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2013, Methods in molecular biology, ISBN 1627035621, Volume 1053.
Web Resource
Journal of Molecular Biology, ISSN 0022-2836, 12/2008, Volume 384, Issue 1, pp. 120 - 136
The alkaline phosphatase superfamily comprises a large number of hydrolytic metalloenzymes such as phosphatases and sulfatases. We have characterised a new... 
phosphonate monoester hydrolase | double-displacement mechanism | phosphodiesterase | alkaline phosphatase superfamily | formylglycine | POSTTRANSLATIONAL FORMATION | CATALYTIC PROMISCUITY | ACTIVE-SITE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BURKHOLDERIA CARYOPHILLI PG2982 | ESCHERICHIA-COLI | HUMAN ARYLSULFATASE | PHOSPHOGLYCERATE MUTASE | ESTER HYDROLYSIS | SULFUR PROTEIN ATSB | SITE-SPECIFIC MUTAGENESIS | Glycine - analogs & derivatives | Glycine - metabolism | Hydrolysis - drug effects | Alkaline Phosphatase - metabolism | Crystallography, X-Ray | Rhizobium leguminosarum - enzymology | Mutagenesis - drug effects | Alkaline Phosphatase - chemistry | Protein Structure, Quaternary | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Catalysis | Binding Sites | Phosphoric Diester Hydrolases - metabolism | Protein Structure, Secondary | Models, Molecular | Mutant Proteins - metabolism | Static Electricity | Protein Folding | Phosphoric Diester Hydrolases - chemistry | Substrate Specificity - drug effects | Mutant Proteins - chemistry | Structural Homology, Protein | Kinetics | Evolution, Molecular | Metals - pharmacology | Post-translational modification | Legumes | Enzymes | Cysteine | Phosphatases | Phosphonates | Crystals | Nucleotides | Mimosaceae | Polyols | Nature conservation | Hydrolysis | Beans | Polyethylene glycol | Analysis | Structure | Mass spectrometry | Index Medicus
Journal Article
1995, ISBN 9780849376580, 282
Book
2013, Methods in molecular biology, ISBN 1627035621, Volume 1053.
Web Resource
1988, CRC series in enzyme biology., ISBN 0849343607, 2 v.
Book
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7495, pp. 222 - 227
Activated RAS GTPase signalling is a critical driver of oncogenic transformation and malignant disease. Cellular models of RAS-dependent cancers have been used... 
CELL LUNG-CANCER | RAS-TRANSFORMATION | OVEREXPRESSION | OXIDATIVE STRESS | HMTH1 | MESSENGER-RNA | GENE | MULTIDISCIPLINARY SCIENCES | HUMAN MUTT HOMOLOG | TUMORIGENESIS | SMALL-MOLECULE INHIBITION | ras Proteins - genetics | Colonic Neoplasms - genetics | Proto-Oncogene Proteins p21(ras) | Pyridines - chemistry | Colonic Neoplasms - drug therapy | Humans | Substrate Specificity | DNA Breaks, Single-Stranded - drug effects | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | Phosphoric Monoester Hydrolases - biosynthesis | DNA Repair Enzymes - metabolism | Female | Antineoplastic Agents - pharmacology | DNA Repair Enzymes - antagonists & inhibitors | Homeostasis - drug effects | Aminoquinolines - pharmacology | DNA Repair Enzymes - chemistry | Disease Models, Animal | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Pyrazoles - pharmacology | Crystallization | Models, Molecular | Proto-Oncogene Proteins - genetics | Antineoplastic Agents - chemistry | Mice, SCID | Nucleotides - metabolism | Xenograft Model Antitumor Assays | Animals | Colonic Neoplasms - pathology | DNA Repair | DNA Repair Enzymes - biosynthesis | Proteomics | Protein Conformation | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Phosphoric Monoester Hydrolases - metabolism | Phosphoric Monoester Hydrolases - chemistry | Crizotinib | Enzymes | Colon cancer | Physiological aspects | Genetic aspects | Research | Nucleotides | Studies | Oxidative stress | Inhibitor drugs | Medical prognosis | Homeostasis | Mutation | Kinases | Experiments | Cancer | Index Medicus | Life Sciences | crizotinib | cancer | stereoselectivity | MTH1 | DNA repair | drug
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2010, Volume 107, Issue 28, pp. 12564 - 12569
Here we show that the functional human ortholog of Greatwall protein kinase (Gwl) is the microtubule-associated serine/threonine kinase-like protein, MAST-L.... 
