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Journal Article
Molecular cancer therapeutics, ISSN 1535-7163, 03/2017, Volume 16, Issue 3, pp. 516 - 528
.... The liver is the most common site of metastasis. Mitogen-activated protein kinase kinase (MEK) inhibitors improve survival in V600 BRAF-mutated cutaneous melanoma patients but have limited efficacy in patients with uveal melanoma... 
Life Sciences & Biomedicine | Oncology | Science & Technology | Proto-Oncogene Proteins c-met - metabolism | Phosphoinositide-3 Kinase Inhibitors | Apoptosis - drug effects | Humans | Hepatic Stellate Cells - metabolism | Apoptosis - genetics | Drug Resistance, Neoplasm | JNK Mitogen-Activated Protein Kinases - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Melanoma - genetics | Pyrimidinones - pharmacology | Antineoplastic Agents - pharmacology | Uveal Neoplasms - metabolism | Melanoma - metabolism | GTP-Binding Protein alpha Subunits, Gq-G11 - genetics | Uveal Neoplasms - genetics | Uveal Neoplasms - pathology | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - pathology | Uveal Neoplasms - drug therapy | Hepatocyte Growth Factor - metabolism | Signal Transduction - drug effects | Melanoma - drug therapy | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | Cell Cycle - drug effects | Pyridones - pharmacology | Phosphorylation | Liver | AKT protein | Metastasis | Kinases | Metastases | Proteins | Liver cancer | Conditioning | Explants | Stellate cells | Hepatocyte growth factor | MEK inhibitors | Melanoma | Poly(ADP-ribose) polymerase | MAP kinase | Resistance factors | Patients | 1-Phosphatidylinositol 3-kinase | Ron protein | Signaling | Inhibitors | Hepatocytes | Protein kinase | Stromal cells | Isoforms | Cancer | Apoptosis | Index Medicus | melanoma | MEK | skin cancers | signal transduction | liver | uveal melanoma
Journal Article
ChemMedChem, ISSN 1860-7179, 07/2016, Volume 11, Issue 14, pp. 1517 - 1530
Journal Article
Journal Article
Neuro-oncology (Charlottesville, Va.), ISSN 1523-5866, 06/2018, Volume 20, Issue 6, pp. 764 - 775
...: An unbiased phosphoproteomic screen quantified phosphorylation changes associated with chronic exposure to the mTOR inhibitor rapamycin, and our analysis implicated a role for glycogen synthase kinase (GSK... 
microtubule | GSK3B | MEK | glioblastoma | MAP1B | mTOR | tubulin | glioma | cancer | ERK | Oncology | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | RNA, Small Interfering - genetics | Phosphoinositide-3 Kinase Inhibitors | Phosphorylation | Cell Proliferation | Antibiotics, Antineoplastic - pharmacology | Microtubule-Associated Proteins - genetics | TOR Serine-Threonine Kinases - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Glycogen Synthase Kinase 3 beta - genetics | Male | Phosphatidylinositol 3-Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Proto-Oncogene Proteins c-akt - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | TOR Serine-Threonine Kinases - genetics | Glioblastoma - genetics | Biomarkers, Tumor - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Proto-Oncogene Proteins c-akt - metabolism | Signal Transduction | Glycogen Synthase Kinase 3 beta - antagonists & inhibitors | Microtubule-Associated Proteins - antagonists & inhibitors | Mice, SCID | Glycogen Synthase Kinase 3 beta - metabolism | Sirolimus - pharmacology | Phosphatidylinositol 3-Kinases - genetics | Xenograft Model Antitumor Assays | Animals | Glioblastoma - pathology | Mice, Inbred NOD | Biomarkers, Tumor - genetics | Mice | Glioblastoma - drug therapy | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Apoptosis | Index Medicus | Basic and Translational Investigations
Journal Article