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PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, pp. e76405 - e76405
Journal Article
Journal Article
Leukemia, ISSN 0887-6924, 09/2018, Volume 32, Issue 9, pp. 1958 - 1969
The PI 3-kinases (PI3K) are essential mediators of chemokine receptor signaling necessary for migration of chronic lymphocytic leukemia (CLL) cells and their... 
G-BETA-GAMMA | P110-GAMMA ISOFORM | ONCOLOGY | PHOSPHATIDYLINOSITOL 3-KINASE | REGULATORY SUBUNITS | CHRONIC LYMPHOCYTIC-LEUKEMIA | SURVIVAL SIGNALS | ZAP-70 EXPRESSION | HEMATOLOGY | MARROW STROMAL CELLS | T-LYMPHOCYTES | DIFFERENTIAL ROLES | Leukemia, B-Cell - metabolism | Class I Phosphatidylinositol 3-Kinases - genetics | Class I Phosphatidylinositol 3-Kinases - metabolism | Class Ib Phosphatidylinositol 3-Kinase - genetics | Humans | Cell Survival - genetics | Lymphoma, B-Cell - genetics | Cell Movement - genetics | Gene Knockdown Techniques | CD40 Ligand - metabolism | Class Ib Phosphatidylinositol 3-Kinase - metabolism | ZAP-70 Protein-Tyrosine Kinase - metabolism | Antineoplastic Agents - pharmacology | B-Lymphocytes - pathology | Gene Expression Regulation, Neoplastic - drug effects | Mesenchymal Stem Cells - metabolism | B-Lymphocytes - metabolism | Quinazolinones - pharmacology | Cell Survival - drug effects | Cell Adhesion - genetics | Lymphoma, B-Cell - metabolism | Purines - pharmacology | Interleukin-4 - metabolism | Leukemia, B-Cell - pathology | Cell Adhesion - drug effects | Chemotaxis - genetics | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Cell Movement - drug effects | Leukemia, B-Cell - genetics | Lymphoma, B-Cell - pathology | Cytoskeleton - metabolism | Chemokines - metabolism | Class Ib Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Mutation | Immunoglobulin Heavy Chains - genetics | CXCL12 protein | Leukocyte migration | Leukemia | Cytology | Adhesion tests | ZAP-70 protein | Kinases | CD40L protein | Cell morphology | Cell adhesion & migration | Interleukin 4 | Actin | Inhibition | Chronic lymphatic leukemia | Crosslinking | Lymphatic leukemia | Adhesion | 1-Phosphatidylinositol 3-kinase | Inhibitors | Lymphocytes B | Morphology | Stromal cells | Cell lines | Chemokines | Cell migration | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 29, pp. 12256 - 12266
Class IA PI3Ks are involved in the generation of the key lipid signaling molecule phosphatidylinositol 3,4,5-trisphosphate (PIP3), and inappropriate activation... 
EXCHANGE MASS-SPECTROMETRY | G-BETA-GAMMA | P110-ALPHA | PROTEIN | SPECIFICITY | RAS MUTATIONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISTINCT | FUNCTIONAL-ANALYSIS | PHOSPHOLIPASE A | BINDING | Class I Phosphatidylinositol 3-Kinases - genetics | Phosphatidylinositol Phosphates - metabolism | Class I Phosphatidylinositol 3-Kinases - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Phosphatidylinositol 3-Kinases - metabolism | Spodoptera | Deuterium Exchange Measurement | Sf9 Cells | Proto-Oncogene Proteins p21(ras) - chemistry | Protein Interaction Domains and Motifs | Peptide Fragments - genetics | Second Messenger Systems | Proto-Oncogene Proteins p21(ras) - metabolism | Recombinant Proteins - metabolism | Peptide Fragments - metabolism | Mutagenesis, Site-Directed | Class I Phosphatidylinositol 3-Kinases - chemistry | Phosphatidylinositol 3-Kinases - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Protein Transport | Phosphatidylinositol 3-Kinases - genetics | Point Mutation | Peptide Fragments - chemistry | Animals | Protein Conformation | Enzyme Activation | Lipid Bilayers - metabolism | Liposomes | Amino Acid Substitution | Index Medicus | hydrogen exchange mass spectrometry | Signal Transduction | lipid–protein interaction | Ras protein | phosphatidylinositide 3-kinase (PI 3-kinase) | lipid signaling | phosphoinositide
Journal Article
Biochemical Journal, ISSN 0264-6021, 11/2014, Volume 463, Issue 3, pp. 413 - 427
The Vps34 (vacuolar protein sorting 34) class III PI3K (phosphoinositide 3-kinase) phosphorylates PtdIns (phosphatidylinositol) at endosomal membranes to... 
