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Journal of Eukaryotic Microbiology, ISSN 1066-5234, 09/2016, Volume 63, Issue 5, pp. 657 - 678
Comparison of the genomes of free‐living Bodo saltans and those of parasitic trypanosomatids reveals that the transition from a free‐living to a parasitic life... 
Trypanosoma | Leishmania | parasitism | adaptation | Leptomonas | Phytomonas | lateral gene transfer | Lateral gene transfer | Parasitism | Adaptation | LIFE-CYCLE | DEPENDENT PHOSPHOFRUCTOKINASE | FATTY-ACID SYNTHESIS | DIFFERENTIAL EXPRESSION | DIHYDROOROTATE DEHYDROGENASE | INSECT TRYPANOSOMATIDS | MICROBIOLOGY | BLOOD-STREAM FORM | SOLANESYL-DIPHOSPHATE SYNTHASE | COMPLEX-I | UBIQUINONE BIOSYNTHESIS | Mitochondria - enzymology | Dolichol - metabolism | Reactive Oxygen Species | Genes, Protozoan - genetics | Trypanosomatina - genetics | Microbodies - metabolism | Ubiquinone - metabolism | Vitamins - metabolism | Pyrimidines - biosynthesis | Eukaryota - metabolism | Protozoan Proteins - genetics | Protein Prenylation | Pyrimidines - metabolism | Amino Acids - metabolism | Coenzymes - metabolism | Trypanosomatina - metabolism | Urea - metabolism | Phospholipids - metabolism | Kinetoplastida - metabolism | Gluconeogenesis | Bacteria - metabolism | Oxidoreductases - metabolism | Purines - metabolism | Carbohydrate Metabolism | Ergosterol - biosynthesis | Lipid Metabolism | Mitochondria - metabolism | Kinetoplastida - enzymology | Mevalonic Acid - metabolism | Bacteria - genetics | Peroxisomes - metabolism | Polyamines - metabolism | Trypanosomatina - enzymology | Eukaryota - genetics | Kinetoplastida - genetics | Folic Acid - metabolism | Glycolysis | Purines - biosynthesis | Pentose Phosphate Pathway | Oxidases | Thiols | Isoenzymes | Genes | Genomics | Tryptophan | Carbohydrate metabolism | Phylogeny | Fatty acids | Fructose | Glucose metabolism | Pyrimidines | Anopheles | Lysine | Physiological aspects | Comparative analysis | Phosphotransferases
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 03/2017, Volume 102, Issue 3, pp. 810 - 821
Context: Polycystic ovary syndrome ( PCOS) is a complex syndrome showing clinical features of an endocrine/metabolic disorder, including hyperinsulinemia and... 
POLYCYSTIC-OVARY-SYNDROME | IONIZATION-MASS-SPECTROMETRY | RISK-FACTORS | TESTOSTERONE | BIOLOGICAL SAMPLES | ENDOCRINOLOGY & METABOLISM | IMPAIRED GLUCOSE-TOLERANCE | NONALCOHOLIC STEATOHEPATITIS | FAT-CELL LIPOLYSIS | OLDER CHINESE | OBESE WOMEN | Arachidonic Acid - metabolism | Gas Chromatography-Mass Spectrometry | Linoleic Acid - metabolism | Humans | Dehydroepiandrosterone Sulfate - metabolism | Case-Control Studies | Young Adult | Testosterone - metabolism | Polycystic Ovary Syndrome - complications | Diet, High-Fat | Mass Spectrometry | Chromatography, Liquid | Adult | Female | Hyperandrogenism - metabolism | Fatty Acids - metabolism | Phosphatidylglycerols - metabolism | Disease Models, Animal | Hyperinsulinism - metabolism | Ceramides - metabolism | Hyperinsulinism - complications | Polycystic Ovary Syndrome - metabolism | Cholesterol, HDL - metabolism | Obesity - complications | Eicosapentaenoic Acid - metabolism | Rats | Sex Hormone-Binding Globulin - metabolism | Lipid Metabolism | Fatty Acids, Unsaturated - metabolism | Rats, Sprague-Dawley | Obesity - metabolism | Triglycerides - metabolism | Hyperandrogenism - complications | Insulin - metabolism | Animals | Cholesterol, LDL - metabolism | Phosphatidic Acids - metabolism | Androgens - metabolism | Blood Glucose - metabolism | Docosahexaenoic Acids - metabolism | Polycystic ovary syndrome | Obesity | Hyperinsulinemia | Lecithin | Polyunsaturated fatty acids | Lipids | Mass spectroscopy | Liquid chromatography | Phospholipids | Metabolism | Arachidonic acid | Insulin | Fatty acids | Patients | Chromatography | Biological activity | Subgroups | Gas chromatography | Androgens | Molecular modelling | Metabolites | Lipid metabolism | Mass spectrometry | Metabolic disorders
Journal Article
Science, ISSN 0036-8075, 8/2010, Volume 329, Issue 5995, pp. 1085 - 1088
Recognition of lipids by proteins is important for their targeting and activation in many signaling pathways, but the mechanisms that regulate such... 
