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Journal of Clinical Investigation, ISSN 0021-9738, 07/2010, Volume 120, Issue 7, pp. 2355 - 2369
Metformin is widely used to treat hyperglycemia in individuals with type 2 diabetes. Recently the LKB1/AMP-activated protein kinase (LKB1/AMPK) pathway was... 
MEDICINE, RESEARCH & EXPERIMENTAL | RESPIRATORY-CHAIN | SKELETAL-MUSCLE | PHOSPHOENOLPYRUVATE CARBOXYKINASE | ACTIVATED PROTEIN-KINASE | GLUCOKINASE TRANSLOCATION | GLUCOSE-METABOLISM | COACTIVATOR TORC2 | AICA RIBOSIDE | UPSTREAM KINASE | ISOLATED RAT HEPATOCYTES | Glucose-6-Phosphatase - genetics | Hypoglycemic Agents - metabolism | Diabetes Mellitus, Type 2 - genetics | Gluconeogenesis - drug effects | Diabetes Mellitus, Type 2 - metabolism | Hepatocytes - metabolism | Metformin - metabolism | AMP-Activated Protein Kinases | Hyperglycemia - genetics | Liver - drug effects | Protein-Serine-Threonine Kinases - metabolism | Liver - metabolism | Metformin - pharmacology | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Glucose - genetics | Glucose - pharmacology | Glucose-6-Phosphatase - metabolism | Hypoglycemic Agents - pharmacology | Mice, Knockout | Hyperglycemia - metabolism | Phosphoenolpyruvate Carboxykinase (ATP) - genetics | Up-Regulation - drug effects | Animals | Gluconeogenesis - genetics | Glucose-6-Phosphatase - biosynthesis | Phosphoenolpyruvate Carboxykinase (ATP) - metabolism | Glucose - metabolism | Mice | Protein-Serine-Threonine Kinases - pharmacology | Type 2 diabetes | Control | Usage | Genetic aspects | Research | Metformin | Gene expression | Drug therapy | Health aspects | Gluconeogenesis | Up-Regulation | Glucose-6-Phosphatase | gluconeogenesis, animal models | Liver | Protein-Serine-Threonine Kinases | Glucose | LKB1 | Life Sciences | Hypoglycemic Agents | Phosphoenolpyruvate Carboxykinase (ATP) | Human health and pathology | Hyperglycemia | Hepatocytes | AMPK | Endocrinology and metabolism | Diabetes Mellitus, Type 2
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2015, Volume 60, Issue 2, pp. 195 - 207
Journal Article
Nature Communications, ISSN 2041-1723, 02/2017, Volume 8, Issue 1, p. 14420
Journal Article
Journal Article
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 08/2018, Volume 315, Issue 2, pp. G249 - G258
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2014, Volume 111, Issue 29, pp. 10684 - 10689
Journal Article
Journal Article
Clinical science (London, England : 1979), ISSN 0143-5221, 11/2015, Volume 129, Issue 10, pp. 839 - 850
Increased glucose production and reduced hepatic glycogen storage contribute to metabolic abnormalities in diabetes. Irisin, a newly identified myokine,... 
irisin | glycogenesis | liver | diabetes | gluconeogenesis | insulin resistance | MEDICINE, RESEARCH & EXPERIMENTAL | CIRCULATING IRISIN | SERUM | OBESITY | METABOLISM | GSK3 | INSULIN-RESISTANCE | Glucose-6-Phosphatase - genetics | Glycogen Synthase - metabolism | Heterocyclic Compounds, 3-Ring - pharmacology | Diabetes Mellitus, Type 2 - genetics | Gluconeogenesis - drug effects | Humans | Male | Phosphatidylinositol 3-Kinases - metabolism | Diabetes Mellitus, Type 2 - metabolism | Hepatocytes - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Liver - drug effects | Glycogen - biosynthesis | Phosphorylation - drug effects | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Hepatocytes - drug effects | Fibronectins - pharmacology | Fibronectins - administration & dosage | Liver - metabolism | Mice, Inbred C57BL | Cells, Cultured | Diabetes Mellitus, Type 2 - prevention & control | Insulin Resistance | Morpholines - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Fibronectins - blood | Blotting, Western | Glucose-6-Phosphatase - metabolism | Hep G2 Cells | Phosphoenolpyruvate Carboxykinase (ATP) - genetics | Animals | Class I Phosphatidylinositol 3-Kinases | Gluconeogenesis - genetics | Signal Transduction - drug effects | Phosphoenolpyruvate Carboxykinase (ATP) - metabolism | Glucose - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors
Journal Article