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1996, Handbook of immunopharmacology. Drugs, ISBN 0122107209, 247
Non-selective inhibitors of cyclic nucleotide phosphodiesterase (PDE), such as theophylline, have been used extensively since 1958. In the decade of the '70s,... 
Phosphodiesterases | Therapeutic use | Inhibitors | Cyclic nucleotide phosphodiesterases | Clinical & internal medicine
eBook
Mini-Reviews in Medicinal Chemistry, ISSN 1389-5575, 06/2015, Volume 15, Issue 9, pp. 762 - 775
The chemistry of 1,3,4-thiadiazoles is very well known. A universal and commonly used method of the synthesis of different 2,5-disubstituted 1,3,4-thiadiazoles... 
1,3,4-thiadiazoles | Cyclooxygenase inhibitors | Leishmanicidal agents | Metalloproteinases inhibitors | Anticonvulsant activity | Diuretics | Carbonic anhydrase inhibitors | Anticancer agents | VITRO ANTITUBERCULOSIS ACTIVITY | CHEMISTRY, MEDICINAL | leishmanicidal agents | GYNECOLOGIC-ONCOLOGY-GROUP | SELECTIVE PDE7 INHIBITORS | HELICOBACTER-PYLORI ACTIVITY | HUMAN ISOFORM-II | IN-VITRO | metalloproteinases inhibitors | anticonvulsant activity | carbonic anhydrase inhibitors | diuretics | AMINOPEPTIDASE-N INHIBITORS | cyclooxygenase inhibitors | SUBSTITUTED 1,3,4-THIADIAZOLES | CARBONIC-ANHYDRASE INHIBITORS | Phosphodiesterase Inhibitors - therapeutic use | Carbonic Anhydrase Inhibitors - chemistry | Humans | Matrix Metalloproteinase Inhibitors - chemistry | Antineoplastic Agents - therapeutic use | Cyclooxygenase Inhibitors - chemistry | Antineoplastic Agents - chemistry | Matrix Metalloproteinase Inhibitors - metabolism | Matrix Metalloproteinase Inhibitors - therapeutic use | Neoplasms - drug therapy | Antineoplastic Agents - metabolism | Animals | Phosphodiesterase Inhibitors - metabolism | Thiadiazoles - chemistry | Thiadiazoles - therapeutic use | Protein Binding | Phosphodiesterase Inhibitors - chemistry | Thiadiazoles - metabolism | Carbonic Anhydrase Inhibitors - metabolism | Cyclooxygenase Inhibitors - therapeutic use | Quantitative Structure-Activity Relationship | Carbonic Anhydrase Inhibitors - therapeutic use
Journal Article
2014, Methods and principles in medicinal chemistry, ISBN 9783527682348, Volume 61.
Web Resource
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2013, Volume 23, Issue 11, pp. 3438 - 3442
Journal Article
Current Opinion in Pharmacology, ISSN 1471-4892, 2012, Volume 12, Issue 3, pp. 275 - 286
Highlights ► Roflumilast has been approved for the treatment of severe exacerbations of COPD. ► Roflumilast provides benefit in patients prescribed LABAs and... 
Internal Medicine | Medical Education | OBSTRUCTIVE PULMONARY-DISEASE | CYCLIC-AMP | INDUCED AIRWAY INFLAMMATION | IN-VIVO EFFICACY | HUMAN LUNG FIBROBLASTS | CD4(+) T-CELLS | PHARMACOLOGY & PHARMACY | NECROSIS-FACTOR-ALPHA | PHOSPHODIESTERASE TYPE-4 INHIBITOR | RANDOMIZED CLINICAL-TRIALS | ALLERGEN CHALLENGE | Phosphodiesterase Inhibitors - therapeutic use | Asthma - metabolism | Phosphodiesterase Inhibitors - adverse effects | Phosphodiesterase 3 Inhibitors - pharmacology | Humans | Respiratory System - enzymology | Drug Therapy, Combination - adverse effects | Phosphodiesterase 4 Inhibitors - adverse effects | Pulmonary Disease, Chronic Obstructive - metabolism | Phosphodiesterase 3 Inhibitors - adverse effects | Molecular Targeted Therapy - adverse effects | Phosphoric Diester Hydrolases - metabolism | Asthma - enzymology | Phosphodiesterase 4 Inhibitors - therapeutic use | Phosphodiesterase Inhibitors - pharmacology | Phosphodiesterase 3 Inhibitors - therapeutic use | Phosphodiesterase 4 Inhibitors - pharmacology | Asthma - drug therapy | Phosphoric Diester Hydrolases - chemistry | Pulmonary Disease, Chronic Obstructive - enzymology | Animals | Respiratory System - metabolism | Respiratory System - drug effects | Isoenzymes - antagonists & inhibitors | Pulmonary Disease, Chronic Obstructive - drug therapy | Respiratory tract diseases | Respiratory agents | Care and treatment | Drug therapy | Lung diseases
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 03/2006, Volume 533, Issue 1-3, pp. 110 - 117
Phosphodiesterases hydrolyse intracellular cyclic nucleotides, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) into inactive 5′... 
