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Drug Design, Development and Therapy, ISSN 1177-8881, 2010, Volume 4, pp. 147 - 158
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 04/2012, Volume 22, Issue 7, pp. 2585 - 2589
Journal Article
Molecular Nutrition and Food Research, ISSN 1613-4125, 11/2011, Volume 55, Issue 11, pp. 1677 - 1689
Scope: Curcumin inhibits proliferation of many cancer cells. Cyclic nucleotide phosphodiesterases (PDEs), by hydrolyzing intracellular cyclic... 
CAMP/cGMP | DNMT1 | Rolipram | Nimodipine | Cancer | CANCER-CELLS | APOPTOSIS | HEMI-METHYLATED DNA | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES | FOOD SCIENCE & TECHNOLOGY | DOWN-REGULATION | VASCULAR SMOOTH-MUSCLE | ARREST | SRA DOMAIN | ENDOTHELIAL-CELLS | GENE-EXPRESSION | cAMP/cGMP | Neoplasm Proteins - antagonists & inhibitors | Cyclin-Dependent Kinase Inhibitor Proteins - metabolism | Molecular Targeted Therapy | Neoplasm Proteins - metabolism | RNA, Messenger - metabolism | DNA (Cytosine-5-)-Methyltransferases - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 1 - antagonists & inhibitors | Isoenzymes - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Melanoma - metabolism | Recombinant Proteins - metabolism | Cell Survival - drug effects | DNA (Cytosine-5-)-Methyltransferase 1 | Isoenzymes - genetics | Curcumin - pharmacology | Cyclic Nucleotide Phosphodiesterases, Type 1 - metabolism | Phosphodiesterase Inhibitors - pharmacology | Nuclear Proteins - metabolism | Animals | Cyclic GMP - metabolism | Melanoma - drug therapy | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Antineoplastic Agents, Phytogenic - pharmacology | Cell Cycle - drug effects | Cyclic Nucleotide Phosphodiesterases, Type 1 - genetics | Isoenzymes - antagonists & inhibitors | Cell proliferation | Ca super(2+)/calmodulin-dependent phosphodiesterase | 3',5'-Cyclic-nucleotide phosphodiesterase | DNMT1 protein | Melanoma | Cyclic AMP | epigenetics | Signal transduction | Cyclic GMP | Cyclin A | Cell cycle | Cyclin-dependent kinase inhibitor p27 | DNA methyltransferase | Curcumin | phosphodiesterase | cyclin-dependent kinase inhibitors | Food | Life Sciences | Cellular Biology | Biochemistry, Molecular Biology
Journal Article
Circulation, ISSN 0009-7322, 08/2014, Volume 130, Issue 6, pp. 496 - 507
Journal Article
1996, The Handbook of immunopharmacology., ISBN 0122107209, xvi, 228
Non-selective inhibitors of cyclic nucleotide phosphodiesterase (PDE), such as theophylline, have been used extensively since 1958. In the decade of the '70s,... 
Phosphodiesterases | Therapeutic use | Inhibitors | Cyclic nucleotide phosphodiesterases | Clinical & internal medicine
Book
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 09/2014, Volume 24, Issue 17, pp. 4084 - 4089
Journal Article
The Journal of Sexual Medicine, ISSN 1743-6095, 01/2013, Volume 10, Issue 1, pp. 130 - 171
Erectile dysfunction (ED) is the most frequently treated male sexual dysfunction worldwide. ED is a chronic condition that exerts a negative impact on male... 
