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Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2016, Volume 124, pp. 82 - 102
Journal Article
Stroke, ISSN 0039-2499, 02/2019, Volume 50, Issue 2, pp. 478 - 486
BACKGROUND AND PURPOSE—Acetylsalicylic acid and clopidogrel are the 2 main antithrombotic drugs for secondary prevention in patients with ischemic stroke (IS)... 
blood-brain barrier | brain edema | magnetic resonance imaging | brain ischemia | cell death | neuroprotection | Stroke (Disease) | Pharmacology, Experimental | Enzyme inhibitors | Innovations | Models | Dosage and administration | Drug therapy | Phosphodiesterases | Health aspects | 10170 | 10181 | Original Contributions | 10178 | 10012 | 10014
Journal Article
Journal Article
Psychopharmacology, ISSN 0033-3158, 3/2016, Volume 233, Issue 6, pp. 1055 - 1066
Phosphodiesterase 3 (PDE3) inhibitor cilostazol ameliorates negative effects of cerebral hypoperfusion against cerebral ischemic injury through the... 
Neurosciences | Stroke | Biomedicine | BDNF | Depression | Chronic mild stress | Cilostazol | Pharmacology/Toxicology | Psychiatry | CHRONIC CEREBRAL HYPOPERFUSION | ANTIDEPRESSANT | BRAIN-INJURY | PSYCHIATRY | NEUROTROPHIC FACTOR | RATS | MECHANISMS | POSTSTROKE DEPRESSION | MODEL | NEUROSCIENCES | NEUROPROTECTION | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | Tetrazoles - pharmacology | Phosphodiesterase 3 Inhibitors - pharmacology | Stroke - complications | Male | Hippocampus - drug effects | Infarction, Middle Cerebral Artery - metabolism | Stress, Psychological - psychology | Corpus Striatum - metabolism | Depression - etiology | Depression - drug therapy | Infarction, Middle Cerebral Artery - complications | Dopaminergic Neurons - metabolism | Infarction, Middle Cerebral Artery - psychology | Stress, Psychological - metabolism | Brain-Derived Neurotrophic Factor - metabolism | Neurogenesis - drug effects | Phosphorylation - drug effects | Disease Models, Animal | Stroke - psychology | Stress, Psychological - drug therapy | Phosphodiesterase 3 Inhibitors - therapeutic use | Hippocampus - metabolism | Stroke - metabolism | Animals | Cyclic AMP Response Element-Binding Protein - metabolism | Corpus Striatum - drug effects | Depression - psychology | Tetrazoles - therapeutic use | Mice | Stress, Psychological - etiology | Stroke (Disease) | Physiological aspects | Stress (Physiology) | Phosphodiesterases | Health aspects | Mental depression | Antidepressants | Rodents | Psychopharmacology
Journal Article
Iranian Journal of Basic Medical Sciences, ISSN 2008-3866, 06/2017, Volume 20, Issue 6, pp. 639 - 647
Objective(s): Recently, we showed that some new synthetic compounds structurally related to cilostamide... 
Cilostamide | Inotropic activity | PDE inhibitor | Isoprenaline | Rat atria | MYOCARDIUM | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | DIAZEPAM | MYOCYTES | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES | AGENT | HEART | TARGETS | PHARMACOLOGY & PHARMACY | NORADRENALINE | Rodents | Original
Journal Article
Current Opinion in Pharmacology, ISSN 1471-4892, 2012, Volume 12, Issue 3, pp. 275 - 286
Highlights ► Roflumilast has been approved for the treatment of severe exacerbations of COPD. ► Roflumilast provides benefit in patients prescribed LABAs and... 
Internal Medicine | Medical Education | OBSTRUCTIVE PULMONARY-DISEASE | CYCLIC-AMP | INDUCED AIRWAY INFLAMMATION | IN-VIVO EFFICACY | HUMAN LUNG FIBROBLASTS | CD4(+) T-CELLS | PHARMACOLOGY & PHARMACY | NECROSIS-FACTOR-ALPHA | PHOSPHODIESTERASE TYPE-4 INHIBITOR | RANDOMIZED CLINICAL-TRIALS | ALLERGEN CHALLENGE | Phosphodiesterase Inhibitors - therapeutic use | Asthma - metabolism | Phosphodiesterase Inhibitors - adverse effects | Phosphodiesterase 3 Inhibitors - pharmacology | Humans | Respiratory System - enzymology | Drug Therapy, Combination - adverse effects | Phosphodiesterase 4 Inhibitors - adverse effects | Pulmonary Disease, Chronic Obstructive - metabolism | Phosphodiesterase 3 Inhibitors - adverse effects | Molecular Targeted Therapy - adverse effects | Phosphoric Diester Hydrolases - metabolism | Asthma - enzymology | Phosphodiesterase 4 Inhibitors - therapeutic use | Phosphodiesterase Inhibitors - pharmacology | Phosphodiesterase 3 Inhibitors - therapeutic use | Phosphodiesterase 4 Inhibitors - pharmacology | Asthma - drug therapy | Phosphoric Diester Hydrolases - chemistry | Pulmonary Disease, Chronic Obstructive - enzymology | Animals | Respiratory System - metabolism | Respiratory System - drug effects | Isoenzymes - antagonists & inhibitors | Pulmonary Disease, Chronic Obstructive - drug therapy | Respiratory tract diseases | Respiratory agents | Care and treatment | Drug therapy | Lung diseases
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2012, Volume 7, Issue 1, p. e30649
It is important to identify effective contraceptive drugs that cause minimal disruption to physiological processes. Phosphodiesterase 3 (PDE3) inhibitors... 
ISOENZYME INHIBITORS | CELLS | IN-VITRO | HEALTH-BENEFITS | OVULATION | MOUSE | BIOLOGY | TYPE-3 INHIBITOR | LUTEINIZATION | CAMP | RHESUS MACAQUES | Contraceptive Agents, Female - adverse effects | Contraceptive Agents, Female - pharmacology | Tetrazoles - pharmacology | Thiophenes - adverse effects | Embryo, Mammalian | Phosphodiesterase 3 Inhibitors - pharmacology | Contraceptive Agents, Female - administration & dosage | Male | Dose-Response Relationship, Drug | Meiosis - drug effects | Tetrazoles - administration & dosage | Fertilization - drug effects | Oocytes - drug effects | Female | Oogenesis - drug effects | Phosphodiesterase 3 Inhibitors - administration & dosage | Phosphodiesterase 3 Inhibitors - adverse effects | Drug Administration Schedule | Cells, Cultured | Thiophenes - pharmacology | Mice, Inbred ICR | Pregnancy | Animals | Oocytes - physiology | Mice | Tetrazoles - adverse effects | Embryonic development | Contraceptives | Heart beat | Pregnant women | Analysis | Body weight | Physiological aspects | Cyclic adenylic acid | Chromosomes | Drugs | Laboratories | Sperm | Biology | Oocytes | Fertility | Medical electronics | Blood pressure | Arrests | Phosphodiesterase | Adenosine | Fertilization | Maturation | Gynecology | Meiosis | FDA approval | Embryos | Obstetrics | Medicine | Heart rate | Studies | Offspring | Side effects | Inhibitors | Infertility | Stem cells | Extrusion | Reproductive technologies | Diabetes | Disruption | Cardiovascular diseases | Potassium | Endocrinology
Journal Article