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Biochemical Journal, ISSN 0264-6021, 08/2011, Volume 438, Issue 1, pp. 53 - 62
Genetic alterations in PI3K (phosphoinositide 3-kinase) signalling are common in cancer and include deletions in PTEN (phosphatase and tensin homologue deleted... 
Phosphoinositide 4-kinase (PI4K) | Pan-phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235; phosphoinositide 3-kinase α (PI3Kα) | PIK3CA | p110α E545k mutation | PIK3CA H1047R mutation | 3T3-L1 ADIPOCYTES | CATALYTIC SUBUNIT | BIOCHEMISTRY & MOLECULAR BIOLOGY | p110 alpha E545K mutation | phosphoinositide 4-kinase (PI4K) | pan-phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235 | BREAST-CANCER | INSULIN | P110-BETA | phosphoinositide 3-kinase alpha (PI3K alpha) | PIK3CA GENE | IN-VIVO | MUTATIONS | INHIBITORS | IA PI3K ISOFORMS | Class Ia Phosphatidylinositol 3-Kinase - metabolism | Humans | Neoplasms, Experimental - prevention & control | Enzyme Inhibitors - therapeutic use | Class Ia Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Mice, Knockout | Neoplasms, Experimental - pathology | Tissue Distribution | Animals | Enzyme Inhibitors - pharmacokinetics | Signal Transduction - drug effects | Protein Isoforms | Mice | Neoplasms, Experimental - metabolism | Tumor Cells, Cultured | Homeodomain Proteins - physiology | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | PI3K, phosphoinositide 3-kinase | BID, twice daily dosing | p110α E545K mutation | mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235; phosphoinositide 3-kinase α (PI3Kα) | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | PKB, protein kinase B | pan-phosphoinositide 3kinase (PI3K) | PI4K, phosphoinositide 4-kinase | QD, once daily dosing | mTOR, mammalian target of rapamycin | TGI, tumour growth inhibition
Journal Article
by Coulter, Tanya I., MRCPI and Chandra, Anita, PhD, FRCPath and Bacon, Chris M., PhD, FRCPath and Babar, Judith, MRCP, FRCR and Curtis, James, PhD and Screaton, Nick, FRCP, FRCR and Goodlad, John R., MD, FRCPath and Farmer, George, MD and Steele, Cathal Laurence, MB and Leahy, Timothy Ronan, MRCPI and Doffinger, Rainer, PhD, FRCPath and Baxendale, Helen, PhD, FRCPath and Bernatoniene, Jolanta, PhD and Edgar, J. David M., FRCP, FRCPath and Longhurst, Hilary J., PhD, FRCPath and Ehl, Stephan, MD, PhD and Speckmann, Carsten, MD and Grimbacher, Bodo, MD, PhD and Sediva, Anna, MD, PhD and Milota, Tomas, MD and Faust, Saul N., PhD, FRCPCH and Williams, Anthony P., PhD, FRCPath and Hayman, Grant, FRCP, FRCPath and Kucuk, Zeynep Yesim, MD and Hague, Rosie, MRCP, FRCPH and French, Paul, MD, MRCS, DipFMS, FRCPath and Brooker, Richard, FRCPCH and Forsyth, Peter, FRCPath and Herriot, Richard, FRCP, FRCPath and Cancrini, Caterina, MD, PhD and Palma, Paolo, MD, PhD and Ariganello, Paola, MD and Conlon, Niall, PhD, FRCPath and Feighery, Conleth, PhD, FRCPath and Gavin, Patrick J., MD and Jones, Alison, PhD, FRCPCH and Imai, Kohsuke, MD, PhD and Ibrahim, Mohammad A.A., PhD, FRCP, FRCPath and Markelj, Gašper, MD and Abinun, Mario, MD, PhD and Rieux-Laucat, Frédéric, PhD and Latour, Sylvain, PhD and Pellier, Isabelle, MD, PhD and Fischer, Alain, MD, PhD and Touzot, Fabien, MD, PhD and Casanova, Jean-Laurent, MD, PhD and Durandy, Anne, MD, PhD and Burns, Siobhan O., MD, PhD and Savic, Sinisa, PhD, FRCPath and Kumararatne, D.S., FRCPath, DPhil (Oxon) and Moshous, Despina, MD, PhD and Kracker, Sven, PhD and Vanhaesebroeck, Bart, PhD, FMedSci and Okkenhaug, Klaus, PhD and Picard, Capucine, MD, PhD and Nejentsev, Sergey, MD, PhD and Condliffe, Alison M., PhD, FRCP and Cant, Andrew James, MD, FRCP, FRCPH
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 139, Issue 2, pp. 597 - 606.e4
Background Activated phosphoinositide 3-kinase δ syndrome (APDS) is a recently described combined immunodeficiency resulting from gain-of-function mutations in... 
