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Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2017, Volume 474, Issue 11, pp. 1867 - 1877
Until recently, one of the major limitations of hydrogen/deuterium exchange mass spectrometry (HDX-MS) was the peptide-level resolution afforded by proteolytic... 
ACTIVATION | AMIDE HYDROGENS | PROTEIN | HDX-MS | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTRAMOLECULAR MIGRATION | KINASE | IDENTIFICATION | CAPTURE DISSOCIATION | BINDING | Oligonucleotides - genetics | Oligonucleotides - chemistry | Class Ia Phosphatidylinositol 3-Kinase - metabolism | Electron Transport | Molecular Weight | Humans | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Enzyme Inhibitors - chemistry | Oligonucleotides - antagonists & inhibitors | Signal Processing, Computer-Assisted | Binding Sites | Peptide Fragments - genetics | Drug Evaluation, Preclinical - methods | Triazines - metabolism | Triazines - pharmacology | Indazoles - chemistry | Enzyme Inhibitors - metabolism | Purines - metabolism | Enzyme Inhibitors - pharmacology | Models, Molecular | Indazoles - metabolism | Recombinant Fusion Proteins - chemistry | Sulfonamides - pharmacology | Class Ia Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Indazoles - pharmacology | Oligonucleotides - metabolism | Peptide Fragments - chemistry | Class I Phosphatidylinositol 3-Kinases | Purines - chemistry | Peptide Fragments - antagonists & inhibitors | Protein Conformation | Quinazolinones - chemistry | Quinazolinones - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Recombinant Fusion Proteins - metabolism | Quinolines - pharmacology | Antineoplastic Agents - metabolism | Tandem Mass Spectrometry | Class Ia Phosphatidylinositol 3-Kinase - chemistry | Deuterium Exchange Measurement | Triazines - chemistry | Antineoplastic Agents - pharmacology | Class Ia Phosphatidylinositol 3-Kinase - genetics | Quinazolinones - pharmacology | Peptide Fragments - metabolism | Reproducibility of Results | Sulfonamides - chemistry | Purines - pharmacology | Quinolines - chemistry | Phosphatidylinositol 3-Kinases - chemistry | Antineoplastic Agents - chemistry | Phosphatidylinositol 3-Kinases - genetics | Quinolines - metabolism | Sulfonamides - metabolism | Index Medicus | 1 | s | 4 | ETD | PI3K | 39 | MS | 8 | 10
Journal Article
Analytical and Bioanalytical Chemistry, ISSN 1618-2642, 1/2013, Volume 405, Issue 1, pp. 203 - 213
Liquid chromatography coupled to tandem mass spectrometry has been compared to shotgun analysis with the objective of finding the best compromise for a single... 
Biochemistry, general | Chemistry | Analytical Chemistry | Food Science | Characterization and Evaluation of Materials | Shotgun | Liquid chromatography | Phospholipids | Laboratory Medicine | Mass spectrometry | Environmental Monitoring/Analysis | CHEMISTRY, ANALYTICAL | MULTIPLE PRECURSOR | BIOLOGICAL SAMPLES | BIOCHEMICAL RESEARCH METHODS | SHOTGUN LIPIDOMICS | TANDEM MASS-SPECTROMETRY | QUANTITATIVE-ANALYSIS | ENERGY COLLISIONAL ACTIVATION | DRIVEN FRAGMENTATION PROCESSES | MECHANISTIC PROPOSAL | DATA-DEPENDENT ACQUISITION | ELECTROSPRAY-IONIZATION | Reproducibility of Results | Chromatography, High Pressure Liquid - methods | Phosphatidylinositols - chemistry | Phosphatidylserines - chemistry | Phospholipids - chemistry | Phosphatidylcholines - chemistry | Fungi - metabolism | Carbon - chemistry | Lipids - chemistry | Phosphatidylglycerols - chemistry | Chemistry Techniques, Analytical | Phosphatidic Acids - chemistry | Acyltransferases - chemistry | Chromatography, Liquid - methods | Phosphatidylethanolamines - chemistry | Tandem Mass Spectrometry - methods | Yeast fungi | Physiological aspects | Microbiological chemistry | Chemical properties | Research | Identification and classification | Methods | Index Medicus | Polyethylenes | Atomic properties | Shotguns | Carbon | Fatty acids | Strain | Analytical chemistry | Life Sciences | Quantitative Methods | Biochemistry, Molecular Biology | Genomics | Neurons and Cognition | Neurobiology | Biomolecules | Chemical Sciences
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2012, Volume 55, Issue 21, pp. 9312 - 9330
DYRKs (dual specificity, tyrosine phosphorylation regulated kinases) and CLKs (cdc2-like kinases) are implicated in the onset and development of Alzheimer's... 
