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Nature (London), ISSN 1476-4687, 03/2019, Volume 567, Issue 7747, pp. 262 - 266
Cyclic GMP-AMP (cGAMP) synthase (cGAS) detects infections or tissue damage by binding to microbial or self DNA in the cytoplasm(1). Upon binding DNA, cGAS... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Nucleotides, Cyclic - metabolism | Interferons - biosynthesis | Beclin-1 - deficiency | Vesicular Transport Proteins - metabolism | Humans | Endoplasmic Reticulum - metabolism | Autophagy-Related Protein 5 - genetics | Autophagy-Related Protein-1 Homolog - metabolism | DNA Viruses - metabolism | Interferons - immunology | Autophagy | DNA Viruses - genetics | Sea Anemones | Membrane Proteins - deficiency | HEK293 Cells | Membrane Proteins - metabolism | Nucleotidyltransferases - metabolism | Protein-Serine-Threonine Kinases - metabolism | Phosphate-Binding Proteins | Signal Transduction | Membrane Proteins - genetics | DNA, Viral - metabolism | Class III Phosphatidylinositol 3-Kinases - metabolism | Autophagosomes - metabolism | Cytosol - virology | Protein Transport | Carrier Proteins - genetics | Animals | Autophagy-Related Protein-1 Homolog - deficiency | Carrier Proteins - metabolism | Monomeric GTP-Binding Proteins - metabolism | Autophagy-Related Protein 5 - deficiency | Autophagy-Related Protein 5 - metabolism | Beclin-1 - genetics | Golgi Apparatus - metabolism | Mice | Beclin-1 - metabolism | Autophagy-Related Protein-1 Homolog - genetics | Nucleotides, Cyclic - immunology | Evolution, Molecular | Biological research | Autophagy (Cytology) | Enzymes | Physiological aspects | Interferon | Research | Cytoplasm | Biology, Experimental | Index Medicus
Journal Article
Biochimica et biophysica acta. Molecular cell research, ISSN 0167-4889, 02/2014, Volume 1843, Issue 2, pp. 372 - 386
Colorectal neoplasia differentially expressed (CRNDE) is a novel gene that is activated early in colorectal cancer but whose regulation and functions are... 
lncRNA | IGF1 | Insulin | CRNDE | Colorectal cancer | Warburg effect | LncRNA | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Insulin-Like Growth Factor I - pharmacology | Glucose Transporter Type 4 - metabolism | TOR Serine-Threonine Kinases - metabolism | Colorectal Neoplasms - genetics | Humans | Phosphatidylinositol 3-Kinases - metabolism | RNA, Messenger - metabolism | raf Kinases - metabolism | RNA Interference | Metabolism - drug effects | Insulin-Like Growth Factor II - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Colorectal Neoplasms - metabolism | Metabolism - genetics | Insulin - pharmacology | RNA, Messenger - genetics | RNA, Long Noncoding - genetics | Signal Transduction - genetics | Transcriptome - genetics | Down-Regulation - drug effects | Down-Regulation - genetics | Insulin-Like Growth Factor II - metabolism | Gene Expression Regulation - drug effects | Insulin - metabolism | Lactates - metabolism | Signal Transduction - drug effects | Models, Biological | Cell Line, Tumor | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Colorectal Neoplasms - pathology | RNA, Long Noncoding - metabolism | Insulin-Like Growth Factor I - metabolism | Mitogen-Activated Protein Kinases - metabolism | RNA, Small Interfering - metabolism | RNA | Genes | Analysis | Physiological aspects | Glucose | Gene expression | Dextrose | Epigenetic inheritance
Journal Article
Current biology, ISSN 0960-9822, 01/2016, Volume 26, Issue 1, pp. 120 - 128
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 10/2002, Volume 277, Issue 41, pp. 38205 - 38211
Journal Article
Journal Article
Cell host & microbe, ISSN 1931-3128, 04/2011, Volume 9, Issue 4, pp. 263 - 272
Shigella, the Gram-negative enteroinvasive bacterium that causes shigellosis, relies on its type III secretion system (TTSS) and injected effectors to modulate... 
