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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2013, Volume 110, Issue 32, pp. 13114 - 13119
Efficient and productive virus infection often requires viral countermeasures that block innate immunity. The IFN-inducible 2',5'-oligoadenylate (2-5A)... 
Coronavirus | Rotavirus | RNA | Liver | Antivirals | Viruses | Amino acids | Mice | Infections | Murine hepatitis virus | Interferon-stiumulated gene | RNA capping enzyme | Nidovirales | Reoviridae | APOPTOSIS | PROTEIN | MOUSE HEPATITIS-VIRUS | 2',5'-OLIGOADENYLATE SYNTHETASE | MULTIDISCIPLINARY SCIENCES | interferon-stiumulated gene | IDENTIFICATION | VIRULENCE | ROTAVIRUS | PATHOGENESIS | REPLICATION | PROSTATE-CANCER | Endoribonucleases - genetics | Humans | Rotavirus - physiology | Rotavirus - immunology | Molecular Sequence Data | RNA Viruses - physiology | Immunoblotting | Murine hepatitis virus - physiology | Host-Pathogen Interactions - immunology | Murine hepatitis virus - immunology | Rotavirus - metabolism | Macrophages - virology | Oligoribonucleotides - metabolism | RNA Viruses - immunology | Binding Sites - immunology | Capsid Proteins - immunology | RNA Virus Infections - immunology | Macrophages - immunology | Viral Nonstructural Proteins - immunology | 2',5'-Oligoadenylate Synthetase - metabolism | Amino Acid Sequence | Cell Line | Phosphoric Diester Hydrolases - metabolism | Endoribonucleases - metabolism | Capsid Proteins - metabolism | Murine hepatitis virus - metabolism | Cells, Cultured | Viral Nonstructural Proteins - genetics | Phosphoric Diester Hydrolases - genetics | RNA Virus Infections - virology | RNA Viruses - metabolism | Binding Sites - genetics | Mice, Knockout | Phosphoric Diester Hydrolases - immunology | Sequence Homology, Amino Acid | Immunity, Innate - immunology | Macrophages - metabolism | Animals | 2',5'-Oligoadenylate Synthetase - immunology | Adenine Nucleotides - metabolism | Viral Nonstructural Proteins - metabolism | Mutation | Capsid Proteins - genetics | Endoribonucleases - immunology | RNA viruses | Antiviral agents | Immune response | Physiological aspects | Dosage and administration | Research | Phosphodiesterases | Health aspects | Biological Sciences
Journal Article
Journal Article
Journal of Autoimmunity, ISSN 0896-8411, 2016, Volume 72, pp. 102 - 112
Journal Article
Immunity, ISSN 1074-7613, 02/2015, Volume 42, Issue 2, pp. 279 - 293
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2014, Volume 193, Issue 2, pp. 617 - 626
T cells exhibit high-speed migration within the paracortical T zone of lymph nodes (LNs) as they scan cognate Ags displayed by dendritic cells in the tissue... 
MIGRATION | ORGANS | LYSOPHOSPHATIDIC ACID RECEPTOR | INTEGRIN ACTIVATION | DENDRITIC CELLS | CHEMOKINES | IMMUNOLOGY | CONTRIBUTES | BINDING | MYOSIN-IIA | LYMPHOCYTES | Propionates - pharmacology | Receptors, Lysophosphatidic Acid - metabolism | Oligonucleotide Array Sequence Analysis | rhoA GTP-Binding Protein - immunology | Lymphocyte Function-Associated Antigen-1 - metabolism | Receptors, Lysophosphatidic Acid - genetics | rhoA GTP-Binding Protein - metabolism | Transcriptome - immunology | rhoA GTP-Binding Protein - genetics | Cell Movement - genetics | Lymphocyte Function-Associated Antigen-1 - immunology | Cell Movement - immunology | Signal Transduction - immunology | Myosin Type II - metabolism | rho-Associated Kinases - metabolism | Lysophospholipids - pharmacology | Female | Myosin Type II - genetics | Microscopy, Fluorescence, Multiphoton | Chemokine CCL21 - pharmacology | Phosphoric Diester Hydrolases - metabolism | Mice, Inbred C57BL | Stromal Cells - metabolism | Cells, Cultured | Lymph Nodes - metabolism | Phosphodiesterase Inhibitors - pharmacology | rho-Associated Kinases - genetics | Stromal Cells - immunology | Phosphoric Diester Hydrolases - genetics | Signal Transduction - genetics | Transcriptome - genetics | Lymph Nodes - immunology | Reverse Transcriptase Polymerase Chain Reaction | Isoxazoles - pharmacology | Phosphoric Diester Hydrolases - immunology | Cell Movement - drug effects | Organophosphonates - pharmacology | Animals | Receptors, Lysophosphatidic Acid - immunology | T-Lymphocytes - cytology | Lymphocyte Function-Associated Antigen-1 - genetics | Anilides - pharmacology | Myosin Type II - immunology | T-Lymphocytes - immunology | rho-Associated Kinases - immunology | Mice
Journal Article
Journal Article
Journal of allergy and clinical immunology, ISSN 0091-6749, 2012, Volume 129, Issue 2, pp. 448 - 455.e5
Journal Article
PLoS pathogens, ISSN 1553-7374, 2011, Volume 7, Issue 8, p. e1002204
Klebsiella pneumoniae causes significant morbidity and mortality worldwide, particularly amongst hospitalized individuals. The principle mechanism for... 
