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American journal of human genetics, ISSN 0002-9297, 2016, Volume 99, Issue 5, pp. 1190 - 1198
Uveal melanoma (UM) is a rare intraocular tumor that, similar to cutaneous melanoma, originates from melanocytes. To gain insights into its genetics, we... 
OCULAR MELANOMA | CELLS | COLORECTAL-CANCER | PROTEINS DLK1 | METASTASES | GENETICS & HEREDITY | RISK | EXPRESSION | RADIATION | SF3B1 | SOMATIC MUTATIONS | Melanoma - diagnosis | Exons | Humans | Middle Aged | Male | Phosphoproteins - metabolism | Case-Control Studies | RNA Splicing Factors - metabolism | DNA Copy Number Variations | Melanoma - genetics | Melanocytes - pathology | Tumor Suppressor Proteins - genetics | Aged, 80 and over | Ubiquitin Thiolesterase - metabolism | Adult | Female | Membrane Proteins - metabolism | Eukaryotic Initiation Factor-1 - metabolism | GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism | Tumor Suppressor p53-Binding Protein 1 - metabolism | GTP-Binding Protein alpha Subunits, Gq-G11 - genetics | Uveal Neoplasms - genetics | Genome-Wide Association Study | Tumor Suppressor Proteins - metabolism | GTP-Binding Protein alpha Subunits - metabolism | Tumor Suppressor p53-Binding Protein 1 - genetics | Membrane Proteins - genetics | Eukaryotic Initiation Factor-1 - genetics | Ubiquitin-Protein Ligases - metabolism | GTP-Binding Protein alpha Subunits - genetics | Phosphoproteins - genetics | RNA Splicing Factors - genetics | Ubiquitin Thiolesterase - genetics | Skin Neoplasms | Uveal Neoplasms - diagnosis | Aged | Mutation | Ubiquitin-Protein Ligases - genetics | Genetic aspects | Nucleotide sequencing | Methods | Melanoma | DNA sequencing | Report
Journal Article
Journal of Applied Physiology, ISSN 8750-7587, 05/2012, Volume 112, Issue 9, pp. 1529 - 1537
In this study, the coordinated activation of ubiquitin-proteasome pathway (UPP), autophagy-lysosomal pathway (ALP), and mitochondrial remodeling including... 
Muscle protein degradation | Mitochondrial remodelling | Mitophagy | LC3b | MuRF1 | MAMMALIAN TARGET | mitochondrial remodelling | SPORT SCIENCES | PHYSIOLOGY | ACTIVATED PROTEIN-KINASE | muscle protein degradation | EXERCISE-INDUCED MUSCLE | COORDINATE ACTIVATION | FOXO TRANSCRIPTION FACTORS | HUMAN SKELETAL-MUSCLE | MITOCHONDRIAL FISSION | mitophagy | RESISTANCE EXERCISE | GENE-EXPRESSION | C2C12 MYOTUBES | Protein Kinases - metabolism | AMP-Activated Protein Kinases - metabolism | Phosphorylation | TOR Serine-Threonine Kinases - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Middle Aged | Serine | Ubiquitin - metabolism | Male | Physical Endurance | Insulin - blood | Phosphoproteins - metabolism | Autophagy | Tripartite Motif Proteins | Quadriceps Muscle - enzymology | Time Factors | Forkhead Transcription Factors - metabolism | Mitochondrial Proteins - metabolism | Muscle Proteins - metabolism | Adult | Proto-Oncogene Proteins c-akt - metabolism | Quadriceps Muscle - pathology | Autophagy-Related Protein 12 | Mitochondrial Membrane Transport Proteins - metabolism | Mitochondria, Muscle - enzymology | Signal Transduction | Mitochondria, Muscle - pathology | Small Ubiquitin-Related Modifier Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | SKP Cullin F-Box Protein Ligases - metabolism | Energy Intake | GTP Phosphohydrolases - metabolism | Autophagy-Related Protein 5 | Energy Metabolism | Biopsy | Running | Proteasome Endopeptidase Complex - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Blood Glucose - metabolism | Forkhead Box Protein O3
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 2012, Volume 287, Issue 35, pp. 29579 - 29588
Mammalian target of rapamycin complex 2 (mTORC2) is a key activator of protein kinases that act downstream of insulin and growth factor signaling. Here we... 
