X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatases (505) 505
animals (414) 414
phosphoric monoester hydrolases - metabolism (361) 361
humans (339) 339
mice (314) 314
index medicus (220) 220
phosphoric monoester hydrolases - genetics (209) 209
phosphorylation (208) 208
inositol polyphosphate 5-phosphatases (201) 201
signal transduction (201) 201
biochemistry & molecular biology (138) 138
immunology (121) 121
phosphoric monoester hydrolases - physiology (112) 112
activation (105) 105
cell biology (105) 105
src homology domains (105) 105
cell line (100) 100
phosphatidylinositol 3-kinases - metabolism (96) 96
mice, knockout (95) 95
cells, cultured (82) 82
phosphatases (79) 79
protein (78) 78
mice, inbred c57bl (76) 76
inositol (73) 73
phosphatidylinositol phosphates - metabolism (69) 69
protein binding (68) 68
male (67) 67
phosphoric monoester hydrolases - chemistry (67) 67
tyrosine phosphorylation (65) 65
tyrosine - metabolism (62) 62
fc-gamma-riib (59) 59
female (59) 59
negative regulation (57) 57
ship2 (57) 57
signal-transduction (57) 57
phosphatidylinositol 3-kinase (55) 55
receptors, igg - metabolism (55) 55
receptor (54) 54
ship (53) 53
proto-oncogene proteins - metabolism (52) 52
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatases - metabolism (51) 51
hematology (50) 50
molecular sequence data (50) 50
transfection (50) 50
amino acid sequence (48) 48
cell line, tumor (48) 48
expression (47) 47
proto-oncogene proteins c-akt - metabolism (47) 47
adaptor proteins, signal transducing (46) 46
rats (46) 46
cancer (44) 44
cells (43) 43
phosphoinositide 3-kinase (43) 43
intracellular signaling peptides and proteins (42) 42
phosphoproteins - metabolism (42) 42
mutation (41) 41
proteins (41) 41
blotting, western (40) 40
phosphatidylinositol 3,4,5-trisphosphate (40) 40
protein tyrosine phosphatases - metabolism (40) 40
proto-oncogene proteins c-akt (40) 40
signal transduction - physiology (40) 40
antigens, cd - metabolism (39) 39
inositol phosphatase ship (39) 39
research (39) 39
down-regulation (38) 38
inflammation (38) 38
protein tyrosine phosphatase, non-receptor type 6 (38) 38
enzyme activation (37) 37
protein tyrosine phosphatase, non-receptor type 11 (37) 37
proteins - metabolism (37) 37
signal transduction - drug effects (37) 37
abridged index medicus (36) 36
article (36) 36
gene expression (36) 36
inositol polyphosphate 5-phosphatase (36) 36
insulin (36) 36
phosphoric monoester hydrolases - antagonists & inhibitors (36) 36
b-lymphocytes - metabolism (35) 35
tumor cells, cultured (35) 35
analysis (34) 34
phosphoric monoester hydrolases - deficiency (34) 34
polyphosphate 5-phosphatase (34) 34
protein structure, tertiary (34) 34
calcium - metabolism (33) 33
models, biological (33) 33
phosphatase (33) 33
apoptosis (32) 32
b-lymphocytes - immunology (31) 31
cell membrane - metabolism (31) 31
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatases - genetics (31) 31
research article (31) 31
time factors (31) 31
in-vivo (30) 30
multidisciplinary sciences (30) 30
cos cells (29) 29
hematopoietic-cells (29) 29
insulin - pharmacology (29) 29
kinase (29) 29
kinases (29) 29
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal Article
European Journal of Immunology, ISSN 0014-2980, 06/2017, Volume 47, Issue 6, pp. 932 - 945
The phosphoinositide phosphatase SHIP is a critical regulator of immune cell activation. Despite considerable study, the mechanisms controlling SHIP activity... 
Inhibitory receptors | Homeostasis | Signal transduction | Protein–protein interactions | Cellular activation | SYSTEMIC-LUPUS-ERYTHEMATOSUS | IMMUNOLOGY | Protein-protein interactions | FC-GAMMA-RIIB | B-CELLS | BRUTONS TYROSINE KINASE | NEGATIVE REGULATION | IN-VIVO | INOSITOL POLYPHOSPHATE 5-PHOSPHATASE | ANTIGEN RECEPTOR | DOMAIN-CONTAINING INOSITOL-5-PHOSPHATASE | HEMATOPOIETIC STEM | Mast Cells - immunology | B-Lymphocytes - enzymology | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases - genetics | Phosphorylation | T-Lymphocytes - enzymology | Dendritic Cells - immunology | Humans | Gene Expression Regulation | Phosphatidylinositol 3-Kinases - metabolism | Signal Transduction - genetics | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases - chemistry | Mast Cells - enzymology | Killer Cells, Natural - enzymology | Macrophages - enzymology | Animals | B-Lymphocytes - immunology | Proteins - metabolism | Dendritic Cells - enzymology | Killer Cells, Natural - immunology | T-Lymphocytes - immunology | Mice | Macrophages - immunology | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases - metabolism | Phosphatases | Dendritic cells | Cellular signal transduction | B cells | T cells | Health aspects | Phosphatidylinositol 3,4,5-triphosphate | Disorders | Activation | Lymphocytes T | T cell receptors | Macrophages | Phosphatase | Modulators | Fc receptors | Receptors | Cell activation | Control | Enzymatic activity | Lymphocytes B | Lymphocytes | Ships | Mast cells | Receptor mechanisms | Brakes | Inositol-1,4,5-trisphosphate 5-phosphatase | Activation analysis | Immune system
Journal Article
eLife, ISSN 2050-084X, 08/2017, Volume 6
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 08/2017, Volume 118, Issue 8, pp. 2271 - 2284
ABSTRACT A typical hallmark of diabetic kidney disease (DKD) is an excessive deposition of extracellular matrix (ECM) in the glomerulus and renal... 
