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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2007, Volume 104, Issue 19, pp. 7809 - 7814
Journal Article
Molecular Cell, ISSN 1097-2765, 07/2018, Volume 71, Issue 2, pp. 343 - 351.e4
Journal Article
Journal of Immunology, ISSN 0022-1767, 02/2008, Volume 180, Issue 4, pp. 2538 - 2544
The leukocyte-enriched p110 gamma and p110 delta isoforms of PI3K have been shown to control in vitro degranulation of mast cells induced by cross-linking of... 
RHEUMATOID-ARTHRITIS | CATALYTIC SUBUNIT | MAST-CELL ACTIVATION | P110 DELTA | B-CELL | NEUTROPHIL TRAFFICKING | AIRWAY INFLAMMATION | EMBRYONIC LETHALITY | MICE | IMMUNOLOGY | PI3K-GAMMA | Catalytic Domain - drug effects | Inflammation Mediators - administration & dosage | Hypersensitivity - enzymology | Proto-Oncogene Proteins c-akt - deficiency | Hypersensitivity - immunology | Male | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - genetics | MAP Kinase Signaling System - genetics | Inflammation Mediators - pharmacology | Hypersensitivity - genetics | Proto-Oncogene Proteins c-akt - metabolism | Epitopes - physiology | Isoenzymes - physiology | Mast Cells - immunology | Receptors, IgG - physiology | Isoenzymes - genetics | Mice, Inbred C57BL | Catalytic Domain - genetics | Cells, Cultured | Cell Degranulation - immunology | Mast Cells - enzymology | Mast Cells - drug effects | Mice, Knockout | Phosphatidylinositol 3-Kinases - genetics | Protein Kinase Inhibitors - administration & dosage | Animals | Class I Phosphatidylinositol 3-Kinases | MAP Kinase Signaling System - drug effects | Hypersensitivity - pathology | Phosphatidylinositol 3-Kinases - physiology | Mice | Protein Kinase Inhibitors - pharmacology | Immunoglobulin E - physiology | Isoenzymes - antagonists & inhibitors | Cell Degranulation - drug effects | Index Medicus | Abridged Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 11/2004, Volume 64, Issue 21, pp. 7678 - 7681
Phosphatidylinositol 3'-kinases are lipid kinases with important roles in neoplasia. Recently, a very high frequency of somatic mutations in PIK3CA has been... 
ONCOGENE | ONCOLOGY | PATHWAY | TUMORS | ENDOMETRIOSIS | REGION | Ovarian Neoplasms - genetics | Phosphatidylinositol 3-Kinases - genetics | Breast Neoplasms - genetics | Class I Phosphatidylinositol 3-Kinases | Gene Amplification | Exons | Humans | Phosphatidylinositol 3-Kinases - physiology | Female | Mutation | Index Medicus
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 12/2011, Volume 10, Issue 12, pp. 2426 - 2436
Journal Article
Blood, ISSN 0006-4971, 03/2013, Volume 121, Issue 12, pp. 2274 - 2284
Phosphoinositide-3 kinase (PI3K) pathway activation contributes to mantle cell lymphoma (MCL) pathogenesis, but early-phase studies of the PI3K p110 delta... 
PATHOGENESIS | ACTIVATION | ISOFORMS | GENE | CYCLIN D1 | AKT | MUTATIONS | HEMATOLOGY | PHOSPHOINOSITIDE 3-KINASE | TUMOR-GROWTH | EXPRESSION | Recurrence | Humans | Lymphoma, Mantle-Cell - pathology | Quinazolinones - administration & dosage | Substrate Specificity | Phosphatidylinositol 3-Kinases - metabolism | Gene Expression Regulation, Enzymologic - physiology | Purines - administration & dosage | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Antineoplastic Combined Chemotherapy Protocols - pharmacology | DNA Mutational Analysis | Purines - therapeutic use | Gene Expression Regulation, Neoplastic - drug effects | Gene Expression Regulation, Neoplastic - physiology | Lymphoma, Mantle-Cell - genetics | Lymphoma, Mantle-Cell - metabolism | Gene Expression Regulation, Neoplastic - genetics | Quinazolinones - pharmacology | Purines - pharmacology | Lymphoma, Mantle-Cell - drug therapy | Treatment Outcome | Phosphatidylinositol 3-Kinases - genetics | Protein Kinase Inhibitors - administration & dosage | Drug Resistance, Neoplasm - genetics | Class I Phosphatidylinositol 3-Kinases | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Cell Line, Tumor | Phosphatidylinositol 3-Kinases - physiology | Signal Transduction - physiology | Protein Kinase Inhibitors - pharmacology | Quinazolinones - therapeutic use | Index Medicus | Abridged Index Medicus | Lymphoid Neoplasia
Journal Article
Journal Article
PLoS Genetics, ISSN 1553-7390, 02/2008, Volume 4, Issue 2, pp. e24 - e24
In many organisms, dietary restriction appears to extend lifespan, at least in part, by down-regulating the nutrient-sensor TOR (Target Of Rapamycin). TOR... 
CANINE KIDNEY-CELLS | MESSENGER-RNA | SIGNALING PATHWAY | INDUCED LONGEVITY | TOR | GENES | GENETICS & HEREDITY | NEMATODE CAENORHABDITIS-ELEGANS | SACCHAROMYCES-CEREVISIAE | MEMBRANE-TRANSPORT | 3-KINASE COMPLEX | Phosphotransferases (Alcohol Group Acceptor) - physiology | Genes, Helminth | rab GTP-Binding Proteins - genetics | Autophagy - physiology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Trans-Activators - physiology | Caenorhabditis elegans - physiology | RNA Interference | Receptor, Insulin - genetics | Trans-Activators - genetics | Autophagy - genetics | Vesicular Transport Proteins | Caenorhabditis elegans - growth & development | Animals, Genetically Modified | Caenorhabditis elegans - genetics | Phosphotransferases (Alcohol Group Acceptor) - genetics | Longevity - genetics | Receptor, Insulin - physiology | Phosphatidylinositol 3-Kinases - genetics | rab GTP-Binding Proteins - physiology | Animals | Caenorhabditis elegans Proteins - antagonists & inhibitors | Diet | Receptors, Nicotinic - physiology | Models, Biological | Phosphatidylinositol 3-Kinases - physiology | rab GTP-Binding Proteins - antagonists & inhibitors | Caenorhabditis elegans Proteins - physiology | Mutation | Trans-Activators - antagonists & inhibitors | Caenorhabditis elegans Proteins - genetics | Longevity - physiology | Receptors, Nicotinic - genetics | Index Medicus | Proteins | Medical research | Kinases | Metabolism
Journal Article
Cancer Research, ISSN 0008-5472, 11/2008, Volume 68, Issue 22, pp. 9221 - 9230
Journal Article
Cancer Research, ISSN 0008-5472, 06/2009, Volume 69, Issue 11, pp. 4885 - 4893
Journal Article