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Clinical cancer research, ISSN 1078-0432, 07/2015, Volume 21, Issue 13, pp. 2984 - 2992
Life Sciences & Biomedicine | Oncology | Science & Technology | Nitroimidazoles - pharmacology | Phosphoramide Mustards - pharmacology | Rats | Treatment Outcome | Antineoplastic Agents - therapeutic use | Lung Neoplasms - therapy | Positron-Emission Tomography | Chemoradiotherapy | Cell Hypoxia | Xenograft Model Antitumor Assays | Carcinoma, Non-Small-Cell Lung - therapy | Animals | Imidazoles | Nitroimidazoles - therapeutic use | Phosphoramide Mustards - therapeutic use | Triazoles | Lung Neoplasms - diagnostic imaging | Antineoplastic Agents - pharmacology | Carcinoma, Non-Small-Cell Lung - diagnostic imaging | Radiopharmaceuticals | Index Medicus
Journal Article
Clinical cancer research, ISSN 1078-0432, 05/2011, Volume 17, Issue 9, pp. 2997 - 3004
Life Sciences & Biomedicine | Oncology | Science & Technology | Biological and medical sciences | Medical sciences | Antineoplastic agents | Pharmacology. Drug treatments | Neoplasms - metabolism | Prodrugs - administration & dosage | Cell Hypoxia - physiology | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Dose-Response Relationship, Drug | Nitroimidazoles - adverse effects | Nitroimidazoles - therapeutic use | Phosphoramide Mustards - pharmacokinetics | Phosphoramide Mustards - therapeutic use | Antineoplastic Agents - adverse effects | Phosphoramide Mustards - administration & dosage | Phosphoramide Mustards - adverse effects | Adult | Female | Antineoplastic Agents - pharmacokinetics | Nitroimidazoles - pharmacokinetics | Nitroimidazoles - administration & dosage | Cell Hypoxia - drug effects | Disease Progression | Neoplasms - drug therapy | Prodrugs - adverse effects | Maximum Tolerated Dose | Prodrugs - pharmacokinetics | Models, Biological | Aged | Prodrugs - therapeutic use | Neoplasms - pathology | Index Medicus
Journal Article
The lancet oncology, ISSN 1470-2045, 08/2017, Volume 18, Issue 8, pp. 1089 - 1103
Life Sciences & Biomedicine | Oncology | Science & Technology | Doxorubicin - therapeutic use | Humans | Middle Aged | Antibiotics, Antineoplastic - adverse effects | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Phosphoramide Mustards - blood | Soft Tissue Neoplasms - drug therapy | Male | Nitroimidazoles - blood | Nitroimidazoles - adverse effects | Soft Tissue Neoplasms - surgery | Exanthema - chemically induced | Phosphoramide Mustards - administration & dosage | Phosphoramide Mustards - adverse effects | Female | Doxorubicin - administration & dosage | Nitroimidazoles - administration & dosage | Drug Eruptions - etiology | Hematologic Diseases - chemically induced | Survival Rate | Sarcoma - drug therapy | Disease-Free Survival | Antibiotics, Antineoplastic - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Sarcoma - surgery | Stomatitis - chemically induced | Aged | Doxorubicin - adverse effects | Anthracyclines | Product development | Metastasis | Sarcoma | Analysis | Index Medicus
Journal Article
Clinical cancer research, ISSN 1078-0432, 01/2019, Volume 25, Issue 2, pp. 478 - 486
Life Sciences & Biomedicine | Oncology | Science & Technology | Multiple Myeloma - mortality | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Drug Resistance, Neoplasm | Male | Nitroimidazoles - adverse effects | Multiple Myeloma - drug therapy | Nitroimidazoles - therapeutic use | Phosphoramide Mustards - therapeutic use | Phosphoramide Mustards - administration & dosage | Phosphoramide Mustards - adverse effects | Aged, 80 and over | Female | Nitroimidazoles - administration & dosage | Multiple Myeloma - diagnosis | Kaplan-Meier Estimate | Neoplasm Recurrence, Local | Treatment Outcome | Disease Progression | Retreatment | Multiple Myeloma - etiology | Bortezomib - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Neoplasm Staging | Index Medicus
Journal Article
Journal of clinical oncology, ISSN 0732-183X, 11/2016, Volume 34, Issue 32, pp. 3898 - 3905