DIABETIC MICE | EXTRACELLULAR MATRIX | SRC HOMOLOGY 2 DOMAIN‐CONTAINING INOSITOL 5’‐PHOSPHATASE | PHOSPHATIDYLINOSITOL 3‐KINASE/PROTEIN KINASE B | TRANSFORMING GROWTH FACTOR‐β1 | RENAL TUBULAR CELLS | TRANSFORMING GROWTH FACTOR-β1 | SRC HOMOLOGY 2 DOMAIN-CONTAINING INOSITOL 5’-PHOSPHATASE | PHOSPHATIDYLINOSITOL 3-KINASE/PROTEIN KINASE B | FIBROSIS | ACTIVATION | PROTEIN KINASE B | PHOSPHATIDYLINOSITOL 3-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSFORMING GROWTH FACTOR-1 | SRC HOMOLOGY 2 DOMAIN-CONTAINING INOSITOL 5'-PHOSPHATASE | DIABETIC-NEPHROPATHY | CELL BIOLOGY | TO-MESENCHYMAL TRANSITION | DISEASE | SHIP-1 | STRESS | EXPRESSION | PROGRESSION | TGF-BETA-1 | Epithelial Cells - metabolism | Cadherins - metabolism | Epithelial Cells - drug effects | Humans | Transforming Growth Factor beta1 - metabolism | Extracellular Matrix - metabolism | Inositol Polyphosphate 5-Phosphatases - genetics | Dioxoles - pharmacology | Benzamides - pharmacology | Cadherins - genetics | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases - metabolism | Cell Line | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases - genetics | Extracellular Matrix - drug effects | Inositol Polyphosphate 5-Phosphatases - metabolism | Morpholines - pharmacology | Glucose - pharmacology | Signal Transduction - genetics | Transforming Growth Factor beta1 - genetics | Kidney Tubules - cytology | Phosphatidylinositol 3-Kinase - genetics | Signal Transduction - drug effects | Proto-Oncogene Proteins c-akt - drug effects | Inositol | Phosphatases | Collagen | Bone morphogenetic proteins | Phospholipids | Kidney diseases | Glucose | Muscle proteins | Transforming growth factors | Dextrose | Surgical implants | Epithelial cells | Electrochemical machining | Smooth muscle | Homology | AKT protein | Activation | Biochemistry | Kinases | Phosphatase | E-cadherin | Signal transduction | Biomedical materials | Actin | Ships | Extracellular matrix | Attenuation | Inhibition | Deposition | Diabetes mellitus | Src protein | Inositol 5'-phosphatase | 1-Phosphatidylinositol 3-kinase | Inhibitors | Protein kinase | Fibrosis | Glomerulus | Mice | Diabetes | In vitro methods and tests | Clear cell-type renal cell carcinoma | Kidney transplantation
Journal Article
Nature Cell Biology, ISSN 1465-7392, 09/2018, Volume 20, Issue 9, pp. 1023 - 1023
Endocytosis mediates the cellular uptake of micronutrients and the turnover of plasma membrane proteins. Clathrin-mediated endocytosis is the major uptake... 
CDC42 | DOMAIN | BAR | LINKED MENTAL-RETARDATION | CLATHRIN-INDEPENDENT ENDOCYTOSIS | EGF-RECEPTOR | PATHWAY | LEADING-EDGE | PROTEIN GRAF1 | ACTIN CYTOSKELETON | CELL BIOLOGY | Phosphatidylinositol Phosphates - metabolism | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | cdc42 GTP-Binding Protein - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | GTPase-Activating Proteins - metabolism | Endocytosis | Time Factors | HEK293 Cells | Minor Histocompatibility Antigens - genetics | Cell Membrane - metabolism | Membrane Proteins - metabolism | Protein Interaction Domains and Motifs | Intracellular Signaling Peptides and Proteins - genetics | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases - metabolism | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases - genetics | Signal Transduction | Membrane Proteins - genetics | Rats | Carrier Proteins - genetics | Minor Histocompatibility Antigens - metabolism | Animals | Carrier Proteins - metabolism | cdc42 GTP-Binding Protein - genetics | Protein Binding | GTPase-Activating Proteins - genetics | Clathrin | Cell membranes | Research | Analysis | Cdc42 protein | GTP | Deactivation | Stimulation | Activation | Membrane proteins | Proteins | Phosphatidylinositol | Micronutrients | Receptors | Inositol polyphosphate 5-phosphatase | Dismantling | Guanosinetriphosphatase
Journal Article
Journal Article