Phosphodiesterase inhibitor | Rolipram | Chronic obstructive pulmonary disease | Roflumilast | Cilomilast | Phosphodiesterase | Asthma | roflumilast | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES | EOSINOPHIL INFILTRATION | rolipram | asthma | NECROSIS-FACTOR-ALPHA | GM-CSF RELEASE | PDE4 INHIBITORS | OBSTRUCTIVE PULMONARY-DISEASE | phosphodiesterase inhibitor | CAMP-PHOSPHODIESTERASES | PHARMACOLOGY & PHARMACY | CD8(+) T-LYMPHOCYTES | phosphodiesterase | TNF-ALPHA | cilomilast | ANTIINFLAMMATORY DRUGS | chronic obstructive pulmonary disease | Phosphodiesterase Inhibitors - therapeutic use | Cyclic Nucleotide Phosphodiesterases, Type 4 | Nitriles - pharmacology | Cyclic Nucleotide Phosphodiesterases, Type 5 | Humans | Cyclopropanes - therapeutic use | Benzamides - therapeutic use | Aminopyridines - therapeutic use | Isoenzymes - metabolism | Anti-Inflammatory Agents - therapeutic use | Carboxylic Acids - therapeutic use | Benzamides - pharmacology | Carboxylic Acids - pharmacology | Cyclopropanes - pharmacology | 3',5'-Cyclic-AMP Phosphodiesterases - metabolism | Phosphoric Diester Hydrolases - metabolism | Anti-Inflammatory Agents - pharmacology | Asthma - enzymology | Phosphodiesterase Inhibitors - pharmacology | Clinical Trials as Topic | Asthma - drug therapy | Pulmonary Disease, Chronic Obstructive - enzymology | Animals | 3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors | Aminopyridines - pharmacology | 3',5'-Cyclic-GMP Phosphodiesterases | Cyclohexanecarboxylic Acids | Cyclic Nucleotide Phosphodiesterases, Type 7 | Isoenzymes - antagonists & inhibitors | Nitriles - therapeutic use | Pulmonary Disease, Chronic Obstructive - drug therapy | Hydrolysis | Hypertension | Isoenzymes | Guanosine | Cyclic adenylic acid | Esterases | T cells | Adenylic acid | Cyclic guanylic acid
Journal Article
Nature Communications, ISSN 2041-1723, 04/2016, Volume 7, Issue 1, p. 11360
The prenyl-binding protein PDEδ is crucial for the plasma membrane localization of prenylated Ras. Recently, we have reported that the small-molecule... 
Small Molecule Libraries - pharmacology | Epithelial Cells - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Pyrazoles - chemical synthesis | Antineoplastic Agents - chemical synthesis | Epithelial Cells - drug effects | Humans | Pancreatic Ducts - drug effects | Gene Expression Regulation, Neoplastic | Cyclic Nucleotide Phosphodiesterases, Type 6 - antagonists & inhibitors | Crystallography, X-Ray | Cyclic Nucleotide Phosphodiesterases, Type 6 - chemistry | Cyclic Nucleotide Phosphodiesterases, Type 6 - genetics | Pancreatic Ducts - pathology | Benzimidazoles - chemistry | Pancreatic Ducts - metabolism | Pyrazoles - chemistry | Proto-Oncogene Proteins p21(ras) - chemistry | Phosphodiesterase Inhibitors - chemical synthesis | Antineoplastic Agents - pharmacology | Protein Interaction Domains and Motifs | Phosphodiesterase Inhibitors - chemistry | Binding Sites | Proto-Oncogene Proteins p21(ras) - metabolism | Pyrazoles - pharmacology | Recombinant Proteins - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 6 - metabolism | Gene Expression | Protein Structure, Secondary | Signal Transduction | Phosphodiesterase Inhibitors - pharmacology | Recombinant Proteins - chemistry | Small Molecule Libraries - chemical synthesis | Epithelial Cells - pathology | Recombinant Proteins - genetics | Antineoplastic Agents - chemistry | Pyrazines - chemical synthesis | Pyrazines - chemistry | Small Molecule Libraries - chemistry | Proto-Oncogene Proteins p21(ras) - antagonists & inhibitors | Cell Line, Tumor | Protein Binding | Benzimidazoles - pharmacology | Molecular Docking Simulation | Pyrazines - pharmacology
Journal Article