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Molecular Cell, ISSN 1097-2765, 03/2016, Volume 61, Issue 5, pp. 705 - 719
It is unclear how the Warburg effect that exemplifies enhanced glycolysis in the cytosol is coordinated with suppressed mitochondrial pyruvate metabolism. We... 
hypoxia | K-Ras | PDH | mitochondria | glycolysis | PGK1 | B-Raf | tumorigenesis | PDHK1 | phosphorylation | EGFR | Mitochondria | Phosphorylation | Glycolysis | Hypoxia | Tumorigenesis | PYRUVATE-DEHYDROGENASE KINASE | HISTONE H3 | PKM2 | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-CELLS | HYPOXIA | CANCER | PROMOTES | HUMAN PHOSPHOGLYCERATE KINASE | GENE-TRANSCRIPTION | CELL BIOLOGY | Mitochondria - enzymology | Receptor, Epidermal Growth Factor - genetics | Glioblastoma - enzymology | Cell Proliferation | Prognosis | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Extracellular Signal-Regulated MAP Kinases - metabolism | Pyruvate Dehydrogenase Complex - genetics | Cell Hypoxia | Receptor, Epidermal Growth Factor - metabolism | Transfection | Glioblastoma - genetics | RNA Interference | Time Factors | Female | Peptidylprolyl Isomerase - metabolism | Peptidylprolyl Isomerase - genetics | Phosphoglycerate Kinase - genetics | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Pyruvate Dehydrogenase Complex - metabolism | Signal Transduction | Protein-Serine-Threonine Kinases - genetics | Rats | NIMA-Interacting Peptidylprolyl Isomerase | Mitochondria - pathology | Citric Acid Cycle | Protein Transport | Animals | Mice, Nude | Proto-Oncogene Proteins B-raf - genetics | Glioblastoma - pathology | Cell Line, Tumor | Protein Binding | Enzyme Activation | Mutation | Phosphoglycerate Kinase - metabolism | Lactates | Glucose metabolism | Gliomas | Isomerization | Mitochondrial DNA | Protein kinases | Cells | Medical colleges | Brain tumors
Journal Article
Molecular Cell, ISSN 1097-2765, 03/2017, Volume 65, Issue 5, pp. 917 - 931.e6
Autophagy is crucial for maintaining cell homeostasis. However, the precise mechanism underlying autophagy initiation remains to be defined. Here, we... 
ARD1 | autophagy | tumor | PGK1 | mTOR | Beclin1 | VPS34 | BREAST-CANCER | NUCLEOTIDE SYNTHESIS | METABOLISM | SIGNALING PATHWAY | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHATIDYLINOSITOL 3-KINASE COMPLEXES | GROWTH | TUMOR-CELLS | BETA-CATENIN | TUMORIGENESIS | CELL BIOLOGY | Glioblastoma - enzymology | Glutamine - deficiency | Phosphorylation | Cell Proliferation | TOR Serine-Threonine Kinases - metabolism | Humans | Autophagosomes - enzymology | Brain Neoplasms - pathology | Autophagy | Tumor Hypoxia | TOR Serine-Threonine Kinases - genetics | Transfection | Glioblastoma - genetics | RNA Interference | Time Factors | HEK293 Cells | Female | Acetylation | Phosphoglycerate Kinase - genetics | Brain Neoplasms - enzymology | Signal Transduction | N-Terminal Acetyltransferase A - genetics | Brain Neoplasms - genetics | Class III Phosphatidylinositol 3-Kinases - metabolism | Tumor Burden | Autophagosomes - pathology | Animals | N-Terminal Acetyltransferase A - metabolism | Class III Phosphatidylinositol 3-Kinases - genetics | Mice, Nude | Glioblastoma - pathology | Beclin-1 - genetics | Cell Line, Tumor | N-Terminal Acetyltransferase E - genetics | Protein Binding | Beclin-1 - metabolism | N-Terminal Acetyltransferase E - metabolism | Phosphoglycerate Kinase - metabolism | Enzymes | Medical colleges | Gliomas | Pancreatic cancer | Brain tumors | Physiological aspects | Phospholipids | Protein kinases | Glutamine
Journal Article
Journal Article
Nature, ISSN 0028-0836, 05/2012, Volume 485, Issue 7399, pp. 522 - 525
Peroxisomes are eukaryotic organelles important for the metabolism of long-chain fatty acids(1,2). Here we show that in numerous fungal species, several core... 
YEAST | TRANSPORT | MEMBRANE | SIGNAL-1 | MULTIDISCIPLINARY SCIENCES | COORDINATION | PROTEINS | IDENTIFICATION | SACCHAROMYCES-CEREVISIAE | MICROBODIES | DEHYDROGENASE | Protein Sorting Signals - physiology | Codon, Terminator - genetics | Virulence | Fungi - cytology | Molecular Sequence Data | Ustilago - enzymology | Isoenzymes - chemistry | Fungi - metabolism | Fungi - genetics | Aspergillus nidulans - metabolism | Phosphoglycerate Kinase - chemistry | Isoenzymes - metabolism | Base Sequence | Fungi - pathogenicity | Aspergillus nidulans - enzymology | Ustilago - pathogenicity | Phosphoglycerate Kinase - genetics | Amino Acid Sequence | Isoenzymes - genetics | Alternative Splicing - genetics | Glyceraldehyde-3-Phosphate Dehydrogenases - genetics | Glyceraldehyde-3-Phosphate Dehydrogenases - chemistry | Peroxisomes - metabolism | Protein Transport | Aspergillus nidulans - cytology | Protein Sorting Signals - genetics | Aspergillus nidulans - pathogenicity | Glycolysis | Glyceraldehyde-3-Phosphate Dehydrogenases - metabolism | Peroxisomes - enzymology | Ustilago - growth & development | Ustilago - cytology | Phosphoglycerate Kinase - metabolism | Fungi | Peroxisomes | Gene targeting | Codon | Genetic engineering | Genetic aspects | Research | Properties | Proteins | Enzymes | Efficiency | Homeostasis | Data bases | Cytoplasm
Journal Article
International Journal of Cancer, ISSN 0020-7136, 03/2010, Volume 126, Issue 6, pp. 1513 - 1520
Peritoneal carcinomatosis is a frequent finding in gastric cancer associated with a poor prognosis. The features that enable gastric tumors to disseminate are... 