Parasitology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Virology | Phosphorylation | Bacterial Secretion Systems | Shigella flexneri - genetics | Shigella flexneri - metabolism | Humans | Dysentery, Bacillary - genetics | CD4-Positive T-Lymphocytes - immunology | Cell Membrane - chemistry | Cell Movement - immunology | DNA-Binding Proteins - metabolism | Phosphatidylinositol 4,5-Diphosphate - metabolism | Phosphatidylinositols - metabolism | Chemokines - immunology | Cell Line | CD4-Positive T-Lymphocytes - microbiology | CD4-Positive T-Lymphocytes - cytology | CD4-Positive T-Lymphocytes - metabolism | Phosphatidylinositol 4,5-Diphosphate - deficiency | Blotting, Western | Host-Pathogen Interactions | Transcription Factors - metabolism | Fluorescent Antibody Technique | Bacterial Proteins - metabolism | Dysentery, Bacillary - metabolism | Phosphoric Monoester Hydrolases - metabolism | Hydrolysis | Proteins | Physiological aspects | T cells | Index Medicus | Phosphatidylinositol 4,5-Diphosphate / deficiency | CD4-Positive T-Lymphocytes / metabolism | Dysentery, Bacillary / metabolism | Life Sciences | Cell Membrane / chemistry | Bacterial Proteins / metabolism | Transcription Factors / metabolism | Phosphoric Monoester Hydrolases / metabolism | CD4-Positive T-Lymphocytes / microbiology | Shigella flexneri / metabolism | Microbiology and Parasitology | Phosphatidylinositol 4,5-Diphosphate / metabolism | Phosphatidylinositols / metabolism | DNA-Binding Proteins / metabolism | Shigella flexneri / genetics | CD4-Positive T-Lymphocytes / cytology | Chemokines / immunology | Cell Movement / immunology | CD4-Positive T-Lymphocytes / immunology | Dysentery, Bacillary / genetics
Journal Article
Nature immunology, ISSN 1529-2916, 12/2012, Volume 14, Issue 2, pp. 162 - 171
Signaling through the G protein-coupled receptors for the complement fragments C3a and C5a (C3aR and C5aR, respectively) by dendritic cells and CD4(+) cells... 
Forkhead Transcription Factors - immunology | Cell Communication - immunology | T-Lymphocytes, Regulatory - metabolism | TOR Serine-Threonine Kinases - metabolism | Transforming Growth Factor beta1 - metabolism | Complement C5a - metabolism | Receptors, Complement - metabolism | T-Lymphocytes, Regulatory - immunology | Signal Transduction - immunology | Transforming Growth Factor beta1 - immunology | Forkhead Transcription Factors - metabolism | Class Ib Phosphatidylinositol 3-Kinase - metabolism | T-Lymphocytes, Regulatory - cytology | Interleukin-10 - metabolism | Receptor, Anaphylatoxin C5a - immunology | Cell Differentiation | Proto-Oncogene Proteins c-akt - metabolism | Complement C3a - metabolism | Interleukin-6 - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Receptors, Chemokine - metabolism | Gene Expression Regulation | Mice, Transgenic | Receptors, Chemokine - immunology | Receptor Cross-Talk - immunology | TOR Serine-Threonine Kinases - immunology | Animals | Proto-Oncogene Proteins c-akt - immunology | Receptors, Complement - immunology | Cyclic AMP-Dependent Protein Kinases - immunology | Interleukin-6 - immunology | Mice | Complement C3a - immunology | Complement C5a - immunology | Class Ib Phosphatidylinositol 3-Kinase - immunology | Interleukin-10 - immunology | Receptor, Anaphylatoxin C5a - metabolism | Index Medicus
Journal Article
Autophagy, ISSN 1554-8635, 10/2014, Volume 7, Issue 12, pp. 1448 - 1461
Canonical autophagy is positively regulated by the Beclin 1/phosphatidylinositol 3-kinase class III (PtdIns3KC3) complex that generates an essential... 
WIPI-1 | Atg18 | PtdInsP | LC3 | resveratrol | noncanonical autophagy | Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Autophagy-Related Protein 12 | Cell Line | Autophagy-Related Proteins | Small Ubiquitin-Related Modifier Proteins/metabolism | Phosphatidylinositol Phosphates/metabolism | Protein Transport/drug effects | Humans | Autophagy/drug effects | Lipids/chemistry | Green Fluorescent Proteins/metabolism | Autophagy-Related Protein 7 | Animals | Autophagy-Related Protein 5 | Membrane Proteins/metabolism | Carrier Proteins/drug effects | Wortmannin | Resveratrol | Androstadienes/pharmacology | Stilbenes/pharmacology | Mice | Recombinant Fusion Proteins/metabolism | Phagosomes/drug effects | Ubiquitin-Activating Enzymes/metabolism | Microtubule-Associated Proteins/metabolism | Noncanonical autophagy | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Phosphatidylinositol Phosphates - metabolism | Microtubule-Associated Proteins - metabolism | Protein Transport - drug effects | Stilbenes - pharmacology | Carrier Proteins - drug effects | Recombinant Fusion Proteins - metabolism | Autophagy - drug effects | Lipids - chemistry | Phagosomes - ultrastructure | Membrane Proteins - metabolism | Phagosomes - drug effects | Green Fluorescent Proteins - metabolism | Small Ubiquitin-Related Modifier Proteins - metabolism | Phagosomes - metabolism | Ubiquitin-Activating Enzymes - metabolism | Carrier Proteins - metabolism | Androstadienes - pharmacology | Index Medicus | Basic Research-Paper | Basic Research Paper
Journal Article