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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2007, Volume 104, Issue 2, pp. 612 - 617
Journal Article
Journal Article
BBA - Proteins and Proteomics, ISSN 1570-9639, 2008, Volume 1784, Issue 1, pp. 159 - 185
Journal Article
2010, Current topics in microbiology and immunology, ISBN 9783642148156, Volume 346, 347., v.
PI3K is at the forefront of drug development with the first clinical trials of PI3K pathway inhibitors in progress. This book offers an overview of some key... 
Protein kinases | Protein-tyrosine kinase | Inhibitors | Cell proliferation | Phosphoinositides | Cell death | Apoptosis | Phospholipases
Book
Blood, ISSN 0006-4971, 05/2014, Volume 123, Issue 22, pp. 3390 - 3397
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2001, Volume 276, Issue 13, pp. 9817 - 9824
Estrogen receptors (ERs) mediate most of the biological effects of estrogen in mammary and uterine epithelial cells by binding to estrogen response elements in... 
SIGNAL-TRANSDUCTION | BREAST-CANCER CELLS | TRANSCRIPTIONAL ACTIVATION | PHOSPHORYLATION | 3-KINASE | TAMOXIFEN | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | KINASE-B | BINDING PROTEIN | BCL-2 EXPRESSION | Up-Regulation | Phosphorylation | Receptors, Estrogen - metabolism | Humans | Protein-Serine-Threonine Kinases | Chloramphenicol O-Acetyltransferase - metabolism | Drug Resistance, Neoplasm | Estrogen Antagonists - pharmacology | Phosphatidylinositol 3-Kinases - metabolism | Growth Differentiation Factor 15 | Breast Neoplasms - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Estrogen Receptor alpha | Transfection | PTEN Phosphohydrolase | Time Factors | Phosphoric Monoester Hydrolases - pharmacology | Trefoil Factor-1 | Tumor Cells, Cultured | Chromones - pharmacology | Estrogens - metabolism | Proto-Oncogene Proteins - metabolism | Antineoplastic Agents, Hormonal - pharmacology | Cytokines - metabolism | Signal Transduction | Cell Survival | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Breast Neoplasms - drug therapy | Plasmids - metabolism | Serine - metabolism | Blotting, Western | Cell Division - drug effects | Estrogen Receptor Modulators - pharmacology | Precipitin Tests | Proto-Oncogene Proteins c-akt | Phosphates - metabolism | Animals | Proteins - metabolism | Breast Neoplasms - pathology | Models, Biological | Tamoxifen - pharmacology | Enzyme Activation | COS Cells | Tumor Suppressor Proteins | Apoptosis | AKT protein | ApS2 gene | Bcl-2 protein | macrophage inhibitory cytokine 1 | Index Medicus
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 138, Issue 6, pp. 1672 - 1680.e10
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 139, Issue 2, pp. 519 - 532
Background Severe steroid-insensitive asthma is a substantial clinical problem. Effective treatments are urgently required, however, their development is... 
Allergy and Immunology | influenza | airway hyperresponsiveness | corticosteroids | PI3 kinase | Chlamydia species | histone deacetylase 2 | Severe asthma | miR-21 | respiratory syncytial virus | Haemophilus influenzae | IMMUNE-RESPONSE | INFLAMMATORY RESPONSES | ALLERGIC AIRWAYS DISEASE | TENSIN HOMOLOG | IMMUNOLOGY | RESPIRATORY-INFECTION | NEUTROPHILIC ASTHMA | OBSTRUCTIVE PULMONARY-DISEASE | Chlamydia | INFLUENZA-VIRUS INFECTION | ALLERGY | species | REGULATORY T-CELLS | BACTERIAL-INFECTION | Influenza A Virus, H1N1 Subtype - immunology | Phosphorylation | Humans | Respiratory Syncytial Viruses - immunology | MicroRNAs - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Respiratory Tract Infections - genetics | Chlamydia muridarum - immunology | Asthma - immunology | Pneumonia - immunology | Proto-Oncogene Proteins c-akt - metabolism | Drug Resistance | Disease Models, Animal | Pneumonia - genetics | Histone Deacetylase 2 - genetics | PTEN Phosphohydrolase - genetics | Gene Expression Regulation | PTEN Phosphohydrolase - metabolism | Respiratory Tract Infections - drug therapy | Asthma - drug therapy | Asthma - genetics | Dexamethasone - therapeutic use | Animals | Pneumonia - drug therapy | Haemophilus influenzae - immunology | Respiratory Tract Infections - immunology | Mice | Mice, Inbred BALB C | MicroRNAs - genetics | Histone Deacetylase 2 - metabolism | Antagomirs - genetics | MicroRNA | Research institutes | Analysis | Asthma | Therapeutics | Health aspects | Homeopathy | Materia medica and therapeutics | Respiratory syncytial virus | Pathogenesis | Rodents | Influenza | Tumor necrosis factor-TNF | Chronic obstructive pulmonary disease | Infections | Inflammation | Viral infections | Steroids | Index Medicus | Abridged Index Medicus
Journal Article
Diabetologia, ISSN 0012-186X, 6/2013, Volume 56, Issue 6, pp. 1327 - 1338
It is not clear how small tyrosine kinase inhibitors, such as imatinib mesilate, protect against diabetes and beta cell death. The aim of this study was to... 
EndoC-βH1 cells | Medicine & Public Health | Human Physiology | Cell death | PIP 3 signalling | SHIP2 | Metabolic Diseases | Internal Medicine | c-Abl | Imatinib mesilate | Insulin-producing cells | PIP | signalling | PROTEIN-KINASE | LEUKEMIA CML | BETA-CELLS | SENSITIVITY | RECEPTOR | EndoC-beta H1 cells | TYROSINE KINASE INHIBITORS | GLUCOSE | ENDOCRINOLOGY & METABOLISM | GROWTH-FACTOR | MESYLATE GLEEVEC | PIP3 signalling | Cell Survival - drug effects | Green Fluorescent Proteins - metabolism | Phosphorylation | Phosphatidylinositol Phosphates - metabolism | Humans | Cells, Cultured | PTEN Phosphohydrolase - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Pyrimidines - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Insulin - metabolism | Pyrroles - pharmacology | Signal Transduction - drug effects | Time Factors | HEK293 Cells | Protein Binding | Proto-Oncogene Proteins c-abl - metabolism | Indoles - pharmacology | Benzamides - pharmacology | Protein Kinase Inhibitors - pharmacology | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases | Phosphoric Monoester Hydrolases - metabolism | Cell Membrane - drug effects | Antimitotic agents | Enzymes | Inositol | Pancreatic beta cells | Phosphatases | Analysis | Phospholipids | Diabetes | Antineoplastic agents | Gene expression | Insulin | Cells | Index Medicus | Cell and Molecular Biology | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Cell- och molekylärbiologi | Medicinska och farmaceutiska grundvetenskaper
Journal Article