TRANSCRIPTION FACTORS | DIABETES-MELLITUS | LIPID-METABOLISM | AKT/PKB | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIVER | MOTIF PHOSPHORYLATION | RICTOR | MICE | KINASE-B | INDUCED INSULIN-RESISTANCE | Phosphorylation - physiology | Humans | Glycogen Synthase Kinase 3 beta | GTPase-Activating Proteins - metabolism | Phosphoproteins - metabolism | Cholesterol - genetics | Proto-Oncogene Proteins c-akt - genetics | Fatty Acids - genetics | Forkhead Transcription Factors - metabolism | Insulin Resistance - physiology | Tumor Suppressor Proteins - genetics | Trans-Activators - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Insulin - genetics | Proto-Oncogene Proteins c-akt - metabolism | Fatty Acids - metabolism | Lipogenesis - physiology | Sterol Regulatory Element Binding Protein 1 - metabolism | Tumor Suppressor Proteins - metabolism | Liver - metabolism | Gene Expression Regulation - physiology | Glucose - genetics | Mice, Transgenic | Phosphoproteins - genetics | Transcription Factors - genetics | Forkhead Transcription Factors - genetics | Glycogen Synthase Kinase 3 - metabolism | Hep G2 Cells | Transcription Factors - metabolism | Insulin - metabolism | Animals | Glycogen Synthase Kinase 3 - genetics | Sterol Regulatory Element Binding Protein 1 - genetics | Adaptor Proteins, Signal Transducing - genetics | Glucose - metabolism | Trans-Activators - metabolism | Forkhead Box Protein O1 | Mice | GTPase-Activating Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Cholesterol - biosynthesis | mTOR Complex (mTORC) | Liver Metabolism | mTOR Complex 2 (mTORC2) | Akt | Metabolism | Lipogenesis | Insulin | Gluconeogenesis
Journal Article
Journal of internal medicine, ISSN 0954-6820, 2013, Volume 274, Issue 1, pp. 25 - 40
Obesity increases the risk of metabolic diseases, including insulin resistance and type 2 diabetes, as well as cardiovascular disease. In addition to lipid... 
lipids | NAFLD | storage | lipid droplets | insulin resistance | lipotoxicity | Insulin resistance | Lipids | Storage | Lipotoxicity | Lipid droplets | TRIGLYCERIDE TRANSFER PROTEIN | DE-NOVO LIPOGENESIS | LIVER-SPECIFIC DELETION | LOW-DENSITY LIPOPROTEIN | SKELETAL-MUSCLE | MEDICINE, GENERAL & INTERNAL | TYROSINE-PHOSPHATASE 1B | FATTY-ACID OXIDATION | APOLIPOPROTEIN-B SECRETION | PLECKSTRIN HOMOLOGY DOMAIN | DIFFERENTIATION-RELATED PROTEIN | Humans | Muscle, Skeletal - metabolism | Diabetes Mellitus, Type 2 - metabolism | Phosphoproteins - metabolism | Inflammation - metabolism | Myocardium - metabolism | Lipoproteins - metabolism | Diabetes Mellitus, Type 2 - etiology | Lipogenesis | Fatty Liver - metabolism | Signal Transduction | Obesity - complications | Liver - metabolism | Insulin Resistance | Lipid Metabolism | Heart Failure - metabolism | Immunity, Innate | Toll-Like Receptor 4 - metabolism | Obesity - metabolism | Triglycerides - metabolism | Animals | Carrier Proteins - metabolism | Metabolic Diseases - metabolism | Lipoproteins, VLDL - metabolism | alpha-2-HS-Glycoprotein - metabolism | Perilipin-1 | Type 2 diabetes | Muscles | Development and progression | pleckstrin homology domain | Klinisk medicin | fatty-acid oxidation | low-density lipoprotein | apolipoprotein-b secretion | triglyceride transfer protein | Clinical Medicine | deletion | tyrosine-phosphatase 1b | endoplasmic-reticulum stress | droplet-associated protein | differentiation-related protein | liver-specific
Journal Article
Nature (London), ISSN 1476-4687, 2012, Volume 482, Issue 7384, pp. 216 - 220
Our understanding of Alzheimer's disease pathogenesis is currently limited by difficulties in obtaining live neurons from patients and the inability to model... 
