X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (40165) 40165
Publication (5441) 5441
Newsletter (368) 368
Book Review (328) 328
Book Chapter (228) 228
Conference Proceeding (60) 60
Dissertation (20) 20
Book / eBook (12) 12
Reference (7) 7
Data Set (6) 6
Magazine Article (3) 3
Web Resource (3) 3
Streaming Video (2) 2
Transcript (2) 2
Government Document (1) 1
Newspaper Article (1) 1
Paper (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (21996) 21996
humans (20792) 20792
index medicus (19616) 19616
phosphatidylinositol 3-kinases - metabolism (14033) 14033
signal transduction (9492) 9492
biochemistry & molecular biology (9290) 9290
mice (9276) 9276
cell biology (9161) 9161
proto-oncogene proteins c-akt - metabolism (7729) 7729
phosphorylation (7528) 7528
male (7462) 7462
phosphatidylinositol 3-kinase (6853) 6853
rats (6735) 6735
female (6721) 6721
activation (5810) 5810
apoptosis (5639) 5639
signal transduction - drug effects (5617) 5617
oncology (5477) 5477
proteins (5165) 5165
cell line, tumor (5065) 5065
expression (4978) 4978
cells, cultured (4834) 4834
phosphatidylinositol 3-kinases - antagonists & inhibitors (4421) 4421
cancer (4259) 4259
cell line (3901) 3901
analysis (3805) 3805
phosphatidylinositol 3-kinases - genetics (3803) 3803
research (3803) 3803
kinases (3650) 3650
phosphatidylinositol (3636) 3636
phosphatidylinositols - metabolism (3520) 3520
article (3507) 3507
akt (3187) 3187
mutation (3132) 3132
signal transduction - physiology (3010) 3010
apoptosis - drug effects (2947) 2947
cells (2936) 2936
enzyme inhibitors - pharmacology (2923) 2923
physiological aspects (2861) 2861
gene expression (2772) 2772
neurosciences (2669) 2669
research article (2547) 2547
pharmacology & pharmacy (2515) 2515
multidisciplinary sciences (2439) 2439
blotting, western (2334) 2334
1-phosphatidylinositol 3-kinase (2309) 2309
genetic aspects (2303) 2303
biophysics (2272) 2272
molecular sequence data (2271) 2271
pi3k (2227) 2227
endocrinology & metabolism (2225) 2225
cell proliferation (2210) 2210
pathway (2168) 2168
inhibition (2153) 2153
middle aged (2138) 2138
immunology (2112) 2112
cell proliferation - drug effects (2109) 2109
growth (2109) 2109
morpholines - pharmacology (2101) 2101
physiology (2077) 2077
protein binding (2060) 2060
rats, sprague-dawley (2052) 2052
lipids (2036) 2036
amino acid sequence (1990) 1990
enzyme activation (1977) 1977
chromones - pharmacology (1973) 1973
protein (1943) 1943
adult (1907) 1907
insulin (1905) 1905
phosphorylation - drug effects (1898) 1898
dose-response relationship, drug (1878) 1878
phosphoinositide 3-kinase (1850) 1850
health aspects (1846) 1846
medicine (1840) 1840
transfection (1805) 1805
biology (1796) 1796
akt protein (1783) 1783
gene-expression (1779) 1779
proliferation (1716) 1716
phosphatidylinositol 3-kinases - physiology (1697) 1697
tumors (1686) 1686
time factors (1676) 1676
kinase (1655) 1655
mice, inbred c57bl (1651) 1651
receptor (1649) 1649
in-vitro (1623) 1623
aged (1614) 1614
protein kinases (1614) 1614
survival (1611) 1611
proto-oncogene proteins c-akt - genetics (1591) 1591
cell survival - drug effects (1586) 1586
medicine, research & experimental (1568) 1568
cell membrane - metabolism (1547) 1547
oxidative stress (1544) 1544
in-vivo (1540) 1540
tor serine-threonine kinases - metabolism (1521) 1521
proto-oncogene proteins c-akt (1518) 1518
phospholipids (1495) 1495
proto-oncogene proteins - metabolism (1472) 1472
rodents (1471) 1471
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (40310) 40310
Chinese (93) 93
Russian (72) 72
Japanese (37) 37
French (31) 31
German (23) 23
Korean (8) 8
Spanish (5) 5
Italian (4) 4
Polish (4) 4
Ukrainian (4) 4
Croatian (1) 1
Czech (1) 1
Persian (1) 1
Portuguese (1) 1
Swedish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Analytical and Bioanalytical Chemistry, ISSN 1618-2642, 1/2015, Volume 407, Issue 3, pp. 991 - 1002
Journal Article
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2015, Volume 16, Issue 8, pp. 937 - 948
Summary Background Tumour mutational status is an important determinant of the response of metastatic colorectal cancer to targeted treatments. However, the... 
