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Free Radical Biology and Medicine, ISSN 0891-5849, 2006, Volume 40, Issue 6, pp. 1045 - 1055
Spermatozoa must undergo capacitation to acquire fertilizing ability. Reactive oxygen species (ROS), such as superoxide anion, hydrogen peroxide (H 2O 2), and... 
Superoxide anion | Signal transduction | Spermatozoa | Hydrogen peroxide | Free radicals | Fertilization | Phosphoproteins | Nitric oxide | Protein kinases | phosphoproteins | KINASE SIGNAL-TRANSDUCTION | HUMAN SPERMATOZOA | nitric oxide | free radicals | fertilization | TYROSINE PHOSPHORYLATION | signal transduction | BIOCHEMISTRY & MOLECULAR BIOLOGY | hydrogen peroxide | protein kinases | PHOSPHOINOSITIDE 3-KINASE | spermatozoa | REDOX REGULATION | ENDOTHELIAL-CELLS | ENDOCRINOLOGY & METABOLISM | NITRIC-OXIDE | HYDROGEN-PEROXIDE | superoxide anion | ACROSOME REACTION | Okadaic Acid - pharmacology | Serum Albumin, Bovine - pharmacology | Butadienes - pharmacology | Phosphorylation | Nitriles - pharmacology | Nitric Oxide - pharmacology | Fetal Blood - physiology | Humans | Reactive Oxygen Species - pharmacology | Hydrogen Peroxide - pharmacology | MAP Kinase Kinase 1 - metabolism | Male | Methionine - pharmacology | Proto-Oncogene Proteins c-akt - physiology | Extracellular Signal-Regulated MAP Kinases - metabolism | Peptides - pharmacology | Tyrosine - metabolism | Androstadienes - pharmacology | Methionine - analogs & derivatives | Sperm Capacitation - drug effects | Phosphatidylinositol 3-Kinases - physiology | Benzamides - pharmacology | Tyrosine | Albumin | Oxides | Phosphotransferases | Free radicals (Chemistry)
Journal Article
Psychopharmacology, ISSN 0033-3158, 2/2016, Volume 233, Issue 3, pp. 447 - 456
Cyclic nucleotide phosphodiesterase-2 (PDE2) is a potential therapeutic target for the treatment of cognitive dysfunction. Using the object recognition test... 
Learning and memory | Neurosciences | Protein kinase G | Soluble guanylyl cyclase | Cyclic AMP | Cognition | Phosphodiesterase-2 | Biomedicine | Cyclic GMP | Nitric oxide synthase | Pharmacology/Toxicology | Object recognition test | Psychiatry | Phosphodiesterase inhibitors | SOCIAL-ISOLATION | PSYCHIATRY | NITRIC-OXIDE SYNTHASE | PERIRHINAL CORTEX | INVOLVEMENT | DEPENDENT PROTEIN-KINASE | ELEMENT-BINDING PROTEIN | NEUROSCIENCES | CONSOLIDATION | CGMP | PHARMACOLOGY & PHARMACY | RAT HIPPOCAMPUS | CAMP | Cyclic Nucleotide Phosphodiesterases, Type 2 - antagonists & inhibitors | Memory - drug effects | Phosphoproteins - drug effects | Cyclic GMP - physiology | Nitric Oxide Synthase - antagonists & inhibitors | Male | Guanylate Cyclase - antagonists & inhibitors | Cyclic AMP Response Element-Binding Protein - drug effects | Phosphoproteins - metabolism | Dose-Response Relationship, Drug | Quinoxalines - pharmacology | Cyclic GMP-Dependent Protein Kinases - antagonists & inhibitors | Oxadiazoles - pharmacology | Microfilament Proteins - metabolism | Cell Adhesion Molecules - drug effects | NG-Nitroarginine Methyl Ester - pharmacology | Triazines - pharmacology | Phosphodiesterase Inhibitors - pharmacology | Imidazoles - pharmacology | Cell Adhesion Molecules - metabolism | Mice, Inbred ICR | Protein Kinase Inhibitors | Animals | Recognition (Psychology) - drug effects | Microfilament Proteins - drug effects | Cyclic AMP Response Element-Binding Protein - metabolism | Carbazoles - pharmacology | Phosphodiesterases | Health aspects | Purine nucleotides | Cognition & reasoning | Memory | Rodents | Psychopharmacology
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2001, Volume 276, Issue 1, pp. 251 - 260
Journal Article
Journal of Endodontics, ISSN 0099-2399, 2013, Volume 39, Issue 6, pp. 806 - 812
Journal Article
Circulation Research: Journal of the American Heart Association, ISSN 0009-7330, 03/2003, Volume 92, Issue 4, pp. 411 - 418
ABSTRACT—Two mechanisms are proposed to account for the inhibition of myosin phosphatase (MP) involved in Ca sensitization of vascular muscle, ie,... 