Allergy and Immunology | Activated phosphoinositide 3-kinase δ syndrome | hematopoietic stem cell transplantation | phosphoinositide 3-kinase δ | immunodeficiency | phosphoinositide 3-kinase inhibitor | PIK3CD gene | bronchiectasis | p110δ-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency | Activated phosphoinositide 3-kinase delta syndrome | IMMUNOLOGICAL FEATURES | HYPER-IGM SYNDROME | p110 delta-activating mutation causing senescent T cells | hematopoietic stem cell | COMMON VARIABLE IMMUNODEFICIENCY | PIK3CD | IMMUNOLOGY | lymphadenopathy | REFERENCE VALUES | P110-DELTA | CT | phosphoinositide 3-kinase delta | P110 DELTA | B-CELL | ALLERGY | transplantation | MUTATIONS | Recurrence | Class I Phosphatidylinositol 3-Kinases - genetics | Herpesviridae Infections - mortality | Humans | Middle Aged | Child, Preschool | Infant | Male | Antibiotic Prophylaxis | Respiratory Tract Infections - genetics | Lymphoproliferative Disorders - therapy | Young Adult | Respiratory Tract Infections - mortality | Respiratory Tract Infections - therapy | Immunologic Deficiency Syndromes - mortality | Adult | Female | Surveys and Questionnaires | Herpesviridae Infections - genetics | Child | Immunologic Deficiency Syndromes - therapy | Hematopoietic Stem Cell Transplantation | International Cooperation | Lymphoproliferative Disorders - genetics | Mutation - genetics | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Enzyme Inhibitors - therapeutic use | Lymphoproliferative Disorders - mortality | Animals | Herpesviridae Infections - therapy | Immunoglobulins, Intravenous - therapeutic use | Adolescent | Survival Analysis | Immunologic Deficiency Syndromes - genetics | Mice | Cohort Studies | Immune Deficiencies, Infection, and Systemic Immune Disorders | HSCT, Hematopoietic stem cell transplantation | BALF, Bronchoalveolar lavage fluid | CT, Computed tomography | APDS, Activated phosphoinositide-3 kinase δ syndrome | GOF, Gain of function | PI3K, Phosphoinositide 3-kinase | HSV, Herpes simplex virus | CMV, Cytomegalovirus | OR, Odds ratio | PPV, Pneumococcal polysaccharide vaccine | CNS, Central nervous system
Journal Article
2014, Frontiers Research Topics, ISBN 9782889192441
Web Resource
Biochemical Journal, ISSN 0264-6021, 07/2009, Volume 421, Issue 2, pp. 145 - 156
As an important metabolic pathway, phosphatidylinositol metabolism generates both constitutive and signalling molecules that are crucial for plant growth and... 