CELLULOSE SYNTHESIS | ESCHERICHIA-COLI | CLONING VEHICLES | MICROBIOLOGY | CYCLIC DIGUANYLATE | PILZ DOMAIN | SIGNAL-TRANSDUCTION | VIROLOGY | INTENSIVE-CARE-UNIT | PSEUDOMONAS-AERUGINOSA | SALMONELLA-TYPHIMURIUM | PHASE VARIATION | PARASITOLOGY | Amino Acid Sequence | Phosphoric Diester Hydrolases - metabolism | Phosphorus-Oxygen Lyases - genetics | Transcriptional Activation | Bacterial Proteins - genetics | Molecular Sequence Data | Escherichia coli Proteins - metabolism | Phosphoric Diester Hydrolases - genetics | Fimbriae, Bacterial - genetics | Biofilms | DNA, Bacterial - genetics | Cyclic GMP - analogs & derivatives | Plasmids | Gene Deletion | Cyclic GMP - genetics | Klebsiella pneumoniae - genetics | Escherichia coli Proteins - genetics | Klebsiella pneumoniae - growth & development | Protein Binding | Bacterial Proteins - metabolism | Klebsiella pneumoniae - metabolism | Gene Expression Regulation, Bacterial | Phosphorus-Oxygen Lyases - metabolism | Fimbriae, Bacterial - metabolism | Klebsiella | Polymerase chain reaction | Usage | Gene mutations | Physiological aspects | Research | Microbial mats | Proteins | Medical equipment | Antibiotics | E coli | Pathogenesis | Standard deviation | Nosocomial infections | Gene expression | Experiments | Urogenital system | Bacteriology | Deoxyribonucleic acid--DNA | Deoxyribonucleic acid | DNA
Journal Article
Journal Article
The Journal of infectious diseases, ISSN 1537-6613, 2012, Volume 206, Issue 2, pp. 229 - 237
The development of drugs for neglected infectious diseases often uses parasite-specific enzymes as targets. We here demonstrate that parasite enzymes with... 
Enzymes | Cell nucleus | Cephalopelvic disproportion | Cell cycle | Parasitism | Trypanocidals | Parasites | Inhibitory concentration 50 | Trypanosome | Daughter cells | AFRICAN TRYPANOSOMES | INFECTIOUS DISEASES | TRANSPORTER | SLEEPING SICKNESS | MICROBIOLOGY | IMMUNOLOGY | TBRPDEB1 | DIAMIDINE | ENZYMES | RESISTANCE | INHIBITORS | PARASITE | BLOOD | Research | Phosphodiesterases | Trypanosoma brucei | Analysis | Major and Brief Reports
Journal Article
Molecular Endocrinology, ISSN 1944-9917, 2012, Volume 26, Issue 5, pp. 786 - 797
Brown adipose tissue is a thermogenic organ that dissipates stored energy as heat to maintain body temperature. This process may also provide protection from... 
TISSUE | HIPPOCAMPAL | INVOLVEMENT | ENDOCRINOLOGY & METABOLISM | PREADIPOCYTE PROLIFERATION | FAT | ADIPOCYTE DIFFERENTIATION | RECEPTOR | LPA | IDENTIFICATION | EXPRESSION | Lysophospholipids - metabolism | Embryo, Mammalian | Obesity - immunology | Adipogenesis - drug effects | Diet, High-Fat - adverse effects | Ion Channels - genetics | Male | Mitochondrial Proteins - genetics | RNA, Messenger - metabolism | Adipokines - blood | Subcutaneous Fat - immunology | Subcutaneous Fat - metabolism | Mitochondrial Proteins - metabolism | Subcutaneous Fat - drug effects | Obesity - etiology | Adipose Tissue, Brown - immunology | Cytokines - blood | Fibroblasts - metabolism | Recombinant Proteins - metabolism | Recombinant Proteins - antagonists & inhibitors | Phosphoric Diester Hydrolases - metabolism | Cells, Cultured | Enzyme Inhibitors - pharmacology | Mice, Transgenic | Phosphoric Diester Hydrolases - genetics | Random Allocation | Fibroblasts - pathology | Subcutaneous Fat - pathology | Adipose Tissue, Brown - pathology | Obesity - metabolism | Obesity - pathology | Phosphoric Diester Hydrolases - chemistry | Gene Expression Regulation - drug effects | Animals | Ion Channels - metabolism | Fibroblasts - drug effects | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Mice | Uncoupling Protein 1 | 500 | Original Research | 200
Journal Article