Life Sciences & Biomedicine | Oncology | Science & Technology | Doxorubicin - therapeutic use | Drug Administration Schedule | Humans | Middle Aged | Kaplan-Meier Estimate | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Sarcoma - drug therapy | Sarcoma - pathology | Disease-Free Survival | Neoplasm Metastasis | Neoplasm Grading | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Phosphoramide Mustards - administration & dosage | Phosphoramide Mustards - adverse effects | Placebos | Female | Aged | Doxorubicin - adverse effects | Doxorubicin - administration & dosage | Index Medicus
Journal Article
Cancer biology & therapy, ISSN 1538-4047, 04/2016, Volume 17, Issue 4, pp. 371 - 380
non-small cell lung cancer | hypoxia | ifosfamide | Evofosfamide | hypoxia-activated prodrug | xenograft | Life Sciences & Biomedicine | Oncology | Science & Technology | Carcinoma, Non-Small-Cell Lung - pathology | Ifosfamide - pharmacology | Lung Neoplasms - drug therapy | Ifosfamide - therapeutic use | Nitroimidazoles - pharmacology | Phosphoramide Mustards - pharmacology | Lung Neoplasms - mortality | Humans | Lung Neoplasms - pathology | Carcinoma, Non-Small-Cell Lung - mortality | Xenograft Model Antitumor Assays | Animals | Nitroimidazoles - therapeutic use | Ifosfamide - administration & dosage | Phosphoramide Mustards - therapeutic use | Phosphoramide Mustards - administration & dosage | Mice | Prodrugs - therapeutic use | Carcinoma, Non-Small-Cell Lung - drug therapy | Prodrugs - pharmacology | Nitroimidazoles - administration & dosage | Index Medicus
Journal Article
Anti-cancer drugs, ISSN 0959-4973, 07/2011, Volume 22, Issue 6, pp. 488 - 493
alkylating drugs | cancer therapy | novel anticancer agent | preclinical studies and clinical trials | glufosfamide | β-D-glucose-isophosphoramide mustard | D-19575 | new therapeutic strategy | oxazaphosphorines | Pharmacology & Pharmacy | Oncology | Life Sciences & Biomedicine | Science & Technology | Phosphoramide Mustards - pharmacology | Humans | Glucose - analogs & derivatives | Antineoplastic Agents, Alkylating - pharmacology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Phosphoramide Mustards - pharmacokinetics | Phosphoramide Mustards - therapeutic use | Drug Design | Phosphoramide Mustards - adverse effects | Cell Death - drug effects | Ifosfamide - pharmacokinetics | Cell Survival - drug effects | Glucose - adverse effects | Ifosfamide - pharmacology | Ifosfamide - therapeutic use | Ifosfamide - adverse effects | Antineoplastic Agents, Alkylating - pharmacokinetics | Glucose - pharmacology | Neoplasms - drug therapy | Antineoplastic Agents, Alkylating - therapeutic use | Glucose - pharmacokinetics | Cell Line, Tumor | Glucose - therapeutic use | Ifosfamide - analogs & derivatives | Neoplasms - pathology | Clinical Trials, Phase I as Topic | Clinical Trials, Phase II as Topic | Index Medicus
Journal Article
Oncology, ISSN 0030-2414, 06/2011, Volume 80, Issue 1-2, pp. 50 - 56
Clinical Study | Soft tissue sarcoma | Hypoxia-activated prodrug | Phase I clinical trial | TH-302 | Life Sciences & Biomedicine | Oncology | Science & Technology | Tumors of the skin and soft tissue. Premalignant lesions | Biological and medical sciences | Medical sciences | Dermatology | Tumors | Doxorubicin - therapeutic use | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Young Adult | Nitroimidazoles - adverse effects | Nitroimidazoles - therapeutic use | Phosphoramide Mustards - pharmacokinetics | Phosphoramide Mustards - therapeutic use | Doxorubicin - analogs & derivatives | Phosphoramide Mustards - adverse effects | Aged, 80 and over | Adult | Female | Neoadjuvant Therapy | Doxorubicin - metabolism | Neutropenia - chemically induced | Nitroimidazoles - pharmacokinetics | Drug Eruptions | Abscess - etiology | Anemia - chemically induced | Treatment Outcome | Granulocyte Colony-Stimulating Factor - therapeutic use | Sarcoma - drug therapy | Doxorubicin - pharmacokinetics | Neutropenia - drug therapy | Cellulitis - chemically induced | Disease-Free Survival | Maximum Tolerated Dose | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Sarcoma - surgery | Stomatitis - chemically induced | Aged | Doxorubicin - adverse effects | Lymphopenia - chemically induced | Drug therapy | Pharmacology | Cancer | Index Medicus
Journal Article
Reproductive biomedicine online, ISSN 1472-6483, 2016, Volume 34, Issue 1, pp. 104 - 114
