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1992, ISBN 0881678201, Volume 25., xvii, 429 p. : ill. ; 24 cm.
Book
Nature Biotechnology, ISSN 1087-0156, 01/2010, Volume 28, Issue 1, pp. 63 - 70
Phosphodiesterase 4 (PDE4), the primary cAMP-hydrolyzing enzyme in cells, is a promising drug target for a wide range of conditions. Here we present seven... 
CAMP-SPECIFIC PHOSPHODIESTERASE | PHOSPHORYLATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PROTEIN-KINASE | GENE COMPOSER | SUNCUS-MURINUS | AMP-SPECIFIC PHOSPHODIESTERASE | INHIBITORS | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE | ROLIPRAM BINDING | ANTIDEPRESSANT DRUGS | Phosphodiesterase Inhibitors - therapeutic use | Phosphodiesterase Inhibitors - adverse effects | Humans | Molecular Sequence Data | Crystallography, X-Ray | Structure-Activity Relationship | Benzhydryl Compounds - chemistry | Benzhydryl Compounds - adverse effects | Phenylurea Compounds - adverse effects | Phenylurea Compounds - chemistry | Drug Design | Phosphodiesterase 4 Inhibitors | Behavior, Animal - drug effects | Biological Assay | Phosphodiesterase Inhibitors - chemistry | Benzhydryl Compounds - therapeutic use | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Disease Models, Animal | Allosteric Regulation - drug effects | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | Catalytic Domain | Models, Molecular | Phenylurea Compounds - therapeutic use | Phosphodiesterase Inhibitors - pharmacology | Vomiting - drug therapy | Cognition - drug effects | Animals | Benzhydryl Compounds - pharmacology | Mice | Phenylurea Compounds - pharmacology | Kinetics | Care and treatment | Schizophrenia | Physiological aspects | Genetic aspects | Cellular signal transduction | Cyclic adenylic acid | Research | Phosphodiesterases | Enzymes | Biotechnology | Cellular biology | Molecular biology | Cognitive ability | Crystal structure | Index Medicus
Journal Article
Current Opinion in Pharmacology, ISSN 1471-4892, 2012, Volume 12, Issue 3, pp. 275 - 286
Highlights ► Roflumilast has been approved for the treatment of severe exacerbations of COPD. ► Roflumilast provides benefit in patients prescribed LABAs and... 
Internal Medicine | Medical Education | OBSTRUCTIVE PULMONARY-DISEASE | CYCLIC-AMP | INDUCED AIRWAY INFLAMMATION | IN-VIVO EFFICACY | HUMAN LUNG FIBROBLASTS | CD4(+) T-CELLS | PHARMACOLOGY & PHARMACY | NECROSIS-FACTOR-ALPHA | PHOSPHODIESTERASE TYPE-4 INHIBITOR | RANDOMIZED CLINICAL-TRIALS | ALLERGEN CHALLENGE | Phosphodiesterase Inhibitors - therapeutic use | Asthma - metabolism | Phosphodiesterase Inhibitors - adverse effects | Phosphodiesterase 3 Inhibitors - pharmacology | Humans | Respiratory System - enzymology | Drug Therapy, Combination - adverse effects | Phosphodiesterase 4 Inhibitors - adverse effects | Pulmonary Disease, Chronic Obstructive - metabolism | Phosphodiesterase 3 Inhibitors - adverse effects | Molecular Targeted Therapy - adverse effects | Phosphoric Diester Hydrolases - metabolism | Asthma - enzymology | Phosphodiesterase 4 Inhibitors - therapeutic use | Phosphodiesterase Inhibitors - pharmacology | Phosphodiesterase 3 Inhibitors - therapeutic use | Phosphodiesterase 4 Inhibitors - pharmacology | Asthma - drug therapy | Phosphoric Diester Hydrolases - chemistry | Pulmonary Disease, Chronic Obstructive - enzymology | Animals | Respiratory System - metabolism | Respiratory System - drug effects | Isoenzymes - antagonists & inhibitors | Pulmonary Disease, Chronic Obstructive - drug therapy | Respiratory tract diseases | Respiratory agents | Care and treatment | Drug therapy | Lung diseases
Journal Article
Oral Diseases, ISSN 1354-523X, 01/2015, Volume 21, Issue 1, pp. e25 - e50
By catalyzing hydrolysis of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), cyclic nucleotide phosphodiesterases are critical... 
