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American Journal of Pathology, ISSN 0002-9440, 04/2004, Volume 164, Issue 4, pp. 1199 - 1209
Tissue-nonspecific alkaline phosphatase (TNAP) hydrolyzes the mineralization inhibitor inorganic pyrophosphate (PP ). Deletion of the TNAP gene (Akp2) in mice... 
INFANTILE ARTERIAL CALCIFICATION | HYDROXYAPATITE FORMATION | GELATIN-GEL | NONSPECIFIC ALKALINE-PHOSPHATASE | BONE MINERALIZATION | CELL MEMBRANE GLYCOPROTEIN-1 | EPIPHYSEAL CARTILAGE | MATRIX VESICLES | GROWTH-PLATE | PATHOLOGY | CHONDROCYTE APOPTOSIS | Diphosphates - pharmacology | Diphosphates - metabolism | Pyrophosphatases - deficiency | Sialoglycoproteins - metabolism | Pyrophosphatases - genetics | Inorganic Chemicals | Alkaline Phosphatase - physiology | Membrane Proteins - deficiency | Phosphate Transport Proteins | Membrane Proteins - metabolism | Phosphoric Diester Hydrolases - deficiency | Bone and Bones - physiology | Phosphoric Diester Hydrolases - metabolism | Enzyme-Linked Immunosorbent Assay | Animals, Genetically Modified | Membrane Proteins - genetics | Osteoblasts - drug effects | Cells, Cultured | Calcification, Physiologic - physiology | Osteopontin | Phosphoric Diester Hydrolases - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Pyrophosphatases - metabolism | Animals | Models, Biological | Mice | Regular | Alkaline Phosphatase/physiology | Blotting; Western | Calcification; Physiologic/physiology | Models; Biological | Cells; Cultured | Phosphoric Diester Hydrolases/deficiency/genetics/metabolism | Animals; Genetically Modified | Bone and Bones/physiology | Osteoblasts/drug effects | Sialoglycoproteins/metabolism | Pyrophosphatases/deficiency/genetics/metabolism | Membrane Proteins/deficiency/genetics/metabolism | Diphosphates/metabolism/pharmacology
Journal Article
The Journal of Biochemistry, ISSN 0021-924X, 03/2019, Volume 165, Issue 3, pp. 269 - 275
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2002, Volume 99, Issue 14, pp. 9445 - 9449
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 5, p. e19595
Background: Vascular calcification is an indicator of elevated cardiovascular risk. Vascular smooth muscle cells (VSMCs), the predominant cell type involved in... 
INFANTILE ARTERIAL CALCIFICATION | DENTIN MATRIX PROTEIN-1 | IN-VITRO | ALKALINE-PHOSPHATASE | OSTEOBLASTS | BIOLOGY | BONE MINERALIZATION | REGULATORS | MICE | UP-REGULATION | CHONDROCYTE DIFFERENTIATION | Calcinosis - genetics | Pyrophosphatases - deficiency | Myocytes, Smooth Muscle - pathology | Skull - pathology | Cell Differentiation | Phosphoric Diester Hydrolases - deficiency | Tibia - metabolism | Calcinosis - metabolism | Myocytes, Smooth Muscle - metabolism | Biomarkers - metabolism | Reproducibility of Results | Phosphoric Diester Hydrolases - metabolism | Osteocytes - metabolism | Mice, Inbred C57BL | Cells, Cultured | Up-Regulation - genetics | Aorta - pathology | Pyrophosphatases - metabolism | Osteoblasts - pathology | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Mice | Calcinosis - pathology | Osteoblasts - metabolism | Calcification | Smooth muscle | Phosphatases | Cardiovascular diseases | Analysis | Organic acids | Calcification (ectopic) | Cell culture | Alkaline phosphatase | Ascorbic acid | Media (culture) | Homeostasis | Osteocytes | SOST protein | Glycerophosphate | Phosphatase | Osteoblasts | Proteins | Pit1 protein | Biomedical materials | Mineralization | Rodents | Aorta | Biocompatibility | Health risks | Glycoproteins | Osteoblastogenesis | Coronary vessels | Proteomics | Biomarkers | Mutation | Laboratory animals
Journal Article
PLoS Genetics, ISSN 1553-7390, 2013, Volume 9, Issue 3, p. e1003226
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 01/2011, Volume 336, Issue 1, pp. 64 - 76
Journal Article
The EMBO Journal, ISSN 0261-4189, 11/2007, Volume 26, Issue 22, pp. 4720 - 4731
Defective Tyrosyl‐DNA phosphodiesterase 1 (TDP1) can cause spinocerebellar ataxia with axonal neuropathy (SCAN1), a neurodegenerative syndrome associated with... 