Erectile Dysfunction | Phosphodiesterase Inhibitors | Vacuum Device Therapy | Oral Drug Treatment | Combination Therapies | Transurethral Alprostadil Therapy | Intracavernous Self-Injection Therapy | Intracavernous Self‐Injection Therapy | INTRACAVERNOUS ALPROSTADIL ALFADEX | BENIGN PROSTATIC HYPERPLASIA | PHOSPHODIESTERASE TYPE-5 INHIBITOR | URINARY-TRACT SYMPTOMS | ONCE-A-DAY | LONG-TERM SAFETY | UROLOGY & NEPHROLOGY | QUALITY-OF-LIFE | PLACEBO-CONTROLLED TRIAL | VACUUM CONSTRICTION DEVICE | SELF-INJECTION THERAPY | Phosphodiesterase 5 Inhibitors - adverse effects | Humans | Middle Aged | Sulfones - adverse effects | Male | Alprostadil - therapeutic use | Erectile Dysfunction - therapy | Aged, 80 and over | Imidazoles - therapeutic use | Imidazoles - adverse effects | Risk Factors | Phosphodiesterase 5 Inhibitors - administration & dosage | Alprostadil - adverse effects | Yohimbine - adverse effects | Piperazines - therapeutic use | Sulfones - pharmacokinetics | Carbolines - administration & dosage | Piperazines - adverse effects | Sulfonamides - pharmacokinetics | Yohimbine - therapeutic use | Tadalafil | Vardenafil Dihydrochloride | Pyrimidines - pharmacokinetics | Hypogonadism - therapy | Triazines - adverse effects | Sulfonamides - administration & dosage | Sulfones - administration & dosage | Triazines - pharmacokinetics | Piperazines - administration & dosage | Sulfones - therapeutic use | Age Factors | Triazines - therapeutic use | Imidazoles - administration & dosage | Imidazoles - pharmacokinetics | Phosphodiesterase 5 Inhibitors - pharmacokinetics | Alprostadil - administration & dosage | Erectile Dysfunction - drug therapy | Penile Erection - drug effects | Adult | Phosphodiesterase 5 Inhibitors - therapeutic use | Piperazines - pharmacokinetics | Drug Therapy, Combination | Carbolines - therapeutic use | Carbolines - adverse effects | Pyrimidines - administration & dosage | Erectile Dysfunction - etiology | Sulfonamides - therapeutic use | Pyrimidines - therapeutic use | Triazines - administration & dosage | Hypogonadism - complications | Pyrimidines - adverse effects | Sulfonamides - adverse effects | Aged | Carbolines - pharmacokinetics | Hypertension | Care and treatment | Conservatism | Online health care information services | Impotence | Prosthesis | Chronic diseases | Risk factors | Testosterone | Implants, Artificial | Prostaglandins E | Diabetes | Vasoactive intestinal peptides | Special education
Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2005, Volume 388, Issue 3, pp. 803 - 811
Cyclic nucleotide PDE4 (phosphodiesterase 4) inhibitors are being developed as potent anti-inflammatory drugs for use in chronic lung diseases, but the... 
cAMP phosphodiesterase | Thyroid-stimulating hormone (TSH) | FRTL5 thyroid cell | Protein kinase A activation | SDS/PAGE migration | Phosphodiesterase 4 splice form (PDE4 splice form) | SIGNALING PATHWAYS | ACTIVATION | DROSOPHILA-MELANOGASTER | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEPENDENT PROTEIN-KINASE | HORMONAL-REGULATION | FRTL-5 THYROID-CELLS | CROSS-TALK | thyroid-stimulating hormone (TSH) | GENE | protein kinase A activation | phosphodiesterase 4 splice form (PDE4 splice form) | CAMP-SPECIFIC PHOSPHODIESTERASES | Protein Structure, Tertiary | 3',5'-Cyclic-AMP Phosphodiesterases - metabolism | Cell Line | Testis - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 | Alternative Splicing - genetics | Humans | Liver - metabolism | RNA, Messenger - genetics | Cyclic Nucleotide Phosphodiesterases, Type 3 | RNA, Messenger - analysis | Rats | Male | Gene Expression Profiling | 3',5'-Cyclic-AMP Phosphodiesterases - genetics | Brain - metabolism | Gene Expression Regulation, Enzymologic | Kidney - metabolism | 3',5'-Cyclic-AMP Phosphodiesterases - chemistry | Animals | Myocardium - metabolism | Lung - metabolism | Thyroid Gland - cytology | Thyroid Gland - metabolism | AMV, avian myeloblastosis virus | SDS | UCR, upstream conserved region | PKA, cAMP-dependent protein kinase | RT-PCR, reverse transcriptase PCR | PDE, phosphodiesterase | TSH, thyroid-stimulating hormone | PAGE migration | protein kinase A | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | poly(A)+, polyadenylated
Journal Article