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2006, Subcellular biochemistry, ISBN 9780387275994, Volume 39., xii, 340
This volume describes the current status of the biology of inositols and phosphoinositides with an emphasis on the development in the area since the... 
Inositol phosphates | Inositol | Phosphoinositides
Book
2012, Subcellular biochemistry, ISBN 9789400730120, Volume 58
Web Resource
Journal Article
PLoS Genetics, ISSN 1553-7390, 10/2011, Volume 7, Issue 10, p. e1002319
We previously reported that autosomal recessive demyelinating Charcot-Marie-Tooth (CMT) type 4B1 neuropathy with myelin outfoldings is caused by loss of MTMR2... 
CELLS | PIKFYVE | MYOTUBULARIN-RELATED PROTEIN-2 | PHOSPHOINOSITIDE PHOSPHATASE | DISEASE | GENETICS & HEREDITY | NEURODEGENERATION | PHOSPHATIDYLINOSITOL 3,5-BISPHOSPHATE | GROWTH-FACTOR | MYOPATHY | FAMILY | Axons - enzymology | Phosphatidylinositol Phosphates - metabolism | Heterocyclic Compounds, 3-Ring - pharmacology | Charcot-Marie-Tooth Disease - enzymology | Humans | Phosphatidylinositol 3-Kinases - metabolism | Charcot-Marie-Tooth Disease - genetics | Myelin Sheath - metabolism | Protein Tyrosine Phosphatases, Non-Receptor - genetics | Neurons - metabolism | Peripheral Nerves - metabolism | Phospholipids - metabolism | Charcot-Marie-Tooth Disease - metabolism | Flavoproteins - metabolism | Flavoproteins - genetics | Mice, Inbred C57BL | Axons - metabolism | Rats | Schwann Cells - metabolism | Phospholipids - genetics | Phosphatidylinositol Phosphates - genetics | Mice, Knockout | Phosphatidylinositol 3-Kinases - genetics | Peripheral Nerves - enzymology | Animals | Aminopyridines - pharmacology | Myelin Sheath - genetics | Neurons - enzymology | Protein Tyrosine Phosphatases, Non-Receptor - metabolism | Phosphoinositide Phosphatases | Mice | Mutation | Peripheral Nerves - growth & development | Schwann Cells - enzymology | Phosphatases | Gene mutations | Charcot-Marie-Tooth disease | Physiological aspects | Genetic aspects | Research | Health aspects | Risk factors | Aminopyridines | Heterocyclic Compounds, 3-Ring | Peripheral Nerves | Schwann Cells | Neurons | Phospholipids | Phosphatidylinositol Phosphates | Protein Tyrosine Phosphatases, Non-Receptor | Phosphatidylinositol 3-Kinases | Charcot-Marie-Tooth Disease | Life Sciences | Axons | Myelin Sheath | Genetics | Flavoproteins | Proteins | Yeast | Homeostasis | Kinases | Experiments | Evacuations & rescues
Journal Article
Biochemical Journal, ISSN 0264-6021, 11/2014, Volume 463, Issue 3, pp. 413 - 427
The Vps34 (vacuolar protein sorting 34) class III PI3K (phosphoinositide 3-kinase) phosphorylates PtdIns (phosphatidylinositol) at endosomal membranes to... 
Mammalian target of rapamycin (mTOR) | Phosphoinositide 3-kinase (PI3K) | Protein kinase inhibitor | Signal transduction inhibitor | N-Myc downstream-regulated gene-1 (NDRG1) | Protein Structure, Tertiary | Cell Line | Phosphorylation | Class II Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol Phosphates - metabolism | Class I Phosphatidylinositol 3-Kinases - metabolism | Class II Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Humans | Inositol Polyphosphate 5-Phosphatases | Class III Phosphatidylinositol 3-Kinases - metabolism | Pyrimidines - pharmacology | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Endosomes - metabolism | Amino Acid Motifs | Aminopyridines - pharmacology | Hydrophobic and Hydrophilic Interactions | Protein Binding | Class III Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases | Phosphoric Monoester Hydrolases - metabolism | Protein-Serine-Threonine Kinases - metabolism | SGK3, serum- and glucocorticoid-regulated kinase-3 | signal transduction inhibitor | PI3K, phosphoinositide 3-kinase | ITC, isothermal titration calorimetry | SHIP1 | mTORC, mammalian target of rapamycin complex | EEA1, early endosome antigen 1 | INPP4B, inositol polyphosphate 4-phosphatase type II | TSC2, tuberous sclerosis complex 2 | phosphoinositide 3-kinase (PI3K) | HRP, horseradish peroxidase | PDK1, phosphoinositide-dependent kinase 1 | DMEM, Dulbecco's modified Eagle's medium | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | IP1, inositol phosphate | 4E-BP1, eukaryotic initiation factor 4E-binding protein 1 | PX, Phox homology | mammalian target of rapamycin (mTOR) | Accelerated Publication | PH, pleckstrin homology | PtdIns, phosphatidylinositol | PRAS40, proline-rich Akt substrate 40 kDa | protein kinase inhibitor | 2, Src homology 2-domain-containing inositol phosphatase 1 | Vps34, vacuolar protein sorting 34 | VSV-G, vesicular stomatitis virus glycoprotein
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2017, Volume 474, Issue 11, pp. 1867 - 1877
Until recently, one of the major limitations of hydrogen/deuterium exchange mass spectrometry (HDX-MS) was the peptide-level resolution afforded by proteolytic... 
