Ib Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Mutation | Immunoglobulin Heavy Chains - genetics | CXCL12 protein | Leukocyte migration | Leukemia | Cytology | Adhesion tests | ZAP-70 protein | Kinases | CD40L protein | Cell morphology | Cell adhesion & migration | Interleukin 4 | Actin | Inhibition | Chronic lymphatic leukemia | Crosslinking | Lymphatic leukemia | Adhesion | 1-Phosphatidylinositol 3-kinase | Inhibitors | Lymphocytes B | Morphology | Stromal cells | Cell lines | Chemokines | Cell migration | Index Medicus
Journal Article
by Koboldt, Daniel C and Fulton, Robert S and McLellan, Michael D and Schmidt, Heather and Kalicki-Veizer, Joelle and McMichael, Joshua F and Fulton, Lucinda L and Dooling, David J and Ding, Li and Mardis, Elaine R and Wilson, Richard K and Ally, Adrian and Balasundaram, Miruna and Butterfield, Yaron S. N and Carlsen, Rebecca and Carter, Candace and Chu, Andy and Chuah, Eric and Chun, Hye-Jung E and Coope, Robin J. N and Dhalla, Noreen and Guin, Ranabir and Hirst, Carrie and Hirst, Martin and Holt, Robert A and Lee, Darlene and Li, Haiyan I and Mayo, Michael and Moore, Richard A and Mungall, Andrew J and Pleasance, Erin and Robertson, A. Gordon and Schein, Jacqueline E and Shafiei, Arash and Sipahimalani, Payal and Slobodan, Jared R and Stoll, Dominik and Tam, Angela and Thiessen, Nina and Varhol, Richard J and Wye, Natasja and Zeng, Thomas and Zhao, Yongjun and Birol, Inanc and Jones, Steven J. M and Marra, Marco A and Cherniack, Andrew D and Saksena, Gordon and Onofrio, Robert C and Pho, Nam H and Carter, Scott L and Schumacher, Steven E and Tabak, Barbara and Hernandez, Bryan and Gentry, Jeff and Nguyen, Huy and Crenshaw, Andrew and Ardlie, Kristin and Beroukhim, Rameen and Winckler, Wendy and Getz, Gad and Gabriel, Stacey B and Meyerson, Matthew and Chin, Lynda and Kucherlapati, Raju and Hoadley, Katherine A and Auman, J. Todd and Fan, Cheng and Turman, Yidi J and Shi, Yan and Li, Ling and Topal, Michael D and He, Xiaping and Chao, Hann-Hsiang and Prat, Aleix and Silva, Grace O and Iglesia, Michael D and Zhao, Wei and Usary, Jerry and Berg, Jonathan S and Adams, Michael and Booker, Jessica and Wu, Junyuan and Gulabani, Anisha and Bodenheimer, Tom and Hoyle, Alan P and Simons, Janae V and Soloway, Matthew G and Mose, Lisle E and Jefferys, Stuart R and Balu, Saianand and Parker, Joel S and Hayes, D. Neil and Perou, Charles M and Malik, Simeen and Mahurkar, Swapna and Shen, Hui and Weisenberger, Daniel J and Triche Jr, Timothy and Lai, Phillip H and ... and Canc Genome Atlas Network and Cancer Genome Atlas Network and The Cancer Genome Atlas Network
Nature, ISSN 0028-0836, 10/2012, Volume 490, Issue 7418, pp. 61 - 70
We analysed primary breast cancers by genomic DNA copy number arrays, DNA methylation, exome sequencing, messenger RNA arrays, microRNA sequencing and... 
PATHWAYS | BASAL-LIKE | SUPPRESSOR | PIK3CA GENE | SUBTYPES | P53 STATUS | MULTIDISCIPLINARY SCIENCES | HIGH-FREQUENCY | LUMINAL-B | CANCER | MUTATIONAL EVOLUTION | GATA3 Transcription Factor - genetics | Receptors, Estrogen - metabolism | Oligonucleotide Array Sequence Analysis | Genomics | Humans | Gene Expression Regulation, Neoplastic | Ovarian Neoplasms - pathology | Gene Expression Profiling | Breast Neoplasms - metabolism | Ovarian Neoplasms - genetics | DNA Methylation | DNA Mutational Analysis | Female | Genes, BRCA1 | Genes, Neoplasm - genetics | Breast Neoplasms - classification | RNA, Messenger - genetics | Retinoblastoma Protein - metabolism | DNA Copy Number Variations - genetics | Genes, p53 - genetics | Mutation - genetics | Genetic Heterogeneity | Genome, Human - genetics | Phosphatidylinositol 3-Kinases - genetics | Exome - genetics | Breast Neoplasms - genetics | Class I Phosphatidylinositol 3-Kinases | Breast Neoplasms - pathology | Retinoblastoma Protein - genetics | Genes, erbB-2 - genetics | Proteomics | Protein Array Analysis | RNA, Neoplasm - genetics | MAP Kinase Kinase Kinase 1 - genetics | MicroRNAs - genetics | Breast tumors | Gene mutations | Oncology, Experimental | Genetic aspects | Research | Identification and classification | Cancer | Proteins | DNA methylation | Genetics | Breast cancer | Mutation | Index Medicus
Journal Article
Nature Immunology, ISSN 1529-2908, 01/2014, Volume 15, Issue 1, pp. 88 - 97
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 29, pp. 12256 - 12266
Class IA PI3Ks are involved in the generation of the key lipid signaling molecule phosphatidylinositol 3,4,5-trisphosphate (PIP3), and inappropriate activation... 
EXCHANGE MASS-SPECTROMETRY | G-BETA-GAMMA | P110-ALPHA | PROTEIN | SPECIFICITY | RAS MUTATIONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISTINCT | FUNCTIONAL-ANALYSIS | PHOSPHOLIPASE A | BINDING | Class I Phosphatidylinositol 3-Kinases - genetics | Phosphatidylinositol Phosphates - metabolism | Class I Phosphatidylinositol 3-Kinases - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Phosphatidylinositol 3-Kinases - metabolism | Spodoptera | Deuterium Exchange Measurement | Sf9 Cells | Proto-Oncogene Proteins p21(ras) - chemistry | Protein Interaction Domains and Motifs | Peptide Fragments - genetics | Second Messenger Systems | Proto-Oncogene Proteins p21(ras) - metabolism | Recombinant Proteins - metabolism | Peptide Fragments - metabolism | Mutagenesis, Site-Directed | Class I Phosphatidylinositol 3-Kinases - chemistry | Phosphatidylinositol 3-Kinases - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Protein Transport | Phosphatidylinositol 3-Kinases - genetics | Point Mutation | Peptide Fragments - chemistry | Animals | Protein Conformation | Enzyme Activation | Lipid Bilayers - metabolism | Liposomes | Amino Acid Substitution | Index Medicus | hydrogen exchange mass spectrometry | Signal Transduction | lipid–protein interaction | Ras protein | phosphatidylinositide 3-kinase (PI 3-kinase) | lipid signaling | phosphoinositide
Journal Article
Nature Genetics, ISSN 1061-4036, 2014, Volume 46, Issue 3, pp. 225 - 233
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2013, Volume 110, Issue 4, pp. 1398 - 1403
Diffuse large B-cell lymphoma (DLBCL) is the most common form of lymphoma in adults. The disease exhibits a striking heterogeneity in gene expression profiles... 
Exome | Genes | Cell lines | Medical genetics | Genomes | Genetic mutation | Sequencing |