Phospholipid | Signalling | Plant | PHOSPHATIDYLINOSITOL MONOPHOSPHATE KINASE | POLLEN-TUBE GROWTH | ARABIDOPSIS-THALIANA | MYOINOSITOL POLYPHOSPHATE 5-PHOSPHATASE | INOSITOL 1,3,4-TRISPHOSPHATE 5/6-KINASE | PHOSPHATIDIC-ACID ACCUMULATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEGATIVE REGULATOR | plant | ROOT-HAIR DEVELOPMENT | phospholipid | ABSCISIC-ACID | D-ALPHA | signalling | Plant Proteins - genetics | Plants - metabolism | Oxidative Stress | Signal Transduction | Calcium - metabolism | Models, Biological | Gene Expression Regulation, Plant | Phosphatidylinositols - metabolism | Plant Proteins - metabolism | Phospholipids - metabolism | Inositol Phosphates - metabolism | Plant Roots - growth & development | PLC, phospholipase C | LPP, lipid phosphate phosphatase | PI3K, phosphoinositide 3-kinase | 5PTase, inositol polyphosphate 5-phosphatase | AVR4, avirulence 4 | PIPK, phosphoinositide phosphate kinase | Review | ABA, abscisic acid | DGK, DAG kinase | AtIPK2, Arabidopsis thaliana inositol polyphosphate kinase 2 | SNX1, sorting nexin 1 | PDK1, phosphoinositide-dependent kinase 1 | ZmPLC1, Zea mays PLC1 | F-actin, filamentous actin | LOX2, lipoxygenase 2 | IAA, indoleacetic acid | OsPIPK, Oryza sativa phosphoinositide phosphate kinase | PA, phosphatidic acid | CTR1, constitutive triple response 1 | DAG, diacylglycerol | PIP5K, phosphoinositide phosphate 5-kinase | PP2A, protein phosphatase 2A | AtCP, actin-capping protein | RACK1, receptor for activated C-kinase 1 | IP3R, Ins(1,4,5)P3 receptor | PI4K, phosphoinositide 4-kinase | PLD, phospholipase D | MAPK, mitogen-activated protein kinase
Journal Article
1966, Proceedings of the 2nd Meeting of the Federation of European Biochemical Societies, Vienna, 21-24 April 1965, v. 2, 80
Book
Biochemical Journal, ISSN 0264-6021, 02/2012, Volume 442, Issue 1, pp. 161 - 169
In in vitro studies class-I PI3Ks (phosphoinositide 3-kinases), class-II PI3Ks and mTOR (mammalian target of rapamycin) have all been described as having roles... 
Glucose metabolism | Mammalian target of rapamycin (mTOR) | Phosphoinositide 3-kinase (PI3K) | Insulin | Phosphoinositide 3-kinase catalytic α polypeptide (PIK3CA) | 3T3-L1 ADIPOCYTES | P110-ALPHA | insulin | phosphoinositide 3-kinase catalytic alpha polypeptide (PIK3CA) | PHOSPHATIDYLINOSITOL 3-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INSULIN-SECRETION | KINASE | mammalian target of rapamycin (mTOR) | PHOSPHOINOSITIDE 3-KINASE | SUFFICIENT | phosphoinositide 3-kinase (PI3K) | P110-BETA | ROLES | GROWTH | glucose metabolism | Furans - pharmacology | Enzyme Inhibitors - pharmacology | Motor Activity - drug effects | Pyridines - pharmacokinetics | Male | Imidazoles - pharmacology | Pyrimidines - pharmacology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Sulfonamides - pharmacology | Quinolines - pharmacology | Sulfonamides - pharmacokinetics | Hydrazones - pharmacology | TOR Serine-Threonine Kinases - antagonists & inhibitors | Eating - drug effects | Furans - pharmacokinetics | Animals | Class I Phosphatidylinositol 3-Kinases | Isoenzymes - metabolism | Glucose - metabolism | Pyrimidines - pharmacokinetics | Mice | Pyridines - pharmacology | Hydrazones - pharmacokinetics | Isoenzymes - antagonists & inhibitors | phosphoinositide 3-kinase catalytic α polypeptide (PIK3CA) | GTT, glucose tolerance test | PI3K, phosphoinositide 3-kinase | BMR, basal metabolic rate | PI3KCA, PI3K catalytic α polypeptide | PTT, pyruvate tolerance test | MS, liquid chromatography tandem MS | LC-MS | ATM, ataxia telangiectasia mutated | KI, knockin | KO, knockout | ITT, insulin tolerance test | PIKK, phosphoinositide kinase-related kinase | mTOR, mammalian target of rapamycin
Journal Article
Annual Review of Medicine, ISSN 0066-4219, 1/2016, Volume 67, Issue 1, pp. 11 - 28
Anticancer targeted therapies are designed to exploit a particular vulnerability in the tumor, which in most cases results from its dependence on an oncogene... 
