X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (9973) 9973
Publication (1420) 1420
Book Review (122) 122
Book Chapter (47) 47
Conference Proceeding (16) 16
Book / eBook (13) 13
Newsletter (11) 11
Dissertation (6) 6
Data Set (4) 4
Magazine Article (4) 4
Paper (2) 2
Web Resource (2) 2
Trade Publication Article (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (6210) 6210
humans (4224) 4224
phosphodiesterase inhibitors - pharmacology (4039) 4039
male (3983) 3983
index medicus (3577) 3577
pharmacology & pharmacy (2721) 2721
rats (2572) 2572
female (1660) 1660
mice (1624) 1624
phosphodiesterase (1450) 1450
cyclic amp - metabolism (1392) 1392
in vitro techniques (1163) 1163
dose-response relationship, drug (1142) 1142
3',5'-cyclic-amp phosphodiesterases - antagonists & inhibitors (1050) 1050
biochemistry & molecular biology (1008) 1008
cells, cultured (937) 937
sildenafil citrate (862) 862
rats, sprague-dawley (850) 850
sildenafil (834) 834
phosphodiesterase inhibitors (833) 833
enzyme inhibitors - pharmacology (805) 805
phosphodiesterase inhibitors - therapeutic use (798) 798
camp (788) 788
neurosciences (787) 787
physiology (780) 780
rolipram (769) 769
expression (724) 724
cyclic nucleotide phosphodiesterases, type 4 (711) 711
cell biology (691) 691
cyclic gmp - metabolism (684) 684
piperazines - pharmacology (684) 684
adult (659) 659
rats, wistar (653) 653
chemistry, medicinal (640) 640
3',5'-cyclic-amp phosphodiesterases - metabolism (635) 635
phosphoric diester hydrolases - metabolism (632) 632
middle aged (627) 627
1-methyl-3-isobutylxanthine - pharmacology (626) 626
activation (612) 612
research (586) 586
phosphorylation (582) 582
erectile dysfunction (576) 576
nitric-oxide (574) 574
nitric oxide (561) 561
inhibition (560) 560
calcium - metabolism (559) 559
analysis (548) 548
disease models, animal (545) 545
cells (542) 542
inhibitors (542) 542
article (540) 540
signal transduction (527) 527
research article (525) 525
time factors (523) 523
cyclic amp (520) 520
kinetics (506) 506
guinea pigs (499) 499
inflammation (498) 498
rolipram - pharmacology (495) 495
signal transduction - drug effects (492) 492
in-vitro (483) 483
phosphodiesterases (473) 473
pyrrolidinones - pharmacology (464) 464
apoptosis (459) 459
asthma (456) 456
physiological aspects (442) 442
cell line (441) 441
cardiac & cardiovascular systems (440) 440
structure-activity relationship (440) 440
cyclic-nucleotide phosphodiesterases (426) 426
phosphodiesterase 5 inhibitors - pharmacology (415) 415
proteins (412) 412
colforsin - pharmacology (409) 409
mice, inbred c57bl (392) 392
phosphodiesterase 4 inhibitors - pharmacology (391) 391
sulfones - pharmacology (391) 391
aged (389) 389
respiratory system (389) 389
cgmp (386) 386
rodents (384) 384
vasodilator agents - pharmacology (382) 382
phosphodiesterase inhibitor (381) 381
rabbits (379) 379
pharmacology (378) 378
enzymes (375) 375
erectile dysfunction - drug therapy (375) 375
theophylline - pharmacology (374) 374
urology & nephrology (373) 373
health aspects (370) 370
caffeine - pharmacology (364) 364
purines - pharmacology (364) 364
cyclic-amp (363) 363
imidazoles - pharmacology (359) 359
tadalafil (354) 354
medicine (351) 351
cyclic nucleotide phosphodiesterases, type 4 - metabolism (350) 350
purines (350) 350
multidisciplinary sciences (349) 349
cyclic-nucleotide phosphodiesterase (327) 327
sulfones (327) 327
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (9909) 9909
Japanese (46) 46
Russian (26) 26
Chinese (18) 18
German (15) 15
Spanish (8) 8
French (6) 6
Polish (4) 4
Portuguese (3) 3
Korean (2) 2
Turkish (2) 2
Bulgarian (1) 1
Dutch (1) 1
Hungarian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal Article
Current Opinion in Pharmacology, ISSN 1471-4892, 2012, Volume 12, Issue 3, pp. 275 - 286
Highlights ► Roflumilast has been approved for the treatment of severe exacerbations of COPD. ► Roflumilast provides benefit in patients prescribed LABAs and... 
