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1992, ISBN 0881678201, Volume 25., xvii, 429 p. : ill. ; 24 cm.
Book
Current Opinion in Pharmacology, ISSN 1471-4892, 2012, Volume 12, Issue 3, pp. 275 - 286
Journal Article
Oral diseases, ISSN 1354-523X, 01/2015, Volume 21, Issue 1, pp. e25 - e50
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 11/2008, Volume 105, Issue 49, pp. 19532 - 19537
Cyclic nucleotide phosphodiesterase (PDE) isoforms can influence disease pathogenesis and be novel therapeutic targets. Because lower cAMP levels may... 
Protein isoforms | T lymphocytes | Chronic lymphocytic leukemia | Messenger RNA | Cyclic nucleotides | B lymphocytes | Medical treatment | Apoptosis | Vehicles | B cell leukemia | B cell | Survivin | cAMP | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cyclic Nucleotide Phosphodiesterases, Type 3 - genetics | Cyclic Nucleotide Phosphodiesterases, Type 4 | Humans | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | RNA, Messenger - metabolism | Enzyme Activation - immunology | Cell Division - immunology | Cyclic Nucleotide Phosphodiesterases, Type 7 - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - physiopathology | Membrane Potential, Mitochondrial | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Cyclic AMP - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | 3',5'-Cyclic-AMP Phosphodiesterases - metabolism | B-Lymphocytes - cytology | B-Lymphocytes - enzymology | Phosphodiesterase 3 Inhibitors | Cells, Cultured | Cyclic Nucleotide Phosphodiesterases, Type 7 - metabolism | Phosphodiesterase Inhibitors - pharmacology | 3',5'-Cyclic-AMP Phosphodiesterases - genetics | Gene Expression Regulation, Leukemic | Gene Expression Regulation, Enzymologic | Apoptosis - immunology | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 5 - genetics | Cyclic Nucleotide Phosphodiesterases, Type 7 - antagonists & inhibitors | Physiological aspects | Genetic aspects | Cyclic adenylic acid | Research | Drug therapy | Phosphodiesterases | Index Medicus | Biological Sciences | survivin | apoptosis
Journal Article
European journal of pharmacology, ISSN 0014-2999, 03/2006, Volume 533, Issue 1-3, pp. 110 - 117
Phosphodiesterases hydrolyse intracellular cyclic nucleotides, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) into inactive 5′... 
Phosphodiesterase inhibitor | Rolipram | Chronic obstructive pulmonary disease | Roflumilast | Cilomilast | Phosphodiesterase | Asthma | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Phosphodiesterase Inhibitors - therapeutic use | Cyclic Nucleotide Phosphodiesterases, Type 4 | Nitriles - pharmacology | Cyclic Nucleotide Phosphodiesterases, Type 5 | Humans | Cyclopropanes - therapeutic use | Benzamides - therapeutic use | Aminopyridines - therapeutic use | Isoenzymes - metabolism | Anti-Inflammatory Agents - therapeutic use | Carboxylic Acids - therapeutic use | Benzamides - pharmacology | Carboxylic Acids - pharmacology | Cyclopropanes - pharmacology | 3',5'-Cyclic-AMP Phosphodiesterases - metabolism | Phosphoric Diester Hydrolases - metabolism | Anti-Inflammatory Agents - pharmacology | Asthma - enzymology | Phosphodiesterase Inhibitors - pharmacology | Clinical Trials as Topic | Asthma - drug therapy | Pulmonary Disease, Chronic Obstructive - enzymology | Animals | 3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors | Aminopyridines - pharmacology | 3',5'-Cyclic-GMP Phosphodiesterases | Cyclohexanecarboxylic Acids | Cyclic Nucleotide Phosphodiesterases, Type 7 | Isoenzymes - antagonists & inhibitors | Nitriles - therapeutic use | Pulmonary Disease, Chronic Obstructive - drug therapy | Hydrolysis | Hypertension | Isoenzymes | Guanosine | Cyclic adenylic acid | Esterases | T cells | Adenylic acid | Cyclic guanylic acid | Index Medicus
Journal Article