neurodegeneration | single‐strand breaks | DNA repair | TDP1 | topoisomerase 1 | Topoisomerase 1 | Neurodegeneration | Single-strand breaks | breaks | single-strand | BIOCHEMISTRY & MOLECULAR BIOLOGY | CLEAVABLE COMPLEXES | TOPOISOMERASE-I | MAMMALIAN-CELLS | DNA PHOSPHODIESTERASE TDP1 | DAMAGE | CELL BIOLOGY | SPINOCEREBELLAR ATAXIA | REPLICATION FORKS | CAMPTOTHECIN | dNA repair | AXONAL NEUROPATHY-1 | COVALENT COMPLEXES | Intestines - drug effects | Gamma Rays | Cholesterol - blood | Male | Spleen - drug effects | DNA Breaks, Single-Stranded | Bone Marrow Cells - drug effects | Female | Thymus Gland - growth & development | Antineoplastic Agents - pharmacology | Neurons - metabolism | Phosphoric Diester Hydrolases - deficiency | Spleen - growth & development | Phosphoric Diester Hydrolases - metabolism | Topotecan - pharmacology | DNA Topoisomerases, Type I - metabolism | Bone Marrow Cells - cytology | Cells, Cultured | Hydrogen Peroxide - pharmacology | Thymus Gland - cytology | Phosphoric Diester Hydrolases - genetics | Spleen - cytology | Thymus Gland - drug effects | Serum Albumin - analysis | Mice, Knockout | Animals | Cell Differentiation - drug effects | DNA Repair | Cerebellum - cytology | Mice | Camptothecin - pharmacology | Astrocytes - metabolism | Intestines - cytology | Neurosciences | Cellular biology | Molecular biology | DNA damage | Rodents | single-strand breaks
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2007, Volume 104, Issue 21, pp. 8857 - 8862
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2012, Volume 7, Issue 6, p. e38393
Background: Inorganic pyrophosphate (PPi) is a physiologic inhibitor of hydroxyapatite mineral precipitation involved in regulating mineralized tissue... 
DENTIN MATRIX PROTEIN-1 | IN-VITRO | HYDROXYAPATITE FORMATION | INFANTILE HYPOPHOSPHATASIA | INORGANIC PYROPHOSPHATE | MULTIDISCIPLINARY SCIENCES | CELL MEMBRANE GLYCOPROTEIN-1 | ATTACHMENT APPARATUS | HUMAN PERIODONTAL-LIGAMENT | MECHANICAL-PROPERTIES | ALKALINE-PHOSPHATASE ACTIVITY | Diphosphates - metabolism | Cell Proliferation | Humans | Mandible - pathology | Pyrophosphatases - deficiency | Alkaline Phosphatase - metabolism | Phosphate Transport Proteins - metabolism | Homeostasis | Phosphate Transport Proteins - deficiency | Tooth Root - metabolism | Extracellular Space - metabolism | Time Factors | Gene Expression Regulation, Developmental | Dental Cementum - metabolism | Collagen - biosynthesis | Phosphoric Diester Hydrolases - deficiency | Molar - pathology | Molar - metabolism | Phosphoric Diester Hydrolases - metabolism | Mice, Inbred C57BL | Cells, Cultured | Dental Cementum - pathology | Mice, Knockout | Molar - ultrastructure | Pyrophosphatases - metabolism | Animals | Calcification, Physiologic | Models, Biological | Tooth Root - ultrastructure | Dental Cementum - ultrastructure | Mice | Alkaline Phosphatase - deficiency | Mandible - ultrastructure | Cementogenesis | Phosphatases | Precipitation (Meteorology) | Dentin | Alkaline phosphatase | Surgical implants | Regulators | Animal models | Laboratories | Childrens health | Hydroxyapatite | Biology | Arthritis | mRNA | Phosphatase | Apposition | Proteins | Biomedical materials | Control | Periodontal ligament | Transgenic animals | Mineralization | Bones | Skin diseases | Cements | ANK protein | Inhibition | Growth factors | Pyrophosphatase | Phosphodiesterase | Medical research | Ankylosis | Tissue engineering | Teeth | Histology | Dentistry | Metabolism | Hypophosphatasia | Root development | Children & youth | Studies | Regeneration | Detachment | Calcification | Regulation | Mutation | Cementum
Journal Article