Internal Medicine | Medical Education | OBSTRUCTIVE PULMONARY-DISEASE | CYCLIC-AMP | INDUCED AIRWAY INFLAMMATION | IN-VIVO EFFICACY | HUMAN LUNG FIBROBLASTS | CD4(+) T-CELLS | PHARMACOLOGY & PHARMACY | NECROSIS-FACTOR-ALPHA | PHOSPHODIESTERASE TYPE-4 INHIBITOR | RANDOMIZED CLINICAL-TRIALS | ALLERGEN CHALLENGE | Phosphodiesterase Inhibitors - therapeutic use | Asthma - metabolism | Phosphodiesterase Inhibitors - adverse effects | Phosphodiesterase 3 Inhibitors - pharmacology | Humans | Respiratory System - enzymology | Drug Therapy, Combination - adverse effects | Phosphodiesterase 4 Inhibitors - adverse effects | Pulmonary Disease, Chronic Obstructive - metabolism | Phosphodiesterase 3 Inhibitors - adverse effects | Molecular Targeted Therapy - adverse effects | Phosphoric Diester Hydrolases - metabolism | Asthma - enzymology | Phosphodiesterase 4 Inhibitors - therapeutic use | Phosphodiesterase Inhibitors - pharmacology | Phosphodiesterase 3 Inhibitors - therapeutic use | Phosphodiesterase 4 Inhibitors - pharmacology | Asthma - drug therapy | Phosphoric Diester Hydrolases - chemistry | Pulmonary Disease, Chronic Obstructive - enzymology | Animals | Respiratory System - metabolism | Respiratory System - drug effects | Isoenzymes - antagonists & inhibitors | Pulmonary Disease, Chronic Obstructive - drug therapy | Respiratory tract diseases | Respiratory agents | Care and treatment | Drug therapy | Lung diseases
Journal Article
Cellular Signalling, ISSN 0898-6568, 09/2014, Volume 26, Issue 9, pp. 2016 - 2029
Apremilast, an oral small molecule inhibitor of phosphodiesterase 4 (PDE4), is in development for chronic inflammatory disorders, and has shown efficacy in... 
Phosphodiesterase inhibitor | Apremilast | Spondyloarthropathies | Psoriasis | Preclinical drug evaluation | Psoriatic arthritis | PROTEIN-KINASE-A | CONTROLLED-TRIAL | CAMP-SPECIFIC PHOSPHODIESTERASE | NECROSIS-FACTOR-ALPHA | KAPPA-B | PSORIATIC-ARTHRITIS | CELL BIOLOGY | ORAL PHOSPHODIESTERASE-4 INHIBITOR | CYCLIC-AMP | THALIDOMIDE ANALOGS | B-MEDIATED TRANSCRIPTION | Thalidomide - metabolism | Humans | Male | Thalidomide - pharmacology | Lung Diseases - drug therapy | Thalidomide - analogs & derivatives | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Female | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic AMP - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Vomiting - prevention & control | B-Lymphocytes - metabolism | Disease Models, Animal | Cell Line | Cytokines - metabolism | Immunity, Innate - drug effects | Jurkat Cells | Phosphodiesterase 4 Inhibitors - therapeutic use | Mice, Transgenic | Phosphodiesterase 4 Inhibitors - metabolism | Ferrets | Phosphodiesterase 4 Inhibitors - pharmacology | B-Lymphocytes - drug effects | Adaptive Immunity - drug effects | Animals | B-Lymphocytes - immunology | Protein Binding | T-Lymphocytes - immunology | Mice | Thalidomide - therapeutic use | Dendritic cells | Analysis | Development and progression | Genetic engineering | B cells | Biological response modifiers | T cells
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2017, Volume 60, Issue 13, pp. 5290 - 5305
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 12/2013, Volume 347, Issue 3, pp. 626 - 634
Journal Article
Arthritis Research and Therapy, ISSN 1478-6354, 09/2015, Volume 17, Issue 1, p. 249
Journal Article
Brain Research, ISSN 0006-8993, 2015, Volume 1622, pp. 279 - 291
Journal Article
Drugs, ISSN 0012-6667, 9/2017, Volume 77, Issue 13, pp. 1389 - 1397
Journal Article