Mammalian target of rapamycin (mTOR) | Phosphoinositide 3-kinase (PI3K) | Protein kinase inhibitor | Signal transduction inhibitor | N-Myc downstream-regulated gene-1 (NDRG1) | Protein Structure, Tertiary | Cell Line | Phosphorylation | Class II Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol Phosphates - metabolism | Class I Phosphatidylinositol 3-Kinases - metabolism | Class II Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Humans | Inositol Polyphosphate 5-Phosphatases | Class III Phosphatidylinositol 3-Kinases - metabolism | Pyrimidines - pharmacology | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Endosomes - metabolism | Amino Acid Motifs | Aminopyridines - pharmacology | Hydrophobic and Hydrophilic Interactions | Protein Binding | Class III Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases | Phosphoric Monoester Hydrolases - metabolism | Protein-Serine-Threonine Kinases - metabolism | Index Medicus | SGK3, serum- and glucocorticoid-regulated kinase-3 | signal transduction inhibitor | PI3K, phosphoinositide 3-kinase | ITC, isothermal titration calorimetry | SHIP1 | mTORC, mammalian target of rapamycin complex | EEA1, early endosome antigen 1 | INPP4B, inositol polyphosphate 4-phosphatase type II | TSC2, tuberous sclerosis complex 2 | phosphoinositide 3-kinase (PI3K) | HRP, horseradish peroxidase | PDK1, phosphoinositide-dependent kinase 1 | DMEM, Dulbecco's modified Eagle's medium | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | IP1, inositol phosphate | 4E-BP1, eukaryotic initiation factor 4E-binding protein 1 | PX, Phox homology | mammalian target of rapamycin (mTOR) | Accelerated Publication | PH, pleckstrin homology | PtdIns, phosphatidylinositol | PRAS40, proline-rich Akt substrate 40 kDa | protein kinase inhibitor | 2, Src homology 2-domain-containing inositol phosphatase 1 | Vps34, vacuolar protein sorting 34 | VSV-G, vesicular stomatitis virus glycoprotein
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 07/2009, Volume 8, Issue 7, pp. 1725 - 1738
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 04/2015, Volume 27, Issue 4, pp. 533 - 546
Journal Article
Cancer Cell, ISSN 1535-6108, 07/2014, Volume 26, Issue 1, pp. 136 - 149
Activation of the phosphoinositide 3-kinase (PI3K) pathway occurs frequently in breast cancer. However, clinical results of single-agent PI3K inhibitors have... 
DRUG | INACTIVATION | ADVANCED SOLID TUMORS | MAMMARY-TUMORS | GENE | ONCOLOGY | PATHWAY INHIBITORS | CYCLIN D1 EXPRESSION | GROWTH | PHASE-I | PRECLINICAL EVALUATION | CELL BIOLOGY | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Phosphorylation | Phosphatidylinositol Phosphates - metabolism | Cyclin-Dependent Kinase 4 - genetics | Humans | Drug Resistance, Neoplasm | Phosphatidylinositol 3-Kinases - metabolism | Molecular Targeted Therapy | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | Breast Neoplasms - enzymology | Transfection | MCF-7 Cells | RNA Interference | Time Factors | Female | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - metabolism | Cell Survival - drug effects | Genetic Predisposition to Disease | Retinoblastoma Protein - metabolism | Cyclin-Dependent Kinase 6 - genetics | Treatment Outcome | Cyclin-Dependent Kinase 6 - metabolism | Cyclin-Dependent Kinase 4 - metabolism | Mice, SCID | Breast Neoplasms - drug therapy | Drug Synergism | Phosphatidylinositol 3-Kinases - genetics | Xenograft Model Antitumor Assays | Protein Kinase Inhibitors - administration & dosage | Phenotype | Animals | Breast Neoplasms - genetics | Class I Phosphatidylinositol 3-Kinases | Signal Transduction - drug effects | Breast Neoplasms - pathology | Mice, Nude | Cell Proliferation - drug effects | Mice | Mutation | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Medical colleges | Breast cancer | Index Medicus
Journal Article
Journal Article