AMYLOID BETA-PROTEIN | APP | MICROTUBULE-BINDING | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | DOWN-SYNDROME | MOUSE MODEL | TAU | DYSFUNCTION | FIBROBLASTS | SENILE PLAQUES | Neurons - pathology | Coculture Techniques | Humans | Middle Aged | Amyloid beta-Peptides - secretion | tau Proteins - metabolism | Male | Phosphoproteins - metabolism | Endosomes - metabolism | Synapsins - metabolism | Alzheimer Disease - pathology | Cellular Reprogramming | Protease Inhibitors - pharmacology | Amyloid beta-Protein Precursor - secretion | Proteolysis | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Aged, 80 and over | Female | Neurons - metabolism | Phosphorylation - drug effects | Neurons - drug effects | Fibroblasts - metabolism | Induced Pluripotent Stem Cells - metabolism | Astrocytes - cytology | Biomarkers - metabolism | Induced Pluripotent Stem Cells - pathology | Peptide Fragments - metabolism | Cells, Cultured | Peptide Fragments - secretion | Glycogen Synthase Kinase 3 - metabolism | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Protein Precursor - genetics | Models, Biological | Alzheimer Disease - metabolism | Fibroblasts - cytology | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Enzyme Activation | Messenger RNA | Synthesis | Glycogen | Stem cells | Physiological aspects | Research | Alzheimer's disease | Proteins | Phosphorylation | Neurons | Efficiency | Genomes | Mutation | Alzheimers disease
Journal Article
Journal of Bacteriology, ISSN 0021-9193, 07/2006, Volume 188, Issue 13, pp. 4841 - 50
Journal Article
Reproduction, Fertility and Development, ISSN 1031-3613, 08/2009, Volume 21, Issue 7, pp. 909 - 922
Peroxisome proliferator-activated receptor (PPAR) γ belongs to the PPAR family of nuclear transcription factors whose ligands, such as eicosanoids, fatty acids... 
granulosa | Leydig | SIGNALING PATHWAYS | TISSUE | DEVELOPMENTAL BIOLOGY | ARACHIDONIC-ACID | LEYDIG TUMOR-CELLS | MESSENGER-RNAS | REPRODUCTIVE BIOLOGY | ZOOLOGY | GENE-EXPRESSION | PPAR-GAMMA | STAR GENE | TRANSCRIPTION FACTOR | STIMULATED STEROIDOGENESIS | Cercopithecus aethiops | Male | Leydig Cells - drug effects | Cyclic AMP Response Element Modulator - metabolism | Cyclic CMP - analogs & derivatives | PPAR gamma - metabolism | Phosphoproteins - metabolism | RNA, Messenger - metabolism | Granulosa Cells - drug effects | Granulosa Cells - metabolism | Dose-Response Relationship, Drug | Transfection | Cyclic CMP - pharmacology | Leydig Cells - metabolism | Female | Progesterone - biosynthesis | Steroidogenic Factor 1 - metabolism | Thiazolidinediones - pharmacology | Binding Sites | Sterol Regulatory Element Binding Protein 1 - metabolism | PPAR gamma - genetics | CCAAT-Enhancer-Binding Proteins - metabolism | Promoter Regions, Genetic | GATA4 Transcription Factor - metabolism | Signal Transduction | Proto-Oncogene Proteins c-jun - genetics | Phosphoproteins - genetics | CCAAT-Enhancer-Binding Protein-beta - metabolism | Animals | Proto-Oncogene Proteins c-jun - metabolism | Cyclic AMP Response Element-Binding Protein - metabolism | PPAR gamma - agonists | Cell Line, Tumor | Mice | COS Cells | Mitogen-Activated Protein Kinases - metabolism | Phosphoproteins, metabolism | Proto-Oncogene Proteins c-jun, metabolism | Progesterone, biosynthesis | Proto-Oncogene Proteins c-jun, genetics | Steroidogenic Factor 1, metabolism | CCAAT-Enhancer-Binding Proteins, metabolism | PPAR gamma, metabolism | PPAR gamma, genetics | Phosphoproteins, genetics | RNA, Messenger, metabolism | CCAAT-Enhancer-Binding Protein-beta, metabolism | Leydig Cells, metabolism | GATA4 Transcription Factor, metabolism | Leydig Cells, drug effects | Mitogen-Activated Protein Kinases, metabolism | PPAR gamma, agonists | Granulosa Cells, metabolism | Sterol Regulatory Element Binding Protein 1, metabolism | Cyclic CMP, pharmacology | Cyclic CMP, analogs and derivatives | Cyclic AMP Response Element Modulator, metabolism | Granulosa Cells, drug effects | Cyclic AMP Response Element-Binding Protein, metabolism | Thiazolidinediones, pharmacology
Journal Article
The Journal of neuroscience, ISSN 1529-2401, 2011, Volume 31, Issue 42, pp. 14899 - 14909
Multiple sclerosis is a demyelinating disease that affects similar to 2,000,000 people worldwide. In the advanced stages of the disease, endogenous... 