Hematology, Oncology and Palliative Medicine | KRAS MUTATIONS | 1ST-LINE TREATMENT | LEUCOVORIN | PLUS IRINOTECAN | ONCOLOGY | RANDOMIZED PHASE-III | INHIBITS GROWTH | ACQUIRED-RESISTANCE | FLUOROURACIL | PLACEBO PLUS | TUMOR-GROWTH | Predictive Value of Tests | Proto-Oncogene Proteins p21(ras) | Colorectal Neoplasms - genetics | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | Clinical Trials, Phase III as Topic | Time Factors | DNA Mutational Analysis | Colorectal Neoplasms - drug therapy | Real-Time Polymerase Chain Reaction | Precision Medicine | Receptor, TIE-1 - blood | Phosphatidylinositol 3-Kinases - blood | Genetic Predisposition to Disease | Adenocarcinoma - blood | ras Proteins - blood | Adenocarcinoma - drug therapy | Adenocarcinoma - secondary | Disease Progression | Phenotype | Class I Phosphatidylinositol 3-Kinases | Biomarkers, Tumor - genetics | ras Proteins - genetics | Patient Selection | DNA, Neoplasm - blood | Female | Adenocarcinoma - genetics | Retrospective Studies | Pyridines - therapeutic use | Colorectal Neoplasms - mortality | Colorectal Neoplasms - blood | Kaplan-Meier Estimate | Proportional Hazards Models | Phenylurea Compounds - therapeutic use | Proto-Oncogene Proteins B-raf - blood | Proto-Oncogene Proteins - genetics | Treatment Outcome | Randomized Controlled Trials as Topic | Biomarkers, Tumor - blood | Phosphatidylinositol 3-Kinases - genetics | Disease-Free Survival | Proto-Oncogene Proteins B-raf - genetics | Aged | DNA, Neoplasm - genetics | Colorectal Neoplasms - pathology | Proto-Oncogene Proteins - blood | Adenocarcinoma - mortality | Medical colleges | Medical research | Cancer patients | Prognosis | Liver | DNA | Colorectal cancer | Genetic research | Medicine, Experimental | Metastasis | Life Sciences | Human health and pathology
Journal Article
Nature Genetics, ISSN 1061-4036, 08/2015, Volume 47, Issue 9, pp. 1047 - 1055
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2016, Volume 17, Issue 4, pp. 425 - 439
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2010, Volume 11, Issue 8, pp. 753 - 762
Journal Article
BMC Cancer, ISSN 1471-2407, 02/2014, Volume 14, Issue 1, p. 120
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 497, Issue 7447, pp. 108 - 112
Cancers acquire resistance to systemic treatment as a result of clonal evolution and selection(1,2). Repeat biopsies to study genomic evolution as a result of... 
HETEROGENEITY | LUNG-CANCER | ACTIVATION | EVOLUTION | VARIANTS | AXL | MULTIDISCIPLINARY SCIENCES | TAMOXIFEN RESISTANCE | TUMOR-CELLS | MUTATIONS | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Genomics | Humans | Ovarian Neoplasms - pathology | Lung Neoplasms - pathology | Antineoplastic Agents - therapeutic use | Ovarian Neoplasms - genetics | Neoplasms - genetics | DNA Mutational Analysis | Female | Antineoplastic Agents - pharmacology | DNA, Neoplasm - analysis | Ovarian Neoplasms - drug therapy | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Intercellular Signaling Peptides and Proteins - genetics | Breast Neoplasms - drug therapy | Genome, Human - genetics | Neoplasms - drug therapy | Phosphatidylinositol 3-Kinases - genetics | Drug Resistance, Neoplasm - genetics | Exome - genetics | Breast Neoplasms - genetics | Class I Phosphatidylinositol 3-Kinases | Breast Neoplasms - pathology | Retinoblastoma Protein - genetics | Plasma - chemistry | Alleles | Carcinoma, Non-Small-Cell Lung - drug therapy | DNA, Neoplasm - genetics | Neoplasms - pathology | Mediator Complex Subunit 1 - genetics | Drug Resistance, Neoplasm - drug effects | Evolution, Molecular | Antimitotic agents | Care and treatment | Physiological aspects | Dosage and administration | Genetic aspects | Research | Nucleotide sequencing | Drug resistance | Antineoplastic agents | DNA sequencing | Blood plasma | Cancer | Plasma | Biopsy | Breast cancer | Genomes | Mutation | Patients | Deoxyribonucleic acid--DNA | Tumors
Journal Article