TAU EXON 10 | FUNCTIONAL-LINK | CHEMISTRY, MEDICINAL | DYRK1A OVEREXPRESSION | DOWN-SYNDROME | INTRACELLULAR TARGETS | NEUROFIBRILLARY DEGENERATION | DUAL-SPECIFICITY | PHOSPHATIDYLINOSITOL 3,5-BISPHOSPHATE | AFFINITY-CHROMATOGRAPHY | GLYCOGEN-SYNTHASE KINASE | Stereoisomerism | Humans | Imidazoles - chemistry | Alkaloids - chemical synthesis | Crystallography, X-Ray | Structure-Activity Relationship | Dioxoles - chemical synthesis | Protein Kinase Inhibitors - chemistry | Neuroprotective Agents - pharmacology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Protein-Tyrosine Kinases - chemistry | Dioxoles - pharmacology | Molecular Structure | Pyramidal Cells - drug effects | Cell Death - drug effects | Imidazoles - chemical synthesis | Porifera - chemistry | Pyramidal Cells - cytology | Cell Line | Protein Kinase Inhibitors - chemical synthesis | Brain - cytology | Recombinant Proteins - antagonists & inhibitors | Alkaloids - pharmacology | Neuroprotective Agents - chemistry | Glutamic Acid - pharmacology | Models, Molecular | Rats | Recombinant Proteins - chemistry | Cyclin-Dependent Kinase 2 - chemistry | Imidazoles - pharmacology | Dioxoles - chemistry | Rats, Sprague-Dawley | Brain - drug effects | Neuroprotective Agents - chemical synthesis | Amyloid beta-Protein Precursor - genetics | Animals | Chromatography, Affinity | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | Protein Binding | Mice | Protein Kinase Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - chemistry | In Vitro Techniques | Alkaloids - chemistry | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus | Organic chemistry | Chemical Sciences
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2011, Volume 108, Issue 23, pp. 9431 - 9436
Growing knowledge of the key molecular components involved in biological processes such as endocytosis, exocytosis, and motility has enabled direct testing of... 
Microscopy | Fluorescence | Transmembrane proteins | Lipids | Cell membranes | Chemical composition | Inkjet printers | P branes | Unilamellar liposomes | Membrane proteins | Transmembrane protein | Lipid bilayer | Synthetic biology | Microfluidic jetting | SNARE | transmembrane protein | FUSION | MULTIDISCIPLINARY SCIENCES | DROPLET INTERFACE BILAYERS | microfluidic jetting | PHOSPHOLIPID-MEMBRANES | PRINCIPLES | synthetic biology | UNILAMELLAR VESICLES | SURFACE | lipid bilayer | PROTEINS | RECONSTITUTION | Models, Chemical | R-SNARE Proteins - metabolism | Unilamellar Liposomes - chemistry | Green Fluorescent Proteins - genetics | Phosphatidylcholines - metabolism | Rhodamines - metabolism | Membrane Lipids - chemistry | Qa-SNARE Proteins - chemistry | Phosphatidylinositol 4,5-Diphosphate - metabolism | SNARE Proteins - chemistry | Biological Transport | Membrane Proteins - metabolism | Rhodamines - chemistry | Green Fluorescent Proteins - chemistry | Phosphatidylinositol 4,5-Diphosphate - chemistry | Green Fluorescent Proteins - metabolism | R-SNARE Proteins - genetics | Models, Molecular | Rats | Phosphatidylcholines - chemistry | R-SNARE Proteins - chemistry | Unilamellar Liposomes - metabolism | Microscopy, Confocal | Animals | Membrane Proteins - chemistry | Qa-SNARE Proteins - metabolism | Membrane Lipids - metabolism | Protein Binding | Kinetics | Porosity | Microfluidics - methods | SNARE Proteins - metabolism | Proteins | Cellular biology | Biochemistry | Models | Molecular biology | Index Medicus | Biological Sciences
Journal Article
Oncogene, ISSN 0950-9232, 08/2012, Volume 31, Issue 32, pp. 3655 - 3666
Somatic missense mutations in PIK3CA, which encodes the p110 alpha catalytic subunit of phosphoinositide 3-kinases, occur frequently in human cancers.... 
p110a | crystal structure | growth factor signalling | PIK3CA mutations | inhibitor | lipid binding | DOMAIN | P110-ALPHA | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE-C-ALPHA | PI3K-ALPHA | PHOSPHOINOSITIDE 3-KINASE | PHOSPHATIDYLINOSITOL 3'-KINASE | CANCER | CELL BIOLOGY | PI3K | ONCOLOGY | PATHWAY | GENETICS & HEREDITY | p110 alpha | Sequence Deletion | Class I Phosphatidylinositol 3-Kinases - genetics | Humans | Molecular Sequence Data | Crystallography, X-Ray | Cholesterol - chemistry | Class Ia Phosphatidylinositol 3-Kinase - chemistry | Enzyme Activators - chemistry | Protein Structure, Quaternary | Class Ia Phosphatidylinositol 3-Kinase - genetics | Amino Acid Sequence | Phosphopeptides - chemistry | Catalytic Domain | Protein Structure, Secondary | Class I Phosphatidylinositol 3-Kinases - chemistry | Phosphatidylserines - chemistry | Models, Molecular | Phosphatidylcholines - chemistry | Class Ia Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Chromones - chemistry | Liposomes - chemistry | Animals | Hydrophobic and Hydrophilic Interactions | Protein Binding | Mice | Aniline Compounds - chemistry | Enzyme Activation | Phosphatidylethanolamines - chemistry | Amino Acid Substitution | Tyrosine | Care and treatment | Peptides | Crystals | Chemical properties | Research | Structure | Cancer | Signal transduction | Lipids | Mutation | Kinases | Gene expression | Binding sites | Index Medicus | Regulatory subunits | Hydrophobicity | Electrostatic properties | phosphoinositides | 1-Phosphatidylinositol 3-kinase | Allosteric properties | Missense mutation | Classification | Lipid kinase | Protein-tyrosine kinase receptors | Growth factors | Catalytic subunits | Crystal structure | p110alpha
Journal Article
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