lymphoproliferative disorders | mammalian target of rapamycin (mTOR) | mutation | breast cancer | phosphoinositide 3-kinase (PI3K) AKT | pathway inhibitors | Mammalian target of rapamycin (mTOR) | Phosphoinositide 3-kinase (PI3K)/AKT | Breast cancer | Lymphoproliferative disorders | Mutation | Pathway inhibitors | MEDICINE, RESEARCH & EXPERIMENTAL | PIK3CA MUTATIONS | PHOSPHATIDYLINOSITOL 3-KINASE | TYROSINE KINASE | ESTROGEN DEPRIVATION | phosphoinositide 3-kinase (PI3K)/AKT | PHOSPHOINOSITIDE 3-KINASE | RENAL-CELL CARCINOMA | POSITIVE BREAST-CANCER | MAMMARY-TUMORS | CHRONIC LYMPHOCYTIC-LEUKEMIA | UP-REGULATION | TOR Serine-Threonine Kinases - metabolism | Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Humans | Antineoplastic Agents - therapeutic use | Receptors, Estrogen - analysis | Receptor Protein-Tyrosine Kinases - metabolism | Breast Neoplasms - drug therapy | Proto-Oncogene Proteins c-akt - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | Breast Neoplasms - chemistry | Phosphatidylinositol 3-Kinase - genetics | Signal Transduction - drug effects | Protein Kinase Inhibitors - therapeutic use | Female | Lymphoproliferative Disorders - drug therapy | Receptor, ErbB-2 - analysis | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Molecular Targeted Therapy - methods | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Care and treatment | Protein kinases | Health aspects | Methods | Cancer
Journal Article
Blood, ISSN 0006-4971, 01/2011, Volume 117, Issue 2, pp. 591 - 594
Phosphatidylinositol-3-kinase p110 delta serves as a central integration point for signaling from cell surface receptors known to promote malignant B-cell... 
PHOSPHOINOSITIDE 3-KINASE P110-DELTA | HEMATOLOGY | ANTIGEN RECEPTOR | Lymphoid Neoplasia | Brief Report
Journal Article
Plant, Cell & Environment, ISSN 0140-7791, 08/2017, Volume 40, Issue 8, pp. 1317 - 1331
Previous physiological and pharmacological studies have suggested that the activity of phosphoinositide‐specific phospholipase C (PI‐PLC) plays an important... 
AtPLC4 calcium | salt stress | phosphoinositide‐specific phospholipase C | Arabidopsis | phosphoinositide-specific phospholipase C | phospholipase C | ABIOTIC STRESS | DIFFERENTIAL EXPRESSION | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE | DROUGHT STRESS | phosphoinositide-specific | PLANT SCIENCES | SIGNAL-TRANSDUCTION | INOSITOL 1,4,5-TRISPHOSPHATE | TRANSGENIC ARABIDOPSIS | PHOSPHATIDIC-ACID | ABSCISIC-ACID | PLANT-GROWTH | Amino Acid Sequence | Transcription, Genetic - drug effects | Arabidopsis - physiology | Arabidopsis - drug effects | Arabidopsis - enzymology | Genes, Plant | Sodium Chloride - pharmacology | Seedlings - drug effects | Sodium - metabolism | Mutation - genetics | Salt-Tolerance - drug effects | Arabidopsis - genetics | Gene Expression Regulation, Plant - drug effects | Seedlings - physiology | Time Factors | Calcium Signaling - drug effects | Models, Biological | Phosphoinositide Phospholipase C - metabolism | Phosphoinositide Phospholipase C - chemistry | Stress, Physiological - drug effects | Arabidopsis thaliana | Yuan (China) | Genetically modified plants | Analysis | Genetic engineering | Genetic transcription | Phospholipases | Stresses | Salt tolerance | Salts | Calcium (intracellular) | Transcription | Abiotic stress | Transgenic | Calcium imaging | Programmable logic controllers | Pharmacology | Stress | Seedlings | Phospholipase C | Phospholipase | Salt | Genotype & phenotype | Programmable logic devices | Stress response | Renilla-luciferin 2-monooxygenase
Journal Article