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Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2017, Volume 60, Issue 13, pp. 5290 - 5305
Journal Article
Drugs, ISSN 0012-6667, 9/2017, Volume 77, Issue 13, pp. 1389 - 1397
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2013, Volume 23, Issue 11, pp. 3438 - 3442
Journal Article
Journal Article
Journal Article
Biochemistry, ISSN 0006-2960, 07/2018, Volume 57, Issue 30, pp. 4518 - 4525
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2015, Volume 58, Issue 21, pp. 8616 - 8637
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2016, Volume 124, pp. 82 - 102
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 01/2013, Volume 23, Issue 1, pp. 375 - 381
(−)-6-(7-Methoxy-2-(trifluoromethyl)pyrazolo[1,5- ]pyridin-4-yl)-5-methyl-4,5-dihydropyridazin-3(2 )-one (KCA-1490) exhibits moderate dual PDE3/4-inhibitory... 
Phosphodiesterase (PDE) | Inhaled administration | Dual PDE3/4 inhibitor | Asthma | COPD | MORTALITY | CHRONIC HEART-FAILURE | BRONCHODILATORY ACTIVITY | DESIGN | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | 4,5-DIHYDRO-6-<4-(1H-IMIDAZOL-1-YL)PHENYL>-3(2H)-PYRIDAZINONES | OBSTRUCTIVE PULMONARY-DISEASE | POSITIVE INOTROPIC AGENTS | CORTICOSTEROIDS | CARDIOTONIC AGENTS | ROFLUMILAST | Cyclic Nucleotide Phosphodiesterases, Type 3 - chemistry | Phosphodiesterase 3 Inhibitors - chemistry | Phosphodiesterase 3 Inhibitors - pharmacology | Pyridines - chemistry | Structure-Activity Relationship | Phosphodiesterase 4 Inhibitors - chemical synthesis | Bronchodilator Agents - chemistry | Drug Design | Bronchoalveolar Lavage Fluid - cytology | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Phosphodiesterase 4 Inhibitors - chemistry | Anti-Inflammatory Agents - pharmacology | Administration, Inhalation | Rats | Bronchodilator Agents - pharmacology | Bronchodilator Agents - chemical synthesis | Phosphodiesterase 4 Inhibitors - pharmacology | Pyridazines - chemistry | Phosphodiesterase 3 Inhibitors - chemical synthesis | Animals | Anti-Inflammatory Agents - chemistry | Protein Binding | Leukocytes - drug effects | Anti-Inflammatory Agents - chemical synthesis | Anti-inflammatory drugs | Respiratory agents
Journal Article
Journal Article