Inositols | Yeasts | Medical research | Starvation | Cell growth | Cell nucleus | REPORTS | Lipids | Phospholipids | Lipid metabolism | FNWI top publication | YEAST | LOCALIZATION | HOMEOSTASIS | PROTEIN | MULTIDISCIPLINARY SCIENCES | H+-ATPASE | VACUOLAR | SACCHAROMYCES-CEREVISIAE | TRANSCRIPTION FACTOR | Vacuolar Proton-Translocating ATPases - genetics | Inositol - metabolism | Saccharomyces cerevisiae - genetics | Endoplasmic Reticulum - metabolism | Recombinant Fusion Proteins - metabolism | Vacuolar Proton-Translocating ATPases - metabolism | Proton-Translocating ATPases - metabolism | Saccharomyces cerevisiae - metabolism | Cell Nucleus - metabolism | Proton-Translocating ATPases - genetics | Cation Transport Proteins - metabolism | Protein Phosphatase 1 - genetics | Cation Transport Proteins - genetics | Genes, Fungal | Transcription, Genetic | Cell Membrane - metabolism | Active Transport, Cell Nucleus | Repressor Proteins - metabolism | Gene Expression Regulation, Fungal | Signal Transduction | Repressor Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Protein Phosphatase 1 - metabolism | Inositol - genetics | Saccharomyces cerevisiae Proteins - metabolism | Glucose - metabolism | Protein Binding | Liposomes - metabolism | Phosphatidic Acids - metabolism | Mutation | Saccharomyces cerevisiae - growth & development | Hydrogen-Ion Concentration | Proteins | Biosynthesis | Research | Metabolism | Signal transduction | Membranes | Biochemistry | Cellular biology
Journal Article
1990, ISBN 9780849359781, 145 p. :$bill. ;$c27 cm.
Book
Nature, ISSN 0028-0836, 04/2011, Volume 472, Issue 7341, pp. 57 - 65
Metabolomics studies hold promise for the discovery of pathways linked to disease processes. Cardiovascular disease (CVD) represents the leading cause of death... 
CHLAMYDIA-PNEUMONIAE | TRIMETHYLAMINE-N-OXIDE | DNA METHYLATION | MULTIDISCIPLINARY SCIENCES | MURINE MACROPHAGES | MOUSE | GENE-EXPRESSION | ATHEROSCLEROSIS | MICE | CORONARY-HEART-DISEASE | MASS-SPECTROMETRY | Choline - metabolism | Dietary Fats - metabolism | Metabolomics | Liver - enzymology | Diet - adverse effects | Atherosclerosis - genetics | Betaine - metabolism | Humans | Phosphatidylcholines - administration & dosage | Phosphatidylcholines - metabolism | Choline - blood | Dietary Fats - pharmacology | Oxygenases - metabolism | Cardiovascular Diseases - blood | Female | Atherosclerosis - microbiology | Betaine - blood | Methylamines - pharmacology | Cardiovascular Diseases - diagnosis | Methylamines - metabolism | Receptors, Scavenger - metabolism | Biomarkers - metabolism | Phosphatidylcholines - blood | Cardiovascular Diseases - metabolism | Risk Assessment | Atherosclerosis - chemically induced | Mice, Inbred C57BL | Phosphatidylcholines - pharmacology | Gene Expression Regulation | Methylamines - blood | Gastrointestinal Tract - microbiology | Biomarkers - blood | Dietary Fats - blood | Atherosclerosis - metabolism | Gastrointestinal Tract - metabolism | Cardiovascular Diseases - microbiology | Macrophages - metabolism | Phenotype | Animals | Choline - administration & dosage | Choline - pharmacology | Germ-Free Life | Cholesterol, HDL - blood | Mice | Oxygenases - genetics | Lecithin | Microbiota (Symbiotic organisms) | Physiological aspects | Research | Cardiovascular diseases | Metabolism | Health aspects | Risk factors | Plasma | Nuclear magnetic resonance--NMR | Heart attacks | Pathogenesis | Lipids | Cardiovascular disease | Probiotics | Metabolites | Diet | Atherosclerosis | Bacteria | Insulin resistance | Mass spectrometry | atherosclerosis | intestinal microbiota | choline | diet | phospholipid | metabolomics
Journal Article
Nature Communications, ISSN 2041-1723, 09/2018, Volume 9, Issue 1, pp. 3737 - 13
Journal Article
Cell Metabolism, ISSN 1550-4131, 05/2012, Volume 15, Issue 5, pp. 691 - 702
Numerous studies in humans link a nonsynonymous genetic polymorphism (I148M) in adiponutrin (ADPN) to various forms of fatty liver disease and liver cirrhosis.... 
