X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (2535) 2535
Publication (184) 184
Book Review (161) 161
Conference Proceeding (7) 7
Book Chapter (6) 6
Book / eBook (3) 3
Dissertation (1) 1
Reference (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (2444) 2444
animals (1678) 1678
phosphoric monoester hydrolases - antagonists & inhibitors (1456) 1456
phosphoric monoester hydrolases - metabolism (1170) 1170
humans (863) 863
rats (632) 632
biochemistry & molecular biology (542) 542
phosphorylation (510) 510
kinetics (508) 508
enzyme inhibitors - pharmacology (426) 426
male (423) 423
mice (390) 390
phosphoric monoester hydrolases - genetics (348) 348
hydrogen-ion concentration (267) 267
female (252) 252
cell biology (244) 244
signal transduction (240) 240
in vitro techniques (226) 226
pten phosphohydrolase (203) 203
enzyme activation (201) 201
phosphatases (196) 196
cells, cultured (187) 187
cell line (169) 169
cattle (156) 156
time factors (156) 156
binding sites (149) 149
brain - enzymology (144) 144
activation (143) 143
expression (143) 143
liver - enzymology (143) 143
inositol polyphosphate 5-phosphatases (141) 141
phosphoric monoester hydrolases - physiology (138) 138
proteins (138) 138
cells (137) 137
phosphoric monoester hydrolases - isolation & purification (135) 135
phosphatase (134) 134
enzyme activation - drug effects (129) 129
substrate specificity (129) 129
research (128) 128
hydrolysis (125) 125
pharmacology & pharmacy (125) 125
rabbits (125) 125
molecular sequence data (123) 123
phosphoric monoester hydrolases - chemistry (122) 122
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatases (120) 120
apoptosis (119) 119
phosphatidylinositol 3-kinases - metabolism (118) 118
oncology (117) 117
neurosciences (116) 116
dose-response relationship, drug (115) 115
proto-oncogene proteins c-akt (115) 115
mutation (114) 114
phosphatidylinositol 3-kinases - antagonists & inhibitors (114) 114
calcium - metabolism (113) 113
protein binding (113) 113
tumor cells, cultured (112) 112
magnesium - pharmacology (110) 110
amino acid sequence (109) 109
okadaic acid (106) 106
abridged index medicus (105) 105
enzymes (104) 104
multidisciplinary sciences (104) 104
phosphoric monoester hydrolases - analysis (103) 103
proto-oncogene proteins - metabolism (99) 99
physiological aspects (98) 98
cell line, tumor (96) 96
phosphoric monoester hydrolases (95) 95
chromatography, gel (94) 94
signal transduction - drug effects (93) 93
phosphorylation - drug effects (91) 91
cell membrane - enzymology (90) 90
tumor suppressor proteins - metabolism (90) 90
cancer (89) 89
molecular weight (89) 89
physiology (89) 89
protein (89) 89
article (88) 88
biophysics (88) 88
magnesium (88) 88
immunology (87) 87
adenosine triphosphatases - antagonists & inhibitors (86) 86
protein-serine-threonine kinases - metabolism (86) 86
calcium (85) 85
inhibition (85) 85
cyclic amp - metabolism (84) 84
signal transduction - physiology (84) 84
transfection (83) 83
adenosine triphosphate - metabolism (82) 82
adenosine triphosphate - pharmacology (81) 81
phosphates (81) 81
structure-activity relationship (81) 81
kinase (80) 80
okadaic acid - pharmacology (79) 79
phosphotransferases - metabolism (78) 78
temperature (75) 75
tritium (75) 75
kinases (73) 73
models, biological (73) 73
phosphatidylinositol 3-kinase (73) 73
pten (73) 73
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (2434) 2434
Russian (36) 36
German (35) 35
French (14) 14
Italian (7) 7
Japanese (5) 5
Chinese (3) 3
Polish (2) 2
Slovak (1) 1
Ukrainian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