Hypertension | Rho-kinase | sensitization | Myosin phosphatase | RhoA | PROTEIN-KINASE-C | CARDIAC & CARDIOVASCULAR SYSTEMS | LIGHT-CHAIN PHOSPHATASE | PHOSPHORYLATION | myosin phosphatase | CELL-ADHESION | Ca2+ sensitization | SIGNAL-TRANSDUCTION | ARTERIES | CONTRACTION | NITRIC-OXIDE | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | hypertension | CALCIUM SENSITIZATION | Cyclic GMP - pharmacology | Endothelin-1 - pharmacology | Phosphoprotein Phosphatases - metabolism | Maleimides - pharmacology | Rats, Inbred WKY | rhoA GTP-Binding Protein - metabolism | NG-Nitroarginine Methyl Ester - administration & dosage | Phosphoproteins - metabolism | Threonine - metabolism | Myosin-Light-Chain Phosphatase | Cyclic GMP - analogs & derivatives | Hypertension - chemically induced | rho-Associated Kinases | Muscle Proteins - metabolism | Indoles - pharmacology | Hypertension - enzymology | Phosphorylation - drug effects | Protein-Serine-Threonine Kinases - metabolism | Muscle, Smooth, Vascular - drug effects | Amides - pharmacology | Rats, Inbred SHR | Angiotensin II - pharmacology | Signal Transduction | Cells, Cultured | Enzyme Inhibitors - pharmacology | Intracellular Signaling Peptides and Proteins | Rats | Phosphoprotein Phosphatases - antagonists & inhibitors | Protein Kinase C - antagonists & inhibitors | Enzyme Activation - drug effects | Muscle, Smooth, Vascular - cytology | Rats, Sprague-Dawley | Animals | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology | Pyridines - pharmacology | Muscle, Smooth, Vascular - enzymology
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2012, Volume 287, Issue 1, pp. 91 - 104
GPR55 is activated by L-alpha-lysophosphatidylinositol (LPI) but also by certain cannabinoids. In this study, we investigated the GPR55 pharmacology of various... 
PLANT CANNABINOIDS | NEUROPATHIC PAIN | L-ALPHA-LYSOPHOSPHATIDYLINOSITOL | B-RAF INHIBITORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CB1 RECEPTOR ANTAGONIST | ENDOTHELIAL-CELLS | GPR55 | CANCER-CELL PROLIFERATION | ALLOSTERIC MODULATION | IDENTIFICATION | Analgesics - pharmacology | Plant Extracts - chemistry | Receptor, Cannabinoid, CB2 - agonists | Receptors, G-Protein-Coupled - metabolism | Plant Extracts - pharmacology | Humans | Neuralgia - metabolism | Phosphoproteins - metabolism | Cannabis - chemistry | Pyrazoles - chemistry | Piperidines - pharmacology | Dronabinol - analogs & derivatives | HEK293 Cells | Lysophospholipids - pharmacology | Phosphorylation - drug effects | Dronabinol - pharmacology | Pyrazoles - pharmacology | Allosteric Regulation - drug effects | Piperidines - chemistry | Cannabinoids - chemistry | Cannabinoids - pharmacology | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Analgesics - chemistry | Receptors, G-Protein-Coupled - antagonists & inhibitors | Ligands | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Cannabinoids | G Protein-coupled Receptors (GPCR) | Signal Transduction | AlphaScreen | Allosteric Regulation | Acomplia | PLX-4720 BRAF Inhibitor | Cannabinoid Receptors | Pharmacology | Bitopic Ligand
Journal Article
Neuron, ISSN 0896-6273, 08/2013, Volume 79, Issue 4, pp. 712 - 724
Protein synthesis is critical for circadian clock function, but little is known of how translational regulation controls the master pacemaker in mammals, the... 