ADIPOSE TRIGLYCERIDE LIPASE | COMPARATIVE GENE IDENTIFICATION-58 | LIPID-METABOLISM | MESSENGER-RNA EXPRESSION | FATTY LIVER-DISEASE | FAMILY-MEMBERS | ENZYMES | ENDOCRINOLOGY & METABOLISM | PNPLA3 | CONGENITAL GENERALIZED LIPODYSTROPHY | CHANARIN-DORFMAN-SYNDROME | CELL BIOLOGY | 1-Acylglycerol-3-Phosphate O-Acyltransferase - genetics | Lysophospholipids - metabolism | Up-Regulation | Lipids - genetics | Humans | Cercopithecus aethiops | Acyl Coenzyme A - genetics | Male | Lipids - biosynthesis | Acyltransferases - metabolism | Acyltransferases - genetics | 1-Acylglycerol-3-Phosphate O-Acyltransferase - metabolism | Cysteine Endopeptidases - metabolism | Liver - drug effects | Lipid Metabolism - genetics | Membrane Proteins - metabolism | Dietary Sucrose - metabolism | Phospholipids - metabolism | Acyl Coenzyme A - metabolism | CHO Cells | Fatty Liver - genetics | Phosphatidic Acids - genetics | Cricetinae | Fatty Liver - metabolism | Membrane Proteins - genetics | Liver - metabolism | Models, Molecular | Phospholipids - genetics | Hep G2 Cells | Mice, Knockout | Polymorphism, Genetic | Triglycerides - metabolism | Lysophospholipids - genetics | Animals | Cysteine Endopeptidases - genetics | Mice | Phosphatidic Acids - metabolism | Triglycerides - genetics | COS Cells | Physiological aspects | Medical colleges | Disease susceptibility | Liver diseases | Liver cirrhosis
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2016, Volume 11, Issue 8, pp. e0161803 - 161803
We present a pilot study aimed at determining the effects of expression of ATP-binding cassette member B5 (ABCB5), a previously described marker for... 
OVEREXPRESSION | STEM-CELLS | ACTIVATION | MULTIPARAMETRIC OPTIMIZATION | MULTIDISCIPLINARY SCIENCES | NMR SPECTROSCOPIC ANALYSIS | MULTIDRUG-RESISTANCE | ENERGY-METABOLISM | HYPOXIA | CANCER | P-31 | Melanoma - metabolism | Magnetic Resonance Spectroscopy | Humans | Gene Expression Regulation, Neoplastic | Alanine - metabolism | Melanoma - pathology | Metabolomics - methods | ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics | ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism | Amino Acids - metabolism | Pilot Projects | Lactates - metabolism | Neoplastic Stem Cells - metabolism | RNA Interference | Melanoma - genetics | Glycerylphosphorylcholine - metabolism | Biomarkers, Tumor - metabolism | Cell Line, Tumor | Glucose - metabolism | Biomarkers, Tumor - genetics | Cell Membrane - metabolism | Phosphatidylethanolamines - metabolism | Phospholipids - metabolism | Cell metabolism | Physiological aspects | Genetic aspects | Research | Binding proteins | Melanoma | Energy metabolism | Nuclear magnetic resonance--NMR | Lung cancer | Amino acids | Lipids | Phospholipids | Glucose | Drug resistance | Cell surface | Magnetic resonance spectroscopy | Metabolites | Energy | Spectrum analysis | Interleukin 1 | Inhibition | Lipid metabolism | Water chemistry | Alanine | Degradation products | Statistical analysis | Cold | Phosphorus | Breast cancer | Metabolism | Gene expression | Acids | Stem cells | Glycolysis | Monoclonal antibodies | Hypoxia | Lactic acid | NMR spectroscopy | Surface markers | Tumors | Life Sciences | Cellular Biology | Nuclear magnetic resonance | NMR
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2012, Volume 109, Issue 22, pp. 8517 - 8522
Dietary fish oil containing ω3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), elicit cardioprotective and anti-inflammatory effects... 