by Gad, Helge and Gad, Helge and Koolmeister, Tobias and Koolmeister, Tobias and Jemth, Ann-Sofie and Jemth, Ann-Sofie and Eshtad, Saeed and Eshtad, Saeed and Jacques, Sylvain A and Jacques, Sylvain A and Ström, Cecilia E and Ström, Cecilia E and Svensson, Linda M and Svensson, Linda M and Schultz, Niklas and Schultz, Niklas and Lundbäck, Thomas and Lundbäck, Thomas and Einarsdottir, Berglind Osk and Einarsdottir, Berglind Osk and Saleh, Aljona and Saleh, Aljona and Göktürk, Camilla and Göktürk, Camilla and Baranczewski, Pawel and Baranczewski, Pawel and Svensson, Richard and Svensson, Richard and Berntsson, Ronnie P-A and Berntsson, Ronnie P.-A and Gustafsson, Robert and Gustafsson, Robert and Strömberg, Kia and Strömberg, Kia and Sanjiv, Kumar and Sanjiv, Kumar and Jacques-Cordonnier, Marie-Caroline and Jacques-Cordonnier, Marie-Caroline and Desroses, Matthieu and Desroses, Matthieu and Gustavsson, Anna-Lena and Gustavsson, Anna-Lena and Olofsson, Roger and Olofsson, Roger and Johansson, Fredrik and Johansson, Fredrik and Homan, Evert J and Homan, Evert J and Loseva, Olga and Loseva, Olga and Bräutigam, Lars and Bräutigam, Lars and Johansson, Lars and Johansson, Lars and Höglund, Andreas and Höglund, Andreas and Hagenkort, Anna and Hagenkort, Anna and Pham, Therese and Pham, Therese and Altun, Mikael and Altun, Mikael and Gaugaz, Fabienne Z and Gaugaz, Fabienne Z and Vikingsson, Svante and Vikingsson, Svante and Evers, Bastiaan and Evers, Bastiaan and Henriksson, Martin and Henriksson, Martin and Vallin, Karl S A and Vallin, Karl S.A and Wallner, Olov A and Wallner, Olov A and Hammarström, Lars G.J and Hammarström, Lars G J and Wiita, Elisee and Wiita, Elisee and Almlöf, Ingrid and Almlöf, Ingrid and Kalderén, Christina and Kalderén, Christina and Axelsson, Hanna and Axelsson, Hanna and Djureinovic, Tatjana and Djureinovic, Tatjana and Puigvert, Jordi Carreras and Puigvert, Jordi Carreras and Häggblad, Maria and Häggblad, Maria and Jeppsson, Fredrik and Jeppsson, Fredrik and Martens, Ulf and Martens, Ulf and Lundin, Cecilia and Lundin, Cecilia and Lundgren, B and Lundgren, Bo and Granelli, Ingrid and Granelli, Ingrid and ... and Institutionen för medicin och hälsa and Avdelningen för läkemedelsforskning and Linköpings universitet and Hälsouniversitetet
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7495, pp. 215 - 221
Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes... 
TARGET | CELLS | OXIDATIVE STRESS | REPAIR | HMTH1 | PROTEIN | MULTIDISCIPLINARY SCIENCES | DNA-SYNTHESIS | MUTAGENIC SUBSTRATE | CELLULAR SENESCENCE | 8-OXOGUANINE | Neoplasms - metabolism | Humans | Molecular Conformation | Male | Molecular Targeted Therapy | Pyrimidines - chemistry | Pyrophosphatases - antagonists & inhibitors | Enzyme Inhibitors - pharmacokinetics | Enzyme Inhibitors - chemistry | DNA Repair Enzymes - metabolism | Oxidation-Reduction - drug effects | Female | Deoxyguanine Nucleotides - metabolism | Cell Death - drug effects | DNA Repair Enzymes - antagonists & inhibitors | DNA Repair Enzymes - chemistry | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Cell Survival - drug effects | Catalytic Domain | Reproducibility of Results | Crystallization | Enzyme Inhibitors - pharmacology | Models, Molecular | Pyrimidines - pharmacology | Nucleotides - metabolism | Enzyme Inhibitors - therapeutic use | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Pyrimidines - therapeutic use | Pyrimidines - pharmacokinetics | Mice | DNA Damage | Neoplasms - pathology | Phosphoric Monoester Hydrolases - metabolism | Phosphoric Monoester Hydrolases - chemistry | Prevention | Deoxyribonucleotides | DNA damage | Cancer cells | Physiological aspects | Research | Binding proteins | Cancer | Cytotoxicity | Kinases | Cancer therapies | Defects | Proteins | Genotype & phenotype | Mutagenesis | Rodents | Cell cycle | Mutation | Deoxyribonucleic acid--DNA | Tumors | Apoptosis | Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7495, pp. 222 - 227
Activated RAS GTPase signalling is a critical driver of oncogenic transformation and malignant disease. Cellular models of RAS-dependent cancers have been used... 
CELL LUNG-CANCER | RAS-TRANSFORMATION | OVEREXPRESSION | OXIDATIVE STRESS | HMTH1 | MESSENGER-RNA | GENE | MULTIDISCIPLINARY SCIENCES | HUMAN MUTT HOMOLOG | TUMORIGENESIS | SMALL-MOLECULE INHIBITION | ras Proteins - genetics | Colonic Neoplasms - genetics | Proto-Oncogene Proteins p21(ras) | Pyridines - chemistry | Colonic Neoplasms - drug therapy | Humans | Substrate Specificity | DNA Breaks, Single-Stranded - drug effects | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | Phosphoric Monoester Hydrolases - biosynthesis | DNA Repair Enzymes - metabolism | Female | Antineoplastic Agents - pharmacology | DNA Repair Enzymes - antagonists & inhibitors | Homeostasis - drug effects | Aminoquinolines - pharmacology | DNA Repair Enzymes - chemistry | Disease Models, Animal | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Pyrazoles - pharmacology | Crystallization | Models, Molecular | Proto-Oncogene Proteins - genetics | Antineoplastic Agents - chemistry | Mice, SCID | Nucleotides - metabolism | Xenograft Model Antitumor Assays | Animals | Colonic Neoplasms - pathology | DNA Repair | DNA Repair Enzymes - biosynthesis | Proteomics | Protein Conformation | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Phosphoric Monoester Hydrolases - metabolism | Phosphoric Monoester Hydrolases - chemistry | Crizotinib | Enzymes | Colon cancer | Physiological aspects | Genetic aspects | Research | Nucleotides | Studies | Oxidative stress | Inhibitor drugs | Medical prognosis | Homeostasis | Mutation | Kinases | Experiments | Cancer | Index Medicus | Life Sciences | crizotinib | cancer | stereoselectivity | MTH1 | DNA repair | drug
Journal Article
by Berglund, U. Warpman and Warpman Berglund, U and Sanjiv, K and Sanjiv, K and Gad, H and Gad, H and Kalderén, C and Kalderén, C and Koolmeister, T and Koolmeister, T and Pham, T and Pham, T and Gokturk, C and Gokturk, C and Jafari, R and Jafari, R and Maddalo, G and Maddalo, G and Seashore-Ludlow, B and Seashore-Ludlow, B and Chernobrovkin, A and Chernobrovkin, A and Manoilov, A and Manoilov, A and Pateras, I.S and Pateras, I.S and Rasti, A and Rasti, A and Jemth, A-S and Jemth, A.-S and Almlöf, I and Almlöf, I and Loseva, O and Loseva, O and Visnes, T and Visnes, T and Einarsdottir, B.O and Einarsdottir, B.O and Gaugaz, F.Z and Gaugaz, F.Z and Saleh, A and Saleh, A and Platzack, B and Platzack, B and Wallner, O.A and Wallner, O.A and Vallin, K S A and Vallin, K.S.A and Henriksson, M and Henriksson, M and Wakchaure, P and Wakchaure, P and Borhade, S and Borhade, S and Herr, P and Herr, P and Kallberg, Y and Kallberg, Y and Baranczewski, P and Baranczewski, P and Homan, E.J and Homan, E.J and Wiita, E and Wiita, E and Nagpal, V and Nagpal, V and Meijer, T and Meijer, T and Schipper, N and Schipper, N and Rudd, S.G and Rudd, S.G and Bräutigam, L and Bräutigam, L and Lindqvist, A and Lindqvist, A and Filppula, A and Filppula, A and Lee, T.-C and Lee, T-C and Artursson, P and Artursson, P and Nilsson, J.A and Nilsson, J.A and Gorgoulis, V.G and Gorgoulis, V.G and Lehtiö, J and Lehtiö, J and Zubarev, R.A and Zubarev, R.A and Scobie, M and Scobie, M and Helleday, T and Helleday, Thomas and SP Process Development
Annals of oncology : official journal of the European Society for Medical Oncology, ISSN 0923-7534, 2016, Volume 27, Issue 12, pp. 2275 - 2283
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2004, Volume 101, Issue 47, pp. 16419 - 16424
Stimulation of cells with various peptide growth factors induces the production of phosphatidylinositol 3,4,5-trisphosphate ( PIP ) through activation of... 
Phagocytes | Molecules | Biological Sciences | Cell growth | Phosphatases | NIH 3T3 cells | HEK293 cells | Memory interference | Cell lines | HeLa cells | Oxidation | Peroxiredoxin | Peptide growth factor receptor | Hydrogen peroxide | peroxiredoxin | PHOSPHATIDYLINOSITOL 3-KINASE | MULTIDISCIPLINARY SCIENCES | hydrogen peroxide | CYSTEINE-SULFINIC ACID | NECROSIS-FACTOR-ALPHA | peptide growth factor receptor | SACCHAROMYCES-CEREVISIAE | SIGNAL-TRANSDUCTION | TYROSINE-PHOSPHATASE 1B | REDOX REGULATION | IN-VIVO | HYDROGEN-PEROXIDE | NIH 3T3 Cells | Tumor Suppressor Proteins - antagonists & inhibitors | Humans | Protein Tyrosine Phosphatases - metabolism | Protein Tyrosine Phosphatases - antagonists & inhibitors | Protein Tyrosine Phosphatases - genetics | Transfection | PTEN Phosphohydrolase | Tumor Suppressor Proteins - genetics | Phosphatidylinositol Phosphates - biosynthesis | Peroxidases - metabolism | NADH, NADPH Oxidoreductases - metabolism | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Cell Line | Insulin - pharmacology | NADH, NADPH Oxidoreductases - genetics | Gene Expression | Phosphoric Monoester Hydrolases - genetics | Tumor Suppressor Proteins - metabolism | Oxidation-Reduction | Signal Transduction | Proto-Oncogene Proteins c-sis | Platelet-Derived Growth Factor - pharmacology | Recombinant Proteins - pharmacology | NADPH Oxidase 1 | Hydrogen Peroxide - metabolism | Peroxiredoxins | Animals | Models, Biological | Mice | Epidermal Growth Factor - pharmacology | HeLa Cells | Peroxidases - genetics | Phosphoric Monoester Hydrolases - metabolism | Peptides | Oxidation-reduction reaction | Research | Biochemistry | Tumors | Index Medicus
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 2014, Volume 5, pp. 4930 - 4930
Journal Article
Journal Article