Phosphorylation | Phenotypes | Phosphatases | Mitosis | Metaphase | HeLa cells | Small interfering RNA | Cell separation | Cyclins | Daughter cells | Slippage | Phosphatase | Kinase | Spindle assembly checkpoint | Cell cycle | XENOPUS EGG EXTRACTS | ACTIVATION | cell cycle | spindle assembly checkpoint | MULTIDISCIPLINARY SCIENCES | MITOSIS | kinase | PATHWAY | THROMBOCYTOPENIA | phosphatase | CHECKPOINT | slippage | EXIT | PROGRESSION | Cell Cycle - genetics | Okadaic Acid - pharmacology | RNA, Small Interfering - genetics | Phosphoric Monoester Hydrolases - genetics | Humans | Okadaic Acid - metabolism | Protein-Serine-Threonine Kinases - genetics | Cyclin B1 | Proteins - genetics | Mitosis - drug effects | Proteins - metabolism | Protein Phosphatase 2 - metabolism | Cell Cycle - physiology | Cyclin B - metabolism | Cell Cycle - drug effects | Phosphoric Monoester Hydrolases - metabolism | Protein-Serine-Threonine Kinases - metabolism | RNA, Small Interfering - metabolism | Spindle (Cell division) | Genetic aspects | Properties | Protein kinases | Cell division | Enzymes | Cytokines | Kinases | Enzyme kinetics | Cells | Index Medicus | Protein-Serine-Threonine Kinases | Biochemistry, Molecular Biology | Okadaic Acid | Proteins | Life Sciences | Phosphoric Monoester Hydrolases | Cell Cycle | Cyclin B | RNA, Small Interfering | Protein Phosphatase 2 | Biological Sciences
Journal Article
by Gad, Helge and Gad, Helge and Koolmeister, Tobias and Koolmeister, Tobias and Jemth, Ann-Sofie and Jemth, Ann-Sofie and Eshtad, Saeed and Eshtad, Saeed and Jacques, Sylvain A and Jacques, Sylvain A and Ström, Cecilia E and Ström, Cecilia E and Svensson, Linda M and Svensson, Linda M and Schultz, Niklas and Schultz, Niklas and Lundbäck, Thomas and Lundbäck, Thomas and Einarsdottir, Berglind Osk and Einarsdottir, Berglind Osk and Saleh, Aljona and Saleh, Aljona and Göktürk, Camilla and Göktürk, Camilla and Baranczewski, Pawel and Baranczewski, Pawel and Svensson, Richard and Svensson, Richard and Berntsson, Ronnie P-A and Berntsson, Ronnie P.-A and Gustafsson, Robert and Gustafsson, Robert and Strömberg, Kia and Strömberg, Kia and Sanjiv, Kumar and Sanjiv, Kumar and Jacques-Cordonnier, Marie-Caroline and Jacques-Cordonnier, Marie-Caroline and Desroses, Matthieu and Desroses, Matthieu and Gustavsson, Anna-Lena and Gustavsson, Anna-Lena and Olofsson, Roger and Olofsson, Roger and Johansson, Fredrik and Johansson, Fredrik and Homan, Evert J and Homan, Evert J and Loseva, Olga and Loseva, Olga and Bräutigam, Lars and Bräutigam, Lars and Johansson, Lars and Johansson, Lars and Höglund, Andreas and Höglund, Andreas and Hagenkort, Anna and Hagenkort, Anna and Pham, Therese and Pham, Therese and Altun, Mikael and Altun, Mikael and Gaugaz, Fabienne Z and Gaugaz, Fabienne Z and Vikingsson, Svante and Vikingsson, Svante and Evers, Bastiaan and Evers, Bastiaan and Henriksson, Martin and Henriksson, Martin and Vallin, Karl S A and Vallin, Karl S.A and Wallner, Olov A and Wallner, Olov A and Hammarström, Lars G.J and Hammarström, Lars G J and Wiita, Elisee and Wiita, Elisee and Almlöf, Ingrid and Almlöf, Ingrid and Kalderén, Christina and Kalderén, Christina and Axelsson, Hanna and Axelsson, Hanna and Djureinovic, Tatjana and Djureinovic, Tatjana and Puigvert, Jordi Carreras and Puigvert, Jordi Carreras and Häggblad, Maria and Häggblad, Maria and Jeppsson, Fredrik and Jeppsson, Fredrik and Martens, Ulf and Martens, Ulf and Lundin, Cecilia and Lundin, Cecilia and Lundgren, B and Lundgren, Bo and Granelli, Ingrid and Granelli, Ingrid and ... and Institutionen för medicin och hälsa and Avdelningen för läkemedelsforskning and Linköpings universitet and Hälsouniversitetet
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7495, pp. 215 - 221
Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes... 
TARGET | CELLS | OXIDATIVE STRESS | REPAIR | HMTH1 | PROTEIN | MULTIDISCIPLINARY SCIENCES | DNA-SYNTHESIS | MUTAGENIC SUBSTRATE | CELLULAR SENESCENCE | 8-OXOGUANINE | Neoplasms - metabolism | Humans | Molecular Conformation | Male | Molecular Targeted Therapy | Pyrimidines - chemistry | Pyrophosphatases - antagonists & inhibitors | Enzyme Inhibitors - pharmacokinetics | Enzyme Inhibitors - chemistry | DNA Repair Enzymes - metabolism | Oxidation-Reduction - drug effects | Female | Deoxyguanine Nucleotides - metabolism | Cell Death - drug effects | DNA Repair Enzymes - antagonists & inhibitors | DNA Repair Enzymes - chemistry | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Cell Survival - drug effects | Catalytic Domain | Reproducibility of Results | Crystallization | Enzyme Inhibitors - pharmacology | Models, Molecular | Pyrimidines - pharmacology | Nucleotides - metabolism | Enzyme Inhibitors - therapeutic use | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Pyrimidines - therapeutic use | Pyrimidines - pharmacokinetics | Mice | DNA Damage | Neoplasms - pathology | Phosphoric Monoester Hydrolases - metabolism | Phosphoric Monoester Hydrolases - chemistry | Prevention | Deoxyribonucleotides | DNA damage | Cancer cells | Physiological aspects | Research | Binding proteins | Cancer | Cytotoxicity | Kinases | Cancer therapies | Defects | Proteins | Genotype & phenotype | Mutagenesis | Rodents | Cell cycle | Mutation | Deoxyribonucleic acid--DNA | Tumors | Apoptosis | Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article
Science Signaling, ISSN 1945-0877, 11/2013, Volume 6, Issue 302, pp. rs15 - rs15
Journal Article
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 502, Issue 7473, pp. 672 - 676
Journal Article
Journal Article