Prostaglandins | Receptors | Cellular metabolism | Cyclooxygenase inhibitors | Eicosanoids | Lipids | Phospholipids | Cell membranes | Lipid metabolism | Fatty acids | P388D MACROPHAGES | CYTOSOLIC PHOSPHOLIPASE A | INHIBITION | RAW264.7 CELLS | PROSTAGLANDIN-E SYNTHASE-1 | MULTIDISCIPLINARY SCIENCES | PURIFICATION | N-3 FATTY-ACIDS | CELL-PROLIFERATION | EXPRESSION | ARACHIDONATE | Arachidonic Acid - metabolism | Gas Chromatography-Mass Spectrometry | Male | Macrophages, Peritoneal - cytology | Adenosine Triphosphate - pharmacology | Lipoxygenase - metabolism | Fatty Acids, Omega-3 - pharmacology | Toll-Like Receptor 4 - agonists | Cell Membrane - metabolism | Macrophages, Peritoneal - drug effects | Cell Membrane - drug effects | Cell Line | Fatty Acids, Omega-3 - metabolism | Cells, Cultured | Fatty Acids, Unsaturated - pharmacology | Phospholipases A2 - metabolism | Fatty Acids, Unsaturated - metabolism | Macrophages - cytology | Toll-Like Receptor 4 - metabolism | Blotting, Western | Docosahexaenoic Acids - pharmacology | Macrophages - metabolism | Animals | Signal Transduction - drug effects | Prostaglandin-Endoperoxide Synthases - metabolism | Eicosanoids - metabolism | Arachidonic Acid - pharmacology | Lipopolysaccharides - pharmacology | Membrane Lipids - metabolism | Receptors, Purinergic P2X7 - metabolism | Macrophages - drug effects | Mice | Macrophages, Peritoneal - metabolism | Docosahexaenoic Acids - metabolism | Physiological aspects | Eicosanoic acid | Research | Health aspects | Omega-3 fatty acids | Proteomics | Biological Sciences
Journal Article
Thrombosis and Haemostasis, ISSN 0340-6245, 2014, Volume 111, Issue 3, pp. 518 - 530
Apart from transporting lipids through the body, the human plasma lipoproteins very low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) are also... 
CETP | proteomics | atherothrombosis | LCAT | protein S | Apolipoproteins | coagulation | prenylcysteine oxidase | prothrombin | anti-microbial peptides | cathepcin D | nLC-MS/MS | dermicidin | TFPI-1 | lysozyme C | CD14 | PLTP | lipopolysaccharide binding protein | apoAV | Cardiovascular Biology and Cell Signalling | Prenylcysteine oxidase | Coagulation | Atherothrombosis | Cathepcin D | Lysozyme C | Lipopolysaccharide binding protein | Dermicidin | Antimicrobial peptides | Proteomics | Prothrombin | Protein S | ApoAV | PATTERNS | MASS-SPECTROMETRY | PARAOXONASE-1 | PERIPHERAL VASCULAR DISEASE | DYSLIPIDEMIA | HEMATOLOGY | OXIDATION | apolipoproteins | PROTHROMBINASE | 2-DIMENSIONAL GEL-ELECTROPHORESIS | REVERSE CHOLESTEROL TRANSPORT | ENHANCEMENT | CHYLOMICRONS | Apolipoproteins A - metabolism | Humans | Antimicrobial Cationic Peptides - metabolism | Lipopolysaccharide Receptors - metabolism | Phospholipid Transfer Proteins - metabolism | Protein S - metabolism | Dyslipidemias - blood | Plasma - metabolism | Mass Spectrometry | Blood Coagulation | Lipoproteins - metabolism | Lipoproteins, LDL - metabolism | Prothrombin - metabolism | Apolipoprotein A-V | Computational Biology | Lipid Metabolism | Muramidase - metabolism | Cathepsin D - metabolism | Carbon-Sulfur Lyases - metabolism | Atherosclerosis - blood | Lipoproteins, VLDL - metabolism | Blood Coagulation Disorders - blood | Cholesterol Ester Transfer Proteins - metabolism | Proteome - metabolism | Phosphatidylcholine-Sterol O-Acyltransferase - metabolism
Journal Article