CELLS | VPAC RECEPTOR | OSCILLATORS | NUCLEUS | MOUSE | LIGHT | GENE-EXPRESSION | PACEMAKER | VIP | NEUROSCIENCES | RHYTHMICITY | RNA, Small Interfering - genetics | Vasoactive Intestinal Peptide - metabolism | Nitriles - pharmacology | RNA, Messenger - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Phosphorylation - genetics | Period Circadian Proteins - genetics | Light | Indoles - pharmacology | Suprachiasmatic Nucleus - metabolism | TOR Serine-Threonine Kinases - physiology | Phosphoproteins - physiology | Phosphorylation - drug effects | Carrier Proteins - physiology | Butadienes - pharmacology | Purines - pharmacology | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Gene Expression Regulation - physiology | Circadian Rhythm - physiology | Signal Transduction - genetics | Sirolimus - pharmacology | Mice, Knockout | Gene Expression Regulation - drug effects | Animals | Period Circadian Proteins - metabolism | Signal Transduction - drug effects | Phosphoproteins - deficiency | Cell Line, Tumor | Signal Transduction - physiology | Anthraquinones - pharmacology | Mice | Vasoactive Intestinal Peptide - genetics | RNA, Small Interfering - metabolism | Protein biosynthesis | RNA | Vasoactive intestinal peptides | Genetic translation | Protein binding | Medical research | Circadian rhythm | Kinases | Rodents | Genes | mRNA translation | entrainment | mTOR | 4E-BP1 | circadian clock | synchrony | SCN
Journal Article
Journal Article
Diabetes, ISSN 0012-1797, 10/2002, Volume 51, Issue 10, pp. 3049 - 3054
Journal Article
Journal of Endodontics, ISSN 0099-2399, 2011, Volume 37, Issue 5, pp. 650 - 656
Abstract Introduction Biocompatibility of pulp capping materials is important for successful use in dentistry. These materials should be nontoxic and... 
Endocrinology & Metabolism | Dentistry | pulp capping | Calcium hydroxide-containing cement (DYCAL) | enamel matrix derivative (EMD) | human tooth germ stem cells | mineral trioxide aggregate (MTA) | ODONTOBLASTIC DIFFERENTIATION | IN-VITRO | PROTEIN | DENTISTRY, ORAL SURGERY & MEDICINE | HUMAN PULP CELLS | MODEL | PERIODONTAL-LIGAMENT CELLS | Calcium Hydroxide - pharmacology | Dental Sac - cytology | Humans | Dental Cements - pharmacology | Calcium - analysis | Minerals - pharmacology | Extracellular Matrix Proteins - analysis | Phosphoproteins - analysis | Alkaline Phosphatase - analysis | Pulp Capping and Pulpectomy Agents - pharmacology | Calcium Compounds - pharmacology | Silicates - pharmacology | Tooth Germ - drug effects | Cell Survival - drug effects | Microscopy, Electron, Scanning | Calcification, Physiologic - drug effects | Osteogenesis - drug effects | Biomarkers - analysis | Cells, Cultured | Dental Pulp - cytology | Tooth Germ - cytology | Biocompatible Materials - pharmacology | Dental Enamel Proteins - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Oxides - pharmacology | Cell Differentiation - drug effects | Adolescent | Fluorescent Antibody Technique | Stem Cells - drug effects | Aluminum Compounds - pharmacology | Cell Proliferation - drug effects | Collagen Type I - analysis | Sialoglycoproteins - analysis | Drug Combinations | Public contracts | Stem cells | Universities and colleges | Sects | Hydroxides
Journal Article
Molecular BioSystems, ISSN 1742-206X, 2010, Volume 6, Issue 7, pp. 1195 - 1206
Journal Article
Nature Cell Biology, ISSN 1465-7392, 2009, Volume 11, Issue 5, pp. 644 - 651
Loss of cell division cycle 2 (Cdc2, also known as Cdk1) activity after cyclin B degradation is necessary, but not sufficient, for mitotic exit. Proteins...