PGK1 | CXCR4 | CXCL12 | gastric cancer | cancer dissemination | peritoneal carcinomatosis | Cancer dissemination | Gastric cancer | Peritoneal carcinomatosis | CELLS | METASTASIS | INCREASES | BREAST-CANCER | OVEREXPRESSION | ONCOLOGY | PATHWAY | PROSTATE-CANCER | SECRETION | EXPRESSION | CARCINOMA
Journal Article
Journal Article
Journal Article
The Plant Journal, ISSN 0960-7412, 09/2014, Volume 79, Issue 5, pp. 705 - 716
Summary Arabidopsis thaliana represents a valuable and efficient model to understand mechanisms underlying plant susceptibility to viral diseases. Here, we... 
Watermelon mosaic virus | Potyvirus | resistance gene | Arabidopsis | phosphoglycerate kinase | Phosphoglycerate kinase | Resistance gene | POLYMORPHISM MARKERS | TURNIP-CRINKLE-VIRUS | DEPENDENT RNA-POLYMERASE | INBRED LINE POPULATION | PLANT SCIENCES | TRANSLATION INITIATION-FACTORS | SYMPTOM DEVELOPMENT | 3-PHOSPHOGLYCERATE KINASE | GENOME-LINKED PROTEIN | HYPERSENSITIVE RESPONSE | Chloroplasts - enzymology | Arabidopsis - enzymology | Plant Diseases - immunology | Arabidopsis - immunology | Molecular Sequence Data | Plant Leaves - virology | Seedlings - genetics | Mutation, Missense | Seedlings - enzymology | Arabidopsis Proteins - metabolism | Seedlings - immunology | Plant Diseases - virology | DNA, Plant - chemistry | Plants, Genetically Modified | Cloning, Molecular | Plant Viruses - physiology | Arabidopsis - virology | Plant Leaves - enzymology | Disease Resistance - genetics | Seedlings - virology | DNA, Plant - genetics | Phosphoglycerate Kinase - genetics | Potyvirus - physiology | Amino Acid Sequence | Arabidopsis Proteins - genetics | Chromosome Mapping | Sequence Analysis, DNA | Plant Leaves - immunology | Arabidopsis - genetics | Phenotype | Plant Leaves - genetics | Amino Acid Substitution | Phosphoglycerate Kinase - metabolism | Virus diseases | Proteins | Arabidopsis thaliana | Analysis | Cloning | Genes | Physiological aspects | Genetic research | Health aspects | Plant diseases | Plant resistance
Journal Article
PLoS Genetics, ISSN 1553-7390, 04/2017, Volume 13, Issue 4, p. e1006744
Degeneration and loss of lower motor neurons is the major pathological hallmark of spinal muscular atrophy (SMA), resulting from low levels of... 
UBIQUITIN HOMEOSTASIS | MESSENGER-RNA | MITOCHONDRIAL BIOGENESIS | NEUROLOGICAL DYSFUNCTION | MOUSE MODEL | GENETICS & HEREDITY | SELECTIVE VULNERABILITY | SMN PROTEIN | CHRONIC HEMOLYTIC-ANEMIA | NEUROMUSCULAR-JUNCTIONS | NEURODEGENERATIVE DISEASES | Spinal Cord - metabolism | Spinal Cord - growth & development | Humans | Muscle, Skeletal - metabolism | Prazosin - analogs & derivatives | Prazosin - administration & dosage | Muscular Atrophy, Spinal - genetics | Gene Expression Regulation, Developmental | Spinal Cord - pathology | Adenosine Triphosphate - metabolism | Survival of Motor Neuron 1 Protein - genetics | Phosphoglycerate Kinase - antagonists & inhibitors | Muscular Atrophy, Spinal - physiopathology | Motor Neurons - drug effects | Phosphoglycerate Kinase - genetics | Disease Models, Animal | Muscular Atrophy, Spinal - metabolism | Disease Susceptibility | Axons - metabolism | Mitochondria - metabolism | Survival of Motor Neuron 1 Protein - metabolism | Zebrafish - growth & development | Zebrafish - genetics | Motor Neurons - metabolism | Animals | Energy Metabolism | Axons - pathology | Mice | Muscle, Skeletal - pathology | Zebra fish | Physiological aspects | Development and progression | Models | Genetic aspects | Research | Gene expression | Spinal muscular atrophy | Motor neurons | Neurosciences | Cell survival | SMN protein | Muscles | Zebrafish | Amyotrophic lateral sclerosis | Vulnerability | Phosphoglycerate kinase | Motor task performance | Skeletal muscle | Disease resistance | Mitochondria | Rodents | Phosphoglycerate kinase 1 | Degeneration
Journal Article