protein kinase A (PKA) | phosphodiesterase (PDE) | A‐kinase anchoring protein (AKAP) | signalosome | oral and systemic diseases | cancer | cAMP | Phosphodiesterase (PDE) | Signalosome | A-kinase anchoring protein (AKAP) | Protein kinase A (PKA) | Oral and systemic diseases | Cancer | BONE MORPHOGENETIC PROTEIN-2 | MULTIPLE MOLECULAR-FORMS | GLUCOCORTICOID-INDUCED OSTEOPOROSIS | ROD CGMP PHOSPHODIESTERASE | OBSTRUCTIVE PULMONARY-DISEASE | DENTISTRY, ORAL SURGERY & MEDICINE | CHRONIC LYMPHOCYTIC-LEUKEMIA | DUCHENNE MUSCULAR-DYSTROPHY | TYPE-2 DIABETES-MELLITUS | CAMP-SPECIFIC PHOSPHODIESTERASES | STATIONARY NIGHT BLINDNESS | 3',5'-Cyclic-GMP Phosphodiesterases - drug effects | Phosphodiesterase Inhibitors - therapeutic use | Animals | Signal Transduction - drug effects | 3',5'-Cyclic-GMP Phosphodiesterases - physiology | 3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors | 3',5'-Cyclic-GMP Phosphodiesterases - antagonists & inhibitors | Humans | Phosphodiesterase Inhibitors - pharmacology | 3',5'-Cyclic-AMP Phosphodiesterases - drug effects | Signal Transduction - physiology | 3',5'-Cyclic-AMP Phosphodiesterases - physiology | Medical research | Enzymes | Oral diseases | Mutation | Rodents | Crystal structure | Protein Kinase A | Phosphodiesterase | A Kinase Anchoring Protein | Oral and Systemic Diseases | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin | protein (AKAP) | Clinical Medicine | Endokrinologi och diabetes | A-kinase anchoring | Endocrinology and Diabetes
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 03/2006, Volume 533, Issue 1-3, pp. 110 - 117
Phosphodiesterases hydrolyse intracellular cyclic nucleotides, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) into inactive 5′... 
Phosphodiesterase inhibitor | Rolipram | Chronic obstructive pulmonary disease | Roflumilast | Cilomilast | Phosphodiesterase | Asthma | roflumilast | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES | EOSINOPHIL INFILTRATION | rolipram | asthma | NECROSIS-FACTOR-ALPHA | GM-CSF RELEASE | PDE4 INHIBITORS | OBSTRUCTIVE PULMONARY-DISEASE | phosphodiesterase inhibitor | CAMP-PHOSPHODIESTERASES | PHARMACOLOGY & PHARMACY | CD8(+) T-LYMPHOCYTES | phosphodiesterase | TNF-ALPHA | cilomilast | ANTIINFLAMMATORY DRUGS | chronic obstructive pulmonary disease | Phosphodiesterase Inhibitors - therapeutic use | Cyclic Nucleotide Phosphodiesterases, Type 4 | Nitriles - pharmacology | Cyclic Nucleotide Phosphodiesterases, Type 5 | Humans | Cyclopropanes - therapeutic use | Benzamides - therapeutic use | Aminopyridines - therapeutic use | Isoenzymes - metabolism | Anti-Inflammatory Agents - therapeutic use | Carboxylic Acids - therapeutic use | Benzamides - pharmacology | Carboxylic Acids - pharmacology | Cyclopropanes - pharmacology | 3',5'-Cyclic-AMP Phosphodiesterases - metabolism | Phosphoric Diester Hydrolases - metabolism | Anti-Inflammatory Agents - pharmacology | Asthma - enzymology | Phosphodiesterase Inhibitors - pharmacology | Clinical Trials as Topic | Asthma - drug therapy | Pulmonary Disease, Chronic Obstructive - enzymology | Animals | 3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors | Aminopyridines - pharmacology | 3',5'-Cyclic-GMP Phosphodiesterases | Cyclohexanecarboxylic Acids | Cyclic Nucleotide Phosphodiesterases, Type 7 | Isoenzymes - antagonists & inhibitors | Nitriles - therapeutic use | Pulmonary Disease, Chronic Obstructive - drug therapy | Hydrolysis | Hypertension | Isoenzymes | Guanosine | Cyclic adenylic acid | Esterases | T cells | Adenylic acid | Cyclic guanylic acid
Journal Article