Obstetrics and Gynecology | 4-hydroperoxycyclophamide (4hc) | the ‘burnout’ theory | 4-hydroxycyclophosphamide(4-OHC) | cyclophosphamide metabolites | in vitro | human primordial follicles | phosphoramide mustard (PM) | developing follicles | Life Sciences & Biomedicine | Obstetrics & Gynecology | Reproductive Biology | Science & Technology | Estradiol - metabolism | Cyclophosphamide - analogs & derivatives | Humans | Immunosuppressive Agents - therapeutic use | Ki-67 Antigen - metabolism | Embryo Culture Techniques | Cyclophosphamide - therapeutic use | Freezing | Ovarian Follicle - drug effects | Phosphoramide Mustards - therapeutic use | Time Factors | Anti-Mullerian Hormone - therapeutic use | Cryopreservation | Culture Media | Adolescent | Female | Child | Ovary - metabolism | Index Medicus
Journal Article
International journal of cancer, ISSN 0020-7136, 06/2014, Volume 134, Issue 11, pp. 2726 - 2734
drug distribution | pharmacodynamic markers | TH‐302 | drug penetration | tumor microenvironment | hypoxia‐activated pro‐drug | TH-302 | hypoxia-activated pro-drug | Life Sciences & Biomedicine | Oncology | Science & Technology | Biological and medical sciences | Multiple tumors. Solid tumors. Tumors in childhood (general aspects) | Medical sciences | Tumors | Prostatic Neoplasms - blood supply | Prostatic Neoplasms - pathology | Cell Hypoxia - drug effects | Biomarkers, Tumor - analysis | Humans | Male | Breast Neoplasms - blood supply | Breast Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Taxoids - administration & dosage | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast Neoplasms - pathology | Mice, Nude | Phosphoramide Mustards - administration & dosage | Female | Mice | Prodrugs - therapeutic use | Tumor Cells, Cultured | Prostatic Neoplasms - drug therapy | Doxorubicin - administration & dosage | Nitroimidazoles - administration & dosage | Anthracyclines | Chemotherapy | Health aspects | Cancer | Hypoxia | Apoptosis | Index Medicus
Journal Article
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Full Text
Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition
BMC cancer, ISSN 1471-2407, 05/2015, Volume 15, Issue 1, pp. 422 - 422
Hypoxia-activated prodrug | Xenograft models | DNA damage | in vivo anti-tumor activity | in vitro cytotoxicity | Hypoxia | Chk1 inhibitor | DNA repair | Cancer | In vivo anti-tumor activity | In vitro cytotoxicity | Life Sciences & Biomedicine | Oncology | Science & Technology | Protein Kinases - metabolism | Thiophenes - therapeutic use | Phosphorylation | Phosphoramide Mustards - pharmacology | Apoptosis - drug effects | Colonic Neoplasms - drug therapy | Humans | Antineoplastic Agents - therapeutic use | Phosphoproteins - metabolism | Tumor Suppressor Protein p53 - genetics | CDC2 Protein Kinase - metabolism | Nitroimidazoles - therapeutic use | Phosphoramide Mustards - therapeutic use | Urea - analogs & derivatives | Female | Antineoplastic Agents - pharmacology | DNA Damage - drug effects | Rad51 Recombinase - metabolism | Cell Survival - drug effects | Nitroimidazoles - pharmacology | Thiophenes - pharmacology | Tumor Suppressor Protein p53 - deficiency | HT29 Cells | Urea - therapeutic use | Animals | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | Mice, Nude | Protein Kinase Inhibitors - therapeutic use | Checkpoint Kinase 1 | Mice | Protein Kinase Inhibitors - pharmacology | Histones - metabolism | Mutation | Urea - pharmacology | Tumor proteins | Index Medicus
Journal Article
British journal of cancer, ISSN 0007-0920, 06/2015, Volume 113, Issue 1, pp. 46 - 56
hypoxia | sarcoma | VEGF-A | radiation | Life Sciences & Biomedicine | Oncology | Science & Technology | Activation, Metabolic | Humans | Male | Antineoplastic Agents - therapeutic use | Combined Modality Therapy | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Sarcoma - drug therapy | Xenograft Model Antitumor Assays | Animals | Nitroimidazoles - therapeutic use | Phosphoramide Mustards - pharmacokinetics | Phosphoramide Mustards - therapeutic use | Antineoplastic Agents - pharmacokinetics | Mice | Mice, Inbred BALB C | Hypoxia-Inducible Factor 1, alpha Subunit - physiology | Sarcoma - radiotherapy | Nitroimidazoles - pharmacokinetics | Index Medicus | Translational Therapeutics
Journal Article