OLIGODENDROCYTE PRECURSORS | FIBROBLAST GROWTH FACTOR-2 | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | MEDICAL PROGRESS | DEMYELINATED LESIONS | ENDOTHELIAL-CELLS | MIRROR MOVEMENTS | DOWN-REGULATION | SYNDROME GENE | LINKED KALLMANNS-SYNDROME | NEUROSCIENCES | Oligodendroglia - metabolism | Cricetulus | Humans | Middle Aged | Cerebral Cortex - pathology | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Male | Glial Fibrillary Acidic Protein - metabolism | Phosphoproteins - metabolism | Cerebral Cortex - metabolism | Antigens, CD - metabolism | Oligodendroglia - drug effects | Transfection - methods | Basic Helix-Loop-Helix Transcription Factors - metabolism | Gangliosides - metabolism | Up-Regulation - physiology | Aged, 80 and over | Fibroblast Growth Factor 2 - metabolism | Adult | Female | Membrane Proteins - metabolism | HLA-DR Antigens - metabolism | Extracellular Matrix Proteins - metabolism | Adult Stem Cells - drug effects | Multiple Sclerosis - metabolism | Cricetinae | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Cells, Cultured | Enzyme Inhibitors - pharmacology | Proteoglycans - metabolism | Antigens - metabolism | Multiple Sclerosis - classification | Nerve Tissue Proteins - metabolism | Oligodendroglia - pathology | Up-Regulation - drug effects | Adult Stem Cells - metabolism | Pyrroles - pharmacology | Animals | Zonula Occludens-1 Protein | Antigens, Differentiation, Myelomonocytic - metabolism | Multiple Sclerosis - pathology | Aged | Mice | Postmortem Changes
Journal Article
The EMBO journal, ISSN 1460-2075, 2014, Volume 34, Issue 3, pp. 307 - 325
The protein kinase PINK1 was recently shown to phosphorylate ubiquitin (Ub) on Ser65, and phosphoUb activates the E3 ligase Parkin allosterically. Here, we... 
PINK1 | phosphorylation | deubiquitinase | ubiquitin | Parkin | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | 63-LINKED POLYUBIQUITIN CHAINS | DAMAGED MITOCHONDRIA | CELL BIOLOGY | E3 LIGASE | ACTIVATE PARKIN | BINDING PROTEINS | CROSS-REACTIVITY | CONJUGATING ENZYME | REVEALS | Phosphorylation - physiology | Ubiquitin-Specific Proteases - genetics | Humans | Endosomal Sorting Complexes Required for Transport - genetics | Mitochondrial Proteins - genetics | Phosphoproteins - metabolism | Polyubiquitin - genetics | Allosteric Regulation - physiology | Mitochondrial Proteins - metabolism | Protein Multimerization - physiology | Ubiquitin Thiolesterase - metabolism | TNF Receptor-Associated Factor 6 - genetics | Ubiquitination - physiology | Ubiquitin-Specific Proteases - metabolism | Polyubiquitin - metabolism | Protein Structure, Tertiary | Endopeptidases - metabolism | Endosomal Sorting Complexes Required for Transport - metabolism | Ubiquitin-Protein Ligases - metabolism | Serine - genetics | Ubiquitin-Conjugating Enzymes - genetics | Phosphoproteins - genetics | Transcription Factors - genetics | Ubiquitin Thiolesterase - genetics | Serine - metabolism | Hydrolysis | Transcription Factors - metabolism | Endopeptidases - genetics | Ubiquitin-Conjugating Enzymes - metabolism | Adaptor Proteins, Signal Transducing - genetics | TNF Receptor-Associated Factor 6 - metabolism | Thiolester Hydrolases - genetics | Thiolester Hydrolases - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin-Protein Ligases - genetics | Enzymes | Phosphorylation | Kinases | Crystal structure
Journal Article