ACTIVATION | AMIDE HYDROGENS | PROTEIN | HDX-MS | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTRAMOLECULAR MIGRATION | KINASE | IDENTIFICATION | CAPTURE DISSOCIATION | BINDING | Oligonucleotides - genetics | Oligonucleotides - chemistry | Class Ia Phosphatidylinositol 3-Kinase - metabolism | Electron Transport | Molecular Weight | Humans | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Enzyme Inhibitors - chemistry | Oligonucleotides - antagonists & inhibitors | Signal Processing, Computer-Assisted | Binding Sites | Peptide Fragments - genetics | Drug Evaluation, Preclinical - methods | Triazines - metabolism | Triazines - pharmacology | Indazoles - chemistry | Enzyme Inhibitors - metabolism | Purines - metabolism | Enzyme Inhibitors - pharmacology | Models, Molecular | Indazoles - metabolism | Recombinant Fusion Proteins - chemistry | Sulfonamides - pharmacology | Class Ia Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Indazoles - pharmacology | Oligonucleotides - metabolism | Peptide Fragments - chemistry | Class I Phosphatidylinositol 3-Kinases | Purines - chemistry | Peptide Fragments - antagonists & inhibitors | Protein Conformation | Quinazolinones - chemistry | Quinazolinones - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Recombinant Fusion Proteins - metabolism | Quinolines - pharmacology | Antineoplastic Agents - metabolism | Tandem Mass Spectrometry | Class Ia Phosphatidylinositol 3-Kinase - chemistry | Deuterium Exchange Measurement | Triazines - chemistry | Antineoplastic Agents - pharmacology | Class Ia Phosphatidylinositol 3-Kinase - genetics | Quinazolinones - pharmacology | Peptide Fragments - metabolism | Reproducibility of Results | Sulfonamides - chemistry | Purines - pharmacology | Quinolines - chemistry | Phosphatidylinositol 3-Kinases - chemistry | Antineoplastic Agents - chemistry | Phosphatidylinositol 3-Kinases - genetics | Quinolines - metabolism | Sulfonamides - metabolism | ETD | PI3K
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 8/2008, Volume 182, Issue 4, pp. 685 - 701
Journal Article
Science, ISSN 0036-8075, 3/2010, Volume 327, Issue 5973, pp. 1638 - 1642
Phosphoinositide 3-kinases (PI3Ks) are lipid kinases with diverse roles in health and disease. The primordial PI3K, Vps34, is present in all eukaryotes and has... 
Proteins | Yeasts | Enzymes | Adenosine triphosphatases | Crystals | Lipids | Reports | Catalytic activity | Catalysis | Inhibitory concentration 50 | Phosphatidylinositols | UVRAG | ACTIVATION | BECLIN 1 | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | PHOSPHATIDYLINOSITOL 3-KINASE COMPLEXES | REGULATES AUTOPHAGY | ENDOSOME | HVPS34 | PHOSPHOINOSITIDE 3-KINASE | SACCHAROMYCES-CEREVISIAE | Furans - metabolism | Pyridines - chemistry | Furans - pharmacology | Humans | Crystallography, X-Ray | Phosphatidylinositol 3-Kinases - metabolism | Drosophila Proteins - metabolism | Enzyme Inhibitors - chemical synthesis | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Autophagy - drug effects | Pyrimidines - chemistry | Pyrimidines - metabolism | Furans - chemistry | Enzyme Inhibitors - chemistry | Phosphatidylinositols - metabolism | Cell Membrane - metabolism | Binding Sites | Drosophila Proteins - antagonists & inhibitors | Protein Structure, Tertiary | Catalytic Domain | Adenine - analogs & derivatives | Enzyme Inhibitors - metabolism | Protein Structure, Secondary | Enzyme Inhibitors - pharmacology | Phosphatidylinositol 3-Kinases - chemistry | Adenosine Triphosphatases - metabolism | Models, Molecular | Adenine - pharmacology | Drosophila Proteins - chemistry | Pyrimidines - pharmacology | Phosphatidylinositol 3-Kinases - genetics | Point Mutation | Animals | Pyridines - metabolism | Hydrophobic and Hydrophilic Interactions | Protein Conformation | Adenine - metabolism | Pyridines - pharmacology | Drosophila Proteins - genetics | Drosophila melanogaster | Physiological aspects | Autophagy (Cytology) | Research | Chemical properties | Phosphotransferases | Membranes | Cellular biology | Kinases | Crystal structure
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2007, Volume 104, Issue 13, pp. 5569 - 5574
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2015, Volume 290, Issue 30, pp. 18843 - 18854
Journal Article
Leukemia & Lymphoma, ISSN 1042-8194, 10/2015, Volume 56, Issue 10, pp. 2779 - 2786
Idelalisib is a first-in-class selective, oral, phosphatidylinositol 3-kinase delta (PI3Kδ) inhibitor approved for the treatment of several types of blood... 
phosphatidylinositol 3-kinase delta (PI3Kδ) inhibitor | transaminitis | colitis | pneumonitis | Idelalisib | diarrhea | Idelalisib, phosphatidylinositol 3-kinase delta (PI3Kδ) inhibitor | phosphatidylinositol 3-kinase delta (PI3K) inhibitor | CAL-101 | DELTA | P110-DELTA | PI3K | ONCOLOGY | INHIBITOR | HEMATOLOGY | SUBUNIT | Index Medicus | Reviews | Review
Journal Article