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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2010, Volume 107, Issue 28, pp. 12564 - 12569
Here we show that the functional human ortholog of Greatwall protein kinase (Gwl) is the microtubule-associated serine/threonine kinase-like protein, MAST-L.... 
Phosphorylation | Phenotypes | Phosphatases | Mitosis | Metaphase | HeLa cells | Small interfering RNA | Cell separation | Cyclins | Daughter cells | Slippage | Phosphatase | Kinase | Spindle assembly checkpoint | Cell cycle | XENOPUS EGG EXTRACTS | ACTIVATION | cell cycle | spindle assembly checkpoint | MULTIDISCIPLINARY SCIENCES | MITOSIS | kinase | PATHWAY | THROMBOCYTOPENIA | phosphatase | CHECKPOINT | slippage | EXIT | PROGRESSION | Cell Cycle - genetics | Okadaic Acid - pharmacology | RNA, Small Interfering - genetics | Phosphoric Monoester Hydrolases - genetics | Humans | Okadaic Acid - metabolism | Protein-Serine-Threonine Kinases - genetics | Cyclin B1 | Proteins - genetics | Mitosis - drug effects | Proteins - metabolism | Protein Phosphatase 2 - metabolism | Cell Cycle - physiology | Cyclin B - metabolism | Cell Cycle - drug effects | Phosphoric Monoester Hydrolases - metabolism | Protein-Serine-Threonine Kinases - metabolism | RNA, Small Interfering - metabolism | Spindle (Cell division) | Genetic aspects | Properties | Protein kinases | Cell division | Enzymes | Cytokines | Kinases | Enzyme kinetics | Cells | Index Medicus | Protein-Serine-Threonine Kinases | Biochemistry, Molecular Biology | Okadaic Acid | Proteins | Life Sciences | Phosphoric Monoester Hydrolases | Cell Cycle | Cyclin B | RNA, Small Interfering | Protein Phosphatase 2 | Biological Sciences
Journal Article
by Gad, Helge and Gad, Helge and Koolmeister, Tobias and Koolmeister, Tobias and Jemth, Ann-Sofie and Jemth, Ann-Sofie and Eshtad, Saeed and Eshtad, Saeed and Jacques, Sylvain A and Jacques, Sylvain A and Ström, Cecilia E and Ström, Cecilia E and Svensson, Linda M and Svensson, Linda M and Schultz, Niklas and Schultz, Niklas and Lundbäck, Thomas and Lundbäck, Thomas and Einarsdottir, Berglind Osk and Einarsdottir, Berglind Osk and Saleh, Aljona and Saleh, Aljona and Göktürk, Camilla and Göktürk, Camilla and Baranczewski, Pawel and Baranczewski, Pawel and Svensson, Richard and Svensson, Richard and Berntsson, Ronnie P-A and Berntsson, Ronnie P.-A and Gustafsson, Robert and Gustafsson, Robert and Strömberg, Kia and Strömberg, Kia and Sanjiv, Kumar and Sanjiv, Kumar and Jacques-Cordonnier, Marie-Caroline and Jacques-Cordonnier, Marie-Caroline and Desroses, Matthieu and Desroses, Matthieu and Gustavsson, Anna-Lena and Gustavsson, Anna-Lena and Olofsson, Roger and Olofsson, Roger and Johansson, Fredrik and Johansson, Fredrik and Homan, Evert J and Homan, Evert J and Loseva, Olga and Loseva, Olga and Bräutigam, Lars and Bräutigam, Lars and Johansson, Lars and Johansson, Lars and Höglund, Andreas and Höglund, Andreas and Hagenkort, Anna and Hagenkort, Anna and Pham, Therese and Pham, Therese and Altun, Mikael and Altun, Mikael and Gaugaz, Fabienne Z and Gaugaz, Fabienne Z and Vikingsson, Svante and Vikingsson, Svante and Evers, Bastiaan and Evers, Bastiaan and Henriksson, Martin and Henriksson, Martin and Vallin, Karl S A and Vallin, Karl S.A and Wallner, Olov A and Wallner, Olov A and Hammarström, Lars G.J and Hammarström, Lars G J and Wiita, Elisee and Wiita, Elisee and Almlöf, Ingrid and Almlöf, Ingrid and Kalderén, Christina and Kalderén, Christina and Axelsson, Hanna and Axelsson, Hanna and Djureinovic, Tatjana and Djureinovic, Tatjana and Puigvert, Jordi Carreras and Puigvert, Jordi Carreras and Häggblad, Maria and Häggblad, Maria and Jeppsson, Fredrik and Jeppsson, Fredrik and Martens, Ulf and Martens, Ulf and Lundin, Cecilia and Lundin, Cecilia and Lundgren, B and Lundgren, Bo and Granelli, Ingrid and Granelli, Ingrid and ... and Institutionen för medicin och hälsa and Avdelningen för läkemedelsforskning and Linköpings universitet and Hälsouniversitetet
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7495, pp. 215 - 221
Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes... 
TARGET | CELLS | OXIDATIVE STRESS | REPAIR | HMTH1 | PROTEIN | MULTIDISCIPLINARY SCIENCES | DNA-SYNTHESIS | MUTAGENIC SUBSTRATE | CELLULAR SENESCENCE | 8-OXOGUANINE | Neoplasms - metabolism | Humans | Molecular Conformation | Male | Molecular Targeted Therapy | Pyrimidines - chemistry | Pyrophosphatases - antagonists & inhibitors | Enzyme Inhibitors - pharmacokinetics | Enzyme Inhibitors - chemistry | DNA Repair Enzymes - metabolism | Oxidation-Reduction - drug effects | Female | Deoxyguanine Nucleotides - metabolism | Cell Death - drug effects | DNA Repair Enzymes - antagonists & inhibitors | DNA Repair Enzymes - chemistry | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Cell Survival - drug effects | Catalytic Domain | Reproducibility of Results | Crystallization | Enzyme Inhibitors - pharmacology | Models, Molecular | Pyrimidines - pharmacology | Nucleotides - metabolism | Enzyme Inhibitors - therapeutic use | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Pyrimidines - therapeutic use | Pyrimidines - pharmacokinetics | Mice | DNA Damage | Neoplasms - pathology | Phosphoric Monoester Hydrolases - metabolism | Phosphoric Monoester Hydrolases - chemistry | Prevention | Deoxyribonucleotides | DNA damage | Cancer cells | Physiological aspects | Research | Binding proteins | Cancer | Cytotoxicity | Kinases | Cancer therapies | Defects | Proteins | Genotype & phenotype | Mutagenesis | Rodents | Cell cycle | Mutation | Deoxyribonucleic acid--DNA | Tumors | Apoptosis | Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article
Science Signaling, ISSN 1945-0877, 11/2013, Volume 6, Issue 302, pp. rs15 - rs15
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 502, Issue 7473, pp. 672 - 676
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7495, pp. 222 - 227
Activated RAS GTPase signalling is a critical driver of oncogenic transformation and malignant disease. Cellular models of RAS-dependent cancers have been used... 
CELL LUNG-CANCER | RAS-TRANSFORMATION | OVEREXPRESSION | OXIDATIVE STRESS | HMTH1 | MESSENGER-RNA | GENE | MULTIDISCIPLINARY SCIENCES | HUMAN MUTT HOMOLOG | TUMORIGENESIS | SMALL-MOLECULE INHIBITION | ras Proteins - genetics | Colonic Neoplasms - genetics | Proto-Oncogene Proteins p21(ras) | Pyridines - chemistry | Colonic Neoplasms - drug therapy | Humans | Substrate Specificity | DNA Breaks, Single-Stranded - drug effects | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | Phosphoric Monoester Hydrolases - biosynthesis | DNA Repair Enzymes - metabolism | Female | Antineoplastic Agents - pharmacology | DNA Repair Enzymes - antagonists & inhibitors | Homeostasis - drug effects | Aminoquinolines - pharmacology | DNA Repair Enzymes - chemistry | Disease Models, Animal | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Pyrazoles - pharmacology | Crystallization | Models, Molecular | Proto-Oncogene Proteins - genetics | Antineoplastic Agents - chemistry | Mice, SCID | Nucleotides - metabolism | Xenograft Model Antitumor Assays | Animals | Colonic Neoplasms - pathology | DNA Repair | DNA Repair Enzymes - biosynthesis | Proteomics | Protein Conformation | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Phosphoric Monoester Hydrolases - metabolism | Phosphoric Monoester Hydrolases - chemistry | Crizotinib | Enzymes | Colon cancer | Physiological aspects | Genetic aspects | Research | Nucleotides | Studies | Oxidative stress | Inhibitor drugs | Medical prognosis | Homeostasis | Mutation | Kinases | Experiments | Cancer | Index Medicus | Life Sciences | crizotinib | cancer | stereoselectivity | MTH1 | DNA repair | drug
Journal Article
Journal Article
Cell, ISSN 0092-8674, 2006, Volume 126, Issue 1, pp. 107 - 120
The p53 tumor-suppressor protein prevents cancer development through various mechanisms, including the induction of cell-cycle arrest, apoptosis, and the... 
CANCER-CELLS | GLUCOSE-6-PHOSPHATE-DEHYDROGENASE | ARREST | OXIDATIVE STRESS | ACTIVATION | PENTOSE-PHOSPHATE PATHWAY | GENE | GLUCOSE-METABOLISM | FRUCTOSE-2,6-BISPHOSPHATASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | P53 | CELL BIOLOGY | Reactive Oxygen Species - metabolism | Humans | DNA Repair - physiology | Cell Survival - genetics | Genomic Instability - physiology | Molecular Sequence Data | Apoptosis - genetics | Fructose-Bisphosphatase - isolation & purification | Proteins - isolation & purification | Tumor Suppressor Protein p53 - genetics | Phosphoric Monoester Hydrolases - isolation & purification | Fructosediphosphates - metabolism | Glycolysis - genetics | DNA Damage - physiology | Cell Transformation, Neoplastic - genetics | Base Sequence | Energy Metabolism - genetics | Chromosomes, Human, Pair 12 - genetics | Amino Acid Sequence | Phosphoric Monoester Hydrolases - genetics | Oxidative Stress - genetics | Tumor Suppressor Protein p53 - metabolism | Gene Expression Regulation - physiology | Intracellular Signaling Peptides and Proteins | Cell Transformation, Neoplastic - metabolism | Down-Regulation - physiology | Proteins - genetics | Fructose-Bisphosphatase - metabolism | Proteins - metabolism | Cell Line, Tumor | Signal Transduction - physiology | Fructose-Bisphosphatase - genetics | Phosphoric Monoester Hydrolases - metabolism | Glycolysis | Genetic research | Tumor suppressor genes | Research | Apoptosis | Prevention | Oncology, Experimental | Tumor proteins | Fructose | Cancer